Abstracts tagged "WNT Signaling"

Abstract Number: 2929 • 2017 ACR/ARHP Annual Meeting
WNT5A Promotes Tissue Fibrosis By Wnt/PCP-Dependent Activation of Latent TGF-β
Chih-Wei Chen¹, Thuong Trinh-Minh², Neng-Yu Lin², Yun Zhang³, Florian Groeber⁴, Christian Beyer⁵, Georg Schett⁶ and Jörg Distler⁷, ¹Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ²Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Translational Center Würzburg, Fraunhofer Ins. IGB, Würzburg, Germany, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁶Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Canonical Wnt/β-catenin signaling has emerged as a core pathway of fibrosis. They role of non-canonical Wnt signaling, however, has not been systematically studied. In…
Abstract Number: 809 • 2016 ACR/ARHP Annual Meeting
Micrornas Targeting the Wnt Signalling Pathway in Black African Patients with Diffuse Cutaneous Systemic Sclerosis
Mohammed Tikly¹, Jacqueline Frost², Michèle Ramsay³, Eulalia Marti Puig⁴, Raquel Rabionet⁴, Xavier Estivill⁴ and Marc Friedländer⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ²University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, Sydney Brenner Institute for Molecular Biosciences, University of the Witwatersrand, Johannesburg, South Africa, ⁴Center for Genomic Regulation, Barcelona, Spain, ⁵Department of Molecular Biosciences, The Wenner-Gren Institute, Science for Life Laboratory, Stockholm, Sweden
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system, vasculature and extracellular matrix [1]. Dysregulation of the Wnt pathway has been implicated in…
Abstract Number: 1096 • 2016 ACR/ARHP Annual Meeting
Augmentation of Wnt Signaling By IL-1β in Fibroblast-like Synoviocytes
Satoshi Yamasaki¹, Yusuke Yoshida² and Eiji Sugiyama², ¹Hiroshima University Hospital, Hiroshima, Japan, ²Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Wnt family proteins canonically stabilize β-catenin to activate T-cell factor (TCF) for the transcription of several genes, including Runx2, which is important for osteoblastogenesis.…
Abstract Number: 1104 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Chronic Tendinopathy
Vishal Deshmukh¹, Timothy Seo¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Chronic tendinopathy is an inflammatory and degenerative condition caused by injuries or overuse. Current therapeutic options focus on alleviating the symptoms and pain rather…
Abstract Number: 1444 • 2016 ACR/ARHP Annual Meeting
Differential Expression of Wnt Inhibitors before and after Joint Inflammation Onset in Rat Arthritis Could Partly Explain Paradoxical Effect of Sclerostin Inhibition
Guillaume Courbon¹, Raphaelle Lamarque², Marie-Thérèse Linossier², Norbert Laroche², Thierry Thomas³, Laurence Vico² and Hubert Marotte³, ¹SAINBIOSE INSERM U1059, University of Lyon, Saint-Etienne, France, ²SAINBIOSE INSERM U1059, University of Lyon, Saint Etienne, France, ³SAINBIOSE INSERM U1059 and Rheumatology department, University of Lyon and University Hospital of Saint Etienne, Saint Etienne, France
Background/Purpose: Periarticular bone loss in rheumatoid arthritis is considered to be mainly related to synovial inflammation, leading to uncoupling between decreased bone formation and increased…
Abstract Number: 1848 • 2016 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulates Collagen Type III Synthesis Via β-Catenin Activation in Vitro and in Vivo
Jin Zhang¹, Gibran Shaikh², Carmen Corciulo³, Tuere Wilder³, Miguel Perez-Aso¹, Aranzazu Mediero¹ and Bruce Cronstein¹, ¹Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, NYU School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Fibrosis of skin and other organs is a hallmark of Scleroderma. We and others have previously reported that A2AR plays a role in skin…
Abstract Number: 1856 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Scleroderma
Vishal Deshmukh¹, Allison Hood², Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Scleroderma is an autoimmune fibrotic disease, which presents skin manifestations among others. The Wnt pathway plays an important role in inflammation, skin fibrosis, and…
Abstract Number: 2120 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04690) As a Potential Treatment for Degenerative Disc Disease
Charlene Barroga¹, Vishal Deshmukh¹, Luis Dellamary¹, Josh Stewart¹, Haide Hu², John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Degenerative Disc Disease (DDD), one of the main causes of low back pain, is characterized by degeneration of intervertebral disc, nucleus pulposus (NP), and…
Abstract Number: 2143 • 2016 ACR/ARHP Annual Meeting
A Small Molecule, SM04690, Has Inhibitory Effects on the Wnt Pathway and Inflammation in Vitro, with Potential Implications for the Treatment of Osteoarthritis
Vishal Deshmukh¹, Maureen Ibanez¹, Charlene Barroga¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Osteoarthritis (OA) involves thinning cartilage and increased subchondral bone. Amongst many cellular processes, inflammation has been associated with OA. Wnt signaling plays a…
Abstract Number: 2350 • 2016 ACR/ARHP Annual Meeting
Radiographic Outcomes from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
Christopher J. Swearingen¹, Sharmila Majumdar², Ismail Simsek¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²University of California San Francisco, San Francisco, CA
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional impairment, disability, and joint space narrowing due to degradation of articular cartilage and bone remodeling. The…
Abstract Number: 2704 • 2016 ACR/ARHP Annual Meeting
Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04755) As a Potential Topical Treatment for Psoriasis
Vishal Deshmukh¹, Melinda Pedraza¹, Maureen Ibanez¹, Luis Dellamary¹, Josh Stewart¹, Timothy Seo¹, Benoit Melchior¹, John Hood² and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²Samumed, LLC (formerly), San Diego, CA
Background/Purpose: Psoriasis is an auto-immune disease of the skin, characterized by inflammation and fibrosis producing patches of red, itchy and scaly skin. Wnt signaling plays…
Abstract Number: 2719 • 2016 ACR/ARHP Annual Meeting
Discriminating Value of Calprotectin in Disease Activity and Progression of Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis
Jinxian Huang¹, Zhihua Yin², Guoxiang Song³, Shengjin Cui⁴, Jinzhao Jiang⁴ and Lijun Zhang⁴, ¹Rheumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, ²Rheumatology, The Fourth People’s Hospital of Shenzhen, Shenzhen, China, ³The Third People’s Hospital of Shenzhen, Shenzhen, China, ⁴The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Background/Purpose: Due to the limitation of early diagnosis of ankylosing spondylitis (AS), updated criteria in recent years introduced the concept of axial spondyloarthritis (axSpA) and…
Abstract Number: 2993 • 2016 ACR/ARHP Annual Meeting
Membrane-Type 1 Matrix Metalloproteinase Controls Osteo- and Chondrogenesis By a Proteolysis-Independent Mechanism Mediated By Its Cytoplasmic Tail
Yang Qing¹, Mukundan Attur², Thorsten Kirsch³, You Jin Lee³, Shoshana Yakar⁴, Zhomgbo Liu⁵, Steven B. Abramson⁶ and Paolo Mignatti⁷, ¹Medicine, New York University School of Medicine, New York, NY, ²Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ³Orthopaedic Surgery, New York University, New York, NY, ⁴Basic Science and Craniofacial Biology, College of Dentistry, New York University, New York, NY, ⁵New York University, New York, NY, ⁶Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ⁷Medicine, New York University, New York, NY
Background/Purpose: We aimed to understand the mechanism by which membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) controls bone and cartilage homeostasis. MT1-MMP, a cell-membrane-bound proteinase with…
Abstract Number: 2994 • 2016 ACR/ARHP Annual Meeting
Binding of Periostin to Discoidin Domain Receptor-1 (DDR1) Promotes Cartilage Degeneration By Inducing MMP-13 Expression
Yang Qing¹, Paolo Mignatti², Austin Ramme³, Thorsten Kirsch³, Jyoti Patel⁴ and Mukundan Attur⁴, ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine, New York University, New York, NY, ³Orthopaedic Surgery, New York University, New York, NY, ⁴Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: We and others have previously shown that periostin (Postn) expression is dramatically elevated in cartilage and sub-chondral bone in OA patients and surgical models…
Abstract Number: 2995 • 2016 ACR/ARHP Annual Meeting
WISP1/CCN4 Aggravates Experimental Osteoarthritis and Is Associated with Disease Progression in Early Osteoarthritis Patients
Martijn H. van den Bosch¹, Arjen B. Blom¹, Azusa Maeda², Tina Kilts², Wim B. van den Berg³, Peter L. van Lent³, Marian F. Young² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²NIDCR/NIH, Bethesda, MD, ³Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we described strongly increased expression of Wnt2b…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].