Date: Saturday, November 6, 2021
Session Title: Pediatric Rheumatology – Clinical Poster I: JIA (0241–0265)
Session Type: Poster Session A
Session Time: 8:30AM-10:30AM
Background/Purpose: The 2020 Rheumatoid Arthritis Clinical Practice Guidelines by the Ministry of Health, Labour, and Welfare Research Group recommends the JADAS27 as a measure of disease activity in transitional and adult JIA, reflecting the characteristics of JIA-affected joint localization, and citing the possibility of underestimation by the DAS28. We compared the validity of DAS28-ESR and JADAS27 in transitional and adult JIA.
Methods: Patients aged 18 years or older at the time of the study with an onset of younger than 18 years were selected from the prospective observational studies of IORRA conducted by the Institute of Rheumatology, Tokyo Women’s Medical University.
Results: A total of 3,528 cases (age 39.1(SD 15.1) years at the survey, 13.5 (SD 3.8) years of onset, 25.6 (SD 16.0) years of disease duration) were included in the study. Activity according to both disease activity indices in order of high, medium, low disease activity and remission were DAS28-ESR (mean 2.9, SD 1.3):5.5%, 31.7%, 19.5%, 43.3%, JADAS27 (mean 7.6 , SD 6.3): 65.2%, 16.3%, 7.8%, 10.7%, and JADAS 27 and JADAS 27 presented a higher disease activity configuration than DAS28-ESR. The high frequency of active joints was 23.0% in the hands and 12.4% in the elbows. JADAS27-specific joints were active in the ankle (11.3%), neck (2.6%), and hips (1.2%), and in 686 cases (19.4%) with these joints, the DAS28-ESR mean of 2.8 (SD 1.3) and the JADAS27 mean of 7.3 (SD 6.5) was not underestimated by the DAS28-ESR compared to the whole subject.
Conclusion: JADAS27 has been applied to the severity classification of articular JIA as the designated incurable disease in Japan and is socially important in transitional and adult JIA, but it is necessary to recognize the difference between the JADAS27 and the DAS28-ESR in its application.
To cite this abstract in AMA style:Miyamae T, Tanaka E, Inoue E, Ikari K, Harigai M. A Comparative Study of the Validity of the DAS28-ESR and JADAS-27 Disease Activity Assessment Indexes for Juvenile Idiopathic Arthritis in Transition and Adults [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/a-comparative-study-of-the-validity-of-the-das28-esr-and-jadas-27-disease-activity-assessment-indexes-for-juvenile-idiopathic-arthritis-in-transition-and-adults/. Accessed May 30, 2023.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/a-comparative-study-of-the-validity-of-the-das28-esr-and-jadas-27-disease-activity-assessment-indexes-for-juvenile-idiopathic-arthritis-in-transition-and-adults/