Abstracts Archive - Page 1085 of 2607 - ACR Meeting Abstracts

Abstract Number: 2174 • 2019 ACR/ARP Annual Meeting
Test-Retest Reliability and Validity of a Mobile Health Application to Automate the 30 Seconds Chair Stand Test – Preliminary Data to Create a Contemporary Instrument for Randomized Clinical Trials
Lucas Dantas¹, Matthew Harkey ², André Dantas ³, Lori Lyn Price ⁴, Jeffrey Driban ⁵ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³CI&T, Tokyo, Japan, ⁴Tufts Medical Center, Tufts University, Boston, MA, ⁵Tufts Medical Center, Boston
Background/Purpose: Contemporary technologies offer potential solutions to improve and automate data collection of randomized clinical trials by transitioning assessments from the clinic to the real-world.…
Abstract Number: 2175 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of the Anti-ADAMTS-5 Nanobody®, M6495, in Healthy Male Subjects: A Phase I, Placebo-Controlled, First-in-Human Study
Hans Guehring¹, Torben Balchen ², Kosalaram Goteti ³, Jesper Sonne ⁴, Christoph Ladel ¹, Victor Ona ¹, Flavie Moreau ⁵, Anne Bay-Jensen ⁶ and Asger Reinstrup Bihlet ⁶, ¹Merck KGaA, Darmstadt, Germany, ²DanTrials ApS c/o Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ³EMD Serono Research and Development Institute, Inc., Billerica, MA, ⁴Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁵EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁶Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is a serious disease characterized by progressive joint failure and cartilage degeneration. In OA, ADAMTS-5 protease is upregulated, resulting in enhanced cleavage…
Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting
A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Matthew Harkey ², Lori Lyn Price ³, Grace Lo ⁴, Jincheng Pang ⁵, Ming Zhang ⁶ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³Tufts Medical Center, Tufts University, Boston, MA, ⁴Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁵Pfizer, Inc., Cambridge, MA, ⁶Tufts Medical Center, Wentworth Institute of Technology, Boston, MA
Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
Abstract Number: 2177 • 2019 ACR/ARP Annual Meeting
Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews¹, Laura Gold ¹, Michael Nevitt ², Patrick Heagerty ¹ and Peggy Cawthon ³, ¹University of Washington, Seattle, ²University of California at San Francisco, San Francisco, CA, ³University of California San Francisco, San Francisco
Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults. Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes…
Abstract Number: 2178 • 2019 ACR/ARP Annual Meeting
Associations Between Baseline and Longitudinal Quantitative Joint Space Width and Incident Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Jacquelyn Smith¹, Carolina Alvarez ¹, Liubov Arbeeva ¹, Jordan Renner ², Louise Murphy ³, Joanne Jordan ¹, Yvonne Golightly ⁴, Jeffrey Duryea ⁵ and Amanda Nelson ¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ³Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁴University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: To quantify associations between baseline and change in computer-assisted hip quantitative joint space width (qJSW) with incident radiographic (rHOA) or symptomatic (sxHOA) hip OA.Methods:…
Abstract Number: 2179 • 2019 ACR/ARP Annual Meeting
Erosive Hand Osteoarthritis, Metabolic Syndrome and Knee Osteoarthritis: A Cross-sectional Study Using Data from the PROCOAC Cohort
Natividad Oreiro¹, Ignacio Rego-Pérez ¹, Maria T. Silva ¹, Sara Relaño ¹, Mercedes Fernandez-Moreno ², Paula Ramos-Louro ¹, Alejandro Duran-Sotuela ¹, Sonia Pertega ³ and Francisco J. Blanco ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Erosive hand osteoarthritis (EOA) is often considered a more severe form of hand OA. However, more data are needed regarding this phenotype to conclude…
Abstract Number: 2180 • 2019 ACR/ARP Annual Meeting
High Molecular Weight Intraarticular Hyaluronic Acid for the Treatment of Knee Osteoarthritis: A Network Meta-Analysis
Charles Hummer ¹, Felix Angst ², Emil Schemitsch ³, Craig Whittington ⁴, Colleen Manitt ⁵ and Wilson Ngai⁶, ¹Premier Orthopaedics and Sports Medicine, Media, PA, ²Research Department, Rehabilitation Clinic (‘RehaClinic’), Bad Zurzach, Switzerland, ³London Health Sciences Centre, London, Ontario, Canada, ⁴Doctor Evidence, Santa Monica, CA, ⁵International Centre for Professional Development in Health and Medicine, Quebec, Canada, ⁶Sanofi, U.S. Medical Affairs, Bridgewater
Background/Purpose: The 2013 American Academy of Orthopaedic Surgeons (AAOS) clinical practice guideline (CPG) on the treatment of knee OA made a strong recommendation not in…
Abstract Number: 2181 • 2019 ACR/ARP Annual Meeting
Natural Disease Progression in Hand Osteoarthritis: Results from a Belgian Ten-years Prospective Cohort Study
Lisa Pardaens ¹, Tine Vanhaverbeke ¹, Jordy Vandercruyssen ¹ and Ruth Wittoek², ¹Ghent University, Gent, Belgium, ²Ghent University Hospital, Gent University, Gent, Belgium
Background/Purpose: Limited evidence is available about natural disease progression in hand osteoarthritis (HOA). A previous study of the Ghent HOA cohort showed a positive association…
Abstract Number: 2182 • 2019 ACR/ARP Annual Meeting
Relation of MRI-detected Structural Damage in the Knee to Anterior Knee Pain: The MOST Study
Joshua Stefanik¹, Tuhina Neogi ², Mohamed Jarraya ³, Ali Guermazi ⁴, Irina Tolstykh ⁵, John Lynch ⁶, James Torner ⁷, Cora Lewis ⁸ and Erin Macri ⁹, ¹Northeastern University, Boston, ²Boston University School of Medicine, Boston, MA, ³Mercy Catholic Medical Center, Darby, ⁴Boston Medical Center, Boston, ⁵UCSF, San Francisco, ⁶University of California at San Francisco, San Francisco, CA, ⁷University of Iowa at Iowa City, Iowa City, ⁸UAB, Birmingham, ⁹Erasmus MC, Rotterdam, Netherlands
Background/Purpose: Discordance between knee osteoarthritis (OA) and knee pain is common yet not well understood. Specifically, anterior knee pain (AKP) is widely held to be…
Abstract Number: 2183 • 2019 ACR/ARP Annual Meeting
Relation of Intra-Articular Knee Mineralization on CT to Knee Pain in People with or at Risk of Knee Osteoarthritis
Tuhina Neogi¹, John Lynch ², Mohamed Jarraya ³, David Felson ⁴, Na Wang ¹, Michael Nevitt ², James Torner ⁵, Beth Lewis ⁶ and Ali Guermazi ¹, ¹Boston University School of Medicine, Boston, MA, ²University of California at San Francisco, San Francisco, CA, ³Mercy Catholic Medical Center, Darby, ⁴Boston University School of Medicine, Department of Rheumatology, Boston, ⁵University of Iowa at Iowa City, Iowa City, ⁶University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA), particularly in end-stage disease. It is possible that low-grade inflammation related to crystals…
Abstract Number: 2184 • 2019 ACR/ARP Annual Meeting
A Flexion Contracture Is a Risk Factor for Radiographic Progression and Earlier Need for Arthroplasty in Knee Osteoarthritis: Data from the Osteoarthritis Initiative
T Mark Campbell¹ and Dennis McGonagle ², ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²University of Leeds, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis. Knee OA is often accompanied by a knee flexion contracture (FC), but the impact of…
Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Frank Roemer ², Erin Ashbeck ³, ChengCheng Hu ¹, Edward Bedrick ¹, Leena Sharma ⁴ and Ali Guermazi ⁵, ¹University of Arizona, Tucson, AZ, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁴Northwestern University, Chicago, IL, ⁵Boston Medical Center, Boston
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…
Abstract Number: 2186 • 2019 ACR/ARP Annual Meeting
What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Jing Song ¹, David Cella ², Abigail Gilbert³, Rowland Chang ² and Dorothy Dunlop ², ¹Northwestern University Feinberg School of Medicine, Worthington, OH, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the…
Abstract Number: 2187 • 2019 ACR/ARP Annual Meeting
A Low Cartilage Formation & Repair Endotype Predicts Radiographic Progression in Symptomatic Knee Osteoarthritis Patients and Identifies Optimal Responders to a Potential OA Treatment
Yunyun Luo ¹, Jonathan Samuels ², Svetlana Krasnokutsky ³, Inger Byrjalsen ¹, Jeppe Andersen ⁴, Asger Bihlet ⁵, Yi He ¹, Morten Karsdal ⁶, Steven Abramson ⁷, Mukundan Attur ³ and Anne Bay-Jensen¹, ¹Nordic Bioscience, Herlev, Denmark, ²NYU Langone Medical Center, New Yort, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Nordic Bioscience, Clinical development, Herlev, Denmark, ⁵Nordic Bioscience Clinical Development, Herlev, Denmark, ⁶Nordic Bioscience, Copenhagen, Denmark, ⁷NYU School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Osteoarthritis (OA) is a highly heterogeneous disease, which suggest that multiple endotypes exist. Identification and characterization of such endotypes may assist in precision medicine…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…

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