Abstracts tagged "T cells"

Abstract Number: 2900 • 2018 ACR/ARHP Annual Meeting
Impaired TCR Signaling Paves the Way for Cytokine Hyper-Responsiveness in Arthritogenic T Cells
Judith Ashouri¹, Lih-Yun Hsu¹, Dmitry Rychkov², Marina Sirota², Lisa Lattanza³, Eric Hansen³, Julie Zikherman¹ and Arthur Weiss¹, ¹Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, ³Orthopedic Surgery, University of California, San Francisco, San Francisco, CA
Background/Purpose: The inability to identify relevant arthritogenic CD4 T cells in patients and in murine disease models has limited our understanding of disease initiating events…
Abstract Number: 134 • 2018 ACR/ARHP Annual Meeting
Exploration of T-Cell Signatures Following TCR Stimulation Using Single Cell RNA-Seq to Inform Treatment Response Studies in Rheumatoid Arthritis
Paul Martin¹, James Ding¹, Ben Mulhearn¹, Sebastien Viatte¹ and Stephen Eyre^1,2, ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Background/Purpose: For rheumatoid arthritis (RA), as with many other rheumatic diseases, the importance of determining which therapy will work best, early in disease, to prevent…
Abstract Number: 797 • 2018 ACR/ARHP Annual Meeting
Absolute Reduction of Peripheral CD4+ Regulatory T Cells in Patients with Systemic Sclerosis and Its Restoration By Short-Term and Low Dose IL-2 Treatment
Lili Shang¹, Jing Luo², Chong Gao³, Jingman Yuan¹, Qian Li¹, Xiaoli Liu¹, Huiying Gao¹ and Xiao-Feng Li⁴, ¹Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, ²the Second Hospital of Shanxi Medical University, Taiyuan, China, ³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁴Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: The aim of the present study was to investigate whether the imbalance of CD4+ T subsets can be corrected by supplementing low dose interleukin -2 (IL-2).Methods:…
Abstract Number: 2032 • 2018 ACR/ARHP Annual Meeting
Effector T Helper Cell Differentiation and Cytokine Secretion Are Increased in Young Children with Juvenile Idiopathic Arthritis
Anna Patrick¹, Thomas Aune², Jessica Duis³ and T. Brent Graham⁴, ¹Pediatric Rheumatology, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN, ²Medicine, Vanderbilt University Medical Center, Division of Rheumatology, Nashville, TN, ³Pediatrics, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Medical Genetics and Genomic Medicine, Nashville, TN, ⁴Pediatrics, Monroe Carell Junior Children's Hospital at Vanderbilt, Division of Pediatric Rheumatology, Nashville, TN
Background/Purpose: T cells play a critical role in the body’s response to pathogens. A naïve T helper (Th0) cell proliferates in response to antigen encounter…
Abstract Number: 2903 • 2018 ACR/ARHP Annual Meeting
Single Cell Association Testing Identifies an Expanded Th1-Skewed Cytotoxic Effector CD4+ T Cell Subset in Rheumatoid Arthritis
Chamith Fonseka¹, Deepak Rao², Nikola Teslovich³, Ilya Korsunsky⁴, Susan Hannes⁵, Kamil Slowikowski¹, Michael Gurish⁶, Laura T. Donlin⁷, James A. Lederer⁸, Michael Weinblatt⁹, Elena Massarotti⁹, Jonathan Coblyn⁹, Simon Helfgott¹⁰, Derrick J. Todd¹¹, Vivian P. Bykerk¹², Elizabeth Karlson¹³, Joerg Ermann¹⁴, Yvonne C. Lee¹⁵, Michael Brenner¹⁶ and Soumya Raychaudhuri^1,17, ¹Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, ⁴Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁸Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁹Brigham and Women's Hospital, Boston, MA, ¹⁰Division of Rheumatology, Brigham and Women’s Hospital, Boston, MA, ¹¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹²Deptartment of Rheumatology, Hospital for Special Surgery, New York, NY, ¹³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ¹⁵Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁶Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁷Program in Medical and Population Genetics, Broad Institute, Boston, MA
Background/Purpose: Defining the precise CD4+ T cell subsets that are dysregulated in RA patients is critical to deciphering pathogenesis. Here we present Mixed effects modeling…
Abstract Number: 136 • 2018 ACR/ARHP Annual Meeting
Alpn-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Disease in Multiple Mouse Models of Autoimmunity
Stacey Dillon¹, Katherine Lewis¹, Lawrence Evans², Ryan Swanson², Jing Yang³, Martin Wolfson⁴, Michelle Seaberg¹, Kayla Susmilch⁵, Sherri Mudri¹, Mark Rixon⁴, Stanford Peng⁶ and Kristine Swiderek⁷, ¹Translational Sciences, Alpine Immune Sciences, Seattle, WA, ²Immunology, Alpine Immune Sciences, Seattle, WA, ³Clinical, R&D, Alpine Immune Sciences, SEATTLE, WA, ⁴Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, ⁵Translational Sciences, Alpine Immune Sciences, SEATTLE, WA, ⁶Clinical, R&D, Alpine Immune Sciences, Seattle, WA, ⁷Research, Alpine Immune Sciences, SEATTLE, WA
Background/Purpose: CD28 and Inducible T-cell Costimulator (ICOS) are two related costimulatory molecules within the immunoglobulin superfamily (IgSF) expressed on T cells and interacting with CD80/CD86…
Abstract Number: 845 • 2018 ACR/ARHP Annual Meeting
New Insights in Lupus Dermatitis: Differential Regulation and Roles of Tissue-Resident Dendritic Cell Subsets in the Pathogenesis of Autoimmune Skin Inflammation
Ram R. Singh, Miguel-Angel Gutierrez, Peter Kim, Darshan Randhawa, Rachael Philips, Jennifer K. King and Anna Eriksson, Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA
Background/Purpose: Acquired or self antigens in tissues are taken to lymphoid organs to elicit protective immunity or tolerance, respectively. This is accomplished by dendritic cells…
Abstract Number: 2052 • 2018 ACR/ARHP Annual Meeting
Immune Therapy of Rheumatoid Arthritis Patients with a Microbiome-Derived, Self/Non-Self Peptide Induces Clinically Relevant Immune Tolerance Pivoting on Immune Checkpoint-Expressing, Therapy-Induced Tregs
Salvatore Albani¹, Jing Yao Leong² and Theodorus van den Broek³, ¹Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore, ²Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, ³University Medical Center of Utrecht, Utrecht, Netherlands
Background/Purpose: We have previously reported in patients with RA abnormal inflammatory T cell responses to an E. coli peptide (dnaJP1) which shares homology with the…
Abstract Number: 137 • 2018 ACR/ARHP Annual Meeting
Autoantibody-Inducing CD4 T (aiCD4 T) Cells Which Induce Systemic Lupus Erythematosus (SLE) Contain Follicular Helper T Cell in Addition to the Major IL-21-Producing CXCR5-ICOShiPD1hi Population: Self-Organized Criticality Theory As the Cause of SLE
Ken Tsumiyama and Shunichi Shiozawa, Institute for Rheumatic Diseases, Nagahama, Japan
Background/Purpose: We have shown that repeated immunization with antigen induces systemic lupus erythematosus (SLE) in the mice otherwise not prone to spontaneous autoimmune diseases. We…
Abstract Number: 879 • 2018 ACR/ARHP Annual Meeting
IL-31 Protein Expression in Lesional Skin Correlates with Itch in Dermatomyositis
Nithin Reddy^1,2, Majid Zeidi³ and Victoria P. Werth⁴, ¹Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Corporal Michael J. Crescenz VAMC, Philadelphia, PA, ³Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ⁴Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Dermatomyositis (DM) is an inflammatory myopathy where itch is a major contributor to impaired quality of life. Previously, we have shown that a cytokine…
Abstract Number: 2074 • 2018 ACR/ARHP Annual Meeting
Micrornas Deregulation in Monocytes and T CD4 Lymphocytes from Patients with Axial Spondyloarthritis
Olivier Fogel¹, Andreas Bugge Tinggaard², Maud Fagny¹, Nelly Sigrist³, Elodie Roché³, Laurence Leclère³, Jean-François Deleuze⁴, Maxime Dougados⁵, Corinne Miceli-Richard^6,7 and Jorg Tost¹, ¹Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Laboratory for Epigenetics and Environment, Evry, France, ²Aarhus University, Department of Biomedicine, Aarhus, Denmark, ³Laboratory for Epigenetics and Environment, Evry, France, ⁴Centre National de Recherche en Génomique Humaine, Evry, France, ⁵Paris Descartes University, Hôpital Cochin, Paris, France, ⁶Department of Immunology, Pasteur Institute, Immunoregulation Unit, Paris, France, ⁷Department of Rheumatology, Paris Descartes University, Hôpital Cochin, Paris, France
Background/Purpose: MicroRNAs have been shown to play a crucial role during innate or adaptive immune response. Deregulation of miRNAs has been described in several autoimmune…
Abstract Number: 138 • 2018 ACR/ARHP Annual Meeting
Distinct Roles of Tfh2, SLAMF7+ Tfh1 Cells and Th1 Cells in the Pathogenesis of IgG4-RD
Kazuhiko Higashioka¹, Masahiro Ayano¹, Yasutaka Kimoto², Hiroki Mitoma¹, Mitsuteru Akahoshi¹, Yojiro Arinobu¹, Koichi Akashi¹, Takahiko Horiuchi³ and Hiroaki Niro⁴, ¹Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a novel disease entity characterized by the infiltration of IgG4-secreting plasmablasts (PBs) and the generation of germinal centers in various…
Abstract Number: 934 • 2018 ACR/ARHP Annual Meeting
HIV Protease Inhibitors Cure Lupus-Prone Mice and Prevent T Helper 17 Cell-Driven Inflammation By Inhibiting CD95-Non-Apoptotic Signaling Pathway
Manon Charrier¹, Amanda Poissonnier², Daniel Best², Jean-Philippe Guégan², Nicolas Levoin³, Raphael Pineau², Florence Jouan², Ha Thanh Nguyen², Lucie Morere², Sophie Martin², Melissa Thomas², Estibaliz Lazaro¹, Christophe Richez¹, Isabelle Douchet¹, Thomas Ducret⁴, Pierre Van de Weghe², Patrick Blanco¹, Mickael Jean², Pierre Vacher⁵ and Patrick Legembre², ¹UMR CNRS 5164 - Immunoconcept, Bordeaux, France, ²Chemistry Oncogenesis Stress Signaling, INSERM UMR 1242 Rennes University, Rennes, France, ³Bioprojet Biotech, Saint-Grégoire, France, ⁴INSERM U1218, Bordeaux University, Bordeaux, France, ⁵Actions for onCogenesis understanding and Target Identification in ONcology, INSERM U1218, Bordeaux University, Bordeaux, France
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance to nuclear components; this results in production of autoantibodies, immune…
Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus
Goh Murayama¹, Asako Chiba², Atsushi Nomura³, Hirofumi Amano¹, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake^4,5, ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan, ⁴Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ⁵Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
Abstract Number: 139 • 2018 ACR/ARHP Annual Meeting
Calcium/Calmodulin-Dependent Protein Kinase 4 Promotes GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus
Tomohiro Koga¹, Masataka Umeda², Yushiro Endo³, Toshimasa Shimizu², Remi Sumiyoshi³, Shinya Kawashiri³, Naoki Iwamoto², Kunihiro Ichinose⁴, Mami Tamai⁴, Tomoki Origuchi⁵, Hideki Nakamura² and Atsushi Kawakami², ¹Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Glycolysis is critical for T-cell effector functions, and increased glycolysis leads to autoimmunity. APT production by effector T cells is dependent on the mitochondria-independent…

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