ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1639

Endoscopic Findings in a Scleroderma Cohort with and Without Interstitial Lung Disease

Manpreet Parmar1, Miruna Carnaru 2, Anand Patel 3 and Vivien Hsu 4, 1Rutgers-RWJ Medical School, Matawan, NJ, 2Yale University, New Haven, CT, 3Temple, Philadelphia, PA, 4Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: interstitial lung disease and endoscopy, Systemic sclerosis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Monday, November 11, 2019

Session Title: Systemic Sclerosis & Related Disorders – Clinical Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Gastro-intestinal (GI) involvement is universal in systemic sclerosis (SSc) and may affect the entire length of the bowel, most commonly the esophagus (1).  The pathogenesis is unknown but it is proposed that vasculopathy, immune-mediated abnormalities, fibrosis and atrophy, all contribute to disruption of GI function in SSc.  Esophageal involvement has been associated with more severe scleroderma-related interstitial lung disease (SSc-ILD), which is a major cause of morbidity and mortality (2,3,4).  Pulmonary function tests (PFT) and high resolution chest CT scan (HRCT) are commonly used to evaluate for SSc-ILD.  Common HRCT findings may include potentially reversible changes such as ground glass opacities (GGO), and irreversible findings such as fibrosis, traction bronchiectasis and honeycombing (5).  We sought to study the association of abnormal endoscopic and HRCT findings in our SSc cohort with ILD.

Methods: We examined the records of 140 SSc outpatients, all of whom met the 2013 ACR criteria for SSc (6).  SSc-ILD was confirmed by HRCT associated with restrictive pattern on PFT.  Descriptive HRCT findings included outcomes of honeycombing, bronchiectasis, and GGO. Pearson chi-square tests and student’s t-tests were used to assess differences in distributions of clinical and sociodemographic variable across outcomes, respectively.  Odds ratios of presence of honeycombing, bronchiectasis and GGO were estimated using logistic regression.

Results: A total of 140 SSc patients were enrolled, of whom 71 had endoscopies performed. Among those who were scoped, 68 (96%) had abnormalities detected, of which the majority were gastritis (n=40, 59%) and esophagitis (n=26, 38%).  SSc patients with GGO on HRCT were less likely to have esophagitis than those without GGO (53% vs 25%, p=0.02; table 1).  Patients with gastritis had 3.2 times higher odds of having GGO than patients with esophagitis (95% Confidence interval=0.76-13.41; table 2).  We observed no significant differences in demographics, disease duration or serologic status between SSc patients with and without ILD who had abnormal endoscopies.

Conclusion: Abnormal endoscopies are common in SSc.  Patients with SSc-ILD had a higher prevalence of gastritis relative to esophagitis, and those with gastritis had a higher likelihood of having GGO on HRCT.  Larger prospective studies are needed to elucidate any causal relationship and to better understand the complex relationship between the upper GI tract and pulmonary findings in patients with SSc-ILD.

References:

  1. Tian X. et al: World Journal of Gastroenterology 2013; 19:7062
  2. Wells A. et al: Semin Respir Crit Care 2014; 35: 213
  3. Marie I et al: Arthritis Care & Res 2001; 45: 46
  4. Christmann RB et al: Semin Arthritis Rheum 2010; 40: 241
  5. Yabuuch H et al: Clinical Radiology 2014; 69: 758
  6. Hoogen et al: Arthritis Rheumatol 2013: 65: 2737 and Ann Rheum Dis 2013: 72: 1747


Disclosure: M. Parmar, None; M. Carnaru, None; A. Patel, None; V. Hsu, None.

To cite this abstract in AMA style:

Parmar M, Carnaru M, Patel A, Hsu V. Endoscopic Findings in a Scleroderma Cohort with and Without Interstitial Lung Disease [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/endoscopic-findings-in-a-scleroderma-cohort-with-and-without-interstitial-lung-disease/. Accessed January 16, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/endoscopic-findings-in-a-scleroderma-cohort-with-and-without-interstitial-lung-disease/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.