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Abstract Number: 2331

Coping with Rheumatic Stressors in Axial Spondyloarthritis: Association with Patient Characteristics and Disease Phenotypes and Changes Over Time

Marc van Essen1, Dafne capelusnik2, Désirée Van Der Heijde3, Robert Landewé4, Wim van Lankveld5, Astrid Van Tubergen6, Sofia Ramiro7 and Annelies Boonen8, 1Maastricht University, Zeist, Netherlands, 2Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, 5HAN University of Applied Sciences, Arnhem, Netherlands, 6Maastricht university, Maastricht, Netherlands, 7Leiden University Medical Center, Bunde, Netherlands, 8Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands

Meeting: ACR Convergence 2025

Keywords: Ankylosing spondylitis (AS), Cohort Study, Outcome measures, spondyloarthritis

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Session Information

Date: Tuesday, October 28, 2025

Title: (2305–2337) Spondyloarthritis Including Psoriatic Arthritis – Diagnosis, Manifestations, & Outcomes Poster III

Session Type: Poster Session C

Session Time: 10:30AM-12:30PM

Background/Purpose: To identify patient characteristics and disease phenotypes associated with coping strategies in axial spondyloarthritis (axSpA), and assess whether coping strategies change over time.

Methods: Data from the Outcome in AS International Study (OASIS) were used. Coping was assessed using Coping with rheumatic stressors (CORS) at 4 and 6 years of follow-up. The CORS assesses coping with three stressors – pain, limitations, and dependence –, based on 61 items across eight strategies (score 1–4 for each strategy). Factors associated with each strategy were analysed with Generalized Estimation Equations (GEE). Age, sex and education were the main independent variables of interest. Variables with p 

Results: In total 116 patients [72% male, mean age 48 years (SD 12)] had CORS data at ≥1 timepoint. Patients made most use of comforting cognitions (mean: 3.0; (SD: 0.5)) to cope with pain, of pacing (2.4; (0.5)) to cope with limitations and of showing considerations (2.8; (0.5)) to cope with dependence (Tables 1–3). Several differences in preference for coping strategy were seen between patients but without clear patterns. Using the strategies that were most used per stressor as an example, it can be seen that using comforting cognitions to cope with pain was associated with lower (vs higher) education (β: -0.22; (95%CI: -0.41 to -0.03)) and with a higher BMI (0.01; (0.00 to 0.03) (Table 1). Pacing, to cope with limitations, was used more by older individuals (0.01; (0.01 to 0.02)) (Table 2). Showing considerations, to cope with dependence, was used less by those with more comorbidities (-0.10; (-0.19 to 0.00)) (Table 3). When adding axSpA health scores as additional variables to the initial models, coefficients remained largely unchanged across all strategies. As an example, the effect of adding health scores to the comforting cognitions model is shown in table 1 (2nd column). ASDAS, BASFI and MCS (SF-36) had no independent effect, were not effect modifiers and only had some confounding effect on the main relationships of interest. Finally, for the analyses of change over time, 102 patients had full CORS data on both timepoints. Analyses showed that coping strategies did not change over time (range βtime: -0.04 to 0.07/year).

Conclusion: Coping strategies in axSpA appear more strongly influenced by patient characteristics, to a lesser extent disease phenotypes but not by axSpA related health scores. Furthermore, no change over time was found supporting that coping is a trait and more dependent on the person than the disease.

Supporting image 1

Supporting image 2

Supporting image 3


Disclosures: M. van Essen: None; D. capelusnik: None; D. Van Der Heijde: AbbVie, 2, Alfasigma, 2, Annals of the Rheumatic Diseases, 12, Associate editor, ArgenX, 2, Bristol Myers Squibb, 2, Eli Lilly and Company, 2, Grey-Wolf Therapeutics, 2, Imaging Rheumatology BV, 12, Director, Janssen, 2, Journal of Rheumatology, 12, Editorial board member, Novartis, 2, Pfizer, 2, RMD Open, 12, Editoral board member, Takeda, 2, UCB, 2; R. Landewé: AbbVie/Abbott, 2, Bristol-Myers Squibb(BMS), 2, Eli Lilly, 2, Janssen, 2, Joint Imaging BV, 12, Director, Novartis, 2, Pfizer, 2, Rheumatology Consultancy BV, 12, Director, UCB, 2; W. van Lankveld: None; A. Van Tubergen: Janssen, 2, Novartis, 2, 5, 6, UCB, 5; S. Ramiro: AbbVie, 2, 5, Eli Lilly, 2, 5, Galapagos/Alfasigma, 2, 5, Janssen, 2, MSD, 2, 5, Novartis, 2, 5, Pfizer, 2, 5, Sanofi, 2, 5, UCB, 2, 5; A. Boonen: AbbVie/Abbott, 5, Alfasigma, 2, Celgene, 5, Eli Lilly, 2, Novartis, 2, Sandoz, 2, UCB, 2.

To cite this abstract in AMA style:

van Essen M, capelusnik D, Van Der Heijde D, Landewé R, van Lankveld W, Van Tubergen A, Ramiro S, Boonen A. Coping with Rheumatic Stressors in Axial Spondyloarthritis: Association with Patient Characteristics and Disease Phenotypes and Changes Over Time [abstract]. Arthritis Rheumatol. 2025; 77 (suppl 9). https://acrabstracts.org/abstract/coping-with-rheumatic-stressors-in-axial-spondyloarthritis-association-with-patient-characteristics-and-disease-phenotypes-and-changes-over-time/. Accessed .
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