ACR Meeting Abstracts

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Abstracts tagged "Ulcers"

  • Abstract Number: 0688 • ACR Convergence 2024

    Mycophenolate Mofetil Treatment in Limited Cutaneous Systemic Sclerosis Reduces the Risk of Vascular Complication Leading to Treatment Escalation: Emulation of a Target Trial Using Time-dependent Propensity Score-matching

    Enrico De Lorenzis1, Gerlando Natalello2, Fabio Cacciapaglia3, Rossella De Angelis4, Edoardo Cipolletta5, Veronica Codullo6, Giacomo De Luca7, Dilia Giuggioli8, Francesca Ingegnoli9, Valeria Riccieri10, Maria Antonietta D'Agostino11, Clodoveo Ferri12, Marco Matucci Cerinic13 and Silvia Laura Bosello14, 1Catholic University of the Sacred Heart, Roma, Rome, Italy, 2Division of Rheumatology - Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Rome, Italy, 3Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 4Polytechnic University of Marche, Ancona, Italy, Ancona, Italy, 5Polytechnic University of Marche, Ancona, Italy, 6Division of Rheumatology - Policlinico San Matteo, Pavia, Italy, Pavia, Lombardia, Italy, 7Vita-Salute San Raffaele University & IRCCS San Raffaele Hospital, Milan, Milan, Italy, 8Scleroderma Unit, University of Modena and Reggio Emilia, Modena, Italy, 9Division of Clinical Rheumatology, ASST Pini, Dept. of Clinical Sciences & Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Research Center for Environmental Health, Università degli Studi di Milano, Milan, Italy, 10Department of Rheumatology, La Sapienza University of Rome, Rome, Italy, 11Division of Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome, Italy, 12Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Modena, Italy, 13Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 14Unit of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: The prescription of Mycophenolate Mofetil (MMF) represents the primary treatment for interstitial lung disease (ILD) associated with systemic sclerosis (SSc) and is an option…
  • Abstract Number: 1104 • ACR Convergence 2024

    Long-term Follow-up of Patients with Positive Cryofibrinogen Test During the COVID-19 Era

    Carmen Lasa Teja1, Amparo Sánchez-López2, María Enriqueta Peiró3, Mónica Renuncio-García4, Adrián Martín-Gutiérrez5, Carmen Secada Gómez6, Juan Irure-Ventura7, Marcos Lopez-Hoyos8 and Ricardo Blanco-Alonso9, 1Hospital Universitario Marqués de Valdecilla, Riotuerto, Spain, 2Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, 3Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Hospital Universitario Marqués de Valdecilla, Immunology, Santander, Spain, 5Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 6Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 7Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Cantabria, Spain, 8Division of Immunology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, Spain, 9Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: There have been increasing reports of cutaneous manifestations during COVID‐19 pandemic. An increase in awareness by physicians made them to increase the number of…
  • Abstract Number: 1586 • ACR Convergence 2024

    The Relationship Between the Presence, Quantity and Distribution of Cutaneous Telangiectasia and Other Vascular Manifestations of Systemic Sclerosis

    Matthew Wells1, Robyn Domsic2, Ami Shah3, Laura Hummers4, Aishwarya Anilkumar1, Tracy Frech5, Ariane Herrick6, Christopher Denton7, Dinesh Khanna8 and John Pauling1, 1North Bristol NHS Trust, Bristol, United Kingdom, 2Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 4Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, 5Vanderbilt University Medical Center, Nashville, TN, 6University of Manchester, UK, Aberdeen, United Kingdom, 7University College London, Northwood, United Kingdom, 8University of Michigan, Ann Arbor, MI

    Background/Purpose: Telangiectasia are permanently dilated dermal postcapillary venules and are the 2nd most common manifestation (~80%) of systemic sclerosis (SSc) after Raynaud’s phenomenon (RP). The…
  • Abstract Number: 1998 • ACR Convergence 2024

    Association Between Small Interfering RNA Therapy and Autoimmune Diseases: U.S. Prospective Cohort Study

    Liang Sien Chen, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City, Taoyuan, Taiwan (Republic of China)

    Background/Purpose: Monoclonal antibody (mAb) therapy and small interfering RNA (siRNA) therapy represent two cutting-edge approaches in treating various diseases, such as hyperlipidemia. Our study aims…
  • Abstract Number: 2524 • ACR Convergence 2024

    Metabolite Profiling of Saliva for the Discrimination of Behcet’s Disease, Sjogren’s Syndrome, and Recurrent Aphthous Stomatitis

    Sooah Kim1, Ye Ji Jung2, Joong Kyong Ahn3 and Jiwon Hwang4, 1Environment Science & Biotechnology, Jeonju University, Jeonju, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea, 3Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 4Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea

    Background/Purpose: Oral manifestations can be the initial indicators of systemic diseases such as Behcet’s disease (BD) and Sjogren’s syndrome (PSS). The frequency and presentation of…
  • Abstract Number: 1520 • ACR Convergence 2023

    Identifying Core Domains for Clinical Trials in Systemic Sclerosis-Associated Raynaud’s Phenomenon and Digital Ulcers Using the Delphi Consensus Method

    Susanna Proudman1, Michael Hughes2, Nancy Maltez3, Edith Brown4, Virginia Hickey5, shawna grosskleg6, B Shea6, Ariane Herrick7, John Pauling8 and Peter Merkel9, 1Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia, 2Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, United Kingdom, 3Department of Medicine, Division of Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, 4OMERACT, Manchester, United Kingdom, 5OMERACT, Adelaide, Australia, 6OMERACT, Ottawa, ON, Canada, 7University of Manchester, Salford, United Kingdom, 8North Bristol NHS Trust, Bristol, United Kingdom, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The OMERACT Scleroderma Vascular Disease Working Group sought to identify essential core outcome domains for inclusion in clinical trials focusing on Raynaud's phenomenon (RP)…
  • Abstract Number: 1527 • ACR Convergence 2023

    Acute Effects of Intravenous Iloprost on Finger Power Doppler Ultrasound in Scleroderma Patients

    Sofia Testoni1, Luca Magnani2, Caterina Tomassini3, Alessia Laneri3, Carlo Salvarani4 and PIERLUIGI MACCHIONI2, 1Università degli Studi di Modena e Reggio Emilia, San Giovanni in Persiceto, Italy, 2Azienda USL -IRCCS di Reggio Emilia, Reggio Emilia, Italy, 3Università degli Studi di Modena e Reggio Emilia, Modena, Italy, 4Azienda USL -IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy

    Background/Purpose: So far few studies explored ultrasound (US) as a tool to assess vascular subcutaneous involvement in patients affected by systemic sclerosis (SSc). We aim…
  • Abstract Number: 0297 • ACR Convergence 2023

    Characteristics of Anti-MDA-5 Associated Dermatomyositis in Southern California with a Large Hispanic Population: Case Series

    Eaman Alhassan1, Belina Yi2, Jack Rodman1 and Leanna Wise3, 1University of Southern California, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA, 3LAC+USC/Keck Medicine of USC, Pasadena, CA

    Background/Purpose: There is little to no data about the presentation and clinical course of anti-melanoma differentiation-associated gene-5 antibody (anti-MDA-5) dermatomyositis patients in a primarily U.S.…
  • Abstract Number: 0307 • ACR Convergence 2023

    Long-term Prognosis and Recurrence in anti-MDA-5 Antibody-positive Dermatomyositis

    Jun Nakamura1, Takao Nagashima2 and Kojiro Sato2, 1Jichi Medical University, Shimotsuke, Japan, 2Jichi Medical University, Tochigi, Japan

    Background/Purpose: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is frequently complicated by rapidly progressive interstitial lung disease (ILD) and is life-threatening especially in the…
  • Abstract Number: 0630 • ACR Convergence 2023

    Prevalence and Risk Factors for Systemic Sclerosis Digital Ischemic Complications in the Collaborative National Quality and Efficacy Registry

    Marissa Savoie1, Monica Harding2, Jessica Alvey2, John VanBuren2, Shervin Assassi3, Elana Bernstein4, Lorinda Chung5, Luke Evnin6, Tracy Frech7, Jessica Gordon8, Faye Hant9, Laura Hummers10, Dinesh Khanna11, Kimberly Lakin8, Dorota Lebiedz-Odrobina12, Yiming Luo13, Ashima Makol14, Jerry Molitor15, Duncan Moore16, Carrie Richardson17, Nora Sandorfi18, Ami Shah19, Ankoor Shah20, Brian Skaug21, Virginia Steen22, Elizabeth Volkmann23 and Flavia Castelino1, 1Massachusetts General Hospital, Boston, MA, 2University of Utah, Salt Lake City, UT, 3University of Texas McGovern Medical School at Houston, Houston, TX, 4Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 5Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 6Scleroderma Research Foundation, Brisbane, CA, 7Vanderbilt University Medical Center, Nashville, TN, 8Hospital for Special Surgery, New York, NY, 9Medical University of South Carolina, Charleston, SC, 10Johns Hopkins University, Baltimore, MD, 11University of Michigan, Ann Arbor, MI, 12University of Utah, Cottonwood Heights, UT, 13Division of Rheumatology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 14Mayo Clinic, Rochester, MN, Rochester, MN, 15University of Minnesota, Minneapolis, MN, 16Northwestern University, Department of Rheumatology, Chicago, IL, 17Northwestern University, Chicago, IL, 18University of Pennsylvania, Philadelphia, PA, 19Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD, 20Duke University, Durham, NC, 21Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 22Georgetown University School of Medicine, Washington, DC, 23University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Digital ischemic ulcers (DIU) develop in 36-44% of patients with systemic sclerosis (SSc).1,2Prior international observational studies have evaluated characteristics of digital pitting and ulcers…
  • Abstract Number: 1474 • ACR Convergence 2023

    Associations and Outcomes of Critical Peripheral Ischemia in Systemic Lupus Erythematosus (SLE): Data from Indian SLE Inception Cohort for Research (INSPIRE)

    Vineeta Shobha1, Liza Rajasekhar2, Sandra Manuel3, Nayana V3, Ranjan Gupta4, Bidyut Das5, Parasar Ghosh6, Chengappa Kavadichanda7, Ashish J Mathew8, Manish Rathi9, Avinash Jain10, Sumithra Selvam3 and Amita Aggarwal11, 1St. John's National Academy of Health Science, Bangalore, India, 2Nizam's Institute of Medical Sciences, Madhapur, India, 3St. John's Research Institute, Bangalore, India, 4All India Institute of Medical Sciences, New Delhi, India, 5SCB medical college, Cuttack, India, 6Govt of West Bengal, Kolkata, India, 7Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, 8Christian Medical College, Vellore, India, 9Postgraduate Institute of Medical education and Research, Chandigarh, India, 10SMS Medical College, Lucknow, India, 11Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India

    Background/Purpose: Among the cutaneous manifestations of SLE, critical peripheral ischemia (CPI) including digital infarcts and gangrene are considered rare, gangrene occurring only in about 0.2%…
  • Abstract Number: 1518 • ACR Convergence 2022

    Prevalence, Risk Factors and Treatment Patterns of Digital Ischemic Complications in Systemic Sclerosis: A Single Center Cross-Sectional Study

    Ashima Makol1, Alicia Hinze2, Rachel Giblon1, Yasser Radwan3, Tina Gunderson4, David Liedl1, Kenneth J. Warrington4, Cynthia Crowson5 and Paul Wennberg1, 1Mayo Clinic, Rochester, MN, Rochester, MN, 2Mayo Clinic - Rochester, MN, Rochester, MN, 3Mayo Clinic/ Michigan State University, Lansing, MI, 4Mayo Clinic, Rochester, MN, 5Mayo Clinic, Eyota, MN

    Background/Purpose: Digital ischemic complications (DICs, including digital ulcers, digital pitting/scars, gangrene and/or amputation) can significantly impact hand function, disability and overall prognosis in SSc. We…
  • Abstract Number: 1541 • ACR Convergence 2022

    MRI Digital Artery Volume Index (DAVIX) Predicts Future Digital Ulcers and Disease Progression in Systemic Sclerosis

    Michael Hughes1, Stefano Di Donato2, Klodian Gjeloshi3, Giuseppina Abignano4, Fiammetta Danzo3, Giovanni Lettieri G4, Enrico De Lorenzis2, Dominic Bertham5, Philip O’Connor2, Olga Kubassova6 and Francesco Del Galdo2, 1Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust & The University of Manchester, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health and NIHR Biomedical Research Centre, University of Leeds, Leeds, United Kingdom, 3University of Campania ‘‘Luigi Vanvitelli’’, Napoli, Italy, 4Istituto Reumatologico Lucano (IReL), Azienda Ospedaliera Regionale San Carlo, Potenza, Italy, 5NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Image Analysis Group, London, United Kingdom

    Background/Purpose: Fibroproliferative vasculopathy in systemic sclerosis (SSc) is caused by neointima proliferation is a key pathologic feature of SSc which results in arterial vessel narrowing…
  • Abstract Number: 1559 • ACR Convergence 2022

    Long Term Clinical Effects of Apremilast on Behcet’s Disease and Changes in Serum Cytokines

    Yusuke Ushio1, Risa Wakiya2, Kiyo Ueeda3, Tomohiro Kameda2, shusaku nakashima4, Hiromi Shimada2, Mikiya Kato2, taichi miyagi5, Rina Mino6, Kanako Chujo7 and Hiroaki Dobashi8, 1Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, 2Kagawa University, Kagawa, Japan, 3Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 4Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Japan, 5Kagawa University, Kidagun, Japan, 6Kagawa University, Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Miki-cho, Kita-gun, Japan, 7Kagawa University, Miki, Kita District, Kagawa, Japan, 8Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa, Kagawa, Japan

    Background/Purpose: Apremilast, the small-molecule phosphodiesterase -4 inhibitor, was approved for the treatment of recurrent oral ulcers associated with Behcet's disease (BD) in Japan from September…
  • Abstract Number: 2168 • ACR Convergence 2022

    A Novel Pharmaco-Interventional Approach for the Treatment of Refractory Digital Ischemia in Systemic Sclerosis – Percutaneous Revascularization Combined with Intravenous Vasodilatory Therapy

    Lily Romero Karam1, Kevin Honan1, Salman Arain1 and Maureen Mayes2, 1University of Texas Health Science Center at Houston, Houston, TX, 2Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: The combination of Raynaud´s Phenomenon (RP) and vasculopathy, characterized by intimal proliferation and fibrosis, endothelial dysfunction, and smooth-muscle activation, can lead to severe digital…
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