Abstracts tagged "T cells"

Abstract Number: 1641 • 2013 ACR/ARHP Annual Meeting
Bispecific Antibodies For Redirection Of Human Regulatory T Cells To Surface-Inducible Autoantigen La/SS-B
Stefanie Koristka¹, Marc Cartellieri², Claudia Arndt², Anja Feldmann², Irene Michalk², Claudia C. Bippes², Nicole Berndt², Anne Hermsdorf², Slava Stamova², Biji T. Kurien³, Robert Hal Scofield⁴, A. Darise Farris⁵, Judith A. James⁶, Holger Bartsch⁷ and Michael Bachmann², ¹Carl Gustav Carus TU-Dresden, Dresden, Germany, ²Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁵Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁶Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany
Background/Purpose: Adoptive transfer of regulatory T cells (Tregs) represents a promising strategy for treatment of auto- and alloimmunity. However, it is difficult to obtain therapeutically…
Abstract Number: 722 • 2013 ACR/ARHP Annual Meeting
BAFF Promotes T Follicular Helper Cell Development and Germinal Center Generation In Mice
Song Guo Zheng¹, Maogeng Chen¹, Qiang Li² and William Stohl³, ¹Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ²University of Southern California Keck School of Medicine, Los Angeles, CA, ³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: BAFF (B cell activating factor belonging to the TNF family) promotes B cells maturation in germinal center. The generation of germinal center depends on…
Abstract Number: 2411 • 2013 ACR/ARHP Annual Meeting
The Peripheral Blood T Cell Repertoire Before The Clinical Onset Of Rheumatoid Arthritis – a Study Of Incident Cases and Controls
Carl Turesson¹, Ulf Bergström², Edgars Grins³, Olle Melander⁴, Lennart Truedsson⁵, Lennart Jacobsson² and Stefan Jovinge³, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden, ⁴Unit of Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁵Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden
Background/Purpose: Previous studies indicate that circulating antibodies may be detected in individuals who later develop rheumatoid arthritis (RA) years before onset, and T cells have…
Abstract Number: 1621 • 2013 ACR/ARHP Annual Meeting
T Helper 17 Cells and Interferon Type I: Partners In Crime In SLE?
Odilia B.J. Corneth¹, Zana Brkic², Cornelia G. van Helden-Meeuwsen³, Radboud J.E.M. Dolhain⁴, Naomi I. Maria³, Sandra M.J. Paulissen⁴, Nadine Davelaar⁵, Jan Piet van Hamburg⁵, Paul L. Van Daele³, Virgil A. Dalm², Martin van Hagen³, Marjan A. Versnel² and Erik Lubberts⁶, ¹Rheumatology and Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ²Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands, ⁵Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: A hallmark of systemic autoimmune diseases, such as systemic lupus erythematotsus (SLE), is the increased expression of interferon (IFN) type I inducible genes, the…
Abstract Number: 723 • 2013 ACR/ARHP Annual Meeting
Abatacept Is Highly Effective At Inhibiting T Cell Priming and Induces a Unique Transcriptional Profile In CD4⁺t Cells
Agapitos Patakas¹, Rui-Ru Ji², William Weir³, Sean Connolly², Steven G. Nadler², James M. Brewer⁴, Iain B. McInnes⁴ and Paul Garside⁴, ¹Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Department of Immunology and Inflammation, Bristol Myers Squibb Co. Research and Development, Princeton, NJ, ³Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Absence of co-stimulation in the presence of TCR-stimulation has been proposed to induce tolerance via deletion or anergy. Abatacept is a CTLA-4-Ig molecule that…
Abstract Number: 2317 • 2013 ACR/ARHP Annual Meeting
Impact of PVA Coated Nanoparticles On Cellular Viability and Functionality of Immune Cells Obtained From Healthy Donors and Patients With Rheumatoid Arthritis Or Osteoarthritis
Cindy Strehl¹, Timo Gaber¹, Manuela Jakstadt¹, Martin Hahne¹, Saskia Schellmann¹, Barbara Szostak¹, Géraldine Coullerez², Heinrich Hofmann², Gerd Burmester³ and Frank Buttgereit⁴, ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Institute of Materials Powder Technology Laboratory, École polytechnique fédérale de Lausanne, Lausanne, Switzerland, ³Rheumatology and Clinical Immunology, Campus Mitte, Charite University Hospital, Berlin, Germany, ⁴Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Nanotechnology has developed into a key technology of the 21st century. Over the recent years, the number of nanotechnical products has received an enormous…
Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting
Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis
Katalin Mikecz¹, Julia Kurko¹, Timea Ocsko¹, Andras Vida¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Joel A. Block², Robert S. Katz³, Anjali Nair², Carla R. Scanzello⁴ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush Medical College, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
Abstract Number: 724 • 2013 ACR/ARHP Annual Meeting
Dose-Dependent Suppression Of Cytokine Production From T Cells By a Novel Phosphoinositide 3-Kinase Delta Inhibitor
Emily E. Way¹, Kong Chen², Kamal D. Puri³ and Jay K. Kolls², ¹Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³Gilead Sciences, Inc., Seattle, WA
Background/Purpose: The use of specific cytokine inhibitors to treat inflammatory autoimmune conditions is common but typically utilizes monoclonal antibodies, fusion proteins, and other molecules whose…
Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting
A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses
Sang T. Kim, Jin Young Choi, Begona Lainez and Joseph E. Craft, Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…
Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting
A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of T_H1, T_H17 and T Follicular Helper (T_FH) Cells
Nafiseh Talaei¹, Carolina Landolt-Marticorena², Babak Noamani¹, Evelyn Pau³, Nan-Hua Chang⁴ and Joan E. Wither⁵, ¹Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Rheumatology, University Health Network, Toronto, ON, Canada, ³Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
Abstract Number: 1195 • 2012 ACR/ARHP Annual Meeting
Identification of Follicular Helper T Cells As a Novel Cell Population Potentially Involved in the Pathogenesis of Rheumatoid Arthritis
Sharon Ing¹, Anika Alarakhia¹, Elvira Lindwall¹, Austin Fraser¹, Jerald M. Zakem¹, William E. Davis¹, Tamika A. Webb-Detiege¹, Robert Quinet¹ and Xin Zhang², ¹Rheumatology, Ochsner Medical Center, New Orleans, LA, ²Institute of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovium, causing progressive joint destruction and reduction in quality of life…
Abstract Number: 407 • 2012 ACR/ARHP Annual Meeting
The I50V IL4R SNP Is Associated with Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis
Jan Leipe¹, Iryna Prots², Markus A. Schramm¹, Matthias Witt¹, Axel P. Nigg¹, Christiane S. Reindl¹, Claudia Dechant¹, Mathias Grunke¹, Hendrik Schulze-Koops¹ and Alla Skapenko³, ¹Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Friedrich-Alexander-University Erlangen-Nürnberg, Junior Research Group III, Interdisciplinary Center for Clinical Research Nikolaus-Fiebiger Center for Molecular Medicine, Erlangen, ³Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: A single nucleotide polymorphism (SNP) in the IL4R gene (I50V, rs 1805010) has previously been associated with an aggressive destructive course of rheumatoid arthritis…
Abstract Number: 2334 • 2012 ACR/ARHP Annual Meeting
T-Cell Cross Reactivity with Citrullinated Antigen and P. Gingivalis Membrane Antigen Following Infection with P. Gingavalis and/or Injection of Citrullinated Mouse Type II Collagen in DBA/1J Mice
Michael J. Duryee¹, Anand Dusad², Carlos D. Hunter¹, Ke Ren³, Dong Wang⁴, James R. O'Dell⁵, Lynell W. Klassen⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, ⁴Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, ⁵Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE
Background/Purpose: Recently, periodontal disease (PD) has been associated with the risk and progression of RA. Patients with RA complicated by PD have been shown to…
Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting
Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness
Marie-Elise Truchetet¹, Nicolò Costantino Brembilla¹, Elisa Montanari¹, Paola Lonati², Pier Luigi Meroni³ and Carlo Chizzolini¹, ¹University hospital of Geneva, Geneva, Switzerland, ²Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, ³Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy
Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
Abstract Number: 1175 • 2012 ACR/ARHP Annual Meeting
Decreased Frequency of Th17 Cells in Early Rheumatoid Arthritis
Irene Arroyo-Villa¹, M. Belén Bautista-Caro¹, Alejandro Balsa², Pilar Aguado², Laura Nuño², Gema Bonilla³, Amaya Puig-Kröger⁴, Emilio Martín-Mola² and M. Eugenia Miranda-Carús², ¹Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ²Hospital La Paz-IdiPaz, Madrid, Spain, ³Rheumatology, Hospital La Paz, Madrid, Spain, ⁴Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain
Background/Purpose: Our objective was to examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA (eRA) patients. Methods: CD4+ T…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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