Abstracts Archive - Page 1102 of 2425 - ACR Meeting Abstracts

Abstract Number: 1461 • 2018 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase-4 Antibodies Are Not Associated with Worse RA Activity, Symptoms or Impacts
Dana DiRenzo¹, Erika Darrah², Susan J. Bartlett^3,4, Clifton O. Bingham III⁴ and Laura C. Cappelli¹, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine/Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Antibodies to peptidylarginine deiminase (PAD) enzymes have been implicated in the pathogenesis of RA. Previous studies have shown that patients with PAD4 antibodies…
Abstract Number: 1462 • 2018 ACR/ARHP Annual Meeting
Fibrin Deposition and Neutrophil Infiltration of Rheumatoid Arthritis Synovium Are Associated with Duration of Morning Stiffness
Dana Orange¹, Caroline Jiang¹, Edward F. DiCarlo², Tania Pannellini³, Laura T. Donlin⁴, Serene Z. Mirza⁵, Mark P. Figgie⁶, Vivian P. Bykerk⁷, Ana-Maria Orbai⁸, Sarah Mackie⁹ and Susan M. Goodman³, ¹Rockefeller University, New York, NY, ²Laboratory Medicine, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Surgery, Hospital for Special Surgery, New York, NY, ⁷Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Johns Hopkins University School of Medicine, Baltimore, MD, ⁹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom
Background/Purpose: Stiffness is a hallmark of RA, but little is known about the etiology. We investigated stiffness association with RA disease activity and determined whether…
Abstract Number: 1463 • 2018 ACR/ARHP Annual Meeting
Do Anti-Citrullinated Protein Antibodies and Anti-Sjögren’s-Syndrome-Related Antigen a Double Positive Patients with Secondary Sjögren’s Syndrome and RA Have Higher Joint Disease Activity?
Evo Alemao¹, Yogesh Saini², Ying Bao¹, Aarti Rao², Christine K Iannaccone³, Michelle Frits³, Michael E Weinblatt³ and Nancy A. Shadick³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is considered an extra-articular manifestation of RA and is an autoantibody-mediated condition similar to RA. Thus, patients (pts) with sSS…
Abstract Number: 1464 • 2018 ACR/ARHP Annual Meeting
Newer Generation Cyclic Citrullinated Peptide (CCP) 3.1 Assay in the Diagnosis of Rheumatoid Arthritis
James Son¹, Lindsy J. Forbess² and Mariko Ishimori³, ¹Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ²Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (CCP) are important serum markers used in clinical diagnosis of rheumatoid arthritis (RA). Multiple studies have…
Abstract Number: 1465 • 2018 ACR/ARHP Annual Meeting
Absolute Number of Regulatory T Cells Decreased While Osteopontin Increased in Peripheral Blood of New Onset Patients with Rheumatoid Arthritis
Jianfang Xie¹, Jiao-Jiao He², Xiao-Feng Li³ and Chong Gao⁴, ¹the second hospital of shanxi medical university, taiyuan, China, ²The Second Hospital of Shanxi Medical Univerity, Taiyuan, China, ³Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA
Background/Purpose: Rheumatoid arthritis (RA) is a progressive immune-mediated disease involving the synovitis that can culminate in joint destruction and early mortality.IL-17-producing T (Th17) cells and…
Abstract Number: 1466 • 2018 ACR/ARHP Annual Meeting
Altered Count of NK Cells and Non-Classical Monocyte Subpopulation in the Pre-Clinical Phase of Rheumatoid Arthritis
Klára Prajzlerová¹, Olga Kryštůfková², Petra Hánová¹, Hana Hulejová³, Monika Gregová⁴, Karel Pavelka⁴, Jiri Vencovsky¹, Ladislav Šenolt⁵ and Mária Filková¹, ¹Department of Rheumatology, First Faculty of Medicine, Charles University and Rheumatology Institute, Prague, Czech Republic, Prague, Czech Republic, ²Department of Rheumatology, First Faculty of Medicine, Charles University and Rheumatology Institute, Prague, Czech Republic, prague, Czech Republic, ³Rheumatology Institute, Prague, Czech Republic, Prague, Czech Republic, ⁴Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁵First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are detectable long before the manifestation of rheumatoid arthritis (RA). EULAR provided a clinical definition of individuals with arthralgia suspicious…
Abstract Number: 1467 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Activity Monitoring and Multiplex Biomarker Verification By Tageted Proteomics
Lucía González-Rodríguez¹, Valentina Calamia¹, Patricia Fernández², Cristina Ruiz-Romero³, Antonio Julià⁴, Antonio Fernández-Nebro⁵, Jesús Tornero⁶, Sara Marsal⁴ and Francisco J Blanco³, ¹Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Proteomics group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, La Coruña, Spain, ³Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴Rheumatology Research Group, Vall d’Hebron Hospital Research Institute, Barcelona, Spain., Barcelona, Spain, ⁵UGC Reumatología, Instituto de Investigación Biomédica (IBIMA), Hospital Regional Universitario de Málaga, Spain., Málaga, Spain, ⁶Hospital Universitario Guadalajara, Guadalajara, Spain., Guadalajara, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a long-lasting inflammatory autoimmune disorder that ultimately leads to the destruction of joint architecture. The activity of this disease is…
Abstract Number: 1468 • 2018 ACR/ARHP Annual Meeting
Minor Salivary Gland Biopsy: Its Importance in Rheumatoid Arthritis and Secondary Sjögren’s Syndrom
Maria Florencia Rodriguez¹, Cristian Troitiño², Emmanuel Guerra³, Fernando Melo⁴, Anastasia Secco⁵, Natalia Tamborenea³, María Victoria Martire⁶ and Marta Mamani⁴, ¹Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ²Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ³Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ⁶Instituto Médico Platense, La Plata, Argentina
Background/Purpose: Secondary Sjögren's Syndrome (sSS) is a common extraarticular manifestation in patients with Rheumatoid Arthritis (RA). According to the 2002 European American criteria (EA 2002)…
Abstract Number: 1469 • 2018 ACR/ARHP Annual Meeting
Measurement of Anti-Amyloid β Autoantibodies in Patients with Rheumatoid Arthritis
Masao Sato¹, Masao Takemura², Tomohisa Tani³ and Toshiro Ohashi³, ¹R, Ohashi-Tani Orthopaedic, Gifu, Japan, ²Advanced Diagnostic System Research Laboratory, Fujita Health University, Toyoake, Japan, ³Ohashi-Tani Orthopaedic, Gifu, Japan
Background/Purpose: Amyloid β (Aβ) accumulation in the brain is a risk factor for Alzheimer's disease (AD). The incidence of AD increases with age. Rheumatoid arthritis…
Abstract Number: 1470 • 2018 ACR/ARHP Annual Meeting
Russell Bodies and Serological Status in Rheumatoid Arthritis
Michael A. McNamara¹, Susan M. Goodman², Laura T. Donlin³, Dana Orange⁴, Serene Z. Mirza¹, Jackie Szymonifka², Mark P. Figgie⁵, Vivian P. Bykerk² and Edward F. DiCarlo⁶, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁴Rockefeller University, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY, ⁶Laboratory Medicine, Hospital for Special Surgery, New York, NY
Russell Bodies and Serological Status in Rheumatoid Arthritis Background/Purpose: Russell bodies (RBs) are globular aggregates of immunoglobulin produced by plasma cells and identified both within…
Abstract Number: 1471 • 2018 ACR/ARHP Annual Meeting
ECV304 Cells Self-Citrullinate Proteins Targeted By Anti-Citrullinated Protein/Peptide Autoantibodies from Rheumatoid Arthritis Patients
Natalia Regine de Franca Shimabukuro^1,2, Maximilien Lora¹, Mariana Useche³, Zhijie Zhou⁴, Joyce Rauch⁵, Luis Eduardo Coelho Andrade², Henri Menard¹ and Ines Colmegna⁶, ¹The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Federal University of São Paulo, São Paulo, Brazil, ³Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Aurora Medical Centre, Oshkosh, WI, ⁵Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁶The Research Institute of the McGill University Health Centre, Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada
Background/Purpose: Anti-citrullinated protein/peptide autoantibodies (ACPAs) define a major subset of rheumatoid arthritis (RA) patients. Cyclic citrullinated peptides (CCP) are commonly used as the antigen for…
Abstract Number: 1472 • 2018 ACR/ARHP Annual Meeting
Preliminary Analysis of Genetic Variants in the Immune System Related to the Body Mass Index in Early Arthritis Patients
Pablo Moreno Fresneda¹, Nuria Montes², Javier Martin³, David Carmona⁴, Carmen Martinez⁵, Rosa P Gomariz⁶, Amalia Lamana², Ana Triguero-Martinez⁷, Ana M. Ortiz Garcia⁸ and Isidoro Gonzalez-Alvaro⁹, ¹Rheumatology Division, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain, ²Rheumatology, HU La Princesa, Madrid, Spain, ³Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain, ⁴Genetics, Universidad de Granada, Granada, Spain, ⁵Cellular Biology, School of Medicine. Universidad Complutense de Madrid, Madrid, Spain, ⁶Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ⁷Rheumatology Service, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa, Madrid, Spain, ⁸Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁹Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain
Background/Purpose: We have observed in previous analyzes in our early arthritis (EA) cohort that patients with a higher body mass index (BMI) are, more frequently,…
Abstract Number: 1473 • 2018 ACR/ARHP Annual Meeting
Performance of the Meso Scale Multiplex Platform in the Assessment of Serum Cytokines / Chemokines in Rheumatoid Arthritis
Peter M. Maloley¹, Bryant R. England², Harlan Sayles¹, Geoffrey M. Thiele¹, Michael J. Duryee³, Jeffrey Payne⁴ and Ted R. Mikuls⁵, ¹University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, ⁵Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cytokines and chemokines (CK) are central to RA pathogenesis, a fact underscored by the emergence of multiplex immunoassays for quantifying CK values in both…
Abstract Number: 1474 • 2018 ACR/ARHP Annual Meeting
Circulating Transfer RNA-Derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis
Qiong Wu, Quanhu Sheng, Joseph F. Solus, Kasey Vickers, Ryan Allen, Shilin Zhao, Yan Guo, Fei Ye, C Michael Stein and Michelle J. Ormseth, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Small RNAs (sRNAs) are important gene regulators and markers of disease. Transfer RNA (tRNA)-derived sRNAs (tDRs), including tRNA fragments (tRFs) and halves (tRHs), are…
Abstract Number: 1475 • 2018 ACR/ARHP Annual Meeting
Eicosanoid Mediators of Systemic Inflammation and Arthritis in the Elderly
Roxana Coras^1,2, Rekha Narasimhan¹, Arthur Kavanaugh³, Lourdes Mateo⁴, Oswald Quehenberger⁵, Melania Martinez-Morillo⁶ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³University of California, San Diego, School of Medicine, La Jolla, CA, ⁴Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵Pharmacology, Medicine, University of California San Diego, La Jolla, CA, ⁶Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain
Background/Purpose: Elderly-onset RA, EORA, which is defined as rheumatoid arthritis (RA) starting at >60 years of age, has received less attention than young-onset RA. Polymyalgia rheumatica (PMR) is…

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