Abstracts Archive - Page 1154 of 2425 - ACR Meeting Abstracts

Abstract Number: 2242 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Outcomes of Treatment with Febuxostat and Allopurinol in Gout Patients with Kidney Disease
William B. White¹ and Lhanoo Gunawardhana², ¹Cardiology, University of Connecticut School of Medicine, Farmington, CT, ²Takeda Pharmaceuticals International, Deerfield, IL
Background/Purpose: The Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Gout and Cardiovascular Comorbidities (CARES) trial demonstrated that major cardiovascular (CV) outcomes on febuxostat…
Abstract Number: 2243 • 2018 ACR/ARHP Annual Meeting
Sex Difference of the Association between Serum Urate and Blood Pressure in Young Adults
Angelo Gaffo¹, Elizabeth J. Rahn², Tanja Dudenbostel¹, Amy S. Mudano¹, Peng Li³, David T. Redden³, Stephanie Biggers¹, Phillip J. Foster², Paul M. Muntner⁴, Suzanne Oparil⁵, David A. Calhoun⁵ and Kenneth Saag¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Serum urate (sUA) has been associated with blood pressure in most but not all studies. This study aims to test whether there are sex…
Abstract Number: 2244 • 2018 ACR/ARHP Annual Meeting
Comparison of an Interactive Voice Response (IVR) to Smart Phone App to Determine Patient Preference for Reporting Gout Flares
Nada Elmagboul¹, Brian W Coburn², Kenneth Saag¹, Phillip J. Foster³, Amy S. Mudano¹, Joshua A. Melnick⁴, Debra A Bergman², Shuo Yang¹, David T. Redden⁵, Lang Chen¹, Filby Cooper¹, Jeffrey R. Curtis¹ and Ted R. Mikuls⁶, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Gout flares are a major cause of morbidity and are an important outcome in clinical studies. Significant limitations for timely flare ascertainment exist, and…
Abstract Number: 2245 • 2018 ACR/ARHP Annual Meeting
Lubricin/Proteoglycan 4 (PRG4) Inhibits NLRP3 Inflammasome Assembly in Monosodium Urate (MSU)-Crystal Induced Arthritis.
Anthony M. Reginato¹, Changqi Sun², Elsaid A. Khaled³, Tannin A. Schmidt⁴, Olin D. Liang⁵ and Gregory D Jay⁶, ¹Division of Rheumatology, Rhode Island Hospital, Providence, RI, ²Division of Rheumatology, Rhode Island Hospital, Providence, MA, ³Department of Biomedical and Phramaceutical Science, Chapman University School of Pharmacy, Irvine, CA, ⁴Biomedical Engineering, University of Connecticut Health Center, Framington, CT, ⁵Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, ⁶Department of Emergency Medicine, Rhode Island Hospital, Providence, RI
Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocytes. PRG4 has a multifaceted homeostatic role in the joint including…
Abstract Number: 2246 • 2018 ACR/ARHP Annual Meeting
Insulin: Genetic and Physiological Influences on Human Uric Acid Homeostasis
David B. Mount¹, Tony R. Merriman² and Asim Mandal¹, ¹Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²University of Otago, Dunedin, New Zealand
Background/Purpose: Insulin plays a key role in the genesis of hyperuricemia. In particular, hyperinsulinemia in metabolic syndrome is inversely correlated with urinary uric acid (UA)…
Abstract Number: 2247 • 2018 ACR/ARHP Annual Meeting
Predictors of End-Stage Renal Disease (ESRD) in Gout Patients and General Population (GP) Controls – a Role for Interstitial Nephritis, Urate Nephropathy?
Martin Joelsson¹, Lennart Jacobsson¹ and Mats Dehlin², ¹Dept of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden, ²Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Decreased renal excretion of urate is an established risk factor for hyperuricemia, whereas it is less clear if hyperuricemia or gout predict impaired kidney…
Abstract Number: 2248 • 2018 ACR/ARHP Annual Meeting
Genetic Variants Identify Interleukin 37 As an Important Anti-Inflammatory Cytokine in Gout in Humans
Viola Klück¹, Rosanne C. van Deuren¹, Amara Shaukat², Maartje Cleophas¹, Tania O. Crisan³, Nicola Dalbeth⁴, Lisa K. Stamp⁵, Tim Jansen⁶, Matthijs Janssen⁶, Alexander Hoischen¹, Frank van de Veerdonk⁷, Mihai Netea¹, Charles Dinarello⁸, Elan Z. Eisenmesser⁹, Vassili Kalabokis¹⁰, Soohyun Kim¹¹, Tony R. Merriman¹² and Leo .A.B. Joosten¹, ¹Experimental Internal Medicine, Radboud Institute of Molecular Life Sciences, Nijmegen, Netherlands, ²University of Otago, Dunedin, New Zealand, ³Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, ⁴Bone Rsch Grp/Dept of Med, University of Auckland, Auckland, New Zealand, ⁵Department of Medicine, University of Otago, Christchurch, New Zealand, ⁶VieCuri Medical Center, Venlo, Netherlands, ⁷Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ⁸Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ⁹Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, ¹⁰R&D Systems, BioTechne, Inc., Minneapolis, MN, ¹¹Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea, Republic of (South), ¹²Department of Biochemistry, School of Medical Sciences, University of Otago, Dunedin, New Zealand
Background/Purpose: During a gout flare monosodium urate (MSU) crystals induce, in the presence of a secondary stimulus, acute joint inflammation characterized by the recruitment of…
Abstract Number: 2249 • 2018 ACR/ARHP Annual Meeting
Not Just a Swollen Big Toe: Increasing All-Cause Hospitalizations in Patients with Gout in the United States: 1993–2014
Gurkirpal Singh¹ and Alka Mithal², ¹Stanford University School of Medicine, Woodside, CA, ²ICORE, Woodside, CA
Background/Purpose: Gout is a disorder of uric acid metabolism and often presents as acute severe joint pain. However, several recent studies have highlighted systemic complications…
Abstract Number: 2250 • 2018 ACR/ARHP Annual Meeting
Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with Svp-Rapamycin
Pallavi Kolte, Robert LaMothe, Joseph Ferrari, Sheldon Leung, Wesley DeHaan Ph.D., Earl Sands and Takashi Kei Kishimoto, Selecta Biosciences, Watertown, MA
Background/Purpose: Initiation of urate-lowering therapies is typically associated with an increase in gout flares due to mobilization of pro-inflammatory urate crystals. SEL-212 is a novel…
Abstract Number: 2251 • 2018 ACR/ARHP Annual Meeting
Calcific Tendonitis of the Rotator Cuff: Do We Need Steroid Injection after Ultrasound Guided Percutaneous Lavage? Results of a 12-Months Double-Blind Randomized Controlled Study
Christelle Darrieutort-Laffite¹, Stéphane Varin², Guillaume Coiffier³, Jean-David Albert³, Gregoire Cormier² and Benoit Le Goff¹, ¹Rheumatology, Nantes University Hospital, Nantes, France, ²Rheumatology, La Roche-Sur-Yon Hospital, La Roche-Sur-Yon, France, ³Rheumatology, Rennes University Hospital, Rennes, France
Background/Purpose: Rotator cuff calcific tendinopathy is a common condition causing up to 20% of the painful shoulder. Ultrasound-guided percutaneous lavage (UGPL) is indicated after failure…
Abstract Number: 2252 • 2018 ACR/ARHP Annual Meeting
Serum Urate Ant Its Clearance in Patients with Chronic Kidney Disease Under Peritoneal Dialysis
Claudia Diez¹, Javier Pérez-Contreras^1,2 and Mariano Andrés^1,3, ¹Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ²Servicio de Nefrología, Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Hyperuricemia and gout are common in patients with chronic kidney disease (CKD), some ultimately requiring replacement therapy. Serum urate (SU) levels appear to achieve…
Abstract Number: 2253 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Disease, Other Purported Risk Factors, and Allopurinol-Associated Severe Cutaneous Adverse Reactions: A General Population-Based Cohort Study
Na Lu¹, Chio Yokose², Hui Xie^1,3, Gloria Li¹, Sharan K. Rai^4,5, Seoyoung C. Kim⁶ and Hyon K. Choi², ¹Arthritis Research Canada, Richmond, BC, Canada, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ³Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁴Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, ⁶Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: A recent US Medicaid study found that in addition to certain races (Asians and Blacks), older age, female sex, chronic kidney disease (CKD), and…
Abstract Number: 2254 • 2018 ACR/ARHP Annual Meeting
Update of SEL-212 Phase 2 Clinical Data in Symptomatic Gout Patients: Svp-Rapamycin Combined with Pegadricase Mitigates Immunogenicity and Enables Sustained Reduction of Serum Uric Acid Levels, Low Rate of Gout Flares and Monthly Dosing
Earl Sands¹, Alan J. Kivitz², Wesley DeHaan Ph.D.¹, Lloyd Johnston¹ and Takashi Kei Kishimoto¹, ¹Selecta Biosciences, Watertown, MA, ²Altoona Center for Clinical Research, Duncansville, PA
Background/Purpose: Pegylated uricases are promising therapies for the treatment of severe chronic gout, but are limited by their immunogenicity. We have previously shown that synthetic…
Abstract Number: 2255 • 2018 ACR/ARHP Annual Meeting
Increased Cost Burden in an Early Diagnosed Cohort of Uncontrolled Versus Controlled Gout: Analysis of a Large US Payer Database
Brian LaMoreaux¹, Megan Francis-Sedlak² and Robert J Holt², ¹Horizon Pharma USA, Inc, Lake Forest, IL, ²Horizon Pharma USA, Inc., Lake Forest, IL
Background/Purpose: Gout is a progressive systemic inflammatory disease that is widely prevalent, estimated to effect 3.9% or 8.3 million people of the United State (US)…
Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting
Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics
Milena Rodriguez Alvarez¹, Su Zhaz Leon¹, Fernando Cuascut², Naureen Kabani³, Joshy Pathiparampil³, Kristaq Koci⁴, Manjeet Bhamra⁵, Latoya Freeman⁴, Alexandra Kreps⁶, Justin Levinson⁶, Sophia Francis⁶, Vinodkumar Velayndhan⁶, Steve Xie⁷, Abhimanyu Amarnani⁶, Helen Valsamis⁸, Yaacov Anziska⁶, Ellen M. Ginzler⁹ and Isabel M. McFarlane⁹, ¹Rheumatology, SUNY Downstate, Brooklyn, NY, ²Neurology, SUNY Downstate, Brooklyn, NY, ³Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁴Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ⁵Medicine, SUNY Downstate, Brooklyn, NY, ⁶SUNY Downstate, Brooklyn, NY, ⁷NYC Health + Hospitals Kings County, Brooklyn, NY, ⁸Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, ⁹Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…

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