ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 2900 • 2018 ACR/ARHP Annual Meeting

    Impaired TCR Signaling Paves the Way for Cytokine Hyper-Responsiveness in Arthritogenic T Cells

    Judith Ashouri1, Lih-Yun Hsu1, Dmitry Rychkov2, Marina Sirota2, Lisa Lattanza3, Eric Hansen3, Julie Zikherman1 and Arthur Weiss1, 1Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, 3Orthopedic Surgery, University of California, San Francisco, San Francisco, CA

    Background/Purpose: The inability to identify relevant arthritogenic CD4 T cells in patients and in murine disease models has limited our understanding of disease initiating events…
  • Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting

    Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis

    Paul Martin1, James Ding1, Ben Mulhearn1, Sebastien Viatte1 and Stephen Eyre1,2, 1Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

    Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…
  • Abstract Number: 797 • 2018 ACR/ARHP Annual Meeting

    Absolute Reduction of Peripheral CD4+ Regulatory T Cells in Patients with Systemic Sclerosis and Its Restoration By Short-Term and Low Dose IL-2 Treatment

    Lili Shang1, Jing Luo2, Chong Gao3, Jingman Yuan1, Qian Li1, Xiaoli Liu1, Huiying Gao1 and Xiao-Feng Li4, 1Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, 2the Second Hospital of Shanxi Medical University, Taiyuan, China, 3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, 4Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China

    Background/Purpose: The aim of the present study was to investigate whether the imbalance of CD4+ T subsets can be corrected by supplementing low dose interleukin -2 (IL-2).Methods:…
  • Abstract Number: 2032 • 2018 ACR/ARHP Annual Meeting

    Effector T Helper Cell Differentiation and Cytokine Secretion Are Increased in Young Children with Juvenile Idiopathic Arthritis

    Anna Patrick1, Thomas Aune2, Jessica Duis3 and T. Brent Graham4, 1Pediatric Rheumatology, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN, 2Medicine, Vanderbilt University Medical Center, Division of Rheumatology, Nashville, TN, 3Pediatrics, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Medical Genetics and Genomic Medicine, Nashville, TN, 4Pediatrics, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN

    Background/Purpose: T cells play a critical role in the body’s response to pathogens. A naïve T helper (Th0) cell proliferates in response to antigen encounter…
  • Abstract Number: 2903 • 2018 ACR/ARHP Annual Meeting

    Single Cell Association Testing Identifies an Expanded Th1-Skewed Cytotoxic Effector CD4+ T Cell Subset in Rheumatoid Arthritis

    Chamith Fonseka1, Deepak Rao2, Nikola Teslovich3, Ilya Korsunsky4, Susan Hannes5, Kamil Slowikowski1, Michael Gurish6, Laura T. Donlin7, James A. Lederer8, Michael Weinblatt9, Elena Massarotti9, Jonathan Coblyn9, Simon Helfgott10, Derrick J. Todd11, Vivian P. Bykerk12, Elizabeth Karlson13, Joerg Ermann14, Yvonne C. Lee15, Michael Brenner16 and Soumya Raychaudhuri1,17, 1Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, 4Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 9Brigham and Women's Hospital, Boston, MA, 10Division of Rheumatology, Brigham and Women’s Hospital, Boston, MA, 11Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 12Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, 13Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 14Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 15Northwestern University Feinberg School of Medicine, Chicago, IL, 16Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 17Program in Medical and Population Genetics, Broad Institute, Boston, MA

    Background/Purpose: Defining the precise CD4+ T cell subsets that are dysregulated in RA patients is critical to deciphering pathogenesis. Here we present Mixed effects modeling…
  • Abstract Number: 136 • 2018 ACR/ARHP Annual Meeting

    Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Disease in Multiple Mouse Models of Autoimmunity

    Stacey Dillon1, Katherine Lewis1, Lawrence Evans2, Ryan Swanson2, Jing Yang3, Martin Wolfson4, Michelle Seaberg1, Kayla Susmilch5, Sherri Mudri1, Mark Rixon4, Stanford Peng6 and Kristine Swiderek7, 1Translational Sciences, Alpine Immune Sciences, Seattle, WA, 2Immunology, Alpine Immune Sciences, Seattle, WA, 3Clinical, R&D, Alpine Immune Sciences, SEATTLE, WA, 4Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, 5Translational Sciences, Alpine Immune Sciences, SEATTLE, WA, 6Clinical, R&D, Alpine Immune Sciences, Seattle, WA, 7Research, Alpine Immune Sciences, SEATTLE, WA

    Background/Purpose: CD28 and Inducible T-cell Costimulator (ICOS) are two related costimulatory molecules within the immunoglobulin superfamily (IgSF) expressed on T cells and interacting with CD80/CD86…
  • Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting

    New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation

    Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA

    Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…
  • Abstract Number: 2052 • 2018 ACR/ARHP Annual Meeting

    Immune Therapy of Rheumatoid Arthritis Patients with a Microbiome-Derived, Self/Non-Self Peptide Induces Clinically Relevant Immune Tolerance Pivoting on Immune Checkpoint-Expressing, Therapy-Induced Tregs

    Salvatore Albani1, Jing Yao Leong2 and Theodorus van den Broek3, 1Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore, 2Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, 3University Medical Center of Utrecht, Utrecht, Netherlands

    Background/Purpose: We have previously reported in patients with RA abnormal inflammatory T cell responses to an E. coli peptide (dnaJP1) which shares homology with the…
  • Abstract Number: 137 • 2018 ACR/ARHP Annual Meeting

    Autoantibody-Inducing CD4 T (aiCD4 T) Cells Which Induce Systemic Lupus Erythematosus (SLE) Contain Follicular Helper T Cell in Addition to the Major IL-21-Producing CXCR5-ICOShiPD1hi Population: Self-Organized Criticality Theory As the Cause of SLE

    Ken Tsumiyama and Shunichi Shiozawa, Institute for Rheumatic Diseases, Nagahama, Japan

    Background/Purpose: We have shown that repeated immunization with antigen induces systemic lupus erythematosus (SLE) in the mice otherwise not prone to spontaneous autoimmune diseases. We…
  • Abstract Number: 879 • 2018 ACR/ARHP Annual Meeting

    IL-31 Protein Expression in Lesional Skin Correlates with Itch in Dermatomyositis

    Nithin Reddy1,2, Majid Zeidi3 and Victoria P. Werth4, 1Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Corporal Michael J. Crescenz VAMC, Philadelphia, PA, 3Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 4Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Dermatomyositis (DM) is an inflammatory myopathy where itch is a major contributor to impaired quality of life. Previously, we have shown that a cytokine…
  • Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting

    Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis

    Olivier Fogel1, Andreas Bugge Tinggaard2, Maud Fagny1, Nelly Sigrist3, Elodie Roché3, Laurence Leclère3, Jean-François Deleuze4, Maxime Dougados5, Corinne Miceli-Richard6,7 and Jorg Tost1, 1Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, 2Aarhus University, Department of Biomedicine, Aarhus, Denmark, 3Laboratory for Epigenetics and Environment, Evry, France, 4Centre National de Recherche en Génomique Humaine, Evry, France, 5Paris Descartes University, Hôpital Cochin, Paris, France, 6Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, 7Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France

    Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
  • Abstract Number: 138 • 2018 ACR/ARHP Annual Meeting

    Distinct Roles of Tfh2, SLAMF7+ Tfh1 Cells and Th1 Cells in the Pathogenesis of IgG4-RD

    Kazuhiko Higashioka1, Masahiro Ayano1, Yasutaka Kimoto2, Hiroki Mitoma1, Mitsuteru Akahoshi1, Yojiro Arinobu1, Koichi Akashi1, Takahiko Horiuchi3 and Hiroaki Niro4, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: IgG4-related disease (IgG4-RD) is a novel disease entity characterized by the infiltration of IgG4-secreting plasmablasts (PBs) and the generation of germinal centers in various…
  • Abstract Number: 934 • 2018 ACR/ARHP Annual Meeting

    HIV Protease Inhibitors Cure Lupus-Prone Mice and Prevent T Helper 17 Cell-Driven Inflammation By Inhibiting CD95-Non-Apoptotic Signaling Pathway

    Manon Charrier1, Amanda Poissonnier2, Daniel Best2, Jean-Philippe Guégan2, Nicolas Levoin3, Raphael Pineau2, Florence Jouan2, Ha Thanh Nguyen2, Lucie Morere2, Sophie Martin2, Melissa Thomas2, Estibaliz Lazaro1, Christophe Richez1, Isabelle Douchet1, Thomas Ducret4, Pierre Van de Weghe2, Patrick Blanco1, Mickael Jean2, Pierre Vacher5 and Patrick Legembre2, 1UMR CNRS 5164 - Immunoconcept, Bordeaux, France, 2Chemistry Oncogenesis Stress Signaling, INSERM UMR 1242 Rennes University, Rennes, France, 3Bioprojet Biotech, Saint-Grégoire, France, 4INSERM U1218, Bordeaux University, Bordeaux, France, 5Actions for onCogenesis understanding and Target Identification in ONcology, INSERM U1218, Bordeaux University, Bordeaux, France

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance to nuclear components; this results in production of autoantibodies, immune…
  • Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting

    Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus

    Goh Murayama1, Asako Chiba2, Atsushi Nomura3, Hirofumi Amano1, Ken Yamaji1, Naoto Tamura1 and Sachiko Miyake4,5, 1Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, 3JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan, 4Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, 5Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
  • Abstract Number: 139 • 2018 ACR/ARHP Annual Meeting

    Calcium/Calmodulin-Dependent Protein Kinase 4 Promotes GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus

    Tomohiro Koga1, Masataka Umeda2, Yushiro Endo3, Toshimasa Shimizu2, Remi Sumiyoshi3, Shinya Kawashiri3, Naoki Iwamoto2, Kunihiro Ichinose4, Mami Tamai4, Tomoki Origuchi5, Hideki Nakamura2 and Atsushi Kawakami2, 1Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Background/Purpose: Glycolysis is critical for T-cell effector functions, and increased glycolysis leads to autoimmunity. APT production by effector T cells is dependent on the mitochondria-independent…
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