ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 220

Lower Extremity Presarcopenia Is Associated with the Severity of Knee Pain

Yun-Hong Cheon1, Wan-Hee Yoo2, Young Sun Suh3, Hyun-Ok Kim3, Ki-Soo Park4, Sang-Il Lee3 and Hye-Ji Jeon4, 1Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Chonbuk National University School of Medicine, Jeonju, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea, 4Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Osteoarthritis - Clinical Aspects: Imaging and Biomechanics

Session Type: Abstract Submissions (ACR)

Background/Purpose

Presarcopenia, which is defined as skeletal muscle mass loss, and knee pain have been gained attention with ageing. Little is known about the association of lower extremity presarcopenia (LEPS) and severity of knee pain. Thus, this study was conducted to the relationship between severity of self-reported knee pain and LEPS.

Methods

From the 5th Korean National Health and Nutrition Examination Survey (KNHNES V1-2, n=17,476), the data of 721 participants, who underwent dual x-ray absorptiometry (DXA) and bilateral knee plain radiographs, and complained knee pain were analyzed. LEPS was defined as a lower extremity skeletal muscle mass index below -2SD of the value in sex-matched young reference groups. Participant were categorized into 4 groups; normal, LEPS, non-LEPS with obesity (NLEPSO), LEPS with obesity (LEPSO).

Results

LEPS and LEPSO are significantly associated with the severity of knee pain (LEPS 6.9±0.4, LEPSO 7.2±0.5, P<0.05). These results did not change after adjusting for various confounding factors. In participants with non-radiographic knee OA (n=268), the severity of knee pain was related with LEPS (7.2±0.6, P<0.05). In radiographic knee OA participants (n=452), LEPSO was related with severity of knee pain (7.3±0.5, P<0.05). Sex, smoking status, osteoporosis, and vitamin D levels were not related with the severity of self-reported knee pain.

Conclusion

LEPS is directly associated with severity of knee pain. This attribution supports increasing muscle mass is very important to reduce knee pain. Thus, early detection of LEPS may help physicians to detect pain-sensitive LEPS patients who can benefit from early intervention such as exercise.

Disclosure:

Y. H. Cheon,
None;

W. H. Yoo,
None;

Y. S. Suh,
None;

H. O. Kim,
None;

K. S. Park,
None;

S. I. Lee,
None;

H. J. Jeon,
None.

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