Clinical Characteristics of Nonradiographic Axial Spondyloarthritis in Korea: A Comparison with Ankylosing Spondylitis

Hyungjin Kim¹, Hyemin Jeong¹, Seulkee Lee¹, Inyoung Kim¹, Jiwon Hwang², Jaejoon Lee¹, Jinseok Kim³, Eun-Mi Koh⁴ and Hoon-Suk Cha⁵, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³1753-3, Ara-1 Dong, Jeju National University Hospital, Jeju, South Korea, ⁴Dept of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), axial spondyloarthritis and non-radiographic, Clinical

Session Information

Session Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment I

Session Type: Abstract Submissions (ACR)

Background/Purpose: To evaluate the clinical characteristics and outcomes of nonradiographic axial spondyloarthritis (nr-axSpA) in Korean patients.

Methods: A retrospective analysis evaluated 155 patients with nr-axSpA at a single tertiary hospital between January 2001 and January 2011. Baseline characteristics and clinical courses were reviewed and compared with those of patients with ankylosing spondylitis (AS).

Results: The mean age at disease onset was 29.5 ± 10.8 years, and 52 (33.5%) patients were female. The mean age at symptom onset was older (29.5 ± 10.8 vs. 25.9 ± 9.2, respectively, p < 0.001) and the male to female ratio was lower (2:1 vs. 5:1, respectively, p = 0.001) in patients with nr-axSpA compared with patients with AS. The proportion of females was higher among patients with late onset-SpA than early-onset nr-axSpA (55.0 vs. 30.1%, respectively, p = 0.029). Among 74 patients with nr-axSpA, whose follow-up duration was more than 1.5 years, 29 (39.2%) patients progressed to AS during the follow-up period. The proportion of females was lower in progressors that that of non-progressors (13.8 vs. 44.4%, respectively, p = 0.010). Presence of syndesmophyte and minimal X-ray changes at baseline were frequently observed in progressors compared with non-progressors (26.7 vs. 0.0 %, p = 0.006 and 69.0 vs. 35.6%, p = 0.005, respectively).

Conclusion: The predominance of male patients is more prominent among Korean patients with SpA compared with Caucasians. Female nr-axSpA patients had late symptom onset and less progression to AS. X-ray changes at baseline were associated with radiographic progression.

Disclosure:

H. Kim,
None;

H. Jeong,
None;

S. Lee,
None;

I. Kim,
None;

J. Hwang,
None;

J. Lee,
None;

J. Kim,
None;

E. M. Koh,
None;

H. S. Cha,
None.

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