Abstract Number: 145 • 2018 ACR/ARHP Annual Meeting
1,25(OH)2D3 and Dexamethasone Additively Suppress Synovial Fibroblast Activation By CCR6+ T-Helper Memory Cells and Enhance the Effect of Tnfα Blockade
Background/Purpose: Despite improvement in treatment of rheumatoid arthritis (RA) over the past decades, insufficient treatment response and treatment resistance in many patients demonstrate the need…Abstract Number: 1043 • 2018 ACR/ARHP Annual Meeting
Computational Analysis of Potential Self-Antigens in Osteoarthritis
Background/Purpose: Recent work in a subpopulation of individuals with osteoarthritis (OA) suggests that T cells are (1) responding to auto-antigenic stimuli (e.g. peptidoglycan epitopes), (2)…Abstract Number: 2128 • 2018 ACR/ARHP Annual Meeting
The Effect of miRNA-21 Overexpression on the Aberrant T Follicular Helper Cells Differentiation in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by a large number of autoantibodies and multiple organs damage. T follicular helper(Tfh)…Abstract Number: 38 • 2018 ACR/ARHP Annual Meeting
Pre-Clinical Clonally-Expanded aggrecan89-103–Specific CD4+ T Cells Are a Target for Autoimmune Arthritis Prevention
Background/Purpose: In the pre-clinical rheumatoid arthritis (RA) prodrome, autoantibodies and transient symptoms may develop. Pre-clinical autoantibody development suggests concomitant expansion of autoantigen-specific CD4+ follicular helper…Abstract Number: 147 • 2018 ACR/ARHP Annual Meeting
T Follicular Helper Cell Phenotype in RA Patients Receiving Rituximab
Background/Purpose: B and T cells contribute to tissue injury in rheumatoid arthritis (RA). Rituximab (RTX), an anti-CD20 monoclonal antibody, is used for the treatment of…Abstract Number: 1091 • 2018 ACR/ARHP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Is Essential for T Lymphocyte Homeostasis and Decreased Levels of SRSF1 Correlate with Lymphopenia in SLE Patients
Background/Purpose: Lymphopenia is one of the most common clinical features in patients with systemic lupus erythematosus (SLE), and associates with severe disease and comorbidities such…Abstract Number: 2233 • 2018 ACR/ARHP Annual Meeting
Activation and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Gouty Arthritis
Background/Purpose: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. Upon antigen recognition, MAIT…Abstract Number: 39 • 2018 ACR/ARHP Annual Meeting
Allogeneic Mesenchymal Stem Cells Derived Extracellular Vesicles As a Superior Immunosuppressant in Murine Arthritis Therapy
Allogeneic mesenchymal stem cells derived extracellular vesicles as a superior immunosuppressant in murine arthritis therapyRunci Wang1,2, Yi Liu2, Songtao Shi1Affiliation: 1. Department of Anatomy and…Abstract Number: 151 • 2018 ACR/ARHP Annual Meeting
Molecular Mechanisms of Pathogenic T Cell Resilience in Human Arthritis
Background/Purpose: T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and is associated with…Abstract Number: 1583 • 2018 ACR/ARHP Annual Meeting
Low-Dose IL-2 Promotes the Proliferation of Peripheral Regulatory T Cells in Primary Sjogren’s Syndrome to Restore Its Balances with Pro-Inflammatory Lymphocytes
Background/Purpose: To investigate the effect of low-dose IL-2 on the balance of Treg with Teff and other pro-inflammatory lymphocytes in peripheral blood of pSS patients.Methods:…Abstract Number: 2795 • 2018 ACR/ARHP Annual Meeting
IL-23 Acts through IL-23R+ Tfh cells to Promote Pathogenic IgG Autoantibody Formation in Lupus
Background/Purpose: IL-23 is currently a target for several forms of autoimmune diseases, yet its role in promoting pathogenic autoantibody development is less clear. IL-23 was…Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis
Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…Abstract Number: 153 • 2018 ACR/ARHP Annual Meeting
Chemotaxis of Vδ2 T Cells to the Joints Contributes to the Pathogenesis of Rheumatoid Arthritis
Background/Purpose: To explore the role of Vδ2 t cells in the pathogenesis of rheumatoid arthritis (rA) Methods: Sixty-eight patients with RA, 21 patients with osteoarthritis…Abstract Number: 1587 • 2018 ACR/ARHP Annual Meeting
Pathogenic Role of Interleukin 27 in the Nonobese Diabetic Mouse Model of Sjögren Syndrome
Background/Purpose: Sjögren syndrome is an immunologically complex autoimmune disease characteristically targeting the lacrimal and salivary glands leading to progressively worsening oral and ocular health and…Abstract Number: 2797 • 2018 ACR/ARHP Annual Meeting
Regulation of Autoimmune T Cells By the Co-Receptors CD28 and PD-1
Background/Purpose: T cells play a major role in the pathogenesis of Rheumatoid Arthritis (RA). These cells are regulated by signals provided via the T cell…
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