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Abstracts tagged "Ulcers"

  • Abstract Number: 1474 • ACR Convergence 2023

    Associations and Outcomes of Critical Peripheral Ischemia in Systemic Lupus Erythematosus (SLE): Data from Indian SLE Inception Cohort for Research (INSPIRE)

    Vineeta Shobha1, Liza Rajasekhar2, Sandra Manuel3, Nayana V3, Ranjan Gupta4, Bidyut Das5, Parasar Ghosh6, Chengappa Kavadichanda7, Ashish J Mathew8, Manish Rathi9, Avinash Jain10, Sumithra Selvam3 and Amita Aggarwal11, 1St. John's National Academy of Health Science, Bangalore, India, 2Nizam's Institute of Medical Sciences, Madhapur, India, 3St. John's Research Institute, Bangalore, India, 4All India Institute of Medical Sciences, New Delhi, India, 5SCB medical college, Cuttack, India, 6Govt of West Bengal, Kolkata, India, 7Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, 8Christian Medical College, Vellore, India, 9Postgraduate Institute of Medical education and Research, Chandigarh, India, 10SMS Medical College, Lucknow, India, 11Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India

    Background/Purpose: Among the cutaneous manifestations of SLE, critical peripheral ischemia (CPI) including digital infarcts and gangrene are considered rare, gangrene occurring only in about 0.2%…
  • Abstract Number: 1520 • ACR Convergence 2023

    Identifying Core Domains for Clinical Trials in Systemic Sclerosis-Associated Raynaud’s Phenomenon and Digital Ulcers Using the Delphi Consensus Method

    Susanna Proudman1, Michael Hughes2, Nancy Maltez3, Edith Brown4, Virginia Hickey5, shawna grosskleg6, B Shea6, Ariane Herrick7, John Pauling8 and Peter Merkel9, 1Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia, 2Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, United Kingdom, 3Department of Medicine, Division of Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, 4OMERACT, Manchester, United Kingdom, 5OMERACT, Adelaide, Australia, 6OMERACT, Ottawa, ON, Canada, 7University of Manchester, Salford, United Kingdom, 8North Bristol NHS Trust, Bristol, United Kingdom, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The OMERACT Scleroderma Vascular Disease Working Group sought to identify essential core outcome domains for inclusion in clinical trials focusing on Raynaud's phenomenon (RP)…
  • Abstract Number: 1527 • ACR Convergence 2023

    Acute Effects of Intravenous Iloprost on Finger Power Doppler Ultrasound in Scleroderma Patients

    Sofia Testoni1, Luca Magnani2, Caterina Tomassini3, Alessia Laneri3, Carlo Salvarani4 and PIERLUIGI MACCHIONI2, 1Università degli Studi di Modena e Reggio Emilia, San Giovanni in Persiceto, Italy, 2Azienda USL -IRCCS di Reggio Emilia, Reggio Emilia, Italy, 3Università degli Studi di Modena e Reggio Emilia, Modena, Italy, 4Azienda USL -IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy

    Background/Purpose: So far few studies explored ultrasound (US) as a tool to assess vascular subcutaneous involvement in patients affected by systemic sclerosis (SSc). We aim…
  • Abstract Number: 1518 • ACR Convergence 2022

    Prevalence, Risk Factors and Treatment Patterns of Digital Ischemic Complications in Systemic Sclerosis: A Single Center Cross-Sectional Study

    Ashima Makol1, Alicia Hinze2, Rachel Giblon1, Yasser Radwan3, Tina Gunderson4, David Liedl1, Kenneth J. Warrington4, Cynthia Crowson5 and Paul Wennberg1, 1Mayo Clinic, Rochester, MN, Rochester, MN, 2Mayo Clinic - Rochester, MN, Rochester, MN, 3Mayo Clinic/ Michigan State University, Lansing, MI, 4Mayo Clinic, Rochester, MN, 5Mayo Clinic, Eyota, MN

    Background/Purpose: Digital ischemic complications (DICs, including digital ulcers, digital pitting/scars, gangrene and/or amputation) can significantly impact hand function, disability and overall prognosis in SSc. We…
  • Abstract Number: 1541 • ACR Convergence 2022

    MRI Digital Artery Volume Index (DAVIX) Predicts Future Digital Ulcers and Disease Progression in Systemic Sclerosis

    Michael Hughes1, Stefano Di Donato2, Klodian Gjeloshi3, Giuseppina Abignano4, Fiammetta Danzo3, Giovanni Lettieri G4, Enrico De Lorenzis2, Dominic Bertham5, Philip O’Connor2, Olga Kubassova6 and Francesco Del Galdo2, 1Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust & The University of Manchester, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health and NIHR Biomedical Research Centre, University of Leeds, Leeds, United Kingdom, 3University of Campania ‘‘Luigi Vanvitelli’’, Napoli, Italy, 4Istituto Reumatologico Lucano (IReL), Azienda Ospedaliera Regionale San Carlo, Potenza, Italy, 5NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Image Analysis Group, London, United Kingdom

    Background/Purpose: Fibroproliferative vasculopathy in systemic sclerosis (SSc) is caused by neointima proliferation is a key pathologic feature of SSc which results in arterial vessel narrowing…
  • Abstract Number: 1559 • ACR Convergence 2022

    Long Term Clinical Effects of Apremilast on Behcet’s Disease and Changes in Serum Cytokines

    Yusuke Ushio1, Risa Wakiya2, Kiyo Ueeda3, Tomohiro Kameda2, shusaku nakashima4, Hiromi Shimada2, Mikiya Kato2, taichi miyagi5, Rina Mino6, Kanako Chujo7 and Hiroaki Dobashi8, 1Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, 2Kagawa University, Kagawa, Japan, 3Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 4Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 5Kagawa University, Kidagun, Japan, 6Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Miki-cho, Kita-gun, Japan, 7Kagawa University, Miki, Kita District, Kagawa, Japan, 8Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Kagawa, Japan

    Background/Purpose: Apremilast, the small-molecule phosphodiesterase -4 inhibitor, was approved for the treatment of recurrent oral ulcers associated with Behcet's disease (BD) in Japan from September…
  • Abstract Number: 2168 • ACR Convergence 2022

    A Novel Pharmaco-Interventional Approach for the Treatment of Refractory Digital Ischemia in Systemic Sclerosis – Percutaneous Revascularization Combined with Intravenous Vasodilatory Therapy

    Lily Romero Karam1, Kevin Honan1, Salman Arain1 and Maureen Mayes2, 1University of Texas Health Science Center at Houston, Houston, TX, 2Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: The combination of Raynaud´s Phenomenon (RP) and vasculopathy, characterized by intimal proliferation and fibrosis, endothelial dysfunction, and smooth-muscle activation, can lead to severe digital…
  • Abstract Number: 0412 • ACR Convergence 2021

    Prevalence, Distribution, Clinical Correlates and Outcomes of Upper Extremity Macrovascular Disease in Systemic Sclerosis: Results from a Single Center Referral Cohort (2001-2018)

    Ashima Makol1, Caitrin Coffey1, Tina Gunderson1, Alicia Hinze1, Yasser Radwan2, Cynthia Crowson3, David Liedl1, Kenneth Warrington1 and Paul Wennberg1, 1Mayo Clinic, Rochester, MN, 2Michigan State University, Lansing, MI, 3Mayo Clinic, Eyota, MN

    Background/Purpose: To study the prevalence, anatomical distribution, clinical correlates and outcomes of macrovascular disease (MVD) on duplex ultrasound (US) of the upper extremity in Systemic…
  • Abstract Number: 1387 • ACR Convergence 2021

    Macrovascular Dysfunction and Its Clinical Implication in Systemic Sclerosis

    Devender Bairwa1, Chengappa Kavadichanda2, sanket Shah3, Anoop Mathew1, saikumar dunga3, Aishwarya Gopal3, Molly Mary Thabah1 and VirSingh Negi1, 1Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India, 2JIPMER, Pondicherry, India, 3Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

    Background/Purpose: Microvascular dysfunction is a key and determining feature of scleroderma (SSc). But contrary to earlier belief there is emerging evidence to suggest co-occurrence of…
  • Abstract Number: 0405 • ACR Convergence 2020

    Disease Activity and Quality-of-Life Outcomes in Patients with Behçet’s Syndrome Who Achieved and Maintained Oral Ulcer Complete Response with Apremilast Treatment

    Gülen Hatemi1, Alfred Mahr2, Mitsuhiro Takeno3, Doyoung Kim4, Melike Melikoğlu1, Sue Cheng5, Sven Richter5, Michele Brunori6, Maria Paris5, Mindy Chen5 and Yusuf Yazici7, 1Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, Istanbul, Turkey, 2Cantonal Hospital St. Gallen, St. Gallen, Switzerland, 3Nippon Medical School, Graduate School of Medicine, Tokyo, Japan, 4Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, 5Amgen Inc., Thousand Oaks, 6Amgen Europe GmbH, Rotkreuz, Switzerland, 7New York University School of Medicine, New York

    Background/Purpose: Recurrent, painful oral ulcers (OU) are common symptoms of Behçet’s syndrome that can impact daily activities and impair quality of life (QoL) (Kokturk A.…
  • Abstract Number: 0407 • ACR Convergence 2020

    Achievement of Early and Sustained Complete Response of Oral Ulcers with Apremilast Compared with Placebo in Patients with Active Behçet’s Syndrome

    Gülen Hatemi1, Alfred Mahr2, Mitsuhiro Takeno3, Doyoung Kim4, Melike Melikoğlu1, Sue Cheng5, Sven Richter5, Michele Brunori6, Maria Paris5, Mindy Chen5 and Yusuf Yazici7, 1Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, Istanbul, Turkey, 2Cantonal Hospital St. Gallen, St. Gallen, Switzerland, 3Nippon Medical School, Graduate School of Medicine, Tokyo, Japan, 4Yonsei University College of Medicine and Severance Hospital, Seoul, Republic of Korea, 5Amgen Inc., Thousand Oaks, 6Amgen Europe GmbH, Rotkreuz, Switzerland, 7New York University School of Medicine, New York

    Background/Purpose: Painful and recurring oral ulcers (OU) are a common manifestation of Behçet’s syndrome that can interfere with eating and have a negative impact on…
  • Abstract Number: 0425 • ACR Convergence 2020

    MAGIC Syndrome in a Cohort of Patients with Relapsing Polychondritis

    Yiming Luo1, Emily Rose2, Keith Sikora3, Kaitlin Quinn4, Kristina Wells5, Emily Rominger5, Wendy Goodspeed6, Peter C. Grayson7 and Marcela Ferrada6, 1Rheumatology Fellowship and Training Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 2Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethsda, 3Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, 5Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 6Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is an extremely rare condition that encompasses symptoms of relapsing polychondritis (RP) and Behcet’s disease…
  • Abstract Number: 0553 • ACR Convergence 2020

    The US Prevalence of Ulcerative Colitis Associated Peripheral Arthralgias and Arthritis: Data from the National Health & Nutrition Examination Survey (NHANES)

    Oleg Stens1, Hyun-seok Kim2, Jason Hou2 and Michael Weisman3, 1Harbor-UCLA Medical Center, San Diego, CA, 2Baylor College of Medicine, Houston, TX, 3Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA

    Background/Purpose: An association between ulcerative colitis (UC) and peripheral arthritis has been known since the 1930’s and more recently has been described as a part…
  • Abstract Number: 0915 • ACR Convergence 2020

    Clinical Bedside Tools to Assess Systemic Sclerosis Vasculopathy: Can Digital Thermal Monitoring and Sublingual Microscopy Identify Patients with Current or past Digital Ulcers?

    Tracy Frech1, Zhining Ou2, Julie Thomas2 and Angela Presson2, 1University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT

    Background/Purpose: Sublingual microscopy is reported as a useful tool for vasculopathy assessment in SSc.  Digital thermal monitoring (DTM) correlates with flow-mediated dilatation, and may identify…
  • Abstract Number: 1380 • ACR Convergence 2020

    Digital Occlusive Arterial Disease on Laser Doppler Flowmetry Increases the Risk of Digital Ischemic Complications in Systemic Sclerosis: Results from a Single Center Referral Cohort (2001-2018)

    Yasser Radwan1, Tina Gunderson2, Cynthia Crowson2, David Liedl2, Kenneth Warrington3, Paul Wennberg2 and Ashima Makol2, 1Mayo Clinic, Rochester, Minnesota, USA, Lansing, MI, 2Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, 3Mayo Clinic, Rochester, MN

    Background/Purpose: Vascular dysfunction is a key feature of systemic sclerosis (SSc), manifesting clinically as Raynaud’s phenomenon (RP) with or without digital ischemia. Laser doppler flowmetry…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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