Background/Purpose: Uveitis, juvenile idiopathic arthritis (JIA), and JIA-associated uveitis (JIA-U) greatly influence children’s quality of life (QOL). Our aim is to identify demographic, disease, and treatment features that may impact patient-reported outcomes (PROs) over time.

Methods: Patients with Uveitis, JIA, and JIA-U, and their caregivers enrolled in Longitudinal Outcomes of Childhood Uveitis Study (LOCUS) registry completed PROs as age-appropriate. The Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q) measures vision-related QOL and function, and Pediatric Quality of Life Inventory (PedsQL) measures overall QOL. Scores range 0 -100 (higher scores: better QoL). The Revised Childhood Anxiety and Depression Scale (RCADS) assesses anxiety and depression. Scores >70 indicate anxiety or depression. The Childhood Health Assessment Questionnaire (C-HAQ) measures functional disability from JIA with scores range 0 -3 (higher scores: worse function). Generalized estimating equation models were used to identify predictors of QOL.

Results: A total of 19 (21.6%) patients with uveitis, 34 (38.7%) JIA-U and 35 (39.7%) JIA completed 5 visits. The median time between baseline and last visit was 19.7 mo (IQR:15.8-28.6). There was a predominance of female sex in JIA 23 (26.2%) and JIA-U 28 (31.8%) compared to Uveitis 8 (9.1%) (< 0.001). Disease duration was longer in JIA-U 5.2 (IQR: 1.5-9.0) vs. Uveitis 0.8 (IQR: 0.2-2.8) and JIA 1.2 (IQR: 0.5-2.5) (p< 0.001). Patients with uveitis alone and active JIA had worse EYE-Q scores (p < 0.01) compared to JIA-U. Not being on a DMARD, being > 10 y/o, and subsequent visits from baseline were significantly associated with better EYE-Q for parents only. Predictors of better PedsQL were not being on DMARD or NSAIDs, and male sex for parents and children. Those with any form of uveitis had worse PedsQL although only for parents. Patients >10 y/o with inactive arthritis or uveitis had better CHAQ for parents and patients. The use of DMARDs was not associated with CHAQ. RCADS better outcome predictors were male sex, for parents and patients, age < 10 y/o for patients and inactive JIA disease for parents.

Conclusion: Having a diagnosis of uveitis, even more so if it was an isolated disease, was associated with worse physical functioning and vision-related QOL/function and PedsQL. Overall predictors were similar between parents and patients with few differences. Male sex, not being on DMARDS or NSAID, and having inactive JIA were associated with better outcomes. Being >10 y/o was associated with better physical functioning and vision-related QOL/function but worse RCAD. Identification of key predictors that impact quality of life over time will help us begin to tailor interventions to enhance the wellbeing of patients with chronic arthritis and uveitis.

Juvenile idiopathic arthritis associated uveitis (JIA-U); Juvenile idiopathic arthritis (JIA); nonsteroidal anti-inflammatory (NSAID); years (yrs); Intervale interquartile (IQR)

Bonferroni correction was used for multiple analysis

Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q); Pediatric Quality of Life Inventory (PedsQL); Juvenile idiopathic arthritis associated uveitis (JIA-U); Juvenile idiopathic arthritis (JIA); Disease-modifying antirheumatic drug (DMARD); nonsteroidal anti-inflammatory (NSAID); Least Square Mean scores (LS mean)

Pairwise analyses with Tukey’s correction for multiple analysis were significant for:

* JIA vs U and JIA-U vs U

‡JIA vs U

§ Time since baseline significant 7-11 and 18-24 in comparison with baseline

Childhood Health Assessment Questionnaire (C-HAQ); The Revised Childhood Anxiety and Depression Scale (RCADS); Juvenile idiopathic arthritis associated uveitis (JIA-U); Juvenile idiopathic arthritis (JIA); Disease-modifying antirheumatic drug (DMARD); nonsteroidal anti-inflammatory (NSAID); Least Square Mean scores (LS mean)

Pairwise analyses with Tukey’s correction for multiple analysis were significant for:

* Baseline x 7-11 months visit

‡Baseline x 12-17 months visit

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/predictors-of-quality-of-life-in-a-longitudinal-cohort-of-patients-with-uveitis-juvenile-idiopathic-arthritis-and-jia-associated-uveitis/