ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2205

Non-Invasive in Vivo Metabolic Profiling of Inflammation in Joints and Entheses by Optoacoustic Imaging

Koray Tascilar1, Filippo Fagni2, Arnd Kleyer1, Sara Bayat2, Robert Heidemann3, Florian Steiger3, Gerhard Kroenke1, Daniela Bohr4, Andreas Ramming1, Melek Yalcin Mutlu3, Ioanna Minopoulou3, Fabian Hartmann3, Daniel Klett5, Anna Federle5, Adrian Regensburger6, Alexandra L. Wagner6, Ferdinand Knieling6, Markus Neurath5, Georg Schett7, Maximilian Waldner5 and David Simon1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 2University Hospital Erlangen; Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 3University Hospital Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 4Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nurnberg and University Hospital Erlangen, Erlangen, Germany, 5University Hospital Erlangen; Department of Internal Medicine 1 - Gastroenterology, Pulmonology and Immunology, Erlangen, Germany, 6University Hospital Erlangen; Department of Pediatrics and Adolescent Medicine, Erlangen, Germany, 7Universitätsklinikum Erlangen, Erlangen, Germany

Meeting: ACR Convergence 2022

Keywords: Imaging, Joint Structure, Psoriatic arthritis, rheumatoid arthritis, Ultrasound

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, November 14, 2022

Session Title: Abstracts: Imaging of Rheumatic Diseases

Session Type: Abstract Session

Session Time: 3:00PM-4:30PM

Background/Purpose: For individuals with inflammatory arthritis, a detailed metabolic characterization of joints and entheses at the tissue level can aid in early diagnosis and treatment decision (1). The metabolic characteristics of synovitis and enthesitis are, however, poorly understood at the moment. Multispectral optoacoustic tomography (MSOT), an innovative metabolic imaging technology, could be utilized to non-invasively perform metabolic profiling of joints and entheses by stimulating tissues with a near-infrared multispectral laser and detecting the emitted acoustic energy. This allows to quantify tissue components such as oxygenated and deoxygenated haemoglobin, collagen, and lipids in-vivo based on differential absorbance at multiple wavelengths (2, 3). The purpose of this study was to use MSOT to investigate the metabolic features of arthritis and enthesitis in a cohort of patients affected by inflammatory arthritis and healthy controls.

Methods: Healthy controls (HC) and patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) participated in this cross-sectional study (Table 1). The metacarpophalangeal joints, wrists, entheses of lateral epicondyles, patellar, quadriceps, and Achilles tendons were all examined clinically, as well as by ultrasound (US) and MSOT. Haemoglobin, oxygen saturation, collagen, and lipid levels were all assessed using MSOT. Using linear mixed effects models, we estimated scaled mean differences (SMD) between inflamed and uninflamed joints and entheses as identified by clinical examination or US.

Results: We collected 1535 MSOT and 982 US scans from 87 subjects (36 HC, 34 PsA, 17 RA). Entheseal tenderness was not related to metabolic alterations, while US enthesitis was linked to higher collagen content, total haemoglobin and oxygen saturation. Clinical and US arthritis, on the other hand, displayed higher haemoglobin levels but lower oxygen saturation and collagen content. Increased lipid concentration in the joints was related to synovial hypertrophy (Figure 1).

Conclusion: MSOT is a non-invasive method for identifying metabolic alterations in arthritis and enthesitis. In synovitis, these results indicate enhanced synovial cellularity, collagen breakdown, and metabolic demand; whereas in enthesitis, they reflect greater tissue apposition and vascularization. Our findings suggest that synovitis and enthesitis are not only clinically and anatomically-functionally distinct, but also demonstrate markedly different metabolic patterns.

Supporting image 1

Figure 1 – MSOT-measured metabolites in arthritis and enthesitis.
Scaled differences and 95% confidence intervals of MSOT-determined metabolite values by clinical and ultrasonographic findings of and arthritis (A-C) and enthesitis (D-F). Two differences are plotted for each metabolite indicating two multispectral processing algorithms used for estimation. P values were adjusted for multiple testing using a false discovery rate of 5%. NS, not significant. sO2, oxygen saturation.

Supporting image 2

Table 1 – Baseline characteristics.
HC: healthy controls, PsA: psoriatic arthritis; RA: rheumatoid arthritis; SD: standard deviation; IQR: interquartile range; csDMARD: conventional synthetic disease-modifying antirheumatic drugs; b-tsDMARD: biologic and targeted synthetic DMARD.


Disclosures: K. Tascilar, Gılead, AbbVie/Abbott, UCB, Eli Lilly; F. Fagni, None; A. Kleyer, None; S. Bayat, None; R. Heidemann, None; F. Steiger, None; G. Kroenke, None; D. Bohr, None; A. Ramming, Boehringer-Ingelheim, Janssen, Gilead, Novartis, Pfizer; M. Yalcin Mutlu, None; I. Minopoulou, None; F. Hartmann, None; D. Klett, None; A. Federle, None; A. Regensburger, None; A. Wagner, None; F. Knieling, iThera Medical GmbH; M. Neurath, None; G. Schett, None; M. Waldner, iThera Medical GmbH; D. Simon, None.

To cite this abstract in AMA style:

Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Kroenke G, Bohr D, Ramming A, Yalcin Mutlu M, Minopoulou I, Hartmann F, Klett D, Federle A, Regensburger A, Wagner A, Knieling F, Neurath M, Schett G, Waldner M, Simon D. Non-Invasive in Vivo Metabolic Profiling of Inflammation in Joints and Entheses by Optoacoustic Imaging [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/non-invasive-in-vivo-metabolic-profiling-of-inflammation-in-joints-and-entheses-by-optoacoustic-imaging/. Accessed February 4, 2023.
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2022

ACR Meeting Abstracts - https://acrabstracts.org/abstract/non-invasive-in-vivo-metabolic-profiling-of-inflammation-in-joints-and-entheses-by-optoacoustic-imaging/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences