Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: The cause for chronic pain in OA is largely unknown. Over 50% of osteoarthritis (OA) patients show synovial inflammation, even at early stages of the disease. However, if and how this synovial activation contributes to joint pathology and pain, is not known. We aimed to identify pathways that predict progression of cartilage damage and osteophyte (OP) formation in OA. In addition, we identified association between gene expression and pain in a cross-sectional approach.
Methods: From 25 patients with knee OA that entered the CHECK Cohort study (Cohort Hip and Cohort Knee) synovial biopsies were collected at baseline. CHECK is a prospective 10-year follow-up study on patients with early osteoarthritis-related complaints initiated by the Dutch Arthritis Foundation. Progression over 5 years was determined radiographically based on change of joint space width (JSW) and OP size in these radiographs. Pain was assessed at baseline and after 5 years by the WOMAC pain questionnaire. Synovial samples from baseline were studied using histology and microarray (affymetrix U133-plus-2.0), and Functional Annotation Clustering (FAC).
Conclusion: We found evidence for a difference in underlying processes in the synovium regarding progression of cartilage damage and progression of osteophyte formation. The presence of macrophages, in the lining layer, is associated with progression of cartilage damage, whereas synovial expression of MMPs correlated to progression of osteophyte formation. Pain at t=5 yrs was predicted by several nerve fiber related processes and strongly by inflammation.
To cite this abstract in AMA style:Blom AB, van den Bosch MH, Cats H, van den Hoogen F, Lafeber FP, van den Berg WB, van Lent PL, van der Kraan PM. Differential Synovial Expression Patterns in Early Osteoarthritis Predict Pain and Progression of Joint Damage [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/differential-synovial-expression-patterns-in-early-osteoarthritis-predict-pain-and-progression-of-joint-damage/. Accessed August 4, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/differential-synovial-expression-patterns-in-early-osteoarthritis-predict-pain-and-progression-of-joint-damage/