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Abstracts tagged "Outcome measures"

  • Abstract Number: 341 • 2019 ACR/ARP Annual Meeting

    Development of a Multivariable Improvement Measure for Gout

    Naomi Schlesinger1, N. Lawrence Edwards 2, Anthony Yeo 3 and Peter Lipsky 4, 1Division of Rheumatology, Department of Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, 2Department of Medicine, University of Florida, Gainesville, FL, 3Horizon Therapeutics plc, Lake Forest, IL, 4AMPEL BioSolutions, LLC, Charlottesville, VA

    Background/Purpose: Gout is a multifactorial inflammatory disease in which patients experience a wide range of signs and symptoms, including flares, inflammatory arthritis, tophi and disability.…
  • Abstract Number: 356 • 2019 ACR/ARP Annual Meeting

    Gout Flares Become Infrequent During a Treat-to-target Strategy over One Year: Data from the NOR-Gout Study

    Till Uhlig1, Lars Fridtjof Karoliussen 2, Espen A Haavardsholm 2, Tore Kvien 1 and Hilde Hammer 2, 1Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway, 2Diakonhjemmet hospital, Oslo, Norway

    Background/Purpose: Urate lowering therapy (ULT) is expected to prevent new gout flares. Treat-to-target ULT is however often not performed, and more evidence on how often…
  • Abstract Number: 767 • 2019 ACR/ARP Annual Meeting

    Outcome Measures in Large-Vessel Vasculitis: Relationships Between Patient, Physician, Imaging, and Laboratory-Based Domains

    Casey A. Rimland1, Kaitlin Quinn 2, Joel S. Rosenblum 3, Mollie Schwartz 4, K Bates Gribbons 5, Elaine Novakovich 6, Antoine Sreih 7, Peter Merkel 7, Mark A. Ahlman 8 and Peter C. Grayson 9, 1National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, Chapel Hill, NC, 2Georgetown University Hospital/National Institutes of Health, Washington, DC, 3National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Bethesda, MD, 4University of Maryland, Baltimore, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6National Institutes of Health, Bethesda, MD, 7University of Pennsylvania, Philadelphia, PA, 8Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, Bethesda, MD, 9National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD

    Background/Purpose: Large-vessel vasculitis (LVV) is characterized by inflammation of the aorta and its major branches. The most common forms of LVV include giant cell arteritis…
  • Abstract Number: 1655 • 2019 ACR/ARP Annual Meeting

    Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in Patients with Early, Diffuse Cutaneous Systemic Sclerosis

    Kimberly Showalter1, Cynthia Magro 2, Dana Orange 3, Yaxia Zhang 4, Phaedra Agius 5, Jackie Finik 6, Robert Spiera 1 and Jessica Gordon 1, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, 3Rockefeller University, New York, 4Hospital for Special Surgery, New York, 5New York Genome Center, New York City, 6Hospital for Special Surgery, New York, NY, New York, NY

    Background/Purpose: The association between systemic sclerosis (SSc) skin histology and clinical findings is not fully characterized. In two SSc trials, we developed a scoring system…
  • Abstract Number: 2473 • 2019 ACR/ARP Annual Meeting

    Implementing the Psoriatic Arthritis Disease Activity Score (PASDAS) in Routine Clinical Practice: (im)possible?

    Michelle Mulder1, Alfons den Broeder 1, Berbke van Ginneken 1, Elien Mahler 1, Frank van den Hoogen 1, Johanna Vriezekolk 1 and Mark Wenink 1, 1Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease, with involvement of at least five health domains: peripheral joint disease, enthesitis, dactylitis, axial involvement, and skin…
  • Abstract Number: 2840 • 2019 ACR/ARP Annual Meeting

    Reliability, Validity and Responsiveness of PROMIS PF-20 in Patients with Inflammatory Myopathy

    Didem Saygin1, Chester Oddis 1, Nicole Neiman 1, Diane Koontz 1, Siamak Moghadam-Kia 1 and Rohit Aggarwal 1, 1University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare, debilitating systemic diseases characterized by proximal muscle weakness, which limit activities of daily living and…
  • Abstract Number: 481 • 2018 ACR/ARHP Annual Meeting

    Stepping It up: The Use of Physical Activity Monitors As an Outcome Measure in Juvenile Myositis

    Emily Brunner1, Laura Tasan2, Kathryn S. Torok3, Bonny Rockette-Wagner4, Christina K. Zigler5, Kaila Schollaert-Fitch3, Diane Koontz6, Chester V. Oddis7 and Rohit Aggarwal8, 1Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 3Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, 6Internal Medicine Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 7Division of Rheumatology and Clinical Immunology, Department of Medicine, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, 8Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: The use of physical activity monitors (PAM), which objectively quantify free-living movement, may enhance assessment of disease activity in juvenile myositis (JM) clinical trials…
  • Abstract Number: 2687 • 2018 ACR/ARHP Annual Meeting

    Patient-Level Evaluation of Components of the American College of Rheumatology Combined Response Index in Systemic Sclerosis (CRISS) Using Patient-Reported Anchors

    Vivek Nagaraja1, John Powers2, Celia J. F. Lin3, Benjamin Brennan4, Veronica J. Berrocal5 and Dinesh Khanna1, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2University of Maryland School of Medicine, Rockville, MD, 3Genentech, Inc., South San Francisco, CA, 4School of Public Health, University of Michigan, Ann Arbor, MI, 5Div of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Treatment benefit is demonstrated by evidence that interventions have positive impacts on how patients feel, function, and/or survive (FDA Guidance, 21CFR314.510). The ACR CRISS,…
  • Abstract Number: 681 • 2018 ACR/ARHP Annual Meeting

    Identification of Treatment Naïve Patients with Psoriatic Arthritis Who Will Require a TNF Inhibitor

    Dan Gromer1, Laura C. Coates2, Oliver FitzGerald3, Blanca Himes4, Philip Helliwell5 and Alexis Ogdie6, 1University of Pennsylvania, Medical Student, Philadelphia, PA, 2University of Oxford, Oxford, United Kingdom, 3Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, 4Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 5LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 6Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease that affects the skin, joints, and soft tissues. No metrics exist to indicate whether an…
  • Abstract Number: 2783 • 2018 ACR/ARHP Annual Meeting

    EULAR Task Force Recommendations for a Minimum Core Set of Parameters to be Collected in Giant Cell Arteritis Registries and Databases

    Lisa Ehlers1, Johan Askling2, Johannes W. J. Bijlsma3, Maria C. Cid4, Maurizio Cutolo5, Bhaskar Dasgupta6, Christian Dejaco7,8, William G Dixon9, Nils Feltelius10,11, Axel Finckh12, Kate Gilbert13, Sarah Mackie14, Alfred Mahr15, Eric L. Matteson16, Lorna Neill17, Carlo Salvarani18,19, Wolfgang A. Schmidt20, Anja Strangfeld21, Ronald van Vollenhoven22 and Frank Buttgereit1, 1Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, 2Unit of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 3Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 4University of Barcelona, Barcelona, Spain, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 6Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, 7Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria, Graz, Austria, 8Rheumatology, Hospital of Bruneck, Bruneck, Italy, 9Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 10Medical Products Agency, Uppsala, Sweden, 11Cross-Committee Task Force on Registries at the European Medicines Agency, London, United Kingdom, 12University Hospital of Geneva, Geneva, Switzerland, 13Patient Representative from PMRGCAuk, London, United Kingdom, 14NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom, 15Internal Medicine, Saint-Louis Hospital, Paris Diderot University, Paris, France, 16Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 17Patient Representative from PMR-GCA Scotland, Perth, United Kingdom, 18Università di Modena e Reggio Emilia, Modena, Italy, 19Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy, 20Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, 21Epidemiology, German Rheumatism Research Center, Berlin, Germany, 22Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands

    Background/Purpose: Giant cell arteritis (GCA) represents the most common form of primary systemic vasculitis, and is frequently associated with comorbidities related either to the disease…
  • Abstract Number: 723 • 2018 ACR/ARHP Annual Meeting

    Patient-Reported Cognitive Screen Does Not Identify Cognitive Sub-Domains: Exploration of the Subscale Structure of the Perceived Deficits Questionnaire in a Systemic Lupus Erythematosus Cohort

    Lisa Engel1, Jiandong Su1, Emily Nalder2, Yael Goverover3, Monique Gignac4, Carmela Tartaglia5, Nicole Anderson1 and Zahi Touma1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada, 3Department of Occupational Therapy, New York University, New York, NY, 4Instititue for Work and Health, Toronto, ON, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada

    Background/Purpose: Identifying patients with Systemic Lupus Erythematosus related cognitive impairment (SLE-CI) is critical as SLE-CI can negatively affect employment, quality of life, and disease self-management.…
  • Abstract Number: 2857 • 2018 ACR/ARHP Annual Meeting

    An Electronic Audit, Reporting, and Data Correction System Improves the Quantity and Quality of Observational Data Collected for US Veterans Enrolled in the Veterans Affairs Rheumatoid Arthritis Registry

    Grant W. Cannon1,2, Jorge Rogas2, Neill Bell3, Joshua Baker4, Gail S. Kerr5, Angelo Gaffo6, J. Steuart Richards7, Jennifer Barton8, Pascale Schwab8, Ted R. Mikuls9, Namrata Singh10, Liron Caplan11, Deana Lazaro12, Andreas Reimold13 and Brian Sauer2, 1Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 3Salt Lake City VA Medical Center and University of Utah, Dallas VA Medical Center, Dallas, TX, 4Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA, 5Washington VA Medical Center, Georgetown and Howard Universities, Washington, DC, 6Birmingham VA and University of Alabama at Birmingham, Birmingham, AL, 7Pittsburgh VA Medical Center and University of Pittsburgh, Pittsburgh, PA, 8VA Portland Health Care System and Oregon Health and Science, Portland, OR, 9VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 10Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, 11Div of Rheumatology, Denver VA Medical Center and University of Colorado, Aurora, CO, 12Brooklyn VA Medical Center and SUNY Downstate, Brooklyn, NY, 13Rheumatology, Dallas VA Medical Center and University of Texas - Southwestern, Dallas, TX

    Background/Purpose:   The Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry is an observational cohort study of US Veterans with RA at 11 VA Medical…
  • Abstract Number: 1261 • 2018 ACR/ARHP Annual Meeting

    Development a Core Domain Set to Assess Shared Decision Making Interventions in Rheumatology: An OMERACT White Paper to Facilitate Endorsement

    Karine Toupin-April1, Jennifer Barton2,3, Liana Fraenkel4, Alexa Meara5, Linda Li6, Peter Brooks7, Maarten de Wit8, Dawn Stacey9,10, France Légaré11, Beverly Shea9,12,13, Anne Lyddiatt14, Catherine Hofstetter15, Robin Christensen16, Marieke Scholte-Voshaar17,18, Maria Suarez-Almazor19, Annelies Boonen20, Tanya Meade21,22, Lyn March22, Janet Elizabeth Jull9, Willemina Campbell23, Rieke Alten24, Suvi Karuranga25, Esi Morgan26, Jessica Kaufmann27, Sophie Hill27, Lara J. Maxwell9,10, Dorcas Beaton28, Yasser El-Miedany29, Shikha Mittoo30, Susan J. Bartlett31, Jasvinder A. Singh32 and Peter Tugwell33, 1Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada, 2VA Portland Health Care System, Portland, OR, 3Oregon Health & Science University, Portland, OR, 4Yale University School of Medicine, New Haven, CT, 5Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, 6Arthritis Research Canada, Richmond, BC, Canada, 7The University of Melbourne, Victoria, Australia, 8EULAR standing committee of PARE, Zurich, Switzerland, 9University of Ottawa, Ottawa, ON, Canada, 10The Ottawa Hospital Research Institute, Ottawa, ON, Canada, 11Université Laval, Montreal, QC, Canada, 12Bruyere Research Institute, Ottawa, ON, Canada, 13School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, and Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, Canada, 14Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, 15OMERACT patient research partner group, Ottawa, ON, Canada, 16Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, 17University of Twente, Enschede, ON, Netherlands, 18OMERACT patient research partner group, Enschede, Netherlands, 19Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 20Department of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands, Maastricht, Netherlands, 21Western Sydney University, New South Wales, Australia, 22University of Sydney, New South Wales, Australia, 23OMERACT patient research partner group, Toronto, ON, Canada, 24University Medicine Berlin, Berlin, Germany, 25Access to Medicine Foundation, Haarlem, Netherlands, 26University of Cincinnati, Cincinnati, OH, 27La Trobe University, Victoria, Australia, 28Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada, 29Ain Shams University, Cairo, Egypt, 30Involved medicine, Toronto, ON, Canada, 31Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 32Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 33Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada

    Background/Purpose: Shared decision making (SDM) improves decisional outcomes and patient-physician communication and holds great potential for improving the management of various rheumatology conditions. However, the…
  • Abstract Number: 2871 • 2018 ACR/ARHP Annual Meeting

    Comprehensive Provider Judgement Is a Significant Determinant of Major Therapeutic Change in Patients with Moderate to Severe Rheumatoid Arthritis

    Jacob R. Stever1, Brian C. Sauer1 and Grant W. Cannon2, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT

    Background/Purpose:   We have previously reported an evaluation of 941 US Veterans in the Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry that 559 (59%)…
  • Abstract Number: 1446 • 2018 ACR/ARHP Annual Meeting

    The Optimal Joint Set for Ultrasound Assessment of Synovitis in RA: Results from the Rasch Measurement Model

    Elizabeth M.A. Hensor1,2, Alan Tennant3, Philip G. Conaghan1,2, Hilde B Hammer4, Richard J. Wakefield1,2 and Maria Antonietta D'Agostino1,5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, United Kingdom, 3Swiss Paraplegic Research, Nottwil, Switzerland, 4Rheumatology, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Versailles-Saint Quentin en Yvelines University- APHP, Ambroise-Paré Hospital, Boulogne-Billancourt, France

    Background/Purpose: The recently introduced composite OMERACT-EULAR power Doppler (PD)/grey scale (GS) ultrasound (PDUS) scoring system for RA with a proposed 18 joint set was developed…
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