Session Type: Poster Session C
Session Time: 1:00PM-3:00PM
Background/Purpose: Prevalence of subclinical inflammatory lesions is high in patients with cutaneous psoriasis and constitutes a -risk constellation for the development of psoriatic arthritis (PsA)1. However, reliable identification of patients at risk for the transition to PsA remains a challenge, as no molecular marker for progression has yet been identified. 68Ga-labelled selective inhibitor of fibroblast activation protein-α (68Ga-FAPI-04) PET-CT imaging is an advanced imaging modality, which uses a radiotracer targeting fibroblast activation protein, allowing the in vivo and non-invasive visualization of fibroblast activity2. Since synovial and entheseal fibroblasts are abnormally activated in PsA3, we speculated that psoriasis patients at risk for developing PsA could be reliably identified by 68Ga-FAPI-04 PET-CT.
Purpose: To identify patterns of 68Ga-FAPI-04 PET-CT activity associated with an increased risk of developing PsA in a longitudinal cohort of patients affected by cutaneous psoriasis.
Methods: A small cohort of patients with cutaneous psoriasis without any clinical signs of PsA (no arthritis/enthesitis/dactylitis/axial involvement) underwent 68Ga-FAPI-04 PET-CT and were followed-up prospectively to assess the development of PsA according to the CASPAR criteria. At baseline and follow-up all patients received clinical investigation for the presence of musculoskeletal disease (tender/swollen joint count (66/68), clinical assessment of 29 entheseal sites, assessment of dactylitis and of clinical symptoms of inflammatory back pain). In addition, skin disease-specific characteristics (disease duration, psoriasis subtype, presence of nail and scalp involvement) were recorded. 68Ga-FAPI-04 PET-CT images were assessed for the presence of radiotracer uptake at synovial and entheseal sites. Increased radioactivity compared with the background uptake was defined as being positive.
Results: Ten psoriasis patients (6 women/4 men) received 68Ga-FAPI-04 PET-CT (Table 1). Seven patients showed 68Ga-FAPI-04 uptake at synovio-entheseal sites (finger joints, shoulders, knees, tarsus, lumbar facet joints and interspinous ligaments, greater trochanter, ischial tuberosity). Six (85.7%) patients with synovio-entheseal 68Ga-FAPI-04 uptake progressed to PsA. The median PsA-free survival time was 207 (160-240) days (Figure 1). All three patients with a negative imaging developed no signs of PsA after a median follow-up of 301 (301-489) days.
Conclusion: The presence of articular fibroblast activation in psoriasis patients is associated with an increased risk of developing PsA. Fibroblast activity detected by 68Ga-FAPI-04 PET-CT could be a potential molecular biomarker for defining patients at high risk for transition to PsA. However, as the size of this cohort of psoriasis patients is very small further analyses will be necessary to corroborate these findings.
To cite this abstract in AMA style:Fagni F, Simon D, Kleyer A, Tascilar K, Taubmann J, Bayat S, Minopoulou I, Yalcin Mutlu M, Atzinger A, Kuwert T, Schett G, Schmidkonz C. Fibroblast Activation in Psoriasis Patients Assessed by 68Ga-FAPI-04 PET-CT Is Associated with Progression to Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/fibroblast-activation-in-psoriasis-patients-assessed-by-68ga-fapi-04-pet-ct-is-associated-with-progression-to-psoriatic-arthritis/. Accessed February 3, 2023.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/fibroblast-activation-in-psoriasis-patients-assessed-by-68ga-fapi-04-pet-ct-is-associated-with-progression-to-psoriatic-arthritis/