Abstracts tagged "T cells"

Abstract Number: 139 • 2017 Pediatric Rheumatology Symposium
Dysregulation of miRNA in mononuclear cells of patients with enthesitis related arthritis
Amita Aggarwal¹ and Sushma Singh², ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in Asia. Identifying dysregulated microRNA may help in understanding the pathogenesis of ERA.…
Abstract Number: 2 • 2017 Pediatric Rheumatology Symposium
Murine Model of Arthritis Flare Identifies CD8+ Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Nathan Nelson-Maney³, Robert Fuhlbrigge⁴ and Peter A. Nigrovic², ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁴Children's Hospital Colorado, Aurora, CO
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 147 • 2017 Pediatric Rheumatology Symposium
Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis
Lucas Picavet¹, Janneke Peeters², Sandra Coenen³, Arjan Boltjes⁴, Femke van Wijk⁵, Paul Coffer², Bas Vastert⁶ and Jorg van Loosdregt⁷, ¹Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ²Center for Molecular Medicine and Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Utrecht, Utrecht, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Laboratory for Translational Immunity, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…
Abstract Number: 15L • 2016 ACR/ARHP Annual Meeting
Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis vulgaris and Normalizes Skin Pathology Via Concurrent Regulation of IL-17 and IL-10 Levels
Alexandra Zanin-Zhorov¹, Jonathan Weiss¹, Alissa Trzeciak¹, Carmen Arencibia¹, Seetharam Polimera¹, Wei Chen¹, Jingya Zhang¹, Melanie Nyuydzefe¹, Judilyn Fuentes-Duculan², Kathleen Bonifacio², Norma Kunjravia², Inna Cueto², Mark Berger¹, James Krueger², Samuel Waksal¹ and John Ryan¹, ¹Kadmon, New York, NY, ²Rockefeller University, New York, NY

Background/Purpose: Rho-associated kinase 2 (ROCK2) was shown to be implicated in regulation of autoimmunity in mice and humans1. Previous findings demonstrated that oral administration of…
Abstract Number: 648 • 2016 ACR/ARHP Annual Meeting
ABT-122, an Anti-TNF/Anti-IL-17 Dual Variable Domain Antibody, Alters T Cell Responses in Human Subjects
Melanie Ruzek^1,2, Mark Konrad², Donna Conlon³, Kristie M. Grebe², Anthony Slavin³, Heikki T. Mansikka⁴, Carolyn Cuff³ and Robert J. Padley⁴, ¹Immunology Pharmacology, AbbVie Bioresearch Center, Worcester, MA, ²Immunology Discovery, AbbVie, Worcester, MA, ³Immunology Discovery, AbbVie Bioresearch Center, Worcester, MA, ⁴AbbVie Inc., North Chicago, IL
Background/Purpose: ABT-122 is a dual variable domain antibody which neutralizes both TNF and IL-17 and is in Phase II trials for rheumatoid arthritis (RA) and…
Abstract Number: 1904 • 2016 ACR/ARHP Annual Meeting
Elevated GITRL Is Associated with Multi-Organ Involvement and Increased Disease Activity of Primarty Sjogren’s Syndrome and Promotes Pathogenic Th1/17 Differentiation
Xiaolin Sun¹, Yuzhou Gan Sr.², Jing He³ and Zhanguo Li⁴, ¹People's hospital,Peking University, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ³Peking Univerisity People's Hospital, Beijing, China, ⁴Peking University People's Hospital, Beijing, China
Background/Purpose: Accumulating data showed that Glucocorticoid-induced Tumor Necrosis Factor Receptor Family-related Protein (GITR), with its ligand (GITRL), plays an important role in promoting T-cell-mediated immunity…
Abstract Number: 1937 • 2016 ACR/ARHP Annual Meeting
Analysis of Innate and Adaptive Immune Responses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)
Jeremie Dion^1,2, Jonathan London^2,3, Benjamin Chaigne^2,4, Nicolas Dumoitier², Bertrand Dunogué⁵, Pascal Cohen³, Matthieu Groh⁴, Claire Le Jeunne⁴, Luc Mouthon^2,5 and Benjamin Terrier^2,5, ¹Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ³Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁵Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA, formerly called Churg-Strauss syndrome) belongs to ANCA-associated vasculitis and is characterized by late onset asthma, blood and tissue eosinophilia…
Abstract Number: 2882 • 2016 ACR/ARHP Annual Meeting
CD4+ T Helper Cells and Regulatory T Cells in Active Lupus Nephritis – an Imbalance Towards a Predominant Th1 Response?
Danilo Mesquita Jr.¹, Marcello Fabiano Franco², Gianna Mastroianni Kirsztajn¹, Luciana Aparecida Reis¹, Sandro Perazzio³, Fernanda Vieira Mesquita¹, Vanessa Ferreira¹, Luis E C Andrade⁴ and Alexandre W.S. Souza⁵, ¹Internal Medicine, Universidade Federal de São Paulo, São Paulo, Brazil, ²Pathology, Universidade Federal de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁵Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the involvement of multiple organs and systems with aberrations in T cell response,…
Abstract Number: 3147 • 2016 ACR/ARHP Annual Meeting
Remote Inflammation Triggers Autoimmune Arthritis through Th17 Distribution
Nina Chevalier¹, Jian Tan², Linda Mason², Remy Robert², Craig McKenzie², Seth Masters³ and Charles Mackay², ¹University Freiburg Medical Center, Freiburg, Germany, ²Monash University, Melbourne, Australia, ³WEHI, Melbourne, Australia
Background/Purpose: Autoimmune diseases, such as autoimmune inflammatory arthritis, result through breakdown of immune tolerance and development of self-reactive T cells, or autoantibody-producing B cells. Tolerance…
Abstract Number: 660 • 2016 ACR/ARHP Annual Meeting
Expression of the Chemokine Receptor CXCR5 Is Decreased in the Periphery of Patients with Primary Sjogren’s Syndrome
Marie Wahren-Herlenius¹, Lara Adnan Aqrawi¹, Margarita Ivanchenko¹, Albin Björk¹, Jorge Ramírez¹, Marika Kvarnström¹, Janicke Cecilie Liaaen Jensen² and Kathrine Skarstein³, ¹Karolinska Institutet, Stockholm, Sweden, ²University of Oslo, Oslo, Norway, ³University of Bergen, Bergen, Norway
Background/Purpose: CXCR5 is a chemokine receptor expressed on B and T cell subsets, which binds the CXCL13 ligand produced by follicular dendritic cells. It is…
Abstract Number: 1905 • 2016 ACR/ARHP Annual Meeting
Therapeutic Targeting of JAK/STAT Pathway Inhibits Follicular Helper T Cell Maturation and Function
Flora Sagez and Jacques-Eric Gottenberg, Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: T follicular helper (Tfh) cells represent a CD4+T cell subset specialized to provide help to B cells and to induce memory B cell and…
Abstract Number: 1986 • 2016 ACR/ARHP Annual Meeting
Murine Model of Arthritis Flare Identifies Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Robert Fuhlbrigge^1,3 and Peter Nigrovic^1,2, ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Garth Ringheim¹, Jolanta Kosek¹, Lori Capone², Eun Mi Hur¹ and Peter H. Schafer³, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…
Abstract Number: 3216 • 2016 ACR/ARHP Annual Meeting
Integrated High-Dimensional Analyses Reveal a Pathologically Expanded ‘Peripheral’ B Cell-Helper T Cell Population in Rheumatoid Arthritis
Deepak Rao¹, Michael Gurish², Kamil Slowikowski³, Chamith Fonseka², Jennifer Marshall⁴, Yanyan Liu⁵, Laura T. Donlin⁶, Lauren Henderson⁷, Fumitaka Mizoguchi⁸, Nikola Teslovich⁹, Michael Weinblatt¹⁰, Elena Massarotti¹⁰, Jonathan Coblyn¹¹, Simon M. Helfgott¹⁰, Yvonne C. Lee¹², Derrick J. Todd¹⁰, Vivian P. Bykerk¹³, Susan M. Goodman¹⁴, Alessandra B. Pernis¹⁵, Lionel Ivashkiv¹⁴, Elizabeth W. Karlson¹⁰, Peter Nigrovic⁹, Andrew Filer¹⁶, Christopher Buckley¹⁷, James Lederer¹⁸, Soumya Raychaudhuri¹⁹ and Michael Brenner¹, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Rheumatology and Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁷Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ⁸Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ¹⁰Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹²Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹³Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁴Medicine, Hospital for Special Surgery, New York, NY, ¹⁵David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ¹⁶University of Birmingham, Birmingham, United Kingdom, ¹⁷Rheumatology, University of Birmingham, Birmingham, United Kingdom, ¹⁸Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Determining the pathologic functions of T cells that infiltrate target tissues remains a central challenge in autoimmune diseases. In rheumatoid arthritis (RA), the formation…

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