ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "T cells"

  • Abstract Number: 141 • 2018 ACR/ARHP Annual Meeting

    Lymphocyte Activation Gene 3 Plasma Level Is Increased and Associated with Progression in Early Rheumatoid Arthritis

    Janni Maria Pedersen1,2,3, Aida Hansen4, Malene Hvid5, Kim Hørslev-Petersen6, Merete Lund Hetland7, Kristian Stengaard-Pedersen8, Mikkel Østergaard9, Bjarne Kuno Moeller10, Ellen-Margrethe Hauge11, Peter Junker12 and Bent Deleuran1,2, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 3Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 4Biomedicine, Aarhus University, Aarhus, Denmark, 5Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 6King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 7University of Copenhagen, Copenhagen, Denmark, 8Department of Rheumatology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus, Denmark, 9Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 10Department of Immunology, Aarhus University Hospital, Aarhus, Denmark, 11Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus, Denmark, 12Department of Rheumatology C, Odense University Hospital, Odense, Denmark

    Background/Purpose: Lymphocyte activation gene 3 (LAG3) resembles CD4 and is a key checkpoint molecule leading to downregulation of T cell proliferation and antigen presentation via…
  • Abstract Number: 988 • 2018 ACR/ARHP Annual Meeting

    Regulatory T Cells with Skewed Responses and Propionate-Producing Gut Bacteria Increased Simultaneously in Patients with Relapsing Polychondritis

    Jun Shimizu1, Takao Kubota2 and Noboru Suzuki3, 1Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2St. Marianna University School of Medicine, Kawasaki, Japan, 3Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan

    Background/Purpose: Several intestinal bacteria produce short-chain fatty acids (SCFA) by the fermentation of dietary fibers. SCFA in the intestine differentiate regulatory T (Treg) cells by…
  • Abstract Number: 2096 • 2018 ACR/ARHP Annual Meeting

    Ectonucleotidase CD73 Suppresses Autoantibody Production and Arterial Vasculopathy in Murine Lupus

    Ramadan A. Ali1, Nicole R. Pearce1, Srilakshmi Yalavarthi1, Kevin B. Atkins1, Alex A. Gandhi1, Yogendra Kanthi1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: CD73 is a surface nucleotidase that extends into the extracellular space where it generates adenosine from AMP. By regulating a cell’s “purinergic halo,” CD73…
  • Abstract Number: 25 • 2018 ACR/ARHP Annual Meeting

    Circulating CD24hiCD38hi Regulatory B-Cells Influence Th17-Cell Responses in Patients with Granulomatosis with Polyangiitis

    Anouk von Borstel1, Lucas L. Lintermans2, P Heeringa3, Abraham Rutgers2, Coen A. Stegeman1, Jan-Stephan F. Sanders1 and Wayel H. Abdulahad2, 1Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: To investigate whether there is a direct relation between expanded proportions of Th17-effector memory (ThEM17) cells and diminished proportions of regulatory B-cells (Bregs) in…
  • Abstract Number: 143 • 2018 ACR/ARHP Annual Meeting

    Aquaporin 3 (AQP3) Protein Is Highly Expressed in Psoriatic Plaques and AQP3 Gene Expression Strongly Induced By IL-23 in CD4+ Th17 Cells

    Ananta Paine1, Maria de la Luz Garcia-Hernandez2, Benjamin D. Korman2, Judilyn Duculan3, Mayte Suarez-Farinas4, James G. Krueger3 and Christopher T. Ritchlin2, 1Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 2Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 3Laboratory for Investigative Dermatology, Rockefeller University, New York City, New York, USA, New York City, NY, 4Icahn School of Medicine at Mount Sinai, New York City, New York, USA, New York City, NY

    Background/Purpose: Th17, a subset of CD4+ helper T cells, provides protection against pathogens and malignancies, but also promotes immune-mediated-inflammation in a range of disorders including…
  • Abstract Number: 1000 • 2018 ACR/ARHP Annual Meeting

    Surface Adenosine Monophosphate Deaminase 2 As a Novel Regulator Modifying Ectonucleotidase-Driven Generation of Anti-Inflammatory Extracellular Adenosine

    Lisa Ehlers1,2, Aditi Kuppe1,2, Alexandra Damerau3,4, Yuling Chen1,2, Cindy Strehl3,5, Marieluise Kirchner6, Frank Buttgereit1 and Timo Gaber3,5, 1Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, 2German Rheumatism Research Centre Berlin, Berlin, Germany, 3Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 5Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany, 6BIH Core Facility Proteomics, Max Delbrück Centre for Molecular Medicine, Berlin, Germany

    Background/Purpose: Extracellular ATP and adenosine are potent immunomodulatory molecules that accumulate in states of inflammation. ATP/ADP are released from damaged or stressed cells and sequentially…
  • Abstract Number: 2102 • 2018 ACR/ARHP Annual Meeting

    Hyaluronic Acid Synthesis Inhibition Blocks Nephritis and Extends Lifespan in Mice Prone to Lupus

    Abel Suarez-Fueyo1, Seung-Ki Kwok2, Kayaho Maeda3 and George C Tsokos4, 1Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, 2Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), 3Rheumatology, Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA, 4Division of Rheumatology, Department of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA

    Background/Purpose: Hyaluronic acid (HA) is a component of the extracellular matrix and is known to be involved in cancer biology. Although evidence suggests that HA…
  • Abstract Number: 32 • 2018 ACR/ARHP Annual Meeting

    T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice

    Ruth Napier1, Ellen Lee1, Emily Vance1, Paige Snow2, Clare Dawson3, Kimberly Samson4, Amy Moran5, Michael Davey6, Shimon Sakaguchi7 and Holly Rosenzweig1, 1Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 2Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, 3Portland VA, PORTLAND, OR, 4Oregon Health & Science University, Portland, OR, 5Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, 6VA Portland Health Care System, Portland, OR, 7Osaka University, Osaka, Japan

    Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…
  • Abstract Number: 144 • 2018 ACR/ARHP Annual Meeting

    Small Molecule Inhibitor of Bcl-6 Reduces the Tfh Population in Peripheral Blood, Splenic Germinal Center and Ankle Joints in a Collagen-Induced Arthritis Mouse Model of RA

    Nitasha Bhatia1, Sedrick Bradley2, Cara McLeod1, Gbemi Olayemi1, Robert Quinet1, William E. Davis3, Jerald Zakem4 and Xin Zhang1, 1Ochsner Medical Center, New Orleans, LA, 2Ochsner Clinic Foundation, New Orleans, LA, 3University of Queensland School of Medicine, Brisbane, Australia, 4Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic joint inflammation, synovial hyperplasia and progressive destruction of cartilage and bone. T follicular…
  • Abstract Number: 1022 • 2018 ACR/ARHP Annual Meeting

    TNF-α Regulates Plasmacytoid Dendritic Cells By Suppressing IFN-α Production and Enhancing Th1 and Th17 Cell Differentiation

    Antonios Psarras1,2,3, Agne Antanaviciute4, Ian Carr4, Miriam Wittmann1,2, Paul Emery1,5, George C Tsokos6 and Edward M Vital1,2, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 4Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom, 5Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response…
  • Abstract Number: 2109 • 2018 ACR/ARHP Annual Meeting

    Activation of T Follicular Helper Cells through Epigenetic Regulation By STAT1 and STAT4 in Lupus Patients

    Shingo Nakayamada1, Xiaoxue Ma1, Satoshi Kubo1, Yusuke Miyazaki1, Kaoru Yamagata1, Kazuhisa Nakano1 and Yoshiya Tanaka2, 1First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2University of Occupational and Environmental Health, Kitakyushu, Japan

    Background/Purpose: During the T cell differentiation, signal transducer and activators of transcription (STAT) family transcription factors play pivotal roles in specifying T cell lineages. T…
  • Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting

    Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice

    Ruth Napier1, Ellen Lee1, Emily Vance1, Kimberly Samson2, Paige Snow3, Shimon Sakaguchi4 and Holly Rosenzweig1, 1Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 2Oregon Health & Science University, Portland, OR, 3Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, 4Osaka University, Osaka, Japan

    Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
  • Abstract Number: 145 • 2018 ACR/ARHP Annual Meeting

    1,25(OH)2D3 and Dexamethasone Additively Suppress Synovial Fibroblast Activation By CCR6+ T-Helper Memory Cells and Enhance the Effect of Tnfα Blockade

    W Dankers1, C González-Leal1, N Davelaar2, P Asmawidjaja3, A Otten-Mus2, JMW Hazes4, E Colin5 and Erik Lubberts6, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Erasmus Medical Centre, Rotterdam, Netherlands, 5ZGT Almelo, Deventer, Netherlands, 6Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands

    Background/Purpose: Despite improvement in treatment of rheumatoid arthritis (RA) over the past decades, insufficient treatment response and treatment resistance in many patients demonstrate the need…
  • Abstract Number: 1043 • 2018 ACR/ARHP Annual Meeting

    Computational Analysis of Potential Self-Antigens in Osteoarthritis

    Jefferson Lansford1, Liubov Arbeeva2, Benjamin Vincent3, Joanne M. Jordan4, Richard Loeser4 and Amanda Nelson4, 1School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2TARC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Recent work in a subpopulation of individuals with osteoarthritis (OA) suggests that T cells are (1) responding to auto-antigenic stimuli (e.g. peptidoglycan epitopes), (2)…
  • Abstract Number: 2128 • 2018 ACR/ARHP Annual Meeting

    The Effect of miRNA-21 Overexpression on the Aberrant T Follicular Helper Cells Differentiation in Systemic Lupus Erythematosus

    Ming Zhao1, Xiaofei Gao2, Jiali Wu3, Limin Liu1, Haijing Wu2 and Qianjin Lu1, 1Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China, 2The Second Xiangya Hospital of Central South University, Changsha, China, 3Department of Deramtology, The Second Xiangya Hospital of Central South University, Changsha, China

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by a large number of autoantibodies and multiple organs damage. T follicular helper(Tfh)…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • …
  • 32
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology