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Abstract Number: 2679

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

Jeong-Hwa Kang1, Young-Nan Cho1, Hye Mi Jin1, Hyun-Ju Jung1, Sung-Ji Lee1, Seung-Jung Kee2 and Yong-Wook Park1, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: cytokines, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), T cells

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Session Information

Session Title: Systemic Lupus Erythematosus - Human Etiology and Pathogenesis: T and B Cell Signaling and Genetic Variants

Session Type: Abstract Submissions (ACR)

Background/Purpose Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of MAIT cells remains enigmatic in autoimmune diseases. Here, we examined the level and function of MAIT cells in patients with rheumatic diseases.

Methods MAIT cell, cytokine and programmed death-1 (PD-1) levels were measured by flow cytometry.

Results Circulating MAIT cell levels were significantly reduced in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients. In particular, this MAIT cell deficiency was more prominent in CD8+ and double-negative T cell subsets, and significantly correlated with disease activity, such as SLE disease activity index (SLEDAI) and 28-joint disease activity score (DAS28). Interestingly, MAIT cell frequency was significantly correlated with natural killer T (NKT) cell frequency in SLE patients. Interferon-γ production in MAIT cells was impaired in SLE patients, but it was preserved in RA patients. In SLE patients, MAIT cells were poorly activated by α-galactosylceramide-stimulated NKT cells, thereby showing the dysfunction between MAIT cells and NKT cells. Notably, an elevated expression of PD-1 in MAIT cells and NKT cells was associated with SLE. In RA patients, MAIT cell levels were significantly higher in synovial fluid than in peripheral blood.

Conclusion Our study primarily demonstrates that MAIT cells are numerically and functionally deficient in SLE. In addition, we report a novel finding that this MAIT cell deficiency is associated with NKT cell deficiency and elevated PD-1 expression. These abnormalities possibly contribute to dysregulated mucosal immunity in SLE.


Disclosure:

J. H. Kang,
None;

Y. N. Cho,
None;

H. M. Jin,
None;

H. J. Jung,
None;

S. J. Lee,
None;

S. J. Kee,
None;

Y. W. Park,
None.

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