ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "transcription factor"

  • Abstract Number: 0013 • ACR Convergence 2021

    Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts

    Tadashi Hosoya1, Tetsuya Saito2, Hiroyuki Baba2, Nao Tanaka2, Seiji Noda2, Yoji Komiya2, Yasuhiro tagawa2, Akio Yamamoto2 and Shinsuke Yasuda2, 1Tokyo Medical and Dental University(TMDU), Tokyo, Japan, 2Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: Although current inflammation-targeted therapy improved the outcome of patients with rheumatoid arthritis (RA), the achievement of complete disease remission was still challenging. Since synovial…
  • Abstract Number: 0942 • ACR Convergence 2021

    Transcriptional Regulation of Synovial Macrophages in the Aging Joint

    Shang-Yang Chen1, Anna Montgomery1, Anna Woo1, Gaurav Gadhvi1, Harris Perlman1, Carla Cuda1, Dawn Bowdish2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2McMaster University, Hamilton, ON, Canada, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages are critical in maintaining tissue homeostasis, as well as in inflammation and immune response, but their function deteriorates with age increasing susceptibility to…
  • Abstract Number: 1512 • ACR Convergence 2021

    Epigenetic and Transcriptional Programs of CD4+ T Cell Anergy

    Philip Titcombe, Milagros Silva Morales and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 1575 • ACR Convergence 2021

    Urate Crystals Regulate a Distinct JNK-Dependent Metabolic and Inflammatory Response

    Anyan Cheng1, Isidoro Cobo1, Jessica Murillo Saich1, Roxana Coras2, Alyssa Torres3, Addison Lana1, Johannes Schlachetzki1, Ru Liu Bryan4, Robert Terkeltaub5, Elsa Sanchez-Lopez3, Christopher Glass1 and Monica Guma6, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3University of California San Diego, San Diego, CA, 4University of California San Diego and VASDHS, San Diego, CA, 5VA/UCSD, San Diego, CA, 6University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Although metabolic reprograming and its regulation in macrophages after TLR activation is well established, little is known about the regulation and the role of…
  • Abstract Number: 0039 • ACR Convergence 2020

    Identification of a Regulatory Pathway Governing Expression of TRAF1 via a JIA-associated Non-coding Variant

    Qiang Wang1, Marta Martínez2, Matthew Weirauch3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, 3Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Over the past decade, genome-wide association studies (GWAS) have identified TRAF1/C5 locus as a risk locus for rheumatoid diseases including RA and JIA(Plenge, Seielstad…
  • Abstract Number: 0073 • ACR Convergence 2020

    A Cross-Species Map of Neutrophil Inflammatory Responses

    Felix Radtke1, Frank Huang2, Peter Nigrovic3 and Ricardo Grieshaber-Bouyer4, 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Baden-Wurttemberg, Germany, 2Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Darmstadt, Baden-Wurttemberg, Germany, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 4Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Heidelberg, Germany

    Background/Purpose: Neutrophils are important mediators of immune defense as well as key protagonists in immune-mediated disease. How these cells adapt differently to sterile and septic…
  • Abstract Number: 0495 • ACR Convergence 2020

    Epstein Barr Virus (EBV), an Etiologic Factor for Systemic Lupus Erythematosus (SLE), Interacts with SLE Risk Loci Through EBV-encoded Transcription Co-factors (co-TFs)

    Viktoryia Laurynenka1, Xiaoting Chen1, Sreeja Parameswaran1, Shruti Eswar2, Kenneth Kaufman3, Bahram Namjou4, Matthew Weirauch5, Leah Kottyan4 and John Harley6, 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, 3Cincinnati Children’s Hospital Medical Center;US Department of Veterans Affairs Medical Center, Cincinnati, OH, 4Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, Cincinnati, OH, 5Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 6Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: SLE affects millions worldwide. The etiology of this complex autoimmune disease is the consequence of both strong genetic and environmental components. Genome-wide association studies…
  • Abstract Number: 0977 • ACR Convergence 2020

    Expanded T Peripheral Helper Cells and Increased Pathologic B Cell Lung Infiltration in Pristane-induced Murine Lupus in the Absence of BCL6+ Tfh Cells

    Runci Wang1, Pui Lee2, Peter Nigrovic3 and Deepak Rao1, 1Brigham and Women's Hospital, Boston, MA, 21.Boston Children's Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, Newton, MA, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: PD-1hi CXCR5- T peripheral helper (Tph) cells are highly expanded in RA and SLE patients. Like T follicular helper (Tfh) cells, human Tph cells…
  • Abstract Number: 1400 • ACR Convergence 2020

    cAMP Response Element Modulator (CREM)α Promotes PD-1- effector CD4+ T Cells in Psoriasis and Psoriatic Arthritis

    Sigrun Hofmann1, Franz Kapplusch2, Susanne Abraham3, Sarah Northey2, Susanne Russ1, Felix Schulze1, Anna Surace4 and Christian Hedrich5, 1Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 2Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom., Liverpool, United Kingdom, 3Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, Liverpool, United Kingdom, 5University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Psoriasis is a systemic autoimmune/inflammatory condition that primarily affects the skin, but also other organ systems. Effector CD4+ T lymphocytes have been identified as…
  • Abstract Number: 17 • 2019 ACR/ARP Annual Meeting

    Transcription Factor Fli-1 Impacts Lupus Nephritis by Orchestrating CXCL10/CXCR3 Axis

    Xuan Wang1, Mara Lennard Richard 1, Tomika Caldwell 2, Brittany Henry 2, Tammy Nowling 2, Jim Oates 3, Gary Gilkeson 4 and Xian Zhang 1, 1Medical University of South Carolina, Charleston, SC, 2Medical University of South Carolina, Charleston, 3Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 4Division of Rheumatology & Immunology/Ralph H. Johnson VA Medical Center/Medical University of South Carolina, Charleston, SC

    Background/Purpose:  Lupus nephritis is a major cause of death in both animal models and human patients.  Expression of Fli-1, a member of the Ets family…
  • Abstract Number: 111 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor STAT3 Regulates Pathogenic Th17 Responses in Autoimmune Disease via Noncanonical Roles

    Catherine Poholek1, Itay Raphael 2 and Mandy McGeachy 2, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The Th17 lineage of CD4 T cells drives autoimmune diseases such as RA, SLE, IBD, and MS. The JAK2/STAT3 signaling pathway is required for…
  • Abstract Number: 1159 • 2015 ACR/ARHP Annual Meeting

    Transcription Factor SOX5 Promotes Rheumatoid Arthritis Synovial Fibroblast Migration and Invasion By Regulating MMP9 Expression

    Wenfeng Tan1, Yumeng Shi2, Xiaoke Feng2, Fang Wang2, Xiaoxi Wang2, Qiuyue Peng2, Wenhua Xuan2 and zhang miaojia3, 1Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3the First Affiliated Hospitial of Nanjing Medical University, Nanjing, China

    Background/Purpose: SOX5 is known as a transcription factor which primarily involved in in the regulation of embryonic development, cell fate, and chondrogenesis. To date,  little…
  • Abstract Number: 937 • 2013 ACR/ARHP Annual Meeting

    Inhibitor Of DNA Binding 1 Mediates Angiogenesis In Rheumatoid Arthritis By Recruitment Of Endothelial Progenitor Cells

    Takeo Isozaki1, Alisa E. Koch2, M. Asif Amin1, Ali S. Arbab3, Gautam Edhayan4, Christine M. Ha4, Pei-Suen Tsou4, Sean C. Friday4, David A. Fox4 and Jeffrey H. Ruth4, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, 4Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Endothelial progenitor cells (EPCs) are known to induce vasculoproliferative responses within rheumatoid arthritis (RA) synovial tissue (ST). Inhibitor of DNA-Binding 1 (Id1) is a…
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