Abstracts Archive - Page 1191 of 2425 - ACR Meeting Abstracts

Abstract Number: 2798 • 2018 ACR/ARHP Annual Meeting
Expanded T-Cell Clones Are Present in the Synovium before the Clinical Onset of Rheumatoid Arthritis
Giulia Balzaretti^1,2,3, Paul L. Klarenbeek⁴, Marieke E. Doorenspleet⁵, Maria JH de Hair⁶, Barbera C.D. van Schaik⁷, Rebecca Esveldt², Marleen van de Sande¹, Danielle Gerlag⁸, Antoine H.C. van Kampen⁷, Frank Baas^2,9, Paul-Peter Tak¹⁰ and Niek de Vries^3,5, ¹Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Dept. of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Amsterdam Rheumatology and immunology Center | Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, ⁷Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁸GlaxoSmithKline, Stevenage, United Kingdom, ⁹Dept. of Genome Diagnostics, Leiden University, Leiden, Netherlands, ¹⁰GlaxoSmithKline, Cambridge, United Kingdom
Background/Purpose: In healthy individuals with arthralgia and RA-specific autoantibodies (so called at-risk individuals) the presence of expanded B-cell receptor (BCR) clones in peripheral blood (PB)…
Abstract Number: 2799 • 2018 ACR/ARHP Annual Meeting
Sjogren’s Syndrome Minor Salivary Gland CD4+ T Cells Associate with Oral Disease Features and Have a T Follicular Helper-like Transcriptional Profile
Michelle L. Joachims¹, Kerry M. Leehan¹, Mikhail Dozmorov^1,2, Zijian Pan¹, Astrid Rasmussen¹, Lida Radfar³, David M. Lewis⁴, Donald U. Stone^5,6, Kiely Grundahl⁷, R. Hal Scofield^1,8,9, Christopher J. Lessard¹, Jonathan Wren¹, Linda F. Thompson¹, Kathy L. Sivils¹⁰, Jacen Maier-Moore^1,11 and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Biostatistics, Virginia Commonwealth University, Richmond, VA, ³Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁸Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹¹Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX
Background/Purpose: The predominant salivary gland (SG) T cell types contributing to disease in Sjögren’s syndrome (SS) are unclear. This study assessed the frequency and number…
Abstract Number: 2800 • 2018 ACR/ARHP Annual Meeting
Adenosine 2a Receptor Signals Act to Limit Autoimmune Arthritis By Inhibiting Pathogenic Germinal Center T Follicular Helper (GC-Tfh) Cells
Shirdi Schmiel and Daniel L. Mueller, Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: CD4 germinal center (GC)-T follicular helper (Tfh) cells are important in the pathogenesis of autoimmune arthritis. Previous studies have shown that adenosine 2a receptor…
Abstract Number: 2801 • 2018 ACR/ARHP Annual Meeting
A Novel B-Cell-Helper IL-21-Producing CD8+ T Cell Subset Involved in the Pathogenesis of Rheumatoid Arthritis
Kazuhiko Higashioka¹, Masahiro Ayano¹, Yasutaka Kimoto², Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Koichi Akashi¹, Takahiko Horiuchi³ and Hiroaki Niro⁴, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: A plethora of evidence from genome-wide association studies and relevant animal models implicates a pivotal role of T cells in the pathogenesis of rheumatoid…
Abstract Number: 2802 • 2018 ACR/ARHP Annual Meeting
Risk of Ischemic Stroke in Veterans with Systemic Sclerosis: A Nationwide Cohort Study
David Ying^1,2, Milena Gianfrancesco¹, Laura Trupin¹, Jinoos Yazdany¹, Eric Greidinger^3,4 and Gabriela Schmajuk^2,5, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²San Francisco VA Medical Center, San Francisco, CA, ³Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL, ⁴Miami VA Medical Center, Miami, FL, ⁵Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA
Background/Purpose: Previously thought to involve primarily the microvasculature, systemic sclerosis (SSc) has been increasingly linked to macrovascular disease. Cardiovascular and cerebrovascular disease are responsible for…
Abstract Number: 2803 • 2018 ACR/ARHP Annual Meeting
48-Year Trends in Systemic Sclerosis Mortality in the United States, 1968-2015: Steady Decrease for 15 Years after 33 Years of Continuous Increase
Eric Yen, Devanshu Singh and Ram R. Singh, UCLA, Los Angeles, CA
Background/Purpose: A comprehensive evaluation of long-term trends in systemic sclerosis (SSc) mortality is important to understand the influence of recent advances in SSc management and…
Abstract Number: 2804 • 2018 ACR/ARHP Annual Meeting
Identifying Lupus Patients in Electronic Health Records: Development and Validation of Machine Learning Algorithms and Application of Rule-Based Algorithms
April Jorge¹, Victor M. Castro², April Barnado³, Vivian Gainer², Chuan Hong⁴, Tianxi Cai², Robert Carroll⁵, Leslie Crofford³, Karen Costenbader⁶, Katherine P. Liao⁷, Elizabeth Karlson⁶ and Candace H. Feldman⁶, ¹Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Research Information Systems and Computing, Partners Healthcare, Boston, MA, ³Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁴Harvard T.H. Chan School of Public Health, Boston, MA, ⁵Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Brigham and Women's Hospital, Boston, MA
Background/Purpose: To utilize electronic health records (EHR) to study SLE, phenotypic algorithms are needed to accurately identify these patients. We aimed to generate an EHR…
Abstract Number: 2805 • 2018 ACR/ARHP Annual Meeting
Association of Dietary Quality Scores and Incident SLE in the Nurses’ Health Studies
Medha Barbhaiya¹, Bing Lu², Sara K. Tedeschi², Cianna Leatherwood³, Jeffrey A. Sparks³, Elizabeth Karlson² and Karen Costenbader³, ¹Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: High intake of antioxidants, fruits/vegetables, nuts and legumes and low intake of sodium, sweetened beverages, and red/processed meats may reduce inflammatory biomarkers and decrease…
Abstract Number: 2806 • 2018 ACR/ARHP Annual Meeting
Childhood Physical and Sexual Abuse and Risk of Systemic Lupus Erythematosus Among African American Women
Medha Barbhaiya¹, Yvette Cozier², Nelsy Castro-Webb², Sara K. Tedeschi³, Cianna Leatherwood⁴, Lynn Rosenberg² and Karen Costenbader⁴, ¹Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Slone Epidemiology Center, Boston University, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: We and others have previously reported that post-traumatic stress disorder (PTSD) is associated with increased risk of developing SLE. We aimed to investigate the…
Abstract Number: 2807 • 2018 ACR/ARHP Annual Meeting
Association of Exposure to Childhood Abuse with Incident Systemic Lupus Erythematosus in a Longitudinal Cohort of Women
Candace H. Feldman¹, Susan Malspeis², Cianna Leatherwood¹, Laura Kubzansky³, Karen Costenbader¹ and Andrea Roberts⁴, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, ⁴Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Prior studies demonstrated associations between post-traumatic stress disorder and increased risk of incident SLE and between childhood trauma and increased risk of hospitalization for…
Abstract Number: 2808 • 2018 ACR/ARHP Annual Meeting
T-Score As an Indicator of Fracture Risk on Therapy: Evidence from Romosozumab Vs Alendronate Treatment in the Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk Trial
Felicia Cosman¹, E. Michael Lewiecki², Peter R Ebeling³, Eric Hesse⁴, Nicola Napoli⁵, Daria B Crittenden⁶, Maria Rojeski⁶, Wenjing Yang⁶, Cesar Libanati⁷ and Serge Ferrari⁸, ¹Columbia University, New York, NY, ²New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, ³Monash University, Melbourne, Australia, ⁴University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵Campus Bio-Medico University of Rome, Rome, Italy, ⁶Amgen Inc., Thousand Oaks, CA, ⁷UCB Pharma, Brussels, Belgium, ⁸Geneva University Hospital, Geneva, Switzerland
Background/Purpose: BMD is a strong predictor of fracture risk in untreated patients. Recent evidence suggests that BMD achieved during treatment also reflects fracture risk; thus,…
Abstract Number: 2809 • 2018 ACR/ARHP Annual Meeting
Skeletal Benefit/Risk of Long-Term Denosumab Therapy: A Virtual Twin Analysis of Fractures Prevented to Skeletal Safety Events Observed
Serge Ferrari¹, E. Michael Lewiecki², Peter W. Butler³, David L Kendler⁴, Nicola Napoli⁵, Shuang Huang³, Daria B Crittenden³, Nicola Pannacciulli³, E.S. Siris⁶ and Neil Binkley⁷, ¹Geneva University Hospital, Geneva, Switzerland, ²New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, ³Amgen Inc., Thousand Oaks, CA, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Campus Bio-Medico University of Rome, Rome, Italy, ⁶Columbia University Medical Center, New York, NY, ⁷University of Wisconsin–Madison Osteoporosis Clinical Center and Research Program, Madison, WI
Background/Purpose: Osteoporosis is a chronic disease, yet skeletal safety events—atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ)—remain a concern with long-term treatment. Ten…
Abstract Number: 2810 • 2018 ACR/ARHP Annual Meeting
Fracture and Bone Mineral Density Response By Baseline Risk in Patients Treated with Abaloparatide Followed By Alendronate
Benjamin Leder¹, Carol Zapalowski², Ming-Yi Hu³ and Gary Hattersley², ¹Endocrine, Harvard Medical School, Boston, MA, ²Radius Health, Inc., Waltham, MA, ³Biometrics, Radius Health, Inc., Waltham, MA
Background/Purpose: Abaloparatide (ABL) is an anabolic PTHrP analog approved to treat postmenopausal women with osteoporosis at high risk of fracture. In the ACTIVE Phase 3…
Abstract Number: 2811 • 2018 ACR/ARHP Annual Meeting
Abaloparatide Effect on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis Aged 80 Years or Older
Susan L. Greenspan¹, Lorraine A Fitzpatrick², Bruce Mitlak², Yamei Wang², Nicholas C. Harvey³, Chad Deal⁴, Felicia Cosman⁵ and Michael McClung⁶, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Radius Health, Inc., Waltham, MA, ³MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁴Cleveland Clinic, Shaker Heights, OH, ⁵Columbia University College of Physicians and Surgeons, New York, NY, ⁶Oregon Osteoporosis Center, Portland, OR
Background/Purpose: The risk of fracture increases with increasing age. Thus, it is important to understand efficacy and safety of osteoporosis treatments in elderly patients. In…
Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture
Mariana O Perez¹, Diogo S Domiciano¹, Luciene M Reis², Vanda Jorgetti² and Rosa M R Pereira¹, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ²Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…

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