Abstracts Archive - Page 1090 of 2425 - ACR Meeting Abstracts

Abstract Number: 1281 • 2018 ACR/ARHP Annual Meeting
Association of HFE Genotypes with Clinical Severity in Patients with Definite Calcium Pyrophosphate Arthritis
Fernando Perez-Ruiz^1,2,3 and Joana Atxotegi⁴, ¹BioCruces Health Research Institute, Barakaldo, Spain, ²Rheumatology Division, Hospital Universitario Cruces, Baracaldo, Spain, ³University of the Basque Country (UPV/EHU), Bilbao, Spain, ⁴Rheumatology Division, Cruces University Hospital, Barakaldo, Spain
Background/Purpose: several metabolic disturbances that reduce the activity of pyrophosphatases have been associated with development of pyrophosphate arthritis (PPA), but there is scarce data on…
Abstract Number: 1282 • 2018 ACR/ARHP Annual Meeting
Influence of Renal Function on the Velocity of Tophus Resolution and Achievement of Disease Remission in Patients with Chronic Refractory Gout Treated with Pegloticase
Brian F. Mandell¹, Naomi Schlesinger², N. Lawrence Edwards³, Anthony Yeo⁴ and Peter E. Lipsky⁵, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ³Rheumatology, University of Florida Health Science Center, Gainesville, FL, ⁴Horizon Pharma, Lake Forest, IL, ⁵AMPEL BioSolutions, Charlottesville, VA
INFLUENCE OF RENAL FUNCTION ON THE VELOCITY OF TOPHUS RESOLUTION AND ACHEIVEMENT OF DISEASE REMISSION IN PATIENTS WITH CHRONIC REFRACTORY GOUT TREATED WITH PEGLOTICASEBackground/Purpose: Impaired…
Abstract Number: 1283 • 2018 ACR/ARHP Annual Meeting
Calcium Pyrophosphate Crystal Deposition in a Cohort of 48 Patients with Gitelman Syndrome
Emilie Chotard¹, Anne Blanchard², Gilles Gailly¹, Rosa Vargas-Poussou³ and Hang-Korng Ea^4,5, ¹AP-HP, Hôpital Lariboisière, service de rhumatologie, centre Viggo Petersen, PARIS, France, ²AP-HP, Hôpital Européen Georges Pompidou, Service de néphrologie, PARIS, France, ³AP-HP, Hôpital Européen Georges Pompidou, Service de génétique, PARIS, France, ⁴AP-HP, Hôpital Lariboisière, service de rhumatologie, centre Viggo Petersen, Paris, France, ⁵INSERM UMR1132, Bioscar, University Paris Diderot, PARIS, France
Background/Purpose: Gitelman syndrome (GS) is a rare recessively inherited tubulopathy, caused by inactive mutations in SLC12A3 gene encoding the thiazide-sensitive-sodium-chloride transporter. It is characterized by…
Abstract Number: 1284 • 2018 ACR/ARHP Annual Meeting
Initial Pegloticase Serum Levels Predict Persistent Responsiveness in Patients with Chronic Refractory Gout
Kenneth Saag¹, Mitchell Feinman², Herbert S. B. Baraf³, Roy Fleischmann⁴, Arthur Kavanaugh⁵ and Peter E. Lipsky⁶, ¹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²ACME Research, LLC, Orangeburg, SC, ³Arthritis and Rheumatism Associates, Wheaton, MD, ⁴Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, ⁵University of California, San Diego, School of Medicine, La Jolla, CA, ⁶AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Pegloticase is a pegylated recombinant mammalian uricase approved for treatment of persons with chronic gout refractory to standard urate lowering therapy1. Despite an initial…
Abstract Number: 1285 • 2018 ACR/ARHP Annual Meeting
Comparision of Urate Burden in Well and Poorly Controlled Gout Patients: A Dual-Energy CT Study
Min Kyung Chung¹, Hyeran Hyun², Ji Young Hwang² and Jisoo Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea, Republic of (South)
Background/Purpose: Dual-energy computed tomography (DECT) allows sensitive and quantative detection of monosodium urate (MSU) crystals in patients with gout. Although its usefulness in diagnosing gout…
Abstract Number: 1286 • 2018 ACR/ARHP Annual Meeting
Pretreatment and Coadministration with Methotrexate Improved Durability of Pegloticase (Krystexxa) Response: A Prospective, Proof-of-Concept, Case Series
John Botson¹ and Jeff Peterson², ¹Orthopedic Physicians Alaska, Anchorage, AK, ²Western Washington Arthritis Clinic, Bothell, WA
Background/Purpose: Pegloticase is a recombinant DNA-produced porcine-like uricase enzyme which metabolizes relatively insoluble urate to highly soluble allantoin. It is used in the treatment of…
Abstract Number: 1287 • 2018 ACR/ARHP Annual Meeting
Strong Impact of Dysfunctional Variants of ABCG2 on Hyperuricemia and Gout in Children and Adolescents
Blanka Stiburkova^1,2, Katerina Pavelcova^1,3, Marketa Pavlikova¹ and Karel Pavelka⁴, ¹Institute of Rheumatology, Prague, Czech Republic, ²Department of Pediatrics and Adolescent Medicine, Charles University and General University Hospital in Prague, First Faculty of Medicine, Prague, Czech Republic, ³Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Na Slupi 4, Institute of Rheumatology, Prague, Czech Republic
Background/Purpose: Common dysfunctional variants of ABCG2, a high-capacity urate transporter gene, that result in decreased urate excretion, are major causes of hyperuricemia and gout. However,…
Abstract Number: 1288 • 2018 ACR/ARHP Annual Meeting
Association between Musculoskeletal Ultrasonography and Bone Remodeling Markers and the Role of Ultrasonography on Monitoring Treatment Responsiveness in Patients with Gout and Hyperuricemia
Ya-dan Zou^1,2, Ya-nan Fei¹, Hui Gao³, Lin-feng Xie¹, Yu-chao Zhong¹ and Xuewu Zhang³, ¹Peking University People's Hospital, Beijing, China, ²Peking University International Hospital, Beijing, China, ³Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: Musculoskeletal ultrasonography (US) is an invasive method to identify gout related bone damage, while Dickkopf-1 (DKK-1) and receptor activator of nuclear factor-κB ligand（RANKL）are bone…
Abstract Number: 1289 • 2018 ACR/ARHP Annual Meeting
Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplant Population
Andrew Milgroom¹, Mara Onita Lenco¹, Kevin Francis¹, Jeffrey D. Kent², Brian LaMoreaux³ and Brian F. Mandell⁴, ¹Trinity Partners, Waltham, MA, ²Medical Affairs, Horizon Pharma USA, Inc, Lake Forest, IL, ³Horizon Pharma USA, Inc, Lake Forest, IL, ⁴Rheumatology, Cleveland Clinic, Cleveland, OH
Background/Purpose: Gout is a frequent co-morbidity of solid organ transplant (SOT). Cyclosporine (CsA) is often cited as the main cause of gout in SOT, as…
Abstract Number: 1290 • 2018 ACR/ARHP Annual Meeting
Systemic Inflammation and Atherosclerosis in Patients with Gout. Results from the NOR-Gout Study
Silvia Rollefstad¹, Till Uhlig^2,3, Lars Fridtjof Karoliussen³, Hilde B. Hammer⁴ and Anne Grete Semb⁵, ¹Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²University of Oslo, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Systemic inflammation and atherosclerosis in patients with gout. Results from the NOR-Gout studyBackground/Purpose: The association between gout and cardiovascular disease (CVD) is well known, whereas…
Abstract Number: 1291 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Anakinra in Congestive Heart Failure Patients, Including Lvad, with Acute Gouty Arthritis: A Retrospective Study of 36 Patients at an Academic Medical Center
Arash Hassantoufighi¹, Paloma Alejandro², Christopher E. Collins², Florina Constantinescu² and Juhi Bhargava³, ¹Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, washington, DC, ²Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ³Internal Medicine, MedStar Washington Hospital Center/Georgetown University Medical Center, washington, DC
Background/Purpose: Gout is the most common inflammatory arthritis worldwide and many patients with gout are ‘complicated’ by multiple comorbidities including metabolic syndrome, renal disease and…
Abstract Number: 1292 • 2018 ACR/ARHP Annual Meeting
HLA-B*58:01 Genotype and the Risk of Allopurinol-Associated Severe Cutaneous Adverse Reactions in a Predominately Black or African American Population with Advanced Chronic Kidney Disease
Sarah Ford¹, Pamela Kimball¹, Gaurav Gupta¹ and Nehal Shah², ¹Virginia Commonwealth University, Richmond, VA, ²Medicine/Rheumatology, Virginia Commonwealth University, Richmond, VA
Background/Purpose: Allopurinol is the first line urate lowering drug used for treatment of gout. Its most feared side effect includes development of hypersensitivity drug reactions…
Abstract Number: 1293 • 2018 ACR/ARHP Annual Meeting
Identification of New and Rare Variants in ABCG2, SLC22A1 and ALDH16A1 Genes in Crystal-Proven Early-Onset Gout
Corinne Collet¹, Hélène Morel¹, Manon Ricquebourg¹, Martine Cohen-Solal², Jean-Louis Laplanche¹, Tristan Pascart³, Thomas Bardin⁴, Frederic Liote⁵, Pascal Richette⁶ and Hang-Korng Ea⁷, ¹biochemistry, Laribosiere hospital, Paris, France, ²INSERM UMR1132, Paris Diderot University, Paris, France, ³Rheumatology, Groupe Hospitalier de l'Institut Catholique de Lille, Lomme, France, ⁴Rheumatology, Hôpital Lariboisière, Paris, France, ⁵University Paris Diderot, Paris, France, ⁶Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, ⁷INSERM UMR1132, Bioscar, University Paris Diderot, PARIS, France
Background/Purpose: Early-onset or juvenile gout (EOG) without hypoxanthine-guanine phosphoribosyltransferase enzyme deficiency (HPRT, OMIM 300323) and not related to familial juvenile hyperuricemic nephropathy (UMOD, OMIM 300323)…
Abstract Number: 1294 • 2018 ACR/ARHP Annual Meeting
Initial Phase 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin Enables Sustained Reduction of Acute Gout Flares
Rehan Azeem¹, Alan J. Kivitz², Earl Sands¹, Wesley DeHaan Ph.D.³, Lloyd Johnston³ and Takashi Kei Kishimoto³, ¹Selecta Biosciences, Inc, Watertown, MA, ²Altoona Center for Clinical Research, Duncansville, PA, ³Selecta Biosciences, Watertown, MA
Background/Purpose: Pegylated uricases are therapies for treatment of severe chronic gout, particularly for rapid tophi resolution. However, uricases are limited by induction of anti-drug antibodies…
Abstract Number: 1295 • 2018 ACR/ARHP Annual Meeting
Anakinra Is More Effective at Reducing Pain from Acute Crystal Induced Arthritis When Compared to Conventional Therapy: A Retrospective Review at a Tertiary Care Center
Sukhraj Singh¹, Anthony Ocon², Vivek Mehta³, Samah Musa¹ and Ruben Peredo², ¹Internal Medicine, Albany Medical Center, Albany, NY, ²Medicine, Albany Medical Center, Albany, NY, ³Division of Rheumatology, Department of Medicine, Albany Medical College, Albany, NY
Background/Purpose: The management of Acute Crystal-Induced Arthritis (ACIA) relies on NSAIDs, colchicine, and glucocorticoids as conventional therapy. In presence of comorbidities (e.g. renal insufficiency, diabetes…

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