ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "transcription factor"

  • Abstract Number: 1177 • ACR Convergence 2022

    Identification of a New Type of Pro-phagocytic Macrophages in Patients with Systemic Sclerosis

    Amela Hukara1, Tracy Tabib2, Michal Rudnik1, Oliver Distler3, Przemyslaw Blyszczuk1, Robert Lafyatis2 and Gabriela Kania1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 2Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland

    Background/Purpose: Phagocytosis is a crucial cellular process, which under certain immuno-pathological conditions can be activated in macrophages in an uncontrolled manner. Biomarker studies have implicated…
  • Abstract Number: 1727 • ACR Convergence 2022

    BATF Represses BIM Expression to Sustain the T Cell Anergy Program

    Philip Titcombe, Milagros Silva-Morales, Na Zhang and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 0499 • ACR Convergence 2022

    Drivers of Heterogeneity in Synovial Fibroblasts in Rheumatoid Arthritis

    Melanie Smith1, Vianne Gao2, Edward DiCarlo1, Susan Goodman1, Thomas Norman2, Laura Donlin1, Christina Leslie2 and Alexander Rudensky2, 1Hospital for Special Surgery, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplasia of both the synovial lining, which forms the synovial fluid interface, as well as the synovial sublining,…
  • Abstract Number: 0586 • ACR Convergence 2022

    Transcription Factor Fli-1 Impacts CXCL13 Expression and Renal Inflammation in Lupus-like Nephritis of Adult MRL/lpr Mouse

    Shuzo Sato1, Xian Zhang2, Naoki Matsuoka1, Yuya Sumichika1, Kenji Saito1, Shuhei Yoshida1, Haruki Matsumoto1, Jumpei Temmoku1, Yuya Fujita1, Tomoyuki Asano1, Hiroshi Watanabe1 and Kiyoshi Migita1, 1Fukushima Medical University, Fukushima, Japan, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Friend leukemia virus integration 1 (Fli-1) belongs to the Ets family of transcription factors and plays an important role in the development of lupus…
  • Abstract Number: 0606 • ACR Convergence 2022

    Mechanism of Joint-Specific Homeobox D10 Regulation in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

    Hyeonjeong Lee1, Camilla Machado2, Deepa Hammaker3, Wei Wang4, David Boyle5 and Gary S. Firestein6, 1University of California San Diego, San Diego, CA, 2UCSD, San Diego, CA, 3UC San Diego, San Diego, CA, CA, 4University of California San Diego, San Diego, 5UCSD, La Jolla, CA, 6University of California, San Diego, San Diego, CA

    Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) have joint-specific epigenetic and transcriptome profiles. This is particularly notable for homeobox (HOX) genes, which contribute to joint…
  • Abstract Number: 0013 • ACR Convergence 2021

    Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts

    Tadashi Hosoya1, Tetsuya Saito2, Hiroyuki Baba2, Nao Tanaka2, Seiji Noda2, Yoji Komiya2, Yasuhiro tagawa2, Akio Yamamoto2 and Shinsuke Yasuda2, 1Tokyo Medical and Dental University(TMDU), Tokyo, Japan, 2Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: Although current inflammation-targeted therapy improved the outcome of patients with rheumatoid arthritis (RA), the achievement of complete disease remission was still challenging. Since synovial…
  • Abstract Number: 0942 • ACR Convergence 2021

    Transcriptional Regulation of Synovial Macrophages in the Aging Joint

    Shang-Yang Chen1, Anna Montgomery1, Anna Woo1, Gaurav Gadhvi1, Harris Perlman1, Carla Cuda1, Dawn Bowdish2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2McMaster University, Hamilton, ON, Canada, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages are critical in maintaining tissue homeostasis, as well as in inflammation and immune response, but their function deteriorates with age increasing susceptibility to…
  • Abstract Number: 1512 • ACR Convergence 2021

    Epigenetic and Transcriptional Programs of CD4+ T Cell Anergy

    Philip Titcombe, Milagros Silva Morales and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 1575 • ACR Convergence 2021

    Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response

    Anyan Cheng1, Isidoro Cobo1, Jessica Murillo Saich1, Roxana Coras2, Alyssa Torres3, Addison Lana1, Johannes Schlachetzki1, Ru Liu Bryan4, Robert Terkeltaub5, Elsa Sanchez-Lopez3, Christopher Glass1 and Monica Guma6, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3University of California San Diego, San Diego, CA, 4University of California San Diego and VASDHS, San Diego, CA, 5VA/UCSD, San Diego, CA, 6University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
  • Abstract Number: 0039 • ACR Convergence 2020

    Identification of a Regulatory Pathway Governing Expression of TRAF1 via a JIA-associated Non-coding Variant

    Qiang Wang1, Marta Martínez2, Matthew Weirauch3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, 3Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Over the past decade, genome-wide association studies (GWAS) have identified TRAF1/C5 locus as a risk locus for rheumatoid diseases including RA and JIA(Plenge, Seielstad…
  • Abstract Number: 0073 • ACR Convergence 2020

    A Cross-Species Map of Neutrophil Inflammatory Responses

    Felix Radtke1, Frank Huang2, Peter Nigrovic3 and Ricardo Grieshaber-Bouyer4, 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Baden-Wurttemberg, Germany, 2Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Darmstadt, Baden-Wurttemberg, Germany, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 4Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Heidelberg, Germany

    Background/Purpose: Neutrophils are important mediators of immune defense as well as key protagonists in immune-mediated disease. How these cells adapt differently to sterile and septic…
  • Abstract Number: 0495 • ACR Convergence 2020

    Epstein Barr Virus (EBV), an Etiologic Factor for Systemic Lupus Erythematosus (SLE), Interacts with SLE Risk Loci Through EBV-encoded Transcription Co-factors (co-TFs)

    Viktoryia Laurynenka1, Xiaoting Chen1, Sreeja Parameswaran1, Shruti Eswar2, Kenneth Kaufman3, Bahram Namjou4, Matthew Weirauch5, Leah Kottyan4 and John Harley6, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, 3Cincinnati Children’s Hospital Medical Center;US Department of Veterans Affairs Medical Center, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, Cincinnati, OH, 5Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 6Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: SLE affects millions worldwide. The etiology of this complex autoimmune disease is the consequence of both strong genetic and environmental components. Genome-wide association studies…
  • Abstract Number: 0977 • ACR Convergence 2020

    Expanded T Peripheral Helper Cells and Increased Pathologic B Cell Lung Infiltration in Pristane-induced Murine Lupus in the Absence of BCL6+ Tfh Cells

    Runci Wang1, Pui Lee2, Peter Nigrovic3 and Deepak Rao1, 1Brigham and Women's Hospital, Boston, MA, 21.Boston Children's Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, Newton, MA, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: PD-1hi CXCR5- T peripheral helper (Tph) cells are highly expanded in RA and SLE patients. Like T follicular helper (Tfh) cells, human Tph cells…
  • Abstract Number: 1400 • ACR Convergence 2020

    cAMP Response Element Modulator (CREM)α Promotes PD-1- effector CD4+ T Cells in Psoriasis and Psoriatic Arthritis

    Sigrun Hofmann1, Franz Kapplusch2, Susanne Abraham3, Sarah Northey2, Susanne Russ1, Felix Schulze1, Anna Surace4 and Christian Hedrich5, 1Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 2Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom., Liverpool, United Kingdom, 3Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, Liverpool, United Kingdom, 5University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Psoriasis is a systemic autoimmune/inflammatory condition that primarily affects the skin, but also other organ systems. Effector CD4+ T lymphocytes have been identified as…
  • Abstract Number: 17 • 2019 ACR/ARP Annual Meeting

    Transcription Factor Fli-1 Impacts Lupus Nephritis by Orchestrating CXCL10/CXCR3 Axis

    Xuan Wang1, Mara Lennard Richard 1, Tomika Caldwell 2, Brittany Henry 2, Tammy Nowling 2, Jim Oates 3, Gary Gilkeson 4 and Xian Zhang 1, 1Medical University of South Carolina, Charleston, SC, 2Medical University of South Carolina, Charleston, 3Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology & Immunology/Ralph H. Johnson VA Medical Center/Medical University of South Carolina, Charleston, SC

    Background/Purpose:  Lupus nephritis is a major cause of death in both animal models and human patients.  Expression of Fli-1, a member of the Ets family…
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