Altered Risk of Gout According to Change of Metabolic Parameters in Young Adults

Yeonghee Eun¹, In Young Kim², Kyungdo Han³, Seonyoung Kang¹, Seulkee Lee¹, Hoon-Suk Cha¹, Eun-Mi Koh¹, Hyungjin Kim¹ and Jaejoon Lee¹, ¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ²National Police Hospital, Seoul, Republic of Korea, ³Soongsil University, Seoul, Republic of Korea

Meeting: ACR Convergence 2021

Keywords: Crystal-induced arthritis, Epidemiology, metabolic syndrome, risk factors

Session Information

Date: Sunday, November 7, 2021

Session Title: Epidemiology & Public Health Poster II: Inflammatory Arthritis – RA, SpA, & Gout (0560–0593)

Session Type: Poster Session B

Session Time: 8:30AM-10:30AM

Background/Purpose: Previous studies have shown a link between gout and metabolic syndrome (MetS). It is well known that lifestyle modifications such as weight reduction and abstinence from alcohol are effective in the treatment of gout, but data are lacking on how exactly the change of metabolic parameters affects gout. The purpose of this study was to investigate the relationship between gout risk and metabolic parameters in a nationwide population based young adult cohort, and to determine whether changes in metabolic parameters affect gout risk changes.

Methods: Among adults aged 20-39 years who participated in the national health checkup program from 2009 to 2012, 2,598,905 subjects who participated in the health checkup again two years later were included in the analysis to evaluate the effect of changes in metabolic parameters on the occurrence of gout. Outcome was defined as the occurrence of gout, where the ICD-10 code M10 was registered twice in the claim database. Cox proportional hazard model and Kaplan Meier curve were used for analysis.

Results: The mean age of the study population was 32.7 years, and 62.4% were male. The mean follow-up duration was 5.71 years, and 71,245 subjects were newly diagnosed with gout (incidence rate 4.80 per 1,000 person-years). Compared to those who did not have MetS at two health screenings, the risk of gout was 2.5 times higher in those who had MetS consistently (adjusted HR 2.54; 95% CI 2.48, 2.60). The adjusted HR of gout of those who did not have MetS at the first checkup but developed MetS at the second checkup was 1.88, and the adjusted HR of gout of those who had MetS at the first checkup but did not have MetS at the second checkup was 1.76. Each component of MetS was also associated with an increase in the risk of gout, and hypertriglyceridemia and abdominal obesity showed the greatest association.

Conclusion: In young adults, the risk of gout was highest in those with persistent MetS compared to those who did not. Among the components of MetS, hypertriglyceridemia and abdominal obesity had the greatest association with the risk of gout. Management of MetS in young adults is helpful in reducing the risk of gout.

Disclosures: Y. Eun, None; I. Kim, None; K. Han, None; S. Kang, None; S. Lee, None; H. Cha, None; E. Koh, None; H. Kim, None; J. Lee, None.

To cite this abstract in AMA style:

Eun Y, Kim I, Han K, Kang S, Lee S, Cha H, Koh E, Kim H, Lee J. Altered Risk of Gout According to Change of Metabolic Parameters in Young Adults [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 10). https://acrabstracts.org/abstract/altered-risk-of-gout-according-to-change-of-metabolic-parameters-in-young-adults/. Accessed January 16, 2022.

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