Abstracts tagged "T cells"

Abstract Number: 2016 • 2015 ACR/ARHP Annual Meeting
Functional Tertiary Lymphoid Structures within the Kidneys of Lupus Prone Mice Resembles Lymph Nodes in Gene Expression Profiling Analysis and Are Detected By in Vivo Imaging
Premasany Kanapathippillai, Sayed Esmaeil Dorraji and Kristin A Fenton, RNA and Molecular Pathology, UIT, The Artic University of Norway, Tromso, Norway
Background/Purpose: The formation of tertiary lymphoid structures (TLS) are known to occur during the development of several diseases, including systemic lupus erythematosus (SLE), but in…
Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting
Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous
Goh Murayama¹, Asako Chiba², Ken Yamaji³, Naoto Tamura³, Yoshinari Takasaki³ and Sachiko Miyake², ¹Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, ²Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 961 • 2015 ACR/ARHP Annual Meeting
Altered Th Cell Plasticity Favors Th17 Cells in Rheumatoid Arthritis
Jan Leipe¹, Fausto Pirronello², Hendrik Schulze-Koops² and Alla Skapenko², ¹Division of Rheumatology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Previously, T helper (Th) cell subsets have been regarded as irreversibly differentiated endpoints. However, evidence suggests that Th cell differentiation is a plastic process…
Abstract Number: 1760 • 2015 ACR/ARHP Annual Meeting
PD-1 Signaling Interferes with OX40 to Alter the Suppressive Function and Proliferation of CD4+ Regulatory T Cells in Lupus Mice
Maida Wong¹ and Bevra H. Hahn^2,3, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ²Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA
Background/Purpose: In systemic lupus erythematosus (SLE), the dysregulated production of autoantibodies is a consequence of disrupted T cell homeostasis. Programmed death-1 (PD1), a negative regulatory…
Abstract Number: 2467 • 2015 ACR/ARHP Annual Meeting
Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis
Ian D. Ferguson¹, Patricia Griffin², Hiroshi Yano³, Joshua J. Michel², Jeffrey A. Dvergsten⁴, Sarah L. Gaffen⁵, Margalit E. Rosenkranz¹, Daniel A. Kietz¹ and Abbe N. Vallejo¹, ¹Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pediatrics, Duke University Medical Center, Durham, NC, ⁵Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…
Abstract Number: 3029 • 2015 ACR/ARHP Annual Meeting
Increased Plasticity of Non-Classic Th1 Cells Towards the Th17 Phenotype
Antonia Klose¹, Fausto Pirronello¹, Hendrik Schulze-Koops¹, Jan Leipe² and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Mechanisms underlying the predominance of Th17 cells observed in RA are not fully understood. Th cell plasticity is a potential mechanism leading to enrichment…
Abstract Number: 962 • 2015 ACR/ARHP Annual Meeting
Profiling at the Single-Cell Level Reveals Evidence for Antigen-Driven Oligoclonal Expansion of Citrullinated Vimentin-Specific CD4+ T Cells in Peripheral Blood of Rheumatoid Arthritis (RA) Patients
Soi Cheng Law¹, Hendrik Nel¹, Jamie Rossjohn^2,3, Hugh H Reid³, Nicole L La Gruta⁴ and Ranjeny Thomas¹, ¹The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia, ²Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff, England, ³Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Melbourne, Australia, ⁴Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
Background/Purpose: RA is associated with shared epitope (SE)+ HLA-DRB1 alleles, including HLA-DRB1*0401, and development of anti-citrullinated protein autoantibodies. The preferential binding of citrullinated vimentin to…
Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting
Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model
Toshiki Eri¹, Kimito Kawahata², Ei Bannai¹, Takeyuki Kanzaki³, Lisa Akahira¹, Kazuya Michishita¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ³Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan
Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
Abstract Number: 2469 • 2015 ACR/ARHP Annual Meeting
The Lymphocyte Repertoire in Juvenile Dermatomyositis
Lauren A. Henderson¹, Edwin Anderson¹, Robert C. Fuhlbrigge^1,2, Luigi D. Notarangelo^1,3,4 and Susan Kim¹, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Department of Dermatology, Brigham and Women's Hospital, Boston, MA, ³The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, ⁴Harvard Stem Cell Institute, Boston, MA
Background/Purpose: In adult dermatomyositis, clonal populations of T lymphocytes with shared variable (V) gene usage have been identified, suggesting aberrant T cell responses to a…
Abstract Number: 3056 • 2015 ACR/ARHP Annual Meeting
Increased Circulating Th17 Cells, Serum IL-17 and Serum IL-23 in Takayasu’s Arteritis
Ramnath Misra, Durga Prasanna Misra and Smriti Chaurasia, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: The immune mechanisms underlying Takayasu’s arteritis (TA) are not clear. Expanded Th17 T cell subset has been demonstrated in Giant Cell Arteritis. Gamma delta…
Abstract Number: 982 • 2015 ACR/ARHP Annual Meeting
CD4+CD146+ T Cells: The Primed IL-17 Secreting Cells in the Pathogenesis of Psoriatic Arthritis
Siba Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Med/Rheumatology, Univ California Davis/VA Sacramento, Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: CD146, also called melanoma cell adhesion molecule (MCAM), is a cell surface adhesion molecule. A small minority of the T cell population also express…
Abstract Number: 1773 • 2015 ACR/ARHP Annual Meeting
Pan JAK Inhibitor Tofacitinib Ameliorate Autoimmunity and Nephritis in Lupus Prone Mice Via Inhibition of Interferon Signaling Pathway
Keigo Ikeda^1,2, Kunihiro Hayakawa², Maki Fujishiro³, Mikiko Kawasaki³, Takuya Hirai^2,4, Shinji Morimoto^2,4, Yoshinari Takasaki⁵ and Iwao Sekigawa^3,4, ¹Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, ²Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ³Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ⁴Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital, Chiba, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: We previously reported that Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway-mediated regulation of interferon (IFN) regulatory factor (IRF)-related genes may have an…
Abstract Number: 2556 • 2015 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of CD4+ T-Cell Mediated Autoimmune Arthritis
Mattias N.D Svensson¹, Karen M. Doody¹, Cristiano Sacchetti¹, Dennis J. Wu¹, Gisen Kim², Annelie Hellvard³, Brith Bergum³, Piotr Mydel³, Mitchell Kronenberg², Michel L. Tremblay⁴ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Several genome-wide associations studies have in recent years linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 encodes…
Abstract Number: 3082 • 2015 ACR/ARHP Annual Meeting
Nanogel Based Delivery of an Inhibitor of Calcium/ Calmodulin- Dependent Protein Kinase 4 Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice
Kotaro Otomo¹, Tomohiro Koga², Nobuya Yoshida³, Masayuki Mizui⁴, Christina Kriegel⁵, Tarek Fahmy⁶ and George C. Tsokos³, ¹Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Department of Biomedical Engineering, Yale University, New Heaven, CT, ⁶Biomedical and Chemical Engineering, Yale University, New Heaven, CT
Background/Purpose: Treatment of autoimmune diseases is still based on the use of general immunosuppressive drugs which invariably cause severe side effects. This fact has compelled…
Abstract Number: 992 • 2015 ACR/ARHP Annual Meeting
Therapeutic Targeting of CD4+ T Cell Metabolism in Murine Models of Lupus
Laurence Morel¹, Seung-Chul Choi², Zhiwei Xu², Elisabeth Adkins³, Byron Croker² and Derry Roopenian³, ¹Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, ²University of Florida, Gainesville, FL, ³The Jackson Laboratory, Bar Harbor, ME
Background/Purpose: Cellular metabolism controls T cell functions, with TCR-mediated activation enhancing metabolism, and substrate utilization modulating effector functions. Autoreactive CD4 T cells are key effectors…

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