ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1603

Gender-Specific Differences in Chinese Patients with Ankylosing Spondylitis

Weiping Kong1, Caroline Jefferies2, Thomas Learch3, Xiaowei Gan1, Jinrui Cui4, Yuan Xu1, Dier Jin1, Yingze Zhang1, Jianming Wang1, Qingwen Tao1, Xiaoping Yan1, Michael Weisman5 and Mariko Ishimori6, 1China-Japan Friendship Hospital, Beijing, China, 2Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Radiology, Cedars-Sinai Medical Center, Los Angeles, CA, 4Cedars-Sinai Medical Center, Los Angeles, CA, 5Harbor UCLA Medical Center, Los Angeles, CA, 6Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), computed tomography (CT) and cross-sectional studies, Imaging

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, October 22, 2018

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster II: Clinical/Epidemiology Studies

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Growing evidence suggests gender-specific differences in the phenotypes of ankylosing spondylitis (AS). However, a literature search failed to reveal evidence of such differences in Chinese AS patients. We aimed to assess the gender-specific associations with disease patterns of Chinese AS patients.

Methods: This study included 223/60 male/female AS patients, and 98.6% were of Han descent. All AS patients fulfilled the modified New York criteria. Structural damage of sacroiliac (SI) joints, hip joints and spine were evaluated by computed tomography (CT) scans, lumbar and cervical X-ray, respectively. Structural damage of AS was assessed by mSASSS, BASRI-SI, BASRI-spine and BASRI-hip (modified) by a trained rheumatologist and musculoskeletal radiologist with high test inter-rater reliability (average kappa: 87.3%). The association of gender with BASRI-spine category, expressed as odds ratio (OR) and 95% confidence interval (95% CI), was calculated using ordinal logistic regression.

Results: Female AS patients were older than males (p=0.0003), and they also had older age of AS onset (p<0.0001), a lower frequency of HLA-B27 (p=0.018), a higher family history of reported AS in first-degree relatives (p=0.0025) than male patients. Both genders had similar disease duration. Mean levels of CRP (p<0.0001) and ASDAS-CRP (p=0.0284) were significantly higher in male patients than in female patients (Table 1). As previously reported, male AS patients from non-Chinese cohorts had more radiographic damage, more hip impact, worse function and higher diagnostic delays than female patients [PMID: 20357993, 17127685, 26385369]. However, in Chinese AS patients, no gender-associated diagnostic delays or functional impairment were observed. Structural damage severity was worse among male AS patients only at the SI joint, but not at lumbar or cervical spine and hip. After adjusting for age or disease duration and other risk factors (Table 2), no gender-specific association with categorized BASRI-spine was noted (OR=1.91 or 1.46, 95% CI: 0.99 to 3.69 or 0.77 to 2.75, p=0.054 or 0.247).

Conclusion: In a Chinese cohort, female AS patients were observed to have later age of disease onset, but similar severe spine and hip joint structure damage and limited function as male patients. Compared with other racial groups, Chinese female AS patients may have more severe disease and worse outcome.



Disclosure: W. Kong, None; C. Jefferies, None; T. Learch, None; X. Gan, None; J. Cui, None; Y. Xu, None; D. Jin, None; Y. Zhang, None; J. Wang, None; Q. Tao, None; X. Yan, None; M. Weisman, GSK, Lilly, Novartis, Baylx, Celltrion. All are consulting fees, 5, 6; M. Ishimori, None.

To cite this abstract in AMA style:

Kong W, Jefferies C, Learch T, Gan X, Cui J, Xu Y, Jin D, Zhang Y, Wang J, Tao Q, Yan X, Weisman M, Ishimori M. Gender-Specific Differences in Chinese Patients with Ankylosing Spondylitis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/gender-specific-differences-in-chinese-patients-with-ankylosing-spondylitis/. Accessed January 27, 2023.
  • Tweet
  • Email
  • Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/gender-specific-differences-in-chinese-patients-with-ankylosing-spondylitis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences