Abstract Number: 1026 • 2018 ACR/ARHP Annual Meeting
Autoinflammatory Diseases, Particularly SAVI and Candle, Are Driven By Chronically Active Type I Interferons
Background/Purpose: STING Associated Vasculopathy with onset in Infancy (SAVI)is caused by gain-of-function mutations in TMEM173/STING and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature…Abstract Number: 1027 • 2018 ACR/ARHP Annual Meeting
A Novel IL-1 Mediated Autoinflammatory Disease Caused By a Specific Gain-of-Function Mutation in Dysferlin
Background/Purpose: Genetically defined IL-1 mediated autoinflammatory diseases are caused by monogenic defects that regulate inflammasome activity. By whole exome sequencing (WES) analysis we identified one…Abstract Number: 1028 • 2018 ACR/ARHP Annual Meeting
An Entheseal Innate Immune Cell Biological Basis for Differential Efficacy of PDE4 and IL-23 Pathway Blockade between Psoriatic Disease and Rheumatoid Arthritis
Background/Purpose: Both IL-23 and phosphodiesterase (PDE) 4 inhibition are ineffective in RA but show efficacy in PsA-related synovitis despite similar cytokine and molecular profiles between…Abstract Number: 1029 • 2018 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes As Immune Effectors in the Pathogenesis of Synovial Lesion in Antibiotic-Refractory Lyme Arthritis
Background/Purpose: Antibiotic-refractory Lyme arthritis (LA) is characterized by marked proliferative synovitis that persists for months-to-years after oral and IV antibiotic therapy for Borrelia burgdorferi. Although…Abstract Number: 1030 • 2018 ACR/ARHP Annual Meeting
Parenteral Injection of Human Adipose-Derived Mesenchymal Stem Cells Attenuates Inflammation in an Acute Model of Gouty Arthritis
Background/Purpose: The regenerative and immunomodulatory properties of Adipose-Derived Mesenchymal Stem Cells (ASCs) make them a potential therapeutic approach for the treatment of chronic inflammatory diseases,…Abstract Number: 1031 • 2018 ACR/ARHP Annual Meeting
Orally Administered Cherry Juice Inhibits Localized Nfκb Activity and Histopathological Infiltrates in a Murine Model of Gout
Background/Purpose: Gout is caused by the inflammation induced from the precipitation of monosodium urate (MSU) crystals in joints and is the most common inflammatory arthritis…Abstract Number: 1032 • 2018 ACR/ARHP Annual Meeting
Aberrant Sarcoplasmic Expression of the Alarmin ‘High Mobility Group Box Protein 1” (HMGB1) in Patients with Idiopathic Inflammatory Myopathy
Background/Purpose: Components of the innate immune system, such a High Mobility Group Box Protein 1 (HMGB1), may contribute to the initiation, perpetuation and resolution of…Abstract Number: 1033 • 2018 ACR/ARHP Annual Meeting
Comparison of Oral Administration of Diacerein, Intra-Articular Injection of Diacerein Solution, and Intra-Articular Injection of Diacerein-Loaded Nanoparticle in Osteoarthritis Rat Model
Background/Purpose: Osteoarthritis (OA) treatment is typically administered to control symptoms. Diacerein (DIA) reduces interleukin (IL)-1 receptor on chondrocytes and prevents structural degradation of joint tissue.…Abstract Number: 1034 • 2018 ACR/ARHP Annual Meeting
A Conplastic Mice Model of Aging Reveals That Mitochondrial DNA Variation Influences the Process of Joint Deterioration
Background/Purpose: Different studies showed interesting genetic associations between mtDNA haplogroups and OA-related features, including prevalence, incidence and progression of the disease. The aim of this…Abstract Number: 1035 • 2018 ACR/ARHP Annual Meeting
Different Cartilage-Bone Unit in Patients with Primary Osteoarthritis and Secondary Osteoarthritis Caused By Rheumatoid Arthritis
Background/Purpose: Despite distinct aetiologies of joint diseases, the osteoarthritic end-stage of primary osteoarthritis (OA) and rheumatoid arthritis (RA) are described using similar radiological features. However,…Abstract Number: 1036 • 2018 ACR/ARHP Annual Meeting
Effects of Three Potential Anabolic Disease-Modifying Osteoarthritis Drugs – Sprifermin, Insulin-like Growth Factor 1 and Bone Morphogenetic Protein 7 – on Matrix Production and the Phenotype of Articular Chondrocytes
Background/Purpose: Disease-modifying osteoarthritis drugs with an anabolic mode of action should stimulate the growth of new hyaline cartilage. For instance, recombinant human fibroblast growth factor…Abstract Number: 1037 • 2018 ACR/ARHP Annual Meeting
Develop an in Vitro Model to Test the Different Behavior of mtDNA in OA and Healthy Patients, Based on Mitochondrial Activity and Metabolic Response
Background/Purpose: Mitochondrial dysfunction is well documented in OA and has the capacity to alter chondrocyte function and viability, contributing to cartilage degeneration. Several studies have…Abstract Number: 1038 • 2018 ACR/ARHP Annual Meeting
Tenofovir, a Nucleoside Analog Reverse Transcriptase Inhibitor for Treatment of HIV, Promotes Osteoclast Differentiation and Decreases Osteoblast Formation By a Mechanism Depending on ATP Release and Adenosine
Background/Purpose: Human Immunodeficiency Virus (HIV) infection devastates the immune system but also affects tissues and organs such as kidney, liver, central nervous system, heart and…Abstract Number: 1039 • 2018 ACR/ARHP Annual Meeting
Tenofovir Induces Osteopenia and Dipyridamole, an Inhibitor of the Ent-1 Nucleoside Transporter, Reverses the Osteopenic Effect of Tenofovir In Vivo
Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, one of the most commonly used antivirals in HIV, also leads to increases…Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting
The Potential Role of Choline Kinase Alpha in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
ACR Meeting Abstracts