Abstracts tagged "T cells"

Abstract Number: 2815 • 2015 ACR/ARHP Annual Meeting
A Comparison of Th17 Gene Expression in Psoriatic Arthritis Synovial Fluid and Peripheral Blood
Fatima Abji¹, Remy Pollock², Kun Liang³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a destructive inflammatory arthritis that develops in approximately 30% of patients with cutaneous psoriasis. Th17 cells infiltrate psoriatic skin and…
Abstract Number: 3221 • 2015 ACR/ARHP Annual Meeting
Safety and Efficiency of Low-Dose Interleukin-2 Treatment in Systemic Lupus Erythematosus
Jing He¹, Xia Zhang², Yunbo Wei³, Xiaolin Sun⁴, Jianping Guo⁵, Yuebo JIn⁶, Rulin Jia⁶, Lei Zhu⁶, Zhaohua Hou⁷, Yaping Chen⁸, Yuan An⁶, Yuan Jia⁶, Xu Liu⁶, Limin Ren⁶, Ru Li⁶, HUA YE⁹, Shi Chen⁶, Xuewu Zhang¹⁰, Yin Su¹¹, Eric Morand¹², Yu Di¹³ and Zhanguo Li⁶, ¹Peking Univerisity People's Hospital, Beijing, China, ²Department of Rheumatology & immunology, Peking University People's Hospital, Beijing, China, ³Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Science, Shandong, China, ⁴People's hospital,Peking University, Beijing, China, ⁵Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ⁶Peking University People's Hospital, Beijing, China, ⁷Shandong Analysis and Test Center, Beijing, China, ⁸Monash University, Clayton, Austria, ⁹No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, ¹⁰Rheumatology, Peking University People's Hospital, Beijing, China, ¹¹Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ¹²Medicine, Monash University, Clayton, Australia, ¹³Molecular Immunomodulation Laboratory, Monash University, Clayton, Austria
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system involvement, associated with an imbalance between effector and regulatory CD4+ T cells. The…
Abstract Number: 516 • 2015 ACR/ARHP Annual Meeting
Immunological and Ultrasound Characteristics of Patients with Rheumatoid Arthritis in Clinical Remission – Can We Use These to Predict Outcomes?
Hanna Gul¹, Maria Jesus Isorna Porto², Elizabeth M.A. Hensor³, Frederique Ponchel⁴, Richard J. Wakefield⁵ and Paul Emery⁶, ¹Rheumatology, Leeds Institute of Rheumatology and Musculoskeletal Medicine, Leeds, United Kingdom, ²Internal Medicine, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁵University of Leeds, Leeds, United Kingdom, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Remission is the key treatment goal in rheumatoid arthritis (RA). Although clinical remission is increasingly achieved, many patients progress both structurally and functionally. We…
Abstract Number: 1167 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with Adenoviral Overexpression of IL-22 or with Blocking Antibodies Against Endogenous IL-22 Both Reduces Inflammation and Destruction
Marije I. Koenders¹, Debbie M. Roeleveld¹, Loreto Parga¹, Shahla Abdolahi-Roodsaz¹, Fons A.J. van de Loo¹, Jay K. Kolls² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the…
Abstract Number: 1936 • 2015 ACR/ARHP Annual Meeting
STAT3-Regulated Gene Expression in Circulating CD4+ T Cells Discriminates RA Patients Independently of Clinical Parameters in Early Arthritis: A Validation Study
Arthur G Pratt¹, Amy E. Anderson¹, Dennis W Lendrem², Andrew Skelton², Jonathan Massey³, Nisha Nair³, Julie Diboll², Ben Hargreaves², Philip M Brown², Anne Barton^4,5 and John D Isaacs², ¹Institute of Cellular Medicine (Musculoskeletal Research Group), National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom
Background/Purpose: A previously described transcriptional signature present in circulating CD4+ T cells of early rheumatoid arthritis (RA) patients implicated STAT3 signalling as an early pathophysiological…
Abstract Number: 2822 • 2015 ACR/ARHP Annual Meeting
Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis
Elizabeth Mainolfi¹, Susan M. Goodman², Shawn Anderson³, Jon Hill⁴, Thakker Paresh⁵, Meera Ramanujam⁶, Rivka Friedlander⁷, Elli Kim⁷, Dalit Ashany⁸, Ed Purdue⁹, Christine Averill⁹, Michael Nevid⁹, Allison Shaber⁹, Lisa Mandl¹⁰, Steven R. Goldring¹¹, Gerald Nabozny¹ and VP Bykerk², ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, ⁸Rheumatic Disease, Hospital for Special Surgery, New York, NY, ⁹Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, ¹⁰Department of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Hospital for Special Surgery, New York, NY
Background/Purpose: The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…
Abstract Number: 729 • 2015 ACR/ARHP Annual Meeting
The Effect of Belimumab on Peripheral Blood Cells in Patients with Systemic Lupus Erythematosus
Cosmin Dascalu¹, Anne Davidson², Meggan C. Mackay³, Richard Furie⁴, Weiqing Huang⁵ and Cynthia Aranow⁶, ¹Medicine/Rheumatology, North Shore- Long Island Jewish, Manhasset, NY, ²Autoimmunity and Musculoskeletal Diseases, Feinstein Inst for Med Rsch, Manhasset, NY, ³Autoimmune & Musculoskeletal Disorders, The Feinstein Institute for Medical Research, Manhasset, NY, ⁴Division of Rheumatology, North Shore LIJ Health System, Lake Success, NY, ⁵Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Feinstein Institute for Medical Research, Mahasset, NY
Background/Purpose: The anti-BAFF antibody belimumab is the first biologic drug approved for treatment of mild-moderate SLE. While the efficacy of belimumab for this indication is…
Abstract Number: 1362 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Dendritic Cell Maturation & T Cell Activation within the Inflamed Synovium in Rheumatoid Arthritis
Mary Canavan¹, Micheal O'Rourke², Carl Orr², Sharee Basdeo³, Jean Fletcher³, Douglas J. Veale⁴ and Ursula Fearon⁵, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, St Vincent's University Hospital, Dublin, Ireland, ³Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, ⁴St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁵St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland
Background/Purpose: Dendritic cells (DC) are a heterogeneous population of antigen presenting cells which link both innate & adaptive immunity. To date their classification within blood…
Abstract Number: 1939 • 2015 ACR/ARHP Annual Meeting
Anti-GM-CSF Treatment Promotes Synovial Monocyte-Derived Dendritic Cells and Increases Th17 Cells during Experimental Arthritis
Debbie M. Roeleveld¹, Peter M. van der Kraan¹, Wim B. van den Berg¹, Ian P. Wicks² and Marije I. Koenders¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Background/Purpose: Monocyte-derived dendritic cells (MoDCs) differentiate from monocytes under inflammatory conditions like RA, and are very potent in presenting antigen to T cells. GM-CSF-responsive MoDCs…
Abstract Number: 2829 • 2015 ACR/ARHP Annual Meeting
Enhanced Expression of the Transcription Factor T-Bet Alters Pro-Inflammatory Cytokine Profile in Ankylosing Spondylitis
Max C. Lau¹, Patricia Keith¹, Mary-Ellen Costello¹, Linda A. Bradbury¹, Kelly A. Hollis¹, Gethin P. Thomas², Matthew A. Brown^1,3 and Tony J. Kenna¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16x10-10). T-bet is…
Abstract Number: 814 • 2015 ACR/ARHP Annual Meeting
Lupus Drives Atherosclerosis through CD4+CXCR3+ T Cells and Plasmacytoid Dendritic Cells
Tiphaine Goulenok¹, Marc Clement², Nicolas Charles³, Brigitte Escoubet⁴, Marie-Paule Chauveheid⁵, Thomas Papo⁶ and Karim Sacre⁷, ¹University Paris Diderot - APHP - Bichat Hospital, aris, France, ²University Paris Diderot - INSERM U1148, Paris, France, ³INSERM U699, Paris, France, ⁴University Paris- Diderot - APHP - Hôpital Bichat, Paris, France, ⁵Internal Medicine, Bichat-Claude Bernard Hospital, University Paris-7, Paris, France, ⁶CHU Bichat, Paris, France, ⁷Internal Medicine, University Paris-7, INSERM U1149, APHP, Bichat Hospital, Paris, France
Background/Purpose: Accelerated atherosclerosis is the leading cause of death in systemic lupus erythematosus (SLE). How SLE promotes accelerated atherosclerosis remains elusive. The purpose of this…
Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting
Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients
Aurélie Grados¹, Mikael Ebbo¹, Christelle Piperoglou², Matthieu Groh³, Alexis Regent⁴, Maxime Samson⁵, Benjamin Terrier⁶, Nathalie Morel⁷, Sylvain Audia⁵, Francois Maurier⁸, Julie Graveleau⁹, Mohamed Hamidou¹⁰, Amandine Forestier¹¹, Sylvain Palat¹², Emanuelle Bernit¹, Gilles Kaplanski¹³, Frederique Retornaz¹⁴, Bernard Bonotte⁵, Catherine Farnarier¹⁵, Jean-Robert Harle¹⁶, Nathalie Costedoat-Chalumeau⁷, Frederic Vely¹⁷ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Immunology, CIML, AP-HM, Marseille, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Service de médecine interne, Hôpital Cochin, Paris, France, ⁵Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Medecine Interne Hotel Dieu Nantes, Nantes, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, ¹²Service de Medecine Interne, CHU limoges, Limoges, France, ¹³Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, ¹⁴Conseil General 13 cellule recherche, Marseille, France, ¹⁵Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, ¹⁶Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, ¹⁷CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
Abstract Number: 1941 • 2015 ACR/ARHP Annual Meeting
Senescent T-Cells Expedite RANKL-Dependent Bone Loss in Rheumatoid Arthritis
Johannes Fessler¹, Rusmir Husic², Elisabeth Lerchbaum³, Verena Schwetz³, Claudia Stiegler³, Barbara Obermayer-Pietsch³, Winfried B. Graninger⁴ and Christian Dejaco⁵, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria, ⁴Internal Medicine/Rheumatology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria
Background/Purpose: To study the influence of senescent CD28-T-cells on systemic osteoporosis in rheumatoid arthritis (RA) and patients with primary osteoporosis. Methods: Prospective, cross-sectional study on…
Abstract Number: 2830 • 2015 ACR/ARHP Annual Meeting
Synovial Fluid T Cells of Patients with Reactive Arthritis and Undifferentiated Spondyloarthropathy Respond to Salmonella Typhimurium Outer Membrane Protein a and Induces IL17 and IL23 Production By Synovial Fluid Mononuclear Cells
Ramnath Misra¹, Smriti Chaurasia¹, Ajit K Shashny² and Amita Aggarwal^3,4, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Central Institute of Medicinal and Aromatic Plants, Scientist, Lucknow, India, ³Clinical Immunology, Additional Professor Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁴Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: We have previously shown that synovial fluid mononuclear cells (SFMCs) of patients with Reactive arthritis (ReA) and undifferentiated Spondyloarthropathy (uSpA) proliferated to low molecular…
Abstract Number: 820 • 2015 ACR/ARHP Annual Meeting
Peripheral Blood and Disease Features Associated with Complement Components C3 and C4 in SLE
Mikhail Olferiev, David Fernandez, Leila Khalili, Dina Greenman, Mary K. Crow and Kyriakos A. Kirou, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY
Background/Purpose: Decreases in peripheral blood levels of complement components of C3 and C4 are associated with SLE and often indicate a lupus flare. The aim…

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