ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 0469

Factors Associated with Corticosteroid Dosing in the Management of Giant Cell Arteritis

Loukas Kakoullis and Shiv Sehra, Mount Auburn Hospital, Cambridge, MA

Meeting: ACR Convergence 2022

Keywords: Cohort Study, corticosteroids, giant cell arteritis, prognostic factors, Vasculitis

  • Tweet
  • Email
  • Print
Session Information

Date: Saturday, November 12, 2022

Title: Vasculitis – Non-ANCA-Associated and Related Disorders Poster I: Giant Cell Arteritis

Session Type: Poster Session A

Session Time: 1:00PM-3:00PM

Background/Purpose: Corticosteroids are the cornerstone of therapy in patients with giant cell arteritis (GCA). Tapering regiments vary considerably in both dose and duration, while relapses of the disease are common during the tapering of corticosteroids. We sought to evaluate parameters affecting the tapering corticosteroid dose in patients with GCA and the risk of recurrence during the corticosteroid treatment.

Methods: This study was a retrospective cohort of patients with GCA followed at Mount Auburn Hospital, Cambridge, MA, between 2017-2022. Inclusion criteria were the availability of data since the initial evaluation for GCA and through at least 3 months of follow up. Data were extracted from chart reviews and included patient demographics, clinical and laboratory parameters, treatment onset and duration, and episodes of recurrence. Statistical analysis was conducted using IBM SPSS for Windows, Version 27.

Results: Of the 215 records screened based on ICD 10 codes, 50 patients (mean age 75.44, 70% female) were noted to have a true diagnosis of GCA and fulfilled inclusion criteria. Median time between onset of symptoms and steroid administration was 8 days, while the mean dose of prednisone at months 1, 3 and 6 was 39.29 mg, 20.07 mg, and 10.02 mg, respectively. Recurrence of the disease during the first steroid taper was noted in 22 (44%) patients, at a median time of 6 months. Analysis demonstrated that the presence of recurrence during the first steroid taper was negatively correlated with the initiation of treatment within one week of symptom onset (r = -0.353, p = 0.014). In addition, patients who received steroids within one week of symptom onset had significantly reduced odds ratio (OR) of having a recurrence during the first prednisone taper (OR = 0.216; 95% CI = 0.061-0.764; p = 0.017), while the effect was maintained even after adjusting for patient demographic parameters, presence of specific symptoms or baseline markers of inflammation (OR = 0.096; 95% CI = 0.014-0.652; p = 0.017). Kaplan-Meier analysis (Figure 1) showed that early initiation of treatment was associated with longer recurrence-free survival, but this difference did not achieve statistical significance (15.8 vs 13.3 months; p-value = 0.084).Patients with a positive biopsy were found to receive significantly higher doses of prednisone at the 1-month timepoint compared to patients without (mean dose 45.71 vs 34.46, p = 0.00049); however, this difference did not persist at the subsequent time points. Furthermore, patients with a negative biopsy were significantly more likely to be receive prednisone at 40 mg or less at the 1-month timepoint (OR = 11.11; 95% CI = 2.54 – 48.66, p = 0.001), an effect maintained even after adjusting for confounding factors (OR = 8.98; 95% CI = 1.32 – 61.06, p = 0.025), while receiving the reduced dose had no correlation with the development of recurrence.

Conclusion: While early initiation of corticosteroids is critical in order to limit complications, this study demonstrates that it is also associated with reduced odds of recurrence during the first taper of corticosteroids.

Supporting image 1


Disclosures: L. Kakoullis, None; S. Sehra, None.

To cite this abstract in AMA style:

Kakoullis L, Sehra S. Factors Associated with Corticosteroid Dosing in the Management of Giant Cell Arteritis [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/factors-associated-with-corticosteroid-dosing-in-the-management-of-giant-cell-arteritis/. Accessed .
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2022

ACR Meeting Abstracts - https://acrabstracts.org/abstract/factors-associated-with-corticosteroid-dosing-in-the-management-of-giant-cell-arteritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology