Abstracts tagged "T cells"

Abstract Number: 936 • 2018 ACR/ARHP Annual Meeting
Selective Deficiency of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in T Lymphocytes Leads to mTORC1 Activation, Treg Dysfunction and Systemic Autoimmune Disease
Takayuki Katsuyama¹, Hao Li¹, Denis Comte², Michael W. Mosho³, Andrew R. Gillooly³, George C Tsokos⁴ and Vaishali R. Moulton¹, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Rheumatology, Department of Medicine, Boston, MA, ³Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit defects in signaling and cytokine production, and aberrant numbers and/or function of regulatory T…
Abstract Number: 2094 • 2018 ACR/ARHP Annual Meeting
Examining T Cell Exhaustion in Murine Systemic Lupus Erythematosus
Jeremy Tilstra¹, Lyndsay Avery², Ashley Menk², Rachael Gordon², Shuchi Smita³, Lawrence Kane³, Maria Chikina², Greg Delgoffe³ and Mark Shlomchik⁴, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function…
Abstract Number: 141 • 2018 ACR/ARHP Annual Meeting
Lymphocyte Activation Gene 3 Plasma Level Is Increased and Associated with Progression in Early Rheumatoid Arthritis
Janni Maria Pedersen^1,2,3, Aida Hansen⁴, Malene Hvid⁵, Kim Hørslev-Petersen⁶, Merete Lund Hetland⁷, Kristian Stengaard-Pedersen⁸, Mikkel Østergaard⁹, Bjarne Kuno Moeller¹⁰, Ellen-Margrethe Hauge¹¹, Peter Junker¹² and Bent Deleuran^1,2, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ⁴Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁶King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁷University of Copenhagen, Copenhagen, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus, Denmark, ⁹Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ¹⁰Department of Immunology, Aarhus University Hospital, Aarhus, Denmark, ¹¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus, Denmark, ¹²Department of Rheumatology C, Odense University Hospital, Odense, Denmark
Background/Purpose: Lymphocyte activation gene 3 (LAG3) resembles CD4 and is a key checkpoint molecule leading to downregulation of T cell proliferation and antigen presentation via…
Abstract Number: 988 • 2018 ACR/ARHP Annual Meeting
Regulatory T Cells with Skewed Responses and Propionate-Producing Gut Bacteria Increased Simultaneously in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²St. Marianna University School of Medicine, Kawasaki, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Several intestinal bacteria produce short-chain fatty acids (SCFA) by the fermentation of dietary fibers. SCFA in the intestine differentiate regulatory T (Treg) cells by…
Abstract Number: 2096 • 2018 ACR/ARHP Annual Meeting
Ectonucleotidase CD73 Suppresses Autoantibody Production and Arterial Vasculopathy in Murine Lupus
Ramadan A. Ali¹, Nicole R. Pearce¹, Srilakshmi Yalavarthi¹, Kevin B. Atkins¹, Alex A. Gandhi¹, Yogendra Kanthi¹ and Jason S. Knight², ¹University of Michigan, Ann Arbor, MI, ²., University of Michigan, Ann Arbor, MI
Background/Purpose: CD73 is a surface nucleotidase that extends into the extracellular space where it generates adenosine from AMP. By regulating a cell’s “purinergic halo,” CD73…
Abstract Number: 25 • 2018 ACR/ARHP Annual Meeting
Circulating CD24hiCD38hi Regulatory B-Cells Influence Th17-Cell Responses in Patients with Granulomatosis with Polyangiitis
Anouk von Borstel¹, Lucas L. Lintermans², P Heeringa³, Abraham Rutgers², Coen A. Stegeman¹, Jan-Stephan F. Sanders¹ and Wayel H. Abdulahad², ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: To investigate whether there is a direct relation between expanded proportions of Th17-effector memory (ThEM17) cells and diminished proportions of regulatory B-cells (Bregs) in…
Abstract Number: 143 • 2018 ACR/ARHP Annual Meeting
Aquaporin 3 (AQP3) Protein Is Highly Expressed in Psoriatic Plaques and AQP3 Gene Expression Strongly Induced By IL-23 in CD4+ Th17 Cells
Ananta Paine¹, Maria de la Luz Garcia-Hernandez², Benjamin D. Korman², Judilyn Duculan³, Mayte Suarez-Farinas⁴, James G. Krueger³ and Christopher T. Ritchlin², ¹Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ²Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ³Laboratory for Investigative Dermatology, Rockefeller University, New York City, New York, USA, New York City, NY, ⁴Icahn School of Medicine at Mount Sinai, New York City, New York, USA, New York City, NY
Background/Purpose: Th17, a subset of CD4+ helper T cells, provides protection against pathogens and malignancies, but also promotes immune-mediated-inflammation in a range of disorders including…
Abstract Number: 1000 • 2018 ACR/ARHP Annual Meeting
Surface Adenosine Monophosphate Deaminase 2 As a Novel Regulator Modifying Ectonucleotidase-Driven Generation of Anti-Inflammatory Extracellular Adenosine
Lisa Ehlers^1,2, Aditi Kuppe^1,2, Alexandra Damerau^3,4, Yuling Chen^1,2, Cindy Strehl^3,5, Marieluise Kirchner⁶, Frank Buttgereit¹ and Timo Gaber^3,5, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ²German Rheumatism Research Centre Berlin, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ⁵Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany, ⁶BIH Core Facility Proteomics, Max Delbrück Centre for Molecular Medicine, Berlin, Germany
Background/Purpose: Extracellular ATP and adenosine are potent immunomodulatory molecules that accumulate in states of inflammation. ATP/ADP are released from damaged or stressed cells and sequentially…
Abstract Number: 2102 • 2018 ACR/ARHP Annual Meeting
Hyaluronic Acid Synthesis Inhibition Blocks Nephritis and Extends Lifespan in Mice Prone to Lupus
Abel Suarez-Fueyo¹, Seung-Ki Kwok², Kayaho Maeda³ and George C Tsokos⁴, ¹Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, ²Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), ³Rheumatology, Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, ⁴Division of Rheumatology, Department of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA
Background/Purpose: Hyaluronic acid (HA) is a component of the extracellular matrix and is known to be involved in cancer biology. Although evidence suggests that HA…
Abstract Number: 32 • 2018 ACR/ARHP Annual Meeting
T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Paige Snow², Clare Dawson³, Kimberly Samson⁴, Amy Moran⁵, Michael Davey⁶, Shimon Sakaguchi⁷ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ³Portland VA, PORTLAND, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, ⁶VA Portland Health Care System, Portland, OR, ⁷Osaka University, Osaka, Japan
Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…
Abstract Number: 144 • 2018 ACR/ARHP Annual Meeting
Small Molecule Inhibitor of Bcl-6 Reduces the Tfh Population in Peripheral Blood, Splenic Germinal Center and Ankle Joints in a Collagen-Induced Arthritis Mouse Model of RA
Nitasha Bhatia¹, Sedrick Bradley², Cara McLeod¹, Gbemi Olayemi¹, Robert Quinet¹, William E. Davis³, Jerald Zakem⁴ and Xin Zhang¹, ¹Ochsner Medical Center, New Orleans, LA, ²Ochsner Clinic Foundation, New Orleans, LA, ³University of Queensland School of Medicine, Brisbane, Australia, ⁴Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic joint inflammation, synovial hyperplasia and progressive destruction of cartilage and bone. T follicular…
Abstract Number: 1022 • 2018 ACR/ARHP Annual Meeting
TNF-α Regulates Plasmacytoid Dendritic Cells By Suppressing IFN-α Production and Enhancing Th1 and Th17 Cell Differentiation
Antonios Psarras^1,2,3, Agne Antanaviciute⁴, Ian Carr⁴, Miriam Wittmann^1,2, Paul Emery^1,5, George C Tsokos⁶ and Edward M Vital^1,2, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, ⁴Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, ⁵Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response…
Abstract Number: 2109 • 2018 ACR/ARHP Annual Meeting
Activation of T Follicular Helper Cells through Epigenetic Regulation By STAT1 and STAT4 in Lupus Patients
Shingo Nakayamada¹, Xiaoxue Ma¹, Satoshi Kubo¹, Yusuke Miyazaki¹, Kaoru Yamagata¹, Kazuhisa Nakano¹ and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: During the T cell differentiation, signal transducer and activators of transcription (STAT) family transcription factors play pivotal roles in specifying T cell lineages. T…
Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting
Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Kimberly Samson², Paige Snow³, Shimon Sakaguchi⁴ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ⁴Osaka University, Osaka, Japan
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
Abstract Number: 145 • 2018 ACR/ARHP Annual Meeting
1,25(OH)2D3 and Dexamethasone Additively Suppress Synovial Fibroblast Activation By CCR6+ T-Helper Memory Cells and Enhance the Effect of Tnfα Blockade
W Dankers¹, C González-Leal¹, N Davelaar², P Asmawidjaja³, A Otten-Mus², JMW Hazes⁴, E Colin⁵ and Erik Lubberts⁶, ¹Rheumatology, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Erasmus Medical Centre, Rotterdam, Netherlands, ⁵ZGT Almelo, Deventer, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Despite improvement in treatment of rheumatoid arthritis (RA) over the past decades, insufficient treatment response and treatment resistance in many patients demonstrate the need…

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