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Abstract Number: 1629

Significance of Abnormal Nailfold Videocapillarscopy Among Patients with Raynaud’s Phenomenon And/or Suspected Connective Tissue Disease: A Cross-Sectional Single-Center US Experience

Yasser Radwan1, Tina Gunderson 2, Cynthia Crowson 3, Alicia Hinze 1, Kevin Moder 4, Floranne Ernste 4, Shreyasee Amin 4, Uma Thanarajasingam 2, Thomas Osborn 1, Kenneth Warrington 4, Paul Wennberg 4 and Ashima Makol 1, 1Mayo Clinic Minnesota, rochester, MN, 2Mayo Clinic, Rochester, MN, 3Mayo Clinic Rochester, Rochester, 4Mayo Clinic Rochester, rochester, MN

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: connective tissue diseases and Raynaud's phenomenon, nailfold capillaroscopy, Systemic sclerosis

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Session Information

Date: Monday, November 11, 2019

Session Title: Systemic Sclerosis & Related Disorders – Clinical Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Nailfold videocapillaroscopy (NVC) is a simple, non-invasive & highly sensitive tool to evaluate structural abnormalities of the microcirculation in vivo and considered a key clinical finding to help differentiate primary from secondary Raynaud’s phenomenon (RP). It is available at limited centers across the US.  We examined the significance of NVC patterns in an unselected cohort of patients with RP and/or suspected connective tissue disease (CTD) referred to a recently instituted NVC Clinic at our institution.

Methods: Medical records of all patients referred to our NVC Clinic between 1/1/2017 to 3/31/2019 were retrospectively reviewed. Demographics, clinical diagnosis, major organ involvement that can been seen in systemic sclerosis (SSc) or CTDs (interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), digital ulcers (DU) and gastrointestinal dysmotility (GID)) and autoantibodies were abstracted. NVC results (Optilia, 200x; 2nd-5th Digits examined bilaterally) were classified as normal or abnormal (described as non-specific or SSc specific pattern- early, active, late). Fulfilment of ACR/EULAR 2013 SSc classification criteria and Very Early Diagnosis of SSc (VEDOSS) criteria was ascertained. 

Results: 190 patients (mean age 46 ± 15 yrs, 81 % females, 93% white) underwent NVC during the study period. Indications for referral were RP (92%), positive autoantibodies (56%) and/or suspicion for underlying CTD (21%). 

A normal NVC was noted in 102 (54%) patients, of whom 34 patients were considered to have Primary RP. Abnormal NVC was noted in 88 (46%) patients of which 57 (65%) had SSc pattern (39% early,  46% active, and  16% late). Among those with SSc NVC pattern, 26 (46%) met classification criteria for SSc, 48 (84%) fulfilled VEDOSS criteria and 28 (49%) were diagnosed as other CTDs. Among patients met ACR/EULAR 2013 SSc diagnosis, NVC abnormalities were noted in 33 (94%). NVC abnormalities were also notable in patients with other CTDs (Table 1).

Organ involvement was observed more frequently with SSc NVC pattern (Table 2).  Among the 13 patients with SSc NVC pattern (6 early, 7 active) that did not meet criteria for SSc or other CTDs, 3 had ILD, 1 DU and 2 had GID.

Among patients with SSc NVC pattern, 74% had a positive ANA, 37% had SSc specific autoantibodies (anti-centromere 14%, anti-Scl70 12% and anti RNA polymerase-III 14%), and 39% had a positive ENA (16% anti-Ro/SSA, 2% anti-La/SSB, 7% anti-Sm, 16% anti-RNP).

In absence of RP (n=13), SSc pattern was observed in 4 (31%) patients: 3 met VEDOSS, 2 met ACR/EULAR SSc criteria and 1 had Sjogren’s syndrome; 2 had anti-RNA polymerase-III and 1 had anti-Scl70 antibody.

The association of NVC abnormalities (giant capillaries, dilatations, microhemorrhages and avascularity) with organ dysfunction is shown in the figure.

Conclusion: Our study underscores the importance of performing NVC for early diagnosis of SSc. This study supports the role of NVC as a valuable screening tool for evaluation of CTDs where abnormal NVC, particularly SSc pattern, may be associated with a high prevalence of disease-specific autoantibodies and internal organ involvement (particularly ILD and PAH), even in the absence of RP and may signal an evolving CTD.

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Table 1. Nailfold Videocapillaroscopy findings in 190 patients in accordance with clinical diagnosis, with or without Raynaud’s Phenomenon

Table 2. Organ involvement, autoantibodies and nailfold videocapillaroscopy patterns among 190 patients with Raynaud’s phenomenon and/or suspected connective tissue disease

Figure. Association of “SSc pattern” and other nailfold videocapillaroscopy findings with organ involvement


Disclosure: Y. Radwan, None; T. Gunderson, None; C. Crowson, Crescendo Bioscience, 5, Crescendo BioScience Inc., 5, Crescendo Bioscience Inc., 5, Crescendo Biosciences inc., 5, Pfizer, 2; A. Hinze, None; K. Moder, None; F. Ernste, None; S. Amin, None; U. Thanarajasingam, None; T. Osborn, None; K. Warrington, Eli Lilly, 2, GlaxoSmithKline, 2, roche, 2, 8, Roche, 2, 5, 8, Sanofi, 5, sanofi, 5; P. Wennberg, None; A. Makol, None.

To cite this abstract in AMA style:

Radwan Y, Gunderson T, Crowson C, Hinze A, Moder K, Ernste F, Amin S, Thanarajasingam U, Osborn T, Warrington K, Wennberg P, Makol A. Significance of Abnormal Nailfold Videocapillarscopy Among Patients with Raynaud’s Phenomenon And/or Suspected Connective Tissue Disease: A Cross-Sectional Single-Center US Experience [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/significance-of-abnormal-nailfold-videocapillarscopy-among-patients-with-raynauds-phenomenon-and-or-suspected-connective-tissue-disease-a-cross-sectional-single-center-us-experience/. Accessed January 30, 2023.
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