Abstracts tagged "Imaging"

Abstract Number: L04 • ACR Convergence 2024
Performance of an Artificial Intelligence Model Compared to Multiple Human Experts in Scoring Synovitis Severity and Osteophyte Severity on Joint Ultrasound Images
Anders Weber¹, Mads Ammitzbøll Danielsen², Bill Aplin Frederiksen³, Hilde Berner Hammer⁴, Benjamin Schultz Overgaard³, Lene Terslev², Thiusius Rajeeth Savarimuthu⁵ and Soren Andreas Just³, ¹ROPCA, Odense, Denmark, ²Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, ³Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, ⁴Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark
Background/Purpose: To evaluate the agreement of an artificial intelligence (AI) model designed to assess greyscale and Doppler synovitis severity and osteophyte severity in hand joints…
Abstract Number: L20 • ACR Convergence 2024
Automated Ultrasound System ARTHUR with AI Analysis DIANA Matches Expert Rheumatologist in Hand Joint Assessment of Rheumatoid Arthritis Patients
Bill Aplin Frederiksen¹, Mads Ammitzbøll Danielsen², Hilde Berner Hammer³, Benjamin Schultz Overgaard¹, Anders Weber⁴, Lene Terslev², Thiusius Rajeeth Savarimuthu⁵ and Soren Andreas Just¹, ¹Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, ²Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, ³Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁴ROPCA, Odense, Denmark, ⁵Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark
Background/Purpose: To evaluate the precision of ARTHUR (Figure 1), a CE-marked, fully automated ultrasound scanning system that captures ultrasound images of 22 hand joints and…
Abstract Number: 0478 • ACR Convergence 2024
Skin Sodium in Patients with Rheumatoid Arthritis: Association with Blood Pressure and Disease Activity
Carolina Ramirez, Annette Oeser, Rachelle Crescenzi, C. Michael Stein and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Sodium is stored in tissues such as the skin where it may contribute to development and progression of autoimmune diseases and hypertension through activation…
Abstract Number: 0937 • ACR Convergence 2024
A Novel Quantitative Method Reveals Bone-Structural Changes During Course of Inflammatory Arthritis
Anders Nguyen¹, David McBride², Miriam Bollmann¹, Agnieszka Lastowska³ and Mattias Svensson⁴, ¹University of Gothenburg, Göteborg, Sweden, ²Calibr-Skaggs Institute for Innovative Medicines, La Jolla, CA, ³University of Gothenburg, Goteborg, Sweden, ⁴University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by both localized and generalized bone loss. The inhibition of Receptor Activator of Nuclear Factor…
Abstract Number: 1448 • ACR Convergence 2024
The Proportion of Inflammatory Back Pain Patients with an Abnormal Sacral MRI in a Community-Based Primary Care Setting
Emmanuel Katsaros¹, Robb Russel², Melissa Nagare², Cesar Ochoa¹, Fanglong Dong¹ and Michael Weisman³, ¹Western University of Health Sciences, Pomona, CA, ²Southern California University of Health Sciences, Whittier, CA, ³Stanford University, Los Angeles, CA
Background/Purpose: Axial spondyloarthritis (axSpA) is a group of disorders typically occurring before the age of 45 whose common features include disabling inflammatory arthritis of the…
Abstract Number: 1758 • ACR Convergence 2024
Minimal Spinal Radiographic Progression in Patients with Radiographic Axial Spondyloarthritis over 2 Years of Bimekizumab Treatment: Results from a Phase 3 Open-Label Extension Study
Xenofon Baraliakos¹, Sofia Ramiro², Walter Maksymowych³, Mikkel Ostergaard⁴, Ute Massow⁵, Thomas Vaux⁶, Chetan Prajapati⁶, Alexander Marten⁵, Natasha de Peyrecave⁷ and Denis Poddubnyy⁸, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ²Leiden University Medical Center, Bunde, Netherlands, ³University of Alberta, Edmonton, AB, Canada, ⁴Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, ⁵UCB Pharma, Monheim am Rhein, Germany, ⁶UCB Pharma, Slough, United Kingdom, ⁷UCB Pharma, Brussels, Belgium, ⁸Charite-Universitatsmedizin Berlin, Berlin, Germany
Background/Purpose: The effect of bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17F in addition to IL-17A, on structural radiographic progression in the…
Abstract Number: 2066 • ACR Convergence 2024
Comparative Diagnostic Efficacy of Quantitative Measurement of Echo Intensity and Texture versus Qualitative Analysis of Ultrasound Images in Myositis
Takeshi Yoshida¹, Hiroki Yamazaki², Naoko Takamatsu², Yoshinori Taniguchi³, Taiki Nozaki⁴, masataka inoue⁵, Yoshitaka Kumon⁶, yuki matsumoto², Yuki Kanazawa², Masafumi Harada², Ichizo Nishino⁷, Jemima Albayda⁸ and Yuishin Izumi², ¹Chikamori Hospital, Kochi, Kochi, Japan, ²Tokushima University School of Medicine, Tokushima, Japan, ³Kochi University School of Medicine, kochi, Japan, ⁴keio University School of Medicine, Tokyo, Japan, ⁵Hyogo Medical University, Nishinomiya, Japan, ⁶Chikamori Hospital, Kochi, Japan, ⁷National Center of Neurology and Psychiatry, Tokyo, Japan, ⁸Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Recently, the role of imaging tests such as magnetic resonance imaging and ultrasound (US) in the diagnosis and classification of myositis has become increasingly…
Abstract Number: 0201 • ACR Convergence 2024
Use of Infrared Thermography for Expedited Rheumatology Referral in a Primary Care Center
Giovanna Rosas chavez¹, Kiara Aaron², Jeffrey Curtis³, Rahima Begum⁴, Laura Hughes⁴, Brianna Holder⁴ and Maria I. ("Maio") Danila⁵, ¹University of Alabama at Birmingham, Hoover, AL, ²University of Alabama at Birmingham (UAB), Birmingham, AL, ³The University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL
Background/Purpose: Infrared thermography (IRT) can detect joint inflammation in people with suspected inflammatory joint symptoms. Thus, IRT could be a helpful tool to assess joint…
Abstract Number: 0566 • ACR Convergence 2024
How Early Is Early? Unveiling Time to Diagnosis Since Symptom Onset and Its Determinants in Patients Suspected of Early Axial Spondyloarthritis: Data from the SPondyloArthritis Caught Early (SPACE) Cohort
Mary Lucy Marques¹, Desiree van der Heijde², Liese de Bruin³, Miranda van Lunteren⁴, Robert Landewé⁵, Karen Minde Fagerli⁶, Maikel Van Oosterhout⁷, Floris van Gaalen⁸ and Sofia Ramiro⁹, ¹Leiden University Medical Center, Coimbra, Zuid-Holland, Portugal, ²Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ⁵Amsterdam University Medical Center, Meerssen, Netherlands, ⁶Diakonhjemmet Hospital, Oslo, Norway, ⁷Groene Hart Ziekenhuis, Gouda, the Netherlands, Gouda, Netherlands, ⁸LUMC, Leiden, Zuid-Holland, Netherlands, ⁹Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: Patients with chronic back pain (CBP) of less than two-years (2y) duration suspected of axial spondyloarthritis (axSpA) referred to the rheumatologist can be reliably…
Abstract Number: 0959 • ACR Convergence 2024
Radiomics Non-Invasively Conveys Time-Resolved Molecular Pathway Activity in Experimental Fibrosing Interstitial Lung Disease
David Lauer¹, Matthias Brunner², Hubert Gabrys³, Kerstin Klein², Oliver Distler⁴, Britta Maurer⁵ and Janine Gote-Schniering², ¹University Hospital Bern, Bern, Switzerland, ²University of Bern, Bern, Switzerland, ³University Hospital Zurich, Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland, ⁵University Hospital Bern, University Bern, Bern, Switzerland
Background/Purpose: Interstitial lung disease (ILD) is a major cause of mortality in patients with autoimmune-related CTD such as SSc and RA. Molecular characterization of the…
Abstract Number: 1558 • ACR Convergence 2024
Mapping in Healthy Subjects Different Body Areas for Dermal Thickness and Skin Hardness by High Frequency Sonography and Durometry
Maurizio Cutolo¹, Elvis Hysa², Nathalie Berghen³, Tessa Dufour⁴, Andrea Cere⁵, Kaat Wyckstandt³, Emanuele Gotelli¹ and vanessa smith⁶, ¹Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genova, Italy, ²Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genoa, Italy, ³University of Ghent, Ghent, Italy, ⁴University Hospital Ghent, Gent, Belgium, ⁵University of Ghent, Ghent, Belgium, ⁶Ghent University Hospital, Gent, Belgium
Background/Purpose: Skin involvement is a prominent feature of systemic sclerosis (SSc). The reliability of non-invasive tools such as high frequency skin ultrasound (HFSU) and durometry,…
Abstract Number: 1956 • ACR Convergence 2024
Artificial Intelligence Enhanced Analysis of Nailfold Capillaries by Dermatoscopy in Rheumatology Centers
Genessis Maldonado¹, Eduardo Ramos-ibañez², Borja del Carmelo Gracia-Tello³, Radic Mislav⁴ and Tracy Frech¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²University of Zaragoza, Zaragoza, Spain, ³Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain, ⁴University Hospital of Split, Split, Croatia
Background/Purpose: The use of dermatoscopes in rheumatology has been established for several years. However, the application of artificial intelligence for the detection of abnormalities in…
Abstract Number: 2119 • ACR Convergence 2024
IL-17 Blockade Therapy Improves Symptoms in Patients with Active Axial Spondyloarthritis Without Occurrence of New Vertebral Fractures
Chloe Heiting¹, Donald McMahon¹, Douglas Mintz¹, Weijia Yuan¹, Insa Mannstadt¹, Linda A Russell¹, Emily Stein¹, Dalit Ashany² and Susan Goodman³, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Scarsdale, NY, ³Hospital for Special Surgery, New York 10025, NY
Background/Purpose: Axial spondyloarthritis (AxSpA) is characterized by abnormal bone formation and, paradoxically, bone loss accompanied by increased bone fragility and vertebral fracture risk. Tumor necrosis…
Abstract Number: 0218 • ACR Convergence 2024
Incidental Findings on Whole Body 18F-FDG PET/CT in a Rheumatoid Arthritis Clinical Trial Population
Christina Costeas¹, Daniel Solomon², Katherine Liao³, Jon Giles⁴, Joan Bathon⁵ and Jane Kang⁶, and the TARGET Trial Consortium, ¹Columbia University Irving Medical Center, New York, NY, ²Brigham and Women's Hospital, Newton, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Cedars Sinai Medical Center, Los Angeles, CA, ⁵Columbia University, NEW YORK, NY, ⁶Columbia University Medical Center, New York, NY
Background/Purpose: Performing whole body imaging inevitably reveals incidental findings in the majority of cases. A clinical trial was conducted to determine whether different treatment strategies…
Abstract Number: 0633 • ACR Convergence 2024
Novel LINE-1 Reverse Transcriptase Inhibitors Can Suppress Type I Interferon Responses and Are Promising Therapeutics for Lupus
Wenyan Miao¹, Digna de Bruin², Cedric Arisdakessian¹, Jannik Rousel², Jared Steranka¹, Matthijs Moerland², Eric Jacobson¹, Mehrnaz Gharaee-Kermani³, Liyang Diao¹, Craig Dobry³, Nafeeza Hafeez¹, Brian Desrosiers¹, J. Michelle Kahlenberg³, Heike Keilhack¹, Robert Rissmann², Keith M Wilcoxen¹ and Tessa Niemeyer-van der Kolk², ¹Rome Therapeutics, Boston, MA, ²Centre for Human Drug Research, Leiden, Netherlands, ³University of Michigan, Ann Arbor, MI
Background/Purpose: Long Interspersed Element-1 (LINE-1) retrotransposon encodes for two proteins, ORF1p and ORF2p. ORF1p is a chaperone protein while ORF2p contains reverse transcriptase (RT) and…

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