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Abstract Number: 690

Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study

Seung-Geun Lee1, Eun-Kyoung Park2, Ji-Heh Park1, Hee-Sang Tag3 and Geun-Tae Kim4, 1Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, 4Kosin University College of Medicine, Busan, South Korea

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Adipokines, bone remodeling, cytokines, radiography and spondylarthritis

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Session Information

Date: Sunday, November 13, 2016

Session Title: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster I: Axial and Peripheral Spondyloarthritis – Clinical Aspects, Imaging and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:  The immunomodulatory effects of adipokines have been extensively studied in rheumatic diseases, there is a paucity of information regarding their effects on bone metabolism. Our study aimed to investigate the relationship between changes in serum adipokines levels and radiographic progression in patients with ankylosing spondylitis (AS).

Methods:  Twenty male patients with AS naïve to biologics and 11 age- and gender-matched male healthy subjects were consecutively recruited at a university-affiliated rheumatology center. Serum levels of leptin, adiponectin, resistin, TNF- α, IL-6, and DKK-1 were assessed by enzyme-linked immunosorbent assay at baseline and 2 years later. AS patients underwent lateral cervical and lumbar spine radiography baseline and 2 years later. Radiographic progression was defined as worsening of modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) by ≥ 2 units over the 2 years from baseline.

Results:  Baseline serum leptin and adiponectin levels in AS patients did not differ significantly from those in the controls; however, AS patients had a significantly higher resistin levels (5.5 [3.8-7.7] ng/ml) compared to controls (3.8 [1.9-5.1] ng/ml) at baseline (p=0.049). Baseline serum leptin, adiponectin and resistin levels were not correlated with disease activity, functional, metrological indices or mSASSS. Two years later, a significant increase in serum leptin and resistin levels and mSASSS was observed in AS patients, whereas serum DKK-1 levels significantly decreased. Seven (35%) of the 20 AS patients showed radiographic progression after 2 years. Median changes of serum leptin levels during the 2-year follow-up in AS patients with radiographic progression was significantly higher than in those without this feature (1.6 [0.7-7.1] ng/ml vs -0.2 [-0.6-0.5] ng/ml, p=0.002). In multivariable logistic regression models, the magnitude of changes in serum leptin levels over the 2-year period was significantly associated with radiographic progression in AS patients (OR=8.24, 95% CI=1.1-61.6, p=0.04). Additionally, changes in serum adiponectin, resistin, TNF- α, IL-6 and DKK-1 levels were not related to radiographic progression.

Conclusion: Increase in serum leptin levels over a 2-year period significantly correlated with radiographic progression in AS patients. Our findings suggest that leptin may be involved in the pathogenesis of new bone formation in AS. Table 1. Logistic regression models for the radiographic progression in patients with ankylosing spondylitis

Variables

Crude OR

(95% CI)

p

Adjusted OR a

(95% CI)

p

Changes in leptin levels, ng/ml

8.24 (1.1-61.6)

0.04

8.24 (1.1-61.6)

0.04

Age, years 1.12 (0.99-1.21)

0.083

–

–

Disease duration, months

0.99 (0.98-1.02)

0.999

TNF-α blocker use

0.64 (0.11-4.01)

0.64

–

–

Changes in BMI, kg/m2

1.4 (0.73-2.71)

0.311

TNF-α; tumor necrosis factor- α, BMI; body mass index aEstimated using multivariable logistic regression model with backward selection including changes in leptin levels, age and TNF-α blocker use


Disclosure: S. G. Lee, None; E. K. Park, None; J. H. Park, None; H. S. Tag, None; G. T. Kim, None.

To cite this abstract in AMA style:

Lee SG, Park EK, Park JH, Tag HS, Kim GT. Increase in Serum Leptin Levels Is Associated with Radiographic Progression of Male Patients with Ankylosing Spondylitis: A 2-Year Longitudinal Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/increase-in-serum-leptin-levels-is-associated-with-radiographic-progression-of-male-patients-with-ankylosing-spondylitis-a-2-year-longitudinal-study/. Accessed April 11, 2021.
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