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Abstract Number: 1583

Low-Dose IL-2 Promotes the Proliferation of Peripheral Regulatory T Cells in Primary Sjogren’s Syndrome to Restore Its Balances with Pro-Inflammatory Lymphocytes

Miao Miao1, Zhenye Hao1, Yingying Guo1, Xiaoying Zhang1, Sheng-Xiao Zhang1, Jing Luo2, Jinfang Zhao3, Chong Gao4 and Xiao-Feng Li5, 1The Second Hospital of Shanxi Medical University, Taiyuan, China, 2the Second Hospital of Shanxi Medical University, Taiyuan, China, 3The Shanxi Medical University, Taiyuan, China, 4Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, 5Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Sjogren's syndrome, T cells, T-Regulatory Cells and interleukins (IL)

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Session Information

Date: Monday, October 22, 2018

Session Title: Sjögren's Syndrome – Basic and Clinical Science Poster

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: To investigate the effect of low-dose IL-2 on the balance of Treg with Teff and other pro-inflammatory lymphocytes in peripheral blood of pSS patients.

Methods: A total of 190 pSS patients and 30 healthy controls were included in the study. The absolute numbers of total CD4+ T, CD8+ T, B, and NK cells in peripheral blood were determined using flow cytometry and BD TrucountTM tubes, while the percentage of each cell subpopulation and CD4+ cell subsets was measured, and then calculated their absolute numbers. Of the 190 patients, 88 were given subcutaneous injections of small doses of recombinant human IL-2 (rhIL-2, 50*106 IU/day for 5 days) in combination with standard therapy, including glucocorticoids, immunosuppressants, Treatment of biologics or their combinations, while other patients received only standard therapies.

Results: (1) The absolute number of peripheral Treg cells of pSS patients was significantly lower than that of normal controls. (2) The absolute number of Th17 and CD8+ T cells before treatment was not different from that of normal controls, whereas the ratios of Th17/Treg and CD8+T/Treg were higher than normal, indicating that the imbalance of them was caused by insufficient number of Treg cells. Although Th17 and CD8+ T cells increased, Treg cells increased more dramatically, so the ratio returned to normal. Similarly, Th1, Th2, NK, and B cells had similar changes, as shown in Figure 2. (3) Compared with the standard treatment group, low-dose IL-2 increased the proportion of the patients with balanced Th17/Treg, who had a more pronounced improvement in symptoms, and less usage of glucocorticoid and HCQ. (4) There were positive correlations between ESSDAI value and the ratios of Th17/Treg (r=0.121, P=0.01), Th1/Treg (ρ=0.103, P<0.05), Th2/Treg (ρ=0.123, P<0.01), B/Treg (ρ=0.122, P<0.05), CD8+T/Treg (ρ=0.107, P<0.05), but no correlation between ESSDAI value and the ratio of NK/Treg (ρ=0.011, P>0.05).

Conclusion: Low-dose rhIL-2 treatment can promote the proliferation of various cell subsets, but mainly Treg cells, indicating that this treatment can restore the overall balances of Teff/Treg, B/Treg, and NK/Treg. Thus, due to improvement of ESSDAI, the overall balances between Treg and pro-inflammation cells are more important than the change in the single cell subset.


Disclosure: M. Miao, None; Z. Hao, None; Y. Guo, None; X. Zhang, None; S. X. Zhang, None; J. Luo, None; J. Zhao, None; C. Gao, None; X. F. Li, None.

To cite this abstract in AMA style:

Miao M, Hao Z, Guo Y, Zhang X, Zhang SX, Luo J, Zhao J, Gao C, Li XF. Low-Dose IL-2 Promotes the Proliferation of Peripheral Regulatory T Cells in Primary Sjogren’s Syndrome to Restore Its Balances with Pro-Inflammatory Lymphocytes [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/low-dose-il-2-promotes-the-proliferation-of-peripheral-regulatory-t-cells-in-primary-sjogrens-syndrome-to-restore-its-balances-with-pro-inflammatory-lymphocytes/. Accessed February 3, 2023.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/low-dose-il-2-promotes-the-proliferation-of-peripheral-regulatory-t-cells-in-primary-sjogrens-syndrome-to-restore-its-balances-with-pro-inflammatory-lymphocytes/

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