Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases including ankylosing spondylitis and inflammatory bowel disease. Recently, polymorphisms in Card9 were linked to the pathogenesis of a prevalent type of autoimmune arthritis, Rheumatoid arthritis (RA). Here we sought to investigate the role of Card9 in the pathogenesis of arthritis using the genetically susceptible strain of mice (SKG) that develop a T cell-mediated arthritis in response to microbial triggers. Understanding how Card9 affects the pathogenesis of T cell-mediated arthritis will contribute to our understanding of the etiology of RA and development of future therapeutics.
To cite this abstract in AMA style:Napier R, Lee E, Vance E, Samson K, Snow P, Sakaguchi S, Rosenzweig H. Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/card9-is-a-critical-regulator-of-autoimmune-arthritis-in-skg-mice/. Accessed November 25, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/card9-is-a-critical-regulator-of-autoimmune-arthritis-in-skg-mice/