Abstracts tagged "WNT Signaling"

Abstract Number: 2929 • 2017 ACR/ARHP Annual Meeting
WNT5A Promotes Tissue Fibrosis By Wnt/PCP-Dependent Activation of Latent TGF-β
Chih-Wei Chen¹, Thuong Trinh-Minh², Neng-Yu Lin², Yun Zhang³, Florian Groeber⁴, Christian Beyer⁵, Georg Schett⁶ and Jörg Distler⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ²Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Translational Center Würzburg, Fraunhofer Ins. IGB, Würzburg, Germany, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Canonical Wnt/β-catenin signaling has emerged as a core pathway of fibrosis. They role of non-canonical Wnt signaling, however, has not been systematically studied. In…
Abstract Number: 2120 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04690) As a Potential Treatment for Degenerative Disc Disease
Charlene Barroga¹, Vishal Deshmukh¹, Luis Dellamary¹, Josh Stewart¹, Haide Hu², John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Degenerative Disc Disease (DDD), one of the main causes of low back pain, is characterized by degeneration of intervertebral disc, nucleus pulposus (NP), and…
Abstract Number: 2143 • 2016 ACR/ARHP Annual Meeting
A Small Molecule, SM04690, Has Inhibitory Effects on the Wnt Pathway and Inflammation in Vitro, with Potential Implications for the Treatment of Osteoarthritis
Vishal Deshmukh¹, Maureen Ibanez¹, Charlene Barroga¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Osteoarthritis (OA) involves thinning cartilage and increased subchondral bone. Amongst many cellular processes, inflammation has been associated with OA. Wnt signaling plays a…
Abstract Number: 2350 • 2016 ACR/ARHP Annual Meeting
Radiographic Outcomes from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
Christopher J. Swearingen¹, Sharmila Majumdar², Ismail Simsek¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²University of California San Francisco, San Francisco, CA
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional impairment, disability, and joint space narrowing due to degradation of articular cartilage and bone remodeling. The…
Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Vishal Deshmukh¹, Melinda Pedraza¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, Benoit Melchior¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…
Abstract Number: 2719 • 2016 ACR/ARHP Annual Meeting
Discriminating Value of Calprotectin in Disease Activity and Progression of Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
Jinxian Huang¹, Zhihua Yin², Guoxiang Song³, Shengjin Cui⁴, Jinzhao Jiang⁴ and Lijun Zhang⁴, ¹Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, ²Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ³The Third People’s Hospital of Shenzhen, Shenzhen, China, ⁴The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Background/Purpose: Due to the limitation of early diagnosis of ankylosing spondylitis (AS), updated criteria in recent years introduced the concept of axial spondyloarthritis (axSpA) and…
Abstract Number: 2993 • 2016 ACR/ARHP Annual Meeting
Membrane-Type 1 Matrix Metalloproteinase Controls Osteo- and Chondrogenesis By a Proteolysis-Independent Mechanism Mediated By Its Cytoplasmic Tail
Yang Qing¹, Mukundan Attur², Thorsten Kirsch³, You Jin Lee³, Shoshana Yakar⁴, Zhomgbo Liu⁵, Steven B. Abramson⁶ and Paolo Mignatti⁷, ¹Medicine, New York University School of Medicine, New York, NY, ²Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ³Orthopaedic Surgery, New York University, New York, NY, ⁴Basic Science and Craniofacial Biology, College of Dentistry, New York University, New York, NY, ⁵New York University, New York, NY, ⁶Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ⁷Medicine, New York University, New York, NY
Background/Purpose: We aimed to understand the mechanism by which membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) controls bone and cartilage homeostasis. MT1-MMP, a cell-membrane-bound proteinase with…
Abstract Number: 2994 • 2016 ACR/ARHP Annual Meeting
Binding of Periostin to Discoidin Domain Receptor-1 (DDR1) Promotes Cartilage Degeneration By Inducing MMP-13 Expression
Yang Qing¹, Paolo Mignatti², Austin Ramme³, Thorsten Kirsch³, Jyoti Patel⁴ and Mukundan Attur⁴, ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine, New York University, New York, NY, ³Orthopaedic Surgery, New York University, New York, NY, ⁴Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: We and others have previously shown that periostin (Postn) expression is dramatically elevated in cartilage and sub-chondral bone in OA patients and surgical models…
Abstract Number: 2995 • 2016 ACR/ARHP Annual Meeting
WISP1/CCN4 Aggravates Experimental Osteoarthritis and Is Associated with Disease Progression in Early Osteoarthritis Patients
Martijn H. van den Bosch¹, Arjen B. Blom¹, Azusa Maeda², Tina Kilts², Wim B. van den Berg³, Peter L. van Lent³, Marian F. Young² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²NIDCR/NIH, Bethesda, MD, ³Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we described strongly increased expression of Wnt2b…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 1096 • 2016 ACR/ARHP Annual Meeting
Augmentation of Wnt Signaling By IL-1β in Fibroblast-like Synoviocytes
Satoshi Yamasaki¹, Yusuke Yoshida² and Eiji Sugiyama², ¹Hiroshima University Hospital, Hiroshima, Japan, ²Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Wnt family proteins canonically stabilize β-catenin to activate T-cell factor (TCF) for the transcription of several genes, including Runx2, which is important for osteoblastogenesis.…
Abstract Number: 1104 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Chronic Tendinopathy
Vishal Deshmukh¹, Timothy Seo¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Chronic tendinopathy is an inflammatory and degenerative condition caused by injuries or overuse. Current therapeutic options focus on alleviating the symptoms and pain rather…
Abstract Number: 1444 • 2016 ACR/ARHP Annual Meeting
Differential Expression of Wnt Inhibitors before and after Joint Inflammation Onset in Rat Arthritis Could Partly Explain Paradoxical Effect of Sclerostin Inhibition
Guillaume Courbon¹, Raphaelle Lamarque², Marie-Thérèse Linossier², Norbert Laroche², Thierry Thomas³, Laurence Vico² and Hubert Marotte³, ¹SAINBIOSE INSERM U1059, University of Lyon, Saint-Etienne, France, ²SAINBIOSE INSERM U1059, University of Lyon, Saint Etienne, France, ³SAINBIOSE INSERM U1059 and Rheumatology department, University of Lyon and University Hospital of Saint Etienne, Saint Etienne, France
Background/Purpose: Periarticular bone loss in rheumatoid arthritis is considered to be mainly related to synovial inflammation, leading to uncoupling between decreased bone formation and increased…
Abstract Number: 1848 • 2016 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulates Collagen Type III Synthesis Via β-Catenin Activation in Vitro and in Vivo
Jin Zhang¹, Gibran Shaikh², Carmen Corciulo³, Tuere Wilder³, Miguel Perez-Aso¹, Aranzazu Mediero¹ and Bruce Cronstein¹, ¹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, NYU School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Fibrosis of skin and other organs is a hallmark of Scleroderma. We and others have previously reported that A2AR plays a role in skin…
Abstract Number: 1856 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Scleroderma
Vishal Deshmukh¹, Allison Hood², Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Scleroderma is an autoimmune fibrotic disease, which presents skin manifestations among others. The Wnt pathway plays an important role in inflammation, skin fibrosis, and…

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