Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report

Ece Kaptanoglu¹, Ozlem Şahin², Tiraje Tuncer³, Sami Hizmetli¹, Lale Altan⁴, Figen Ayhan⁵, Ajda Bal⁶, Meral Bilgilisoy⁷, Gulnur Bozbas⁸, Lale Cerrahoglu⁹, Remzi Cevik¹⁰, Tuncay Duruoz¹¹, Deniz Dulgeroglu⁶, Gulcan Gurer¹², Savas Gursoy¹³, Simin Hepguler¹⁴, Cahit Kacar¹⁵, Taciser Kaya¹⁶, Meltem Melikoglu¹⁷, Kemal Nas¹⁸, Suheda Ozcakir¹⁹, Senay Ozdolap²⁰, merih Saridogan²¹, Selda Sarikaya²⁰, Dilsad Sindel²², Omer F Şendur⁸, Canan Tikiz²³ and Hatice Ugurlu²⁴, ¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, ²Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey, ³Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey, ⁴Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Uludag University School of Medicine, Bursa, Turkey, ⁵Department of Physical Medicine and Rehabilitation, University of Health Ankara Training and Research Hospital, Ankara, Turkey, ⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, ⁷Department of Physical Medicine and Rehabilitation, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey, ⁸Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁹Department of Physical Medicine and Rehabilitation, Celal Bayar University School of Medicine, Manisa, Turkey, ¹⁰Department of Physical Medicine and Rehabilitation, Dicle University School of Medicine, Diyarbakir, Turkey, ¹¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ¹²Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydin, Turkey, ¹³Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹⁴Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey, ¹⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences İzmir Bozyaka Training and Research Hospital, Izmir, Turkey, ¹⁷Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, ¹⁸Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey, ¹⁹Department of Physical Medicine and Rehabilitation, Uludag University School of Medicine, Bursa, Turkey, ²⁰Department of Physical Medicine and Rehabilitation, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, ²¹Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, ²²Department of Physical Medicine and Rehabilitation, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey, ²³Celal Bayar University School of Medicine, Manisa, Turkey, ²⁴Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: body mass, Knee, osteoarthritis and pain

Session Information

Date: Tuesday, November 7, 2017

Title: Osteoarthritis – Clinical Aspects Poster II: Observational and Epidemiological Studies

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Neuropathic pain (NP) was accused for increased pain and reduced functional capacity in knee osteoarthritis (KO). Here we aimed to find out the prevalence of neuropathic pain and it’s relationship with gender, age, body mass index (BMI), pain, symptom duration and functional status in patients with KO.

Methods:

713 patients with KO were included in the study from the multicenter national cohort conducted by the Turkish League Against Rheumatism-Osteoarthritis Study Group. Sociodemographic variables, BMI, and duration of symptoms were recorded. Pain severity was measured by visual analog scale (VAS), neuropathic pain was assessed by PainDETECT questionnaire and Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire and timed up and go test were used for functional evaluation, and somatosensorial dysfunction and characteristics of pain (night pain, relief of pain on rest, pain on motion, aggrevation of symptoms with cold) were also questioned.

Results:

The mean age of the patients with KO were 63.29± 9.53 and 83.9 % were female, 16.1% were male, mean duration of symptoms was 80.73±86.59 months (1-720 months), and BMI was 31.5±5.4. NP was found in 20.9 % of the patients and 19.2% of the patients were in the unclear range according to PainDETECT. The age, gender and symptom duration of patients were comparable in patients with or without NP. BMI (31.2±5.4 vs 32.0±5.4, p= 0.016), pain severity (6.35±0.12 vs 6.77±0.29, p=0.004), WOMAC function [31 (3-80) vs 43 (5-106), p=0.036] and WOMAC stiffness [3 (0-16) vs 4 (0-8), p=0.014] scores, night pain (68.4% vs 31.5%, p=0.001) and aggrevation of symptoms by cold (70.4% vs 29.5%, p=0.032) were higher in KO patients with NP. There was no difference between the WOMAC total, WOMAC pain and timed up and go test scores, somatosensorial dysfunction, relief of pain on rest and pain on motion of the patients with or without NP.

Conclusion:

BMI and pain severity were higher in KO patients with NP and may probably provoke neuropathic pain which in turn decreases functional capacity. Night pain and aggrevation of symtoms with cold may also be related to neuropathic pain.

Disclosure: E. Kaptanoglu, None; O. Şahin, None; T. Tuncer, None; S. Hizmetli, None; L. Altan, Amgen, MSD; Roche, Abvie,UCB, Phizer, 9; F. Ayhan, None; A. Bal, None; M. Bilgilisoy, None; G. Bozbas, None; L. Cerrahoglu, None; R. Cevik, None; T. Duruoz, AbbVie,Sanovel, 9; D. Dulgeroglu, None; G. Gurer, None; S. Gursoy, None; S. Hepguler, None; C. Kacar, None; T. Kaya, None; M. Melikoglu, None; K. Nas, None; S. Ozcakir, None; S. Ozdolap, None; M. Saridogan, None; S. Sarikaya, None; D. Sindel, Amgen, Novartis and Sandoz,Lilly, 9; O. F. Şendur, None; C. Tikiz, None; H. Ugurlu, None.

To cite this abstract in AMA style:

Kaptanoglu E, Şahin O, Tuncer T, Hizmetli S, Altan L, Ayhan F, Bal A, Bilgilisoy M, Bozbas G, Cerrahoglu L, Cevik R, Duruoz T, Dulgeroglu D, Gurer G, Gursoy S, Hepguler S, Kacar C, Kaya T, Melikoglu M, Nas K, Ozcakir S, Ozdolap S, Saridogan M, Sarikaya S, Sindel D, Şendur OF, Tikiz C, Ugurlu H. Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/neuropathic-pain-in-patients-with-knee-osteoarthritis-and-related-factors-a-multicenter-longitudinal-study-preliminary-report/. Accessed .

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