Abstracts tagged "T cells"

Abstract Number: 139 • 2017 Pediatric Rheumatology Symposium
Dysregulation of miRNA in mononuclear cells of patients with enthesitis related arthritis
Amita Aggarwal¹ and Sushma Singh², ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in Asia. Identifying dysregulated microRNA may help in understanding the pathogenesis of ERA.…
Abstract Number: 2 • 2017 Pediatric Rheumatology Symposium
Murine Model of Arthritis Flare Identifies CD8+ Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Nathan Nelson-Maney³, Robert Fuhlbrigge⁴ and Peter A. Nigrovic², ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁴Children's Hospital Colorado, Aurora, CO
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 147 • 2017 Pediatric Rheumatology Symposium
Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis
Lucas Picavet¹, Janneke Peeters², Sandra Coenen³, Arjan Boltjes⁴, Femke van Wijk⁵, Paul Coffer², Bas Vastert⁶ and Jorg van Loosdregt⁷, ¹Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ²Center for Molecular Medicine and Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Utrecht, Utrecht, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Laboratory for Translational Immunity, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…
Abstract Number: 15L • 2016 ACR/ARHP Annual Meeting
Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis vulgaris and Normalizes Skin Pathology Via Concurrent Regulation of IL-17 and IL-10 Levels
Alexandra Zanin-Zhorov¹, Jonathan Weiss¹, Alissa Trzeciak¹, Carmen Arencibia¹, Seetharam Polimera¹, Wei Chen¹, Jingya Zhang¹, Melanie Nyuydzefe¹, Judilyn Fuentes-Duculan², Kathleen Bonifacio², Norma Kunjravia², Inna Cueto², Mark Berger¹, James Krueger², Samuel Waksal¹ and John Ryan¹, ¹Kadmon, New York, NY, ²Rockefeller University, New York, NY

Background/Purpose: Rho-associated kinase 2 (ROCK2) was shown to be implicated in regulation of autoimmunity in mice and humans1. Previous findings demonstrated that oral administration of…
Abstract Number: 1557 • 2016 ACR/ARHP Annual Meeting
3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-like T Cells in Rheumatoid Arthritis
Lauren Henderson¹, Deepak Rao², Nikola Teslovich^3,4, Sandra King⁵, Fumitaka Mizoguchi⁶, Sarah Ameri⁶, Allyn Morris⁷, Christopher Elco⁸, James Lederer⁹, Scott Martin¹⁰, Barry Simmons¹⁰, John Wright¹⁰, Michael Brenner², Soumya Raychaudhuri^{11,12,13,14,15}, Peter Nigrovic^1,16 and Robert Fuhlbrigge^17,18, ¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ⁵Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁹Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹¹Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹²Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹³Partners Center for Personalized Genetic Medicine, Boston, MA, ¹⁴Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, ¹⁵Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ¹⁶Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ¹⁷Immunology, Boston Children's Hospital, Boston, MA, ¹⁸Dermatology, Brigham and Women’s Hospital, Boston, MA
Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting
Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice
Rebecca Rogier¹, Heather Evans-Marin², Birgitte Walgreen¹, Monique M. Helsen¹, Liduine van den Bersselaar¹, Peter M. van der Kraan¹, Fons A.J. van de Loo³, Peter L. van Lent¹, Jose U. Scher⁴, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdolahi-Roodsaz¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Division of Rheumatology, New York University School of Medicine, New York, NY, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴New York University School of Medicine, New York, NY
Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
Abstract Number: 2582 • 2016 ACR/ARHP Annual Meeting
N-Acetylcysteine Regulates Osteoclastogenesis and Th17 Cell Differentiation in Rheumatoid Arthritis
Kyung-Ann Lee¹, Hae-Rim Kim², Sang Heon Lee³, Bomi Kim⁴ and Kyoung-Woon Kim⁵, ¹Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, The Republic of, ³Department of Internal Medicine,Division of Rheumatology., Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, The Republic of, ⁴Convergent Research Consortium for Immunologic disease, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁵Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: This study aimed to determine the regulatory role of N-Acetyl-L-cysteine (NAC), an antioxidant, in T cell and osteoclast differentiation in rheumatoid arthritis (RA). Methods:…
Abstract Number: 2935 • 2016 ACR/ARHP Annual Meeting
Activation Status of Mucosal-Associated Invariant T Cells Sensitively Reflects Disease Activity of Systemic Lupus Erythematosus
Asako Chiba¹, Goh Murayama², Mie Kitagaichi³, Naoto Tamura⁴, Ken Yamaji², Yoshinari Takasaki⁴ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 1567 • 2016 ACR/ARHP Annual Meeting
A Functional Genomic Screen of Rheumatoid Arthritis Risk Genes in Primary Human T Cells Reveals DDX6 As a Negative Modulator of Cytokine Expression
Rumey Ishizawar¹, Chantel Lester², Jing Cui³, John Doench⁴, Robert Plenge⁵ and Michael Brenner⁶, ¹Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Broad Institute of MIT and Harvard, Cambridge, MA, ⁵Genetics & Pharmacogenomics, Merck Research Laboratories, Merck & Co., Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), genome-wide association studies have identified over 100 risk alleles. A major challenge is identifying causal genes in RA risk loci. As…
Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting
Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Diahann Jansen¹, Elizabeth Klinken¹, Hendrik Nel², Soi Cheng Law², Helen Benham^3,4,5, Lisa Cummins⁶, Matthew Brown⁷, Tony Kenna², Ligong Liu⁸, David Fairlie⁸, Jamie Rossjohn^9,10,11, Mark Morrison³, Ranjeny Thomas³, Paraic O Cuiv¹, James McCluskey¹² and Alexandra Corbett¹², ¹The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, ²The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ³Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, ⁴University of Queensland School of Medicine, Brisbane, Australia, ⁵Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁶Princess Alexandra Hospital, Woolloongabba, Australia, ⁷Queensland University of Technology, Brisbane, Australia, ⁸Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, ⁹Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, ¹⁰Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ¹¹Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, ¹²Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia
Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…
Abstract Number: 2697 • 2016 ACR/ARHP Annual Meeting
Modulator Role of Inducible Costimulator (ICOS) in Spondyloarthritis Animal Model
Luiza Krause¹, Quentin Jouhault², Bilade Cherqaoui¹, Aude Jobart-Malfait¹, Ignacio Anegon³, Gilles Chiocchia⁴ and Maxime A. Breban⁵, ¹INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ²Infection and inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ³U643, INSERM-UMR643- Nantes-CHU, Nantes, France, ⁴Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ⁵Rheumatology, Ambroise Paré Hospital, and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: HLA-B27/hβ2m transgenic rats (B27 rats), a model of spondylarthritis (SpA) develop spontaneous colitis and arthritis. Recently, in vitro studies demonstrated that altered dendritic cells…
Abstract Number: 2937 • 2016 ACR/ARHP Annual Meeting
Regulation of Follicular Helper T (TFH) Cells By ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
Woelsung Yi¹, Sanjay Gupta², Chien-Huan Weng³, Yurii Chinenov⁴, James K. Liao⁵ and Alessandra B. Pernis⁶, ¹Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Weill Cornell Medical College, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Cardiology Section, University of Chicago Medical Center, Chicago, IL, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Follicular helper T (TFH) cells promote humoral responses and serve as a limiting factor for the selection of high affinity germinal center B cells.…
Abstract Number: 1574 • 2016 ACR/ARHP Annual Meeting
The Role of Shelterin Deficiency in the Senescence in T Cells of Rheumatoid Arthritis
Wenjie Zheng¹, Lili Zhang², Hua Chen³ and Yan Zhao¹, ¹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Infection and Immunity, Tianjin people's hospital, Tianjing, China, ³Peking Union Medical College Hospital, Beijing, China
Background/Purpose: T cells abnormality is an essential part in the pathogenesis of rheumatoid arthritis (RA), which includes a signature of premature immune aging, and restricted…
Abstract Number: 1917 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Cells Produce Extracellular Vesicles That Incorporate PD-1 and microRNAs Targeting the PD-1 Pathway in Surrounding Cells
Stinne Greisen^1,2, Yan Yan³, Aida Hansen¹, Morten Venø³, Jens Randel Nyengaard⁴, Malene Hvid⁵, Arlene Sharpe⁶, Jørgen Kjems³ and Bent Deleuran^7,8, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Interdisciplinari Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark, ⁴Clinical Medicine, Electro Microscopy Laboratory, Aarhus University Hospital, Aarhus, Denmark, ⁵Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁶Microbiology and Immunobiology, Harvard Medical School, Boston, MA, ⁷Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark
Background/Purpose: Programmed death-1 (PD-1) is a central marker of T cell exhaustion. Exhausted T cells are present in inflammatory conditions, where they fail to eliminate…

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