ACR Meeting Abstracts

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Abstracts tagged "Outcome measures"

  • Abstract Number: 0256 • ACR Convergence 2021

    Consensus Approach to a Treat to Target Strategy in Juvenile Idiopathic Arthritis Care: Report from the 2020 Pediatric Rheumatology Care and Outcomes Improvement Network Consensus Conference

    Tala El Tal1, Meghan Ryan2, Brian Feldman3, Catherine Bingham4, Jon Burnham5, Michelle Batthish6, Danielle Bullock7, Kerry Ferraro8, Mileka Gilbert9, Beth Gottlieb10, Julia Harris11, Melissa Hazen12, Ronald Laxer13, Tzielan Lee14, Daniel Lovell15, Melissa Mannion16, Laura Noonan17, Edward Oberle18, Anne Paul19, Janalee Taylor20, Jennifer Weiss21, Cagri Yildirim-Toruner22 and Esi Morgan23, 1University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 2University of Minnesota, Vadnais Heights, MN, 3The Hospital for Sick Children, Toronto, ON, Canada, 4Penn State Children's Hospital, Allentown, PA, 5Children's Hospital of Philadelphia, Philadelphia, PA, 6McMaster University, Hamilton, ON, Canada, 7University of Minnesota, Minneapolis, MN, 8Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, OH, 9Medical University of South Carolina, Charleston, SC, 10Cohen Children's Medical Center, Lake Success, NY, 11Children's Mercy Kansas City, Overland Park, KS, 12Boston Children's Hospital, Boston, MA, 13SickKids, Toronto, ON, Canada, 14Stanford University School of Medicine, Palo Alto, CA, 15Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 16University of Alabama at Birmingham, Birmingham, AL, 17Levine Children's Hospital/Carolinas Healthcare System, Charlotte, NC, 18Nationwide Children's Hospital, Columbus, OH, 19Cincinnati Children's Hospital Medical Centre, Cincinnati, OH, 20Cincinnati Children's Hospital, Cincinnati, OH, 21Hackensack University Medical Center, Hackensack, NJ, 22Texas Children's Hospital/Baylor College of Medicine, Houston, TX, 23Seattle Children's Hospital, Seattle, WA

    Background/Purpose: Treat to target (T2T) is a strategy of adjusting treatment until a therapeutic target is reached. There is growing evidence supporting the use and…
  • Abstract Number: 0658 • ACR Convergence 2021

    ACCORD: A Novel Rheumatology Transition Clinic Structure for Adolescent and Young Adult Patients with Childhood Onset Rheumatic Disease

    Rebecca Overbury1, Kelly Huynh2, Tracy Frech1, John Bohnsack1 and Aimee Hersh1, 1University of Utah, Salt Lake City, UT, 2Intermountain Health Care, Salt Lake City, UT

    Background/Purpose: The transition of health care from Pediatric to Adult providers for adolescents and young adults with childhood onset rheumatic disease continues to be associated…
  • Abstract Number: 0792 • ACR Convergence 2021

    Remission Rates of Patients with Rheumatoid Arthritis in a Tertiary Care

    Nils Gildemeister1, Imke Redeker2, Bjoern Buehring1, Ioana Andreica1, David Kiefer3, Xenofon Baraliakos1, Juergen Braun1 and Uta Kiltz1, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2German Rheumatism Research Centre (DRFZ), Berlin, Germany, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Essen, Germany

    Background/Purpose: The main goal of treatment for patients (pts.) with rheumatoid arthritis (RA) is to achieve remission, in order to both, preserve physical function and…
  • Abstract Number: 1258 • ACR Convergence 2021

    Measurement of Specific Organ Domains in Lupus Randomised Controlled Trials

    Kathryn Connelly1, Jeevan Vettivel2, Vera Golder2, Rangi Kandane-Rathnayake2 and Eric Morand3, 1Monash University, Camberwell, Australia, 2Monash University, Clayton, Australia, 3Monash University, Melbourne, Australia

    Background/Purpose: Randomised controlled trials (RCTs) in SLE typically adopt composite responder definitions as primary efficacy endpoints, however outcomes within individual organ domains are also important…
  • Abstract Number: 1809 • ACR Convergence 2021

    Efficacy of Tofacitinib on Enthesitis in Patients with Active Psoriatic Arthritis

    Philip Mease1, Ana-Maria Orbai2, Oliver FitzGerald3, Mohamed Bedaiwi4, Dona L Fleishaker5, Rajiv Mundayat6, Pamela Young7 and Philip S Helliwell8, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland, 4Division of Rheumatology, College of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia, 5Pfizer Inc, Groton, CT, 6Pfizer Inc, New York, NY, 7Pfizer Inc, Collegeville, PA, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Enthesitis (inflammation where the tendon, ligament, or joint capsule insert into the bone) has been associated with higher disease activity and reduced quality of…
  • Abstract Number: 0320 • ACR Convergence 2021

    Performance of the Clinical Trials ESSDAI (ClinTrialsESSDAI), an Adjusted ESSDAI Score, in Two Randomised Clinical Trials in Patients with Primary Sjögren’s Syndrome

    Liseth de Wolff1, Suzanne Arends2, Elena Pontarini3, Michele Bombardieri3, Simon J Bowman4 and Hendrika Bootsma2, 1University Medical Centre Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3Queen Mary University of London, William Harvey Research Institute, London, United Kingdom, 4Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

    Background/Purpose: Recent randomised controlled trials (RCTs) in primary Sjögren’s syndrome (pSS) failed to show clinical efficacy.1-3 Several RCTs used the EULAR Sjögren’s Syndrome Disease Activity…
  • Abstract Number: 0674 • ACR Convergence 2021

    A Behavioral Intervention to Improve Gout Outcomes in African Americans with Gout: A 12-month Multicenter, Randomized Controlled Trial

    Jasvinder Singh1, Kenneth Saag1, Joshua Baker2, Amy Joseph3, Seth Eisen4 and Terence Shaneyfelt1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania, Philadelphia, PA, 3Washington University / St. Louis VA, St Louis, MO, 4Washington University School of Medicine, St Louis, MO

    Background/Purpose: Gout outcomes and severity are worst in African Americans compared to Caucasians with gout. Racial Disparities in gout are well-described. Few or no data…
  • Abstract Number: 0814 • ACR Convergence 2021

    Patient Characteristics, Efficacy, and Treatment Patterns of Tofacitinib Monotherapy in Patients with RA: Contextualization of Randomized Controlled Trial Results with Real-world Data

    Janet Pope1, Axel Finckh2, Lucia Silva-Fernández3, Peter Mandl4, Haiyun Fan5, Jose L Rivas6, Monica Valderrama6 and María Montoro6, 1University of Western Ontario, London, ON, Canada, 2University Hospital of Geneva, Geneve - Vesenaz, Switzerland, 3Hospital Universitari Son Espases, Palma de Mallorca, Spain, 4Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Pfizer Inc, Collegeville, PA, 6Pfizer SLU, Madrid, Spain

    Background/Purpose: Randomized controlled trials (RCTs) have long been considered the gold standard for clinical research, but can be complemented with real-world data (RWD) to further…
  • Abstract Number: 1259 • ACR Convergence 2021

    Association of SLE Responder Index (SRI) Attainment and Long-term Clinical Outcomes

    Kathryn Connelly1, Rangi Kandane-Rathnayake1, Alberta Hoi2, Worawit Louthrenoo3, Laniyati Hamijoyo4, Jiacai Cho5, Aisha Lateef6, Shue-Fen Luo7, Yeong-Jian Wu8, C.S. Lau9, YI-HSING CHEN10, Sandra Navarra11, Leonid Zamora11, Zhanguo Li12, Yuan An12, Sargunan Sockalingam13, Yanjie Hao14, Zhuoli Zhang14, Madelynn Chan15, Yasuhiro Katsumata16, Masayoshi Harigai16, Shereen Oon17, Sang-Cheol Bae18, Sean O’Neill19, Kathryn Gibson19, Jun Kikuchi20, B.M.D.B. Basnayake21, Tsutomu Takeuchi22, Kristine (Pek Ling) Ng23, Fiona Goldblatt24, Annie Law25, Nicola Tugnet26, Yoshiya Tanaka27, Sunil Kumar28, Michael Tee29, Jin Yu Tan30, Chetan Karyekar31, Mandana Nikpour32, Vera Golder1 and Eric Morand33, 1Monash University, Clayton, Australia, 2Department of Rheumatology, Monash Health & Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia, 3Maharaj Nakorn Chiangmai, Chiang Mai, Thailand, 4University of Padjadjaran, Bandung, Indonesia, 5National University Health System (NUHS), Singapore, Singapore, 6National University Hospital, Singapore, Singapore, 7Chang Gung Memorial Hospital, Taipei, Taiwan, 8Chang Gung Memorial Hospital, Taoyuan County, Taiwan, 9University of Hong Kong, Hong Kong, Hong Kong, 10Taichung Veterans General Hospital, Taichung, Taiwan (Republic of China), 11University of Santo Tomas Hospital, Manila, Philippines, 12People's Hospital, Peking University Health Science Center, Beijing, China (People's Republic), 13University of Malaya, Kuala Lumpur, Malaysia, 14Peking University First Hospital, Beijing, China (People's Republic), 15Tan Tock Seng Hospital, Singapore, Singapore, 16Tokyo Women's Medical University School of Medicine, Tokyo, Japan, 17Melbourne Health, Parkville, Australia, 18Hanyang University Medical Center, Seoul, Republic of Korea, 19Liverpool Hospital, Sydney, Australia, 20Keio University School of Medicine, Tokyo, Japan, 21Teaching (General) Hospital, Kandy, Sri Lanka, 22Div. Rheumatology, Keio University, Tokyo, Japan, 23North Shore Hospital, Auckland, New Zealand, 24Flinders Medical Centre, Adelaide, Australia, 25Singhealth, Singapore, Singapore, 26Auckland District Health Board, Auckland, New Zealand, 27University of Occupational and Environmental Health, Kitakyushu, Japan, 28Counties Manukau Health, Auckland, New Zealand, 29University of the Philippines, Quezon City, Philippines, 30Janssen Asia Pacific, Singapore, Singapore, 31Janssen R&D, Spring House, PA, 32University of Melbourne at St Vincent's Hospital, Melbourne, Australia, 33School of Clinical Sciences at Monash Health, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre Clayton, Melbourne, Australia

    Background/Purpose: The SLE Responder Index (SRI) is a composite responder definition employed as a clinical trial endpoint in SLE. Despite its widespread adoption, recent discrepant…
  • Abstract Number: 1863 • ACR Convergence 2021

    Consistent Efficacy with Apremilast in Men and Women to Treat Oral Ulcers Associated with Behçet’s Syndrome: Results from Phase 3 Researching Oral Apremilast Safety and Efficacy in Behçet’s Disease (RELIEF) Study

    Gülen Hatemi1, Alfred Mahr2, Mitsuhiro Takeno3, Doyoung Kim4, Melike Melikoğlu5, Sue Cheng6, Sven Richter6, Shauna Jardon7, Maria Paris6, Mindy Chen6 and Yusuf Yazici8, 1Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, İstanbul, Turkey, 2Kantonsspital St. Gallen, St.Gallen, Switzerland, 3Musashi Kosugi Hospital, Kawasaki, Japan, 4Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, 5Istanbul University‒Cerrahpaşa, İstanbul, Turkey, 6Amgen Inc., Thousand Oaks, CA, 7Amgen Inc., Gilbert, AZ, 8New York University School of Medicine, New York, NY

    Background/Purpose: Painful, recurring oral ulcers (OU) associated with Behçet’s syndrome negatively affect quality of life (QoL). Differences across sexes were reported in the frequency of…
  • Abstract Number: 0336 • ACR Convergence 2021

    The Incremental Clinical Utility of a Multianalyte Assay Panel with Cell-Bound Complement Activation Products versus a Traditional ANA Testing Strategy for the Diagnosis and Treatment of SLE

    Tyler O'Malley1, Fenglong Xie2, yujie Su2, cassie Clinton2, Debra J. Zack1, Jeffrey Curtis3 and John Wegener1, 1Exagen Inc., Vista, CA, 2University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The comparative clinical utility of various diagnostic tests to aid the differential diagnosis of SLE is unclear. We compare the outcomes of testing with…
  • Abstract Number: 0690 • ACR Convergence 2021

    Impact of Achieving 2016 ACR/EULAR Response Criteria on Patient Centered Outcome Measures in Myositis

    Didem Saygin1, Siamak Moghadam-Kia2, Chester Oddis2, Dana Ascherman2, Nicole Neiman2, Diane Koontz2 and Rohit Aggarwal2, 1University of Chicago, Chicago, IL, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The 2016 ACR/EULAR Myositis Response Criteria represent a composite measure that is increasingly being used as a primary end point in myositis clinical trials.…
  • Abstract Number: 0845 • ACR Convergence 2021

    A Non-Interventional Prospective Observational Study of Treatment with Etanercept Biosimilar (SB4) in Rheumatoid Arthritis in Real Life Clinical Practice; Interim Analysis of the ‘BENEFICIAL’ Study

    Panagiotis Athanassiou1, Andreas Bounas2, Dimitrios Boumpas3, Prodromos Sidiropoulos4, Christina Tsalapaki5, Alexandros Garyfallos6, Eleftheria Grika7, Paraskevi Voulgari8, Angeliki Kekki9, Zafeirios Anagnostopoulos9, Georgios Karachalios9 and Nikos Antonakopoulos9, 1Department of Rheumatology, St. Paul’s Hospital of Thessaloniki, Thessaloniki, Greece, 2General Clinic of Patras “Olympion”, Rheumatology, Patras, Greece, 3“Attikon” University Hospital, Rheumatology and Clinical Immunology Unit ,4th University Pathology Clinic, Athens, Greece, 4Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, Heraklion, Greece, 5General Hospital of Athens “Hippokratio", Department of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 6General Hospital of Thessaloniki “Ippokratio" , Τhessaloniki, Greece, Thessaloniki, Greece, 7Rheumatology Clinic, General Hospital “Evangelismos”, Athens, Greece, 8Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, 9Genesis Pharma SA, Athens, Greece, Athens, Greece

    Background/Purpose: SB4 is an etanercept biosimilar that obtained EU regulatory approval in 2016, and became available in Greece in 2018. Due to lack of published…
  • Abstract Number: 1261 • ACR Convergence 2021

    The Impact of Remission and Low Disease Activity Attainment on Health-related Quality of Life in Two Phase III Clinical Trials of Belimumab in Systemic Lupus Erythematosus

    Sharzad Emamikia1, Shereen Oon2, Alvaro Gomez1, Julius Lindblom1, Alexander Borg1, Yvonne Enman1, Eric Morand3, David Grannas4, Ronald van Vollenhoven5, Mandana Nikpour6 and Ioannis Parodis7, 1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Department of Rheumatology, St Vincent's Hospital, Fitzroy, Australia, 3School of Clinical Sciences at Monash Health, Monash University Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre Clayton, Melbourne, Australia, 4Divison of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 5Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology Center, Amsterdam, Netherlands, 6University of Melbourne at St Vincent's Hospital, Melbourne, Australia, 7Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden and Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

    Background/Purpose: Health-related quality of life (HRQoL) is considered one of the most important outcomes in clinical trials of systemic lupus erythematosus (SLE), along with reduction…
  • Abstract Number: 1879 • ACR Convergence 2021

    Delayed Diagnosis of IgG4 Related Disease Is Associated with Worse Outcome: A Retrospective, Real-life Observational Study

    Elisheva Pokroy-Shapira1, Iftach Sagy2, Katya Meridor3 and Yair Molad4, 1Institute of Rheumatology, Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petach Tikva, Israel, 2Clinical Research Center, Soroka University Medical Center, Beer Sheva and Ben Gurion University of the Negev, DVIRA, Israel, 3Tel Aviv Sourasky Medical Center, Kfar Saba, Israel, 4Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petah-Tikva, Israel

    Background/Purpose: The purpose of this study was to characterize clinical and pathological features as well as disease outcome of an Israeli incident cohort of patients…
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