ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1035

Different Cartilage-Bone Unit in Patients with Primary Osteoarthritis and Secondary Osteoarthritis Caused By Rheumatoid Arthritis

Rasmus Klose-Jensen1, Anne Friesgaard Christensen2, Kresten Krarup Keller3 and Ellen-Margrethe Hauge3,4, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus C, Denmark, 2Department of Internal Medicine, Lillebaelt Hospital, Vejle, Vejle, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus, Denmark, 4Clinical medicine, Department of Clinical Medicine, Aarhus University Hospital, Århus N, Denmark

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: cartilage, histopathologic, Osteoarthritis, rheumatoid arthritis (RA) and subchondral bone

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, October 22, 2018

Session Title: Osteoarthritis and Joint Biology – Basic Science Poster I

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Despite distinct aetiologies of joint diseases, the osteoarthritic end-stage of primary osteoarthritis (OA) and rheumatoid arthritis (RA) are described using similar radiological features. However, primary and secondary osteoarthritis may be different at the cartilage-bone unit depending on the pathogenesis. Therefore, the main purpose was to investigate the histological differences in the cartilage-bone unit of the hip joint in patients with primary OA and patients with secondary OA due to RA.

Methods:

Femoral heads were obtained during arthroplasty from twelve patients with primary OA and six patients with secondary OA due to RA. The primary OA patients mean(SD) age was 62(5) years and consisted of six males and six females. The RA patients had a mean age of 63(3) years and consisted of three males and three females. The entire femoral heads were investigated, using design-based stereology methods that utilise random, systematic sampling to provide unbiased and quantitative data. The volume and thickness of the articular cartilage, calcified cartilage and subchondral bone plate were obtained. Osteophytes were, however, studied based on simple area measurements. Data were normalised if not normally distributed, and statistical significance was tested using Student’s t-test.

Results:

Units

Osteoarthritis (n = 12)

Rheumatoid arthritis (n = 6)

P-value

Femoral head Volume#

cm3

21.8 [18.6-25.0]

20.6 [16.8-24.4]

0.60

Articular Cartilage Volume*

cm3

2.4 [2.0-3.0]

1.3 [0.8-2.3]

0.04

Articular Cartilage Thickness#

µm

1134.1 [930.7-1337.6]

721.4 [403.3-1039.5]

0.02

Subchondral bone thicknessº

µm

406.2 [285.3-527.1]

408.6 [185.8-631.5]

0.98

Calcified cartilage thickness*

µm

119.3 [94.1-151.3]

56.6 [25.3-126.5]

0.01

Osteophyte area*

mm2

70.9 [41.4-121]

49.2 [4.7-513]

0.66

*Data are presented as geometric mean and [95% confidence interval]. #Data are presented as mean and [95% confidence interval]. The results were considered significant at P < 0.05.

Conclusion:

Patients with RA had thinner articular and calcified cartilage but were otherwise not significantly different compared with OA patients. Thus, the inflammatory joint in RA was associated with a more pronounced loss of cartilage than the degenerative joint disease in primary osteoarthritis. The increased thickness of calcified cartilage in primary osteoarthritis has been attributed to endochondral ossification, which does not seem to be the case in RA.


Disclosure: R. Klose-Jensen, None; A. F. Christensen, None; K. K. Keller, Pfizer, Inc., 9; E. M. Hauge, AbbVie Inc., 5,UCB, Inc., 5,Roche, 2, 9,Novartis, Inc, 2,MSD, 5, 9,Sobi, 2, 9,Pfizer, Inc., 9,Celgene Corporation, 9.

To cite this abstract in AMA style:

Klose-Jensen R, Christensen AF, Keller KK, Hauge EM. Different Cartilage-Bone Unit in Patients with Primary Osteoarthritis and Secondary Osteoarthritis Caused By Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/different-cartilage-bone-unit-in-patients-with-primary-osteoarthritis-and-secondary-osteoarthritis-caused-by-rheumatoid-arthritis/. Accessed May 26, 2022.
  • Tweet
  • Email
  • Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/different-cartilage-bone-unit-in-patients-with-primary-osteoarthritis-and-secondary-osteoarthritis-caused-by-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.