Session Type: Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: To determine the incidence and risk factors implicated in the development of first cardiovascular (CV) event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) attending Spanish rheumatology clinics after 5 years of follow-up.
Methods: Analysis of data of patients included in an observational prospective study [CARdiovascular in rheuMAtology (CARMA) project] after 5 years of follow-up. The study includes a cohort of patients with CIRD [rheumatoid arthritis (RA, n=775, ankylosing spondylitis (AS, n=738), and psoriatic arthritis (PsA, n=721)], and another cohort of matched individuals (n=677) without CIRD attending outpatient rheumatology clinics from 67 public hospitals in Spain. Cumulative incidence per 1000 patients of CVE was estimated in both cohorts at 5 years from the start of the project. Weibull proportional hazard model was used to calculate the Hazard Ratio (HR) and 95% confidence intervals (95% CI) of the risk factors involved in the development of CV events. Losses to follow-up and their causes were also analyzed.
Results: The total number patient who completed the follow-up visit at 5 years was 2.382 (81.9% of those who started the study). Fifteen patients died due to CVE and sixty due to non-CVE. Cardiovascular cumulative incidence of CVE in patients with CIRD was higher in PsA patients (48.9; 95% CI: 40.7-57.1). The higher risk of developing a first CVE during the 5 years of follow-up was seen in patients with AS (HR: 4.60 ; 95% CI: 1.32-15.99; p=0.02), those with older age (HR:1.09; 95% CI: 1.05-1.13; p< 0.001), higher systolic blood pressure (HR: 2.64; 95% CI: 1.32-5.25; p=0.006), and those with longer duration of the rheumatic disease (HR: 1.07; 95% CI: 1.03-1.12; p=0.002). In contrast, woman gender was a protective factor (HR: 0.45; 95% CI: 0.21-0.99; p=0.047).
Conclusion: Patients with AS prospectively followed-up at rheumatology outpatient clinics showed higher risk of developing a CVE than those with RA or PsA. Besides traditional CV disease risk factors, a longer time course of the disease is a risk factor for the development of CV disease in patients with CIRD.
To cite this abstract in AMA style:Martin-Martinez M, Castañeda S, Sanchez-Alonso F, García-Gómez C, González_Juanatey C, Belmonte-López M, Tornero-Molina J, Santos-Rey J, Sánchez-González C, Moreno E, Moreno-Gil M, Cobo-Ibañez T, Pinto-Tasende J, Babío-Herráez J, Bonilla G, Juan-Mas A, Manero-Ruiz F, Romera-Baurés M, Bachiller-Corral J, Chamizo-Carmona E, Calvo-Catalán J, Sanmartí R, Erausquin-Arruabarrena C, Garcia-Vicuña R, Barbadillo C, Ros-Expósito S, Turrión A, González-Fernández M, Senabre J, Martínez-Pardo S, Ruibal-Escribano A, Giner-Serret E, Berzosa-Sola E, Martínez-Barrio J, Pagán E, Peiró M, Bustabad-Reyes S, Erra-Durán A, González Álvarez B, Cruz Valenciano A, Rivera-Redondo J, Moreno Ramos M, Rodriguez Montero S, Morcillo-Valle M, Navío M, Galindo-Izquierdo M, Riera-Soler M, Fiter J, Llorca J, González-Gay M. Incidence of First Cardiovascular Event in Spanish Patients with Chronic Inflammatory Rheumatic Diseases. Prospective Data After Five Years of Follow Up [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/incidence-of-first-cardiovascular-event-in-spanish-patients-with-chronic-inflammatory-rheumatic-diseases-prospective-data-after-five-years-of-follow-up/. Accessed July 31, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/incidence-of-first-cardiovascular-event-in-spanish-patients-with-chronic-inflammatory-rheumatic-diseases-prospective-data-after-five-years-of-follow-up/