ACR Meeting Abstracts

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  • Abstract Number: 2393 • 2018 ACR/ARHP Annual Meeting

    Is Methotrexate-Induced Nausea in Juvenile Idiopathic Arthritis Influenced By Anxiety or Coping Strategies?

    Nini Kyvsgaard1, Mikael Thastum2, Torben Mikkelsen1, Anne Estmann3 and Troels Herlin1, 1Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus N, Denmark, 2Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus C, Denmark, 3Department of Pediatric Rheumatology, H.C. Andersen's Children's Hospital, Odense, Denmark

    Background/Purpose: Nausea to low-dose methotrexate (MTX) is a significant clinical challenge in the treatment of juvenile idiopathic arthritis (JIA). There exists a large inter-individual variation…
  • Abstract Number: 2394 • 2018 ACR/ARHP Annual Meeting

    Anti-Adalimumab Antibodies Kinetics: An Early Guide for Juvenile Idiopathic Arthritis (JIA) Switching

    Juliana Brunelli1, Clovis A Silva1, Sandra G Pasoto2, Carla GS Saad2, Katia T. Kozu1, Elaine P Leon2, Margarete B Vendramini2, Nicole Fontoura2, Eloisa Bonfa3 and Nadia E Aikawa2, 1Pediatric Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, 2Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, 3Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Anti-adalimumab antibody (AAA) production may lead to reduced adalimumab (ADA) serum levels and therapy failure. There are, however, scarce and conflicting data regarding ADA…
  • Abstract Number: 2395 • 2018 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor-α Inhibitor (TNFi)-Induced Psoriasis: Prevalence and Response to Therapy in Patients with Juvenile Idiopathic Arthritis (JIA) in Two Children’s Hospitals

    Daniel Groth1, Maria Perez2, Simona Nativ3, James R. Treat4, Leslie Castelo-Soccio4, Pamela F. Weiss5, Marissa J. Perman4 and Sivia Lapidus3, 1Pediatrics, Goryeb Children's Hospital, Morristown, NJ, 2Pediatric Gastroenterology, Goryeb Children's Hospital, Morristown, NJ, 3Pediatric Rheumatology, Goryeb Children's Hospital, Morristown, NJ, 4Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, 5Division of Rheumatology, Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: The development of psoriasis while on TNFi is a paradoxical effect of agents that treat psoriasis and is described in larger cohorts inflammatory bowel…
  • Abstract Number: 2396 • 2018 ACR/ARHP Annual Meeting

    Reduction in the Utilization of Prednisone and/or Methotrexate Following the Initiation of Etanercept in Pediatric Patients

    Majed M M Khraishi1, Brad Millson2, John Woolcott3, Lisa Marshall4 and Heather Jones4, 1Memorial University of Newfoundland, St John's, NF, Canada, 2IQVIA, Kanata, ON, Canada, 3Global Outcomes & Evidence, Pfizer, Collegeville, PA, 4Pfizer, Collegeville, PA

     Background/Purpose: In Canada, the pediatric indications of etanercept (ETN) are active ankylosing spondylitis (AS), plaque psoriasis (PsO) and moderate to severely active juvenile idiopathic arthritis…
  • Abstract Number: 2397 • 2018 ACR/ARHP Annual Meeting

    The Impact of Adalimumab on Growth in Patients with Pediatric Enthesitis-Related Arthritis

    Rubén Burgos-Vargas1, Shirley M.L. Tse2, Kirsten Minden3, Pierre Quartier4, Jaclyn K. Anderson5, Kristina Unnebrink6, Ivan Lagunes Galindo5 and Gerd Horneff7, 1Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Charite University Medicine, Berlin, Germany, 4Hopital Necker-Enfants Malades, Paris, France, 5AbbVie Inc., North Chicago, IL, 6AbbVie Deutschland GmbH & Co., Ludwigshafen, Germany, 7Asklepios Clinic Sankt Augustin, and University Hospital of Cologne, Cologne, Germany

    Background/Purpose: Children with one or more subtypes of juvenile idiopathic arthritis, such as enthesitis-related arthritis (ERA), often exhibit growth impairments. The purpose of the analysis…
  • Abstract Number: 2398 • 2018 ACR/ARHP Annual Meeting

    Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of Their Juvenile Arthritis Category

    Dax G. Rumsey1, Jaime Guzman2, Alan Rosenberg3, Adam Huber4, Rosie Scuccimarri5, Natalie J. Shiff6, Alessandra Bruns7, Brian M. Feldman8 and Dean Eurich9, 1Paediatrics, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, 4Dalhousie University, Halifax, NS, Canada, 5Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, 6University of Florida, Gainesville, FL, 7Hospitalier de l’Universite de Sherbrooke, Sherbrooke, QC, Canada, 8Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 9University of Alberta, Edmonton, AB, Canada

    Background/Purpose: To estimate the impact of enthesitis on patient reported outcomes (PROs) in children with juvenile idiopathic arthritis (JIA), irrespective of their JIA category. Methods:…
  • Abstract Number: 2399 • 2018 ACR/ARHP Annual Meeting

    Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children with Arthritis)

    Ciarán M. Duffy1, Adam Baxter-Jones2, Leanne Ward3, Heather Macdonald4, Heather McKay4, Marta Erlandson2, Adam Huber5, Susanne Benseler6, Michele Gibbon7, Jaime Guzman8 and Lori Tucker8, 1Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, 2University of Saskatchewan, Saskatoon, SK, Canada, 3Department of Paediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 4University of British Columbia, Vancouver, BC, Canada, 5IWK Health Centre, Halifax, NS, Canada, 6Alberta Children's Hospital, Calgary, AB, Canada, 7Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 8BC Children's Hospital, Vancouver, BC, Canada

    Bone Density, Structure and Strength in Canadian Children and Youth with Juvenile Idiopathic Arthritis: The LEAP Study (Linking Exercise, Activity, and Pathophysiology in Canadian Children…
  • Abstract Number: 2400 • 2018 ACR/ARHP Annual Meeting

    Validating and Developing a Selected Questionnaire to Predict Early Diagnosis of Juvenile Idiopathic Arthritis in German Population

    Tristan Scheer1, Jens Klotsche2, Claudio A. Len3 and Ivan Foeldvari4, 1Asklepios Campus Hamburg, Semmelweis University Budapest, Hamburg, Germany, 2Program Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, 3Pediatric Rheumatology Unit, Federal University of São Paulo (UNIFESP - Universidade Federal de São Paulo), São Paulo,, Brazil, 4Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatologic disease in children and adolescents with a prevalence of 1:1000 children in Germany.…
  • Abstract Number: 2401 • 2018 ACR/ARHP Annual Meeting

    The Effects of a Gluten-Free Diet in Juvenile Idiopathic Arthritis – a Pilot Study

    Anjali Sura1, Stacey Fogarty-Brown2 and Meredith Riebschleger3, 1Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, 2Pediatrics, University of Michigan, Ann Arbor, MI, 3Pediatric Rheumatology & Health Services Research, University of Michigan, Ann Arbor, MI

    Background/Purpose: The caregivers of children with juvenile idiopathic arthritis (JIA) frequently ask about the utility of dietary restrictions. Some patients and physicians report a good…
  • Abstract Number: 2402 • 2018 ACR/ARHP Annual Meeting

    Acoustic Emissions Generated By the Temporomandibular Joint of Patients with Juvenile Idiopathic Arthritis and Their Implication on Patient Assessment and Screening: A Pilot Study

    Daniel Whittingslow1,2, Hyeon Ki Jeong3, Talia Gergely4, Lori Ponder4, Sampath Prahalad5, Omer Inan3 and Shelly Abramowicz6, 1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, 4Emory University, Atlanta, GA, 5Pediatrics, Emory University, Atlanta, GA, 6Surgery, Emory University/Children's Healthcare of Atlanta, Atlanta, GA

    Background/Purpose: The temperomandibular joint (TMJ) is one of the most commonly affected joints in juvenile idiopathic arthritis (JIA) (up to 45% of cases). There is a discrepancy between…
  • Abstract Number: 2403 • 2018 ACR/ARHP Annual Meeting

    The Therapeutic Alliance Is Associated with a Better Therapeutic Adherence in Children with Juvenile Idiopathic Arthritis: Results of a French Multicenter Study

    Valérie Devauchelle-Pensec1, Anne Lohse2, Francis Guillemin3, Elisabeth Solau-Gervais4, Linda Rossi-Semerano5, Agnès Duquesne6, Irène Lemelle7, Pascal Pillet8, Claire Ballot9, Laurence Goumy10, Tu Anh Tran11, Laeticia Sparsa12, Heloise Reumaux13, Anaïs Arbault14 and Camille Alleyrat15, 1Rheumatology, CHU Brest, Brest, France, 2Rheumatology Department, Hopital Nord Franche Comté, Belfort, France, 3Université de Lorraine, EA4360, APEMAC, Nancy, France, 4Service de Rhumatologie, CHRU de Poitiers, Poitiers, France, 5Paediatric Rheumatology, Hôpital Kremlin Bicêtre, PARIS, France, 64Department of Nephrology-Rheumatology-Dermatology Pediatric - Rheumatology, Hopital Femme-Mère-Enfant, Bron, France, 7Department of pediatric onco-hematology, CHU de Nancy - Hôpitaux de Brabois,, Vandœuvre-Lès-Nancy, France, 8Paediatrics, Hôpital Pellegrin, University Hospital of Bordeaux, Bordeaux, France, 9Department of Pediatric Rheumatology, Hôpital Jean-Minjoz, Besançon, France, 10Pediatric, CHU d'Angers, Angers, France, 11Paediatrics, University Hospital, Nîmes, Nîmes, France, 12Rheumatology, Hopital Emile Muller, Mulhouse, France, 13Pediatric Rheumatology, CHRU Lille, Lille, France, 14Rheumatology, CHU de Dijon, Dijon, France, 15134 Inserm CIC-1433 Clinical Epidemiology, CHRU de Nancy, Hôpitaux de Brabois, Nancy, France

    Background/Purpose: The therapeutic compliance (TC) is a major issue for the management of Juvenile Idiopathic Arthritis (JIA). The chronic nature of this inflammatory rheumatism requires…
  • Abstract Number: 2404 • 2018 ACR/ARHP Annual Meeting

    Quality of Life Assessment in Juvenile Idiopathic Arthritis: A Single Center Assessment

    W. Blaine Lapin1, Taylor Phillips2, Danielle Guttman-Lapin3, Amanda Brown4, Eyal Muscal5 and Filiz O. Seeborg1, 1Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 2Rice University, Houston, TX, 3Aldine Independent School District, Aldine, TX, 4Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Baylor College of Medicine, houston, TX, 5Department of Pediatrics, Division of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, TX

    Background/Purpose: Patients with Juvenile Idiopathic Arthritis (JIA) face physical, social, and emotional issues that affect their quality of life. Health-related quality of life (HRQoL) is…
  • Abstract Number: 2405 • 2018 ACR/ARHP Annual Meeting

    Health-Related Quality of Life, Functioning, and Mental Health of Children with Chronic Non-Infectious Uveitis

    Joseph McDonald1, Curtis Travers2, Courtney McCracken2, Steven Yeh3, Kelly A. Rouster-Stevens4, Patricia Vega-Fernandez4, Elaine Ramsay4, Sampath Prahalad4, Carolyn Drews-Botsch5 and Sheila Angeles-Han6, 1Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Pediatrics, Emory University School of Medicine, Atlanta, GA, 3Ophthalmology, Emory University School of Medicine, Atlanta, GA, 4Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, 5Epidemiology, Emory University School of Public Health, Atlanta, GA, 6Rheumatology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH

    Background/Purpose: Pediatric chronic non-infectious uveitis can lead to ocular complications and vision loss. The ophthalmic clinical exam is primarily used to assess uveitis outcomes but…
  • Abstract Number: 2406 • 2018 ACR/ARHP Annual Meeting

    Clinical Presentation, Management and Long Term Outcome of Pars Planitis (PP), Panuveitis (PU) and Vogt–Koyanagi–Harada Disease (VKH) in Children and Adolescents

    Andreas Reiff, Children’s Hospital of Los Angeles, Los Angeles, CA

    Background/Purpose: Chronic uveitis is a common manifestation of pediatric rheumatologic conditions and may result in irreversible blindness and long term disability. While chronic anterior uveitis…
  • Abstract Number: 2407 • 2018 ACR/ARHP Annual Meeting

    New Onset of Uveitis in Non-Methotrexate Group, Methotrexate Group and Etanercept Group in Juvenile Idiopathic Arthritis

    Mikhail Kostik, Ekaterina Gaidar, Maria Likhacheva, Eugenia Isupova, Irina Chikova, Margarita Dubko, Vera Masalova, Tatiana Likhacheva, Ludmila Snegireva, Tatiana Kornishina, Olga Kalashnikova and Vyacheslav Chasnyk, Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, Russian Federation

    Background/Purpose: Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA), often entirely asymptomatic but could be sight-threatening. The most often prescribed biologics…
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