Abstracts Archive - Page 1048 of 2607 - ACR Meeting Abstracts

Abstract Number: 1618 • 2019 ACR/ARP Annual Meeting
Factors Associated with Damage Accrual in SLE Patients with No Clinical or Serological Disease Activity
Diane Apostolopoulos¹, Rangi Kandane-Rathnayake ¹, Worawit Louthrenoo ², Shue Fen Luo ³, Yeong-Jian Wu ³, Aisha Lateef ⁴, Vera Golder ¹, Sargunan Sockalingam ⁵, Sandra Navarra ⁶, Leonid Zamora ⁷, Laniyati Hamijoyo ⁸, Yasuhiro Katsumata ⁹, Masayoshi Harigai ⁹, Madelynn Chan ¹⁰, Sean O'Neill ¹¹, Fiona Goldblatt ¹², Chak Sing Lau ¹³, Alberta Hoi ¹⁴, Mandana Nikpour ¹⁵ and Eric Morand ¹⁶, ¹Monash University, Melbourne, Australia, ²Chiang Mai University Hospital, Chiang Mai, Thailand, ³Chang Gung Memorial Hospital, Guishan, Taiwan (Republic of China), ⁴National University Hospital, Singapore, Singapore, ⁵University of Malaya, Kuala Lumpur, Malaysia, ⁶University of Santo Tomas Hospital, Manila, Philippines, ⁷Santo Tomas Hospital, Manila, Philippines, ⁸Padjadjaran University, Bandung, Indonesia, ⁹Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan, ¹⁰Tan Tock Seng Hospital, Singapore, Singapore, ¹¹University of NSW, Ingham Institute of Applied Medical Research, Sydney, Australia, ¹²Royal Adelaide Hospital, Adelaide, Australia, ¹³Hong Kong University, Hong Kong, Hong Kong, ¹⁴School of Clinical Sciences, Monash University, Meloburne, Victoria, Australia, ¹⁵St Vincent's Hospital, Melbourne; The University of Melbourne, Melbourne, Australia, ¹⁶Monash University, Melbourne, Victoria, Australia
Background/Purpose: Accrual of irreversible organ damage is a major risk factor for death in SLE. While unmodifiable factors, such as age at disease onset and…
Abstract Number: 1619 • 2019 ACR/ARP Annual Meeting
Early Vascular Ageing as a Predictor of Future Cardiovascular Events and Mortality in Systemic Lupus Erythematosus Patients: A Prospective Cohort Study
Viola Signorini¹, Dina Zucchi ², Chiara Tani ³, Rosa Maria Bruno ⁴, Elena Elefante ³, Chiara Stagnaro ⁵, Linda Carli ³, Alice Parma ³, Francesco Ferro ⁶, Sabina Armenia ⁷, lorenzo Ghiadoni ⁸, Stefano Taddei ⁷ and Marta Mosca ³, ¹Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, pisa, Toscana, Italy, ²Rheumatology Unit. Department of clinical and experimental medicine, University of PIsa, Pisa, Toscana, Italy, ³Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁴Hypertension Unit, Department of clinical e experimental medicine, University di Pisa, Pisa, Italy, ⁵Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ⁷Hypertension Unit, Department of clinical and experimental medicine, University of Pisa, pisa, Italy, ⁸Emergency Unit, Department of clinical and experimental medicine, University of Pisa, pisa, Italy
Background/Purpose: Systemic Lupus Erithematosus (SLE) is associated with increased cardiovascular (CV) risk compared with general population; an accelerated atherosclerosis is considered the main underlying mechanism.…
Abstract Number: 1620 • 2019 ACR/ARP Annual Meeting
T-cell Exhaustion in Prolonged Remission SLE Patients
Francisco Treviño-Tello¹, Guadalupe Lima ¹, Juan Jakez-Ocampo ², Luis Llorente ¹, Yemil Atisha-Fregoso ¹ and Hilda Fragoso-Loyo ³, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, ³Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico
Background/Purpose: Cellular exhaustion is a cellular dysfunction characterized by the progressive loss of the effector function, and an increased expression of multiple inhibitory receptors. Exhaustion…
Abstract Number: 1621 • 2019 ACR/ARP Annual Meeting
The Impact of Disease Activity and Related Factors on Cognitive Dysfunction in SLE
Erik Anderson¹, Elisabeth Ploran ², Joseph Hong ³, Betty Diamond ⁴, Bruce Volpe ⁵, Cynthia Aranow ⁶ and Meggan Mackay ⁷, ¹Northwell Health System, Feinstein Institute for Medical Research, New York, ²Hofstra University, Hempstead, ³Northwell Health System, Feinstein Institute for Medical Research, Manhasset, ⁴Feinstein Institutes for Medical Research, Manhasset, ⁵Feinstein Institutes for Medical Research, Manhasset, NY, ⁶Feinstein Institute for Medical Research, Manhasset, NY, ⁷Feinstein Institute for Medical Research, New York
Background/Purpose: Attribution of cognitive dysfunction (CD) to SLE is compromised by potential confounders. Studies reveal conflicting results on the relationship between CD and disease activity,…
Abstract Number: 1622 • 2019 ACR/ARP Annual Meeting
Cognitive Impairments in SLE Negatively Related to Participation and Quality of Life: A Systematic Review
Sofia Alfred¹, Lina Khoja ¹, Melanie Anderson ², Zahi Touma ³ and Lisa Engel ⁴, ¹University of Toronto, Toronto, Canada, ²University Health Network, Toronto, Canada, ³University Health Network, University of Toronto, Toronto, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems. Approximately 33 to 43% of individuals with SLE experience cognitive impairments…
Abstract Number: 1623 • 2019 ACR/ARP Annual Meeting
Mortality in a SLE Inception Cohort of Hispanic Patients
Maria del Carmen Zamora Medina¹, Jessica Roldan Ortega ², Mario Cesar Ocampo Torres ³, Pilar Lara Reyes ¹, Ivon Bautista Mejia ¹, Alba Cicero Casarrubias ¹ and Juanita Romero-Diaz ⁴, ¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, Mexico, ²Monterrey Institute of Technology and Higher Education, MEXICO CITY, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, ⁴Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico
Background/Purpose: To determine mortality and identify risk factors for mortality at 10 years in a mexican-mestizo SLE inception cohort at a tertiary care center in…
Abstract Number: 1624 • 2019 ACR/ARP Annual Meeting
Progression and Factors Associated with Damage Accrual in a SLE Inception Cohort of Hispanic Patients
Maria del Carmen Zamora Medina¹, Jessica Roldan Ortega ², Mario Cesar Ocampo Torres ³, Pilar Lara Reyes ¹, Alba Cicero Casarrubias ¹, Ivon Bautista Mejia ¹ and Juanita Romero-Diaz ⁴, ¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, Mexico, ²Monterrey Institute of Technology and Higher Education, MEXICO CITY, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, ⁴Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico
Background/Purpose: The aims of our study were to determine the cumulative prevalence of damage at baseline, 5 years and 10 years of follow-up, to identify…
Abstract Number: 1625 • 2019 ACR/ARP Annual Meeting
Severe Infection Prior to Diagnosis of Systemic Lupus Erythematosus (SLE) Is Associated with Disease-Specific Attributes and Long-Term Comorbidities
Yu Deng ¹, Anh Chung ², Abel Kho ¹, Yuan Luo ¹, Rosalind Ramsey-Goldman ² and Theresa Walunas², ¹Northwestern University, Chicago, ²Northwestern University, Chicago, IL
Background/Purpose: Lupus is a systemic autoimmune disease whose mechanism of development is largely unknown. Prior infection is a suspected sentinel event that may trigger disease…
Abstract Number: 1626 • 2019 ACR/ARP Annual Meeting
Baseline Serum Osteopontin (OPN) Level Is Associated with Early Coronary Artery-calcification and Its Progression in Patients with Systemic Lupus Erythematosus
Mario Cesar Ocampo Torres ¹, Elizabeth Olivares-Martinez ² and Juanita Romero-Diaz³, ¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, ²Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico
Background/Purpose: Background/purpose Premature atherosclerosis has been recognized as a major cause of morbidity and mortality in SLE patients. We aimed to determine 1) the incidence…
Abstract Number: 1627 • 2019 ACR/ARP Annual Meeting
Bronchoalveolar Lavage Fluid Analysis and Mortality Risk in Systemic Lupus Erythematosus Patients with Pneumonia and Respiratory Failure
Chien-Chih Lai¹, Yi-Syuan Sun ¹ and Chang-Youh Tsai ², ¹Division of Allergy, Immunology, Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan (Republic of China), ²Division of Allergy, Immunology & Rheumatology/Taipei Veterans General Hospital, Taipei, Taiwan (Republic of China)
Background/Purpose: To evaluate the pathogens from bronchoalveolar lavage fluid (BALF) and risk factors of mortality in SLE patients with pneumonia and respiratory failure.Methods: Twenty-four SLE…
Abstract Number: 1628 • 2019 ACR/ARP Annual Meeting
Lung Function Decline in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the SENSCIS Trial: Subgroup Analysis by Time Since First Non-Raynaud Symptom
Aryeh Fischer¹, Oliver Distler ², Dinesh Khanna ³, Yannick Allanore ⁴, Anna Maria Hoffmann-Vold ⁵, Gabriele Valentini ⁶, Toby Maher ⁷, Martin Aringer ⁸, Leslie Meng ⁹, Margarida Alves ¹⁰, Martina Gahlemann ¹¹, Manuel Quaresma ¹⁰ and Masataka Kuwana ¹², ¹University of Colorado School of Medicine, Denver, Colorado, USA, Denver, CO, ²Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ³Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ⁴Dept. of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, Paris, France, ⁵Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, Napoli, Italy, ⁷National Heart and Lung Institute, Imperial College London, UK and National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK, London, United Kingdom, ⁸Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany, Dresden, Germany, ⁹Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA, Ridgefield, ¹⁰Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, ¹¹Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, ¹²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Interstitial lung disease (ILD) is a common and usually early manifestation of systemic sclerosis (SSc). Decline in lung function in patients with SSc-ILD is…
Abstract Number: 1629 • 2019 ACR/ARP Annual Meeting
Significance of Abnormal Nailfold Videocapillarscopy Among Patients with Raynaud’s Phenomenon And/or Suspected Connective Tissue Disease: A Cross-Sectional Single-Center US Experience
Yasser Radwan¹, Tina Gunderson ², Cynthia Crowson ³, Alicia Hinze ¹, Kevin Moder ⁴, Floranne Ernste ⁴, Shreyasee Amin ⁴, Uma Thanarajasingam ², Thomas Osborn ¹, Kenneth Warrington ⁴, Paul Wennberg ⁴ and Ashima Makol ¹, ¹Mayo Clinic Minnesota, rochester, MN, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic Rochester, rochester, MN
Background/Purpose: Nailfold videocapillaroscopy (NVC) is a simple, non-invasive & highly sensitive tool to evaluate structural abnormalities of the microcirculation in vivo and considered a key…
Abstract Number: 1630 • 2019 ACR/ARP Annual Meeting
Contribution of Chest Wall Muscle Atrophy to Decline of Forced Vital Capacity in Patients with Systemic Sclerosis-associated Interstitial Lung Disease
Takashi Nawata¹, Mikito Suzuki ², Yuichiro Shirai ³ and Masataka Kuwana ³, ¹1. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan. 2. Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, Tokyo, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Tokyo, Japan, ³Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Interstitial lung disease (ILD) is the leading causes in patients with systemic sclerosis (SSc). Forced vital capacity (FVC) is routinely used for assessment of…
Abstract Number: 1631 • 2019 ACR/ARP Annual Meeting
Assessment of the Repeatability and Convergent Validity with Dermal Collagen of High Frequency Ultrasound in Systemic Sclerosis
Victoria Flower¹, Shaney Barratt ², Darren Hart ³, Amanda Mackenzie ⁴, Jacqueline Shipley ³, Stephen Ward ⁴ and John Pauling ¹, ¹Department of Rheumatology, Royal National Hospital of Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, England, United Kingdom, ²North Bristol NHS Trust, Bristol, England, United Kingdom, ³Department of Clinical Measurement, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Trust, Bath, England, United Kingdom, ⁴Centre for Therapeutic Innovation & Department of Pharmacy and Pharmacology, University of Bath, Bath, England, United Kingdom
Background/Purpose: There have been a number of recent negative clinical trials of SSc utilising the modified Rodnan Skin Score. High Frequency Ultrasound (HFUS) allows objective…
Abstract Number: 1632 • 2019 ACR/ARP Annual Meeting
Evidence-based Consensus Statements for the Identification and Management of Interstitial Lung Disease in Systemic Sclerosis
Anna-Maria Hoffmann-Vold¹, Toby M. Maher ², Edward E. Philpot ³, Ali Ashrafzadeh ⁴ and Oliver Distler ⁵, ¹Dept. of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²National Heart and Lung Institute, Imperial College London; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK, London, United Kingdom, ³Respiratory Center of Excellence, IQVIA, Durham, NC, USA, Durham, NC, ⁴Rheumatology Center of Excellence, IQVIA, San Diego, CA, USA, San Diego, CA, ⁵Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Guidelines are needed to aid early recognition and treatment of interstitial lung disease in systemic sclerosis (SSc-ILD). This study was conducted to develop expert…

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