Abstracts tagged "T cells"

Abstract Number: 2724 • 2013 ACR/ARHP Annual Meeting
cAMP Responsive Element Modulator (CREM)α Governs CD8 Expression and Contributes to the Generation of CD3⁺CD4^–CD8^– T Cells in Lupus
Christian M. Hedrich¹, José C. Crispín¹, Thomas Rauen¹, Christina Ioannidis¹, Tomohiro Koga², Noe Rodriguez Rodriguez², Sokratis A. Apostolidis³, Vasileios C. Kyttaris² and George C. Tsokos¹, ¹Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: CD3+CD4-CD8- "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T…
Abstract Number: 1643 • 2013 ACR/ARHP Annual Meeting
Ex Vivo Suppression Of RA Effector T Cells (Teff) By Mapc Media Is Synergistic With Treg
Gali Malul¹, David Soler², Donald D. Anthony³, Hillard M. Lazarus⁴, Nicholas Lehman⁵, Thomas McCormick², Julia M. Sugalski⁶, Anthony E. Ting⁵ and Nora G. Singer⁷, ¹Rheumatology, MetroHealth Medical Center, Cleveland, OH, ²Dermatology, Case Medical Center, Cleveland, OH, ³Medicine, Case Western Reserve University, Cleveland, OH, ⁴Comprehensive Cancer Center, Case Medical Center, Cleveland, OH, ⁵Athersys, Inc., Cleveland, OH, ⁶Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, ⁷Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH
Background/Purpose: Use of mesenchymal/multipotent stem cells (MSCs/MAPCs) is an emerging immune modulatory therapeutic strategy promising for a number of human diseases. Multipotent adult progenitor cells…
Abstract Number: 728 • 2013 ACR/ARHP Annual Meeting
Unraveling The Identity Of FoxP3⁺ Regulatory T-Cells In Gpa-Patients
WH Abdulahad¹, Coen A. Stegeman², MG Huitema¹, Pieter C. Limburg³, Abraham Rutgers¹, Peter Heeringa⁴ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Human FoxP3+ Th-cells are heterogeneous in function and include not only suppressive cells (TRegs) but also non-suppressive cells that abundantly secrete proinflammatory cytokines. We…
Abstract Number: 531 • 2013 ACR/ARHP Annual Meeting
Influenza Infection Of MHC-I Transgenic Mice Reveals That Erap Is Necessary and Sufficient For Generation Of The B27-Specific Immunodominant Epitope
Ali Akram¹ and Robert Inman², ¹Institute of Medical Science and Department of Immunology, University of Toronto and University Health Network (UHN), Toronto, ON, Canada, ²Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Although HLA-B27 and ERAP are known to confer susceptibility to spondyloarthritis (SpA), the role of these elements in modulating host response to infection is…
Abstract Number: 2725 • 2013 ACR/ARHP Annual Meeting
Regulation Of Aberrant CD4 T Cell Activation By Suppressor Of Cytokine Signaling-1 (SOCS1) Mimetic Peptide, Has Relevance To Human Systemic Lupus Erythematosus
Tenisha Wilson¹, Cristina Armbruster², Simone Bedoya², Howard M. Johnson², Westley H. Reeves³, Yi Li⁴, Ying Yi Zheng⁵, Laurence Morel⁶ and Joseph Larkin III², ¹Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL, ²Microbiology and Cell Science, University of Florida, Gainesville, FL, ³Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁴Medicine, University of Florida, Gainesville, FL, ⁵Pathology, University of Florida, Gainesville, FL, ⁶Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease, mediated by aberrantly activated CD4 T cells. Notably, suppressor of cytokine signaling-1 (SOCS1) regulates CD4 T…
Abstract Number: 1645 • 2013 ACR/ARHP Annual Meeting
Circulating CD4+CD161+ T Lymphocytes Are Increased In Seropositive Arthralgia Patients But Decreased In Patients With Newly Diagnosed Rheumatoid Arthritis
Paulina Chalan¹, Bart-Jan Kroesen², Kornelis S.M. van der Geest¹, Minke G. Huitema¹, Wayel H. Abdulahad³, Elisabeth Brouwer¹ and Annemieke M.H. Boots⁴, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Improved understanding of the immune events discriminating between seropositive arthralgia and clinical synovitis is of key importance in rheumatology research. Ample evidence suggests a…
Abstract Number: 711 • 2013 ACR/ARHP Annual Meeting
1,25(OH)₂D₃ Inhibits Th17 Cytokine Production and RORγt Expression Through GATA3/IL4-Dependent and -Independent Mechanisms
Wendy Dankers¹, Jan Piet van Hamburg^2,3, Anne-Marie Mus¹, Patrick S. Asmawidjaja¹, Johannes van Leeuwen⁴, Rudi W. Hendriks⁵, Louis Boon⁶, Edgar Colin⁷ and Erik Lubberts^1,8, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Bioceros, Utrecht, Netherlands, ⁷Department of Rheumatology, ZGT, Almelo, Netherlands, ⁸Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). One important mechanism of disease suppression by vitamin D is inhibition…
Abstract Number: 540 • 2013 ACR/ARHP Annual Meeting
Exploration Of a Novel Therapeutic Target In a Murine Model Of Systemic Lupus Erythematosus: Targeting Sphingosine-1-Phosphate (S1P) Receptors
Christopher Tracy¹, Jess Edison², S. Frattalone² and C. Moratz³, ¹Internal Medicine-Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Department of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ³Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: Systemic lupus erythematous (SLE) is an autoimmune disease characterized by symptomatic flares that often result in terminal organ failure. The pathogenesis is characterized by…
Abstract Number: 2504 • 2012 ACR/ARHP Annual Meeting
SOCS1 Is One of the Key Molecules to Prevent the Plasticity of Regulatory T Cells and the Development of Autoimmunity
Reiko Takahashi¹, Kenji Itoh¹, Fumihiko Kimura¹ and Akihiko Yoshimura², ¹Division of Rheumatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Suppression of autoimmunity or inflamation by regulatory T cells (Tregs) is now well established, recently, natural Foxp3+T cells have been shown to be a…
Abstract Number: 2343 • 2012 ACR/ARHP Annual Meeting
The Therapeutic Antibody Tregalizumab (BT-061) Induces Activation of Regulatory T Cells by Engaging a Unique CD4 Mediated Signaling That Strongly Differs From Signaling Events Induced by Standard Anti-CD4 Antibodies
Bianca Helling¹, Benjamin Daelken¹, Holger Wallmeier², Silke Aigner¹, Chantal Zuber¹, Martin Koenig¹, Andre Engling¹, Frank Osterroth¹, Niklas Czeloth³ and Christoph Uherek¹, ¹Biotest AG, Dreieich, Germany, ²Condor Scientific Computing & Consulting, Sulzbach, Germany, ³Global Research Immunology, Biotest AG, Dreieich, Germany
Background/Purpose: The humanized CD4 specific monoclonal antibody (mAb) tregalizumab is currently being tested in phase II clinical trials in Rheumatoid Arthritis. In contrast to other…
Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E₂ Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar³, Patrick S. Asmawidjaja³, Johanna M.W. Hazes⁴ and Erik Lubberts³, ¹Immunology, Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…
Abstract Number: 857 • 2012 ACR/ARHP Annual Meeting
Impairment of the Inhibitory PD-1-PD-L1 Axis in Giant Cell Arteritis (GCA)
Mazen Nasrallah¹, Augusto Vaglio², Shalini Mohan¹, Bjorn Hartmann³, Joyce Liao⁴, Kenneth J. Warrington⁵, Jorg J. Goronzy³ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Unit of Nephrology, University Hospital of Parma, Parma, Italy, ³Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Giant cell arteritis (GCA) is an autoimmune syndrome characterized by granuloma formation in the media of medium and large arteries. In a healthy immune…
Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4⁺ Regulatory T Cells in (New Zealand Black x New Zealand White )F₁ Lupus-Prone Mice in a Dose-Dependent Manner
Maida Wong¹, Antonio La Cava² and Bevra H. Hahn³, ¹Internal Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Internal Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…
Abstract Number: 2344 • 2012 ACR/ARHP Annual Meeting
Transcriptional Regulation of Garp Expression
Sonja Haupt¹, Qihui Zhou¹, Johannes Thomas Kreuzer¹, Simon Herrmann¹, Hendrik Schulze-Koops¹ and Alla Skapenko², ¹Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Regulatory T cells (Tregs) contribute to immune tolerance and play a pivotal role in the prevention of autoimmune diseases such as rheumatoid arthritis (RA).…
Abstract Number: 1624 • 2012 ACR/ARHP Annual Meeting
Deletion of HLA-B27 T Cells Underlies the Immunodominant Response to Influenza Infection On Class I MHC Transgenic Mice
Ali Akram¹ and Robert D. Inman², ¹Institute of Medical Science and Department of Immunology, University of Toronto and University Health Network (UHN), Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: The role of HLA-B27 in modulating host response to infection is undefined, yet has important implications for the mechanism whereby B27 confers susceptibility to…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.