Abstracts tagged "T cells"

Abstract Number: 139 • 2017 Pediatric Rheumatology Symposium
Dysregulation of miRNA in mononuclear cells of patients with enthesitis related arthritis
Amita Aggarwal¹ and Sushma Singh², ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in Asia. Identifying dysregulated microRNA may help in understanding the pathogenesis of ERA.…
Abstract Number: 2 • 2017 Pediatric Rheumatology Symposium
Murine Model of Arthritis Flare Identifies CD8+ Tissue Resident Memory T Cells in Recurrent Synovitis
Margaret H Chang¹, Anais Levescot², Allyn Morris², Nathan Nelson-Maney³, Robert Fuhlbrigge⁴ and Peter A. Nigrovic², ¹Immunology, Boston Children's Hospital, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁴Children's Hospital Colorado, Aurora, CO
Background/Purpose: There are 75,000 children affected by JIA in the United States. Despite recent therapeutic advances, treatment often requires chronic therapy and is associated with…
Abstract Number: 35 • 2017 Pediatric Rheumatology Symposium
Kv1.3 Expression on Urinary Leukocytes in Lupus Nephritis: Potential for Targeted Immunotherapy
Anne Stevens¹, Andrew Hinkle², Megan Yuasa³, David Peckham⁴, Chelsea Olsen⁵, Craig Philips⁵, Shawn P. Iadonato⁴ and Peter Probst⁶, ¹University of Washington, Pediatrics, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Seattle Children’s Research Institute, Seattle, WA, ⁴Kineta Inc, Seattle, WA, ⁵KPI Therapeutics, Inc., Seattle, WA, ⁶Kineta, Inc, Seattle, WA
Background/Purpose: Lymphocyte activation depends upon a calcium signaling cascade that is regulated by voltage-gated potassium channels. Effector memory T cells (TEM), which are implicated in…
Abstract Number: 147 • 2017 Pediatric Rheumatology Symposium
Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis
Lucas Picavet¹, Janneke Peeters², Sandra Coenen³, Arjan Boltjes⁴, Femke van Wijk⁵, Paul Coffer², Bas Vastert⁶ and Jorg van Loosdregt⁷, ¹Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ²Center for Molecular Medicine and Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht, Netherlands, ³University Medical Center Utrecht, Utrecht, Netherlands, ⁴Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Laboratory for Translational Immunity, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Division of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…
Abstract Number: 15L • 2016 ACR/ARHP Annual Meeting
Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis vulgaris and Normalizes Skin Pathology Via Concurrent Regulation of IL-17 and IL-10 Levels
Alexandra Zanin-Zhorov¹, Jonathan Weiss¹, Alissa Trzeciak¹, Carmen Arencibia¹, Seetharam Polimera¹, Wei Chen¹, Jingya Zhang¹, Melanie Nyuydzefe¹, Judilyn Fuentes-Duculan², Kathleen Bonifacio², Norma Kunjravia², Inna Cueto², Mark Berger¹, James Krueger², Samuel Waksal¹ and John Ryan¹, ¹Kadmon, New York, NY, ²Rockefeller University, New York, NY

Background/Purpose: Rho-associated kinase 2 (ROCK2) was shown to be implicated in regulation of autoimmunity in mice and humans1. Previous findings demonstrated that oral administration of…
Abstract Number: 183 • 2016 ACR/ARHP Annual Meeting
Protective Role of Mucosal-Associated Invariant T (MAIT) Cells in an Imiquimod-Induced Psoriasis Model
Goh Murayama¹, Asako Chiba², Hitomi Toda², Ken Yamaji¹, Naoto Tamura³ and Sachiko Miyake⁴, ¹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Psoriasis is a chronic inflammatory disease of the skin and is often accompanied by arthritis. The underlying pathogenesis of psoriasis is still unclear, but…
Abstract Number: 1612 • 2016 ACR/ARHP Annual Meeting
Abatacept Targets T Follicular Helper Cells in Patients with Rheumatoid Arthritis
Shingo Nakayamada¹, Satoshi Kubo², Maiko Yoshikawa², Yusuke Miyazaki², Ippei Miyagawa³, Shigeru Iwata⁴, Kazuhisa Nakano⁵, Kazuyoshi Saito^6,7 and Yoshiya Tanaka⁸, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵The First department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁷First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, KItakyushu, Japan, ⁸University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), T cells can differentiate into functionally distinct subsets, leading to the persistent inflammation and immune abnormality associated…
Abstract Number: 1919 • 2016 ACR/ARHP Annual Meeting
Analysis of T Cell Repertoire Diversity of CD4+ Memory and NaïVe T Cells By Next Generation Sequencing and Its Association with Rheumatoid Arthritis Disease Parameters
Keiichi Sakurai¹, Hirofumi Shoda¹, Kazuyoshi Ishigaki², Yumi Tsuchida¹, Yasuo Nagafuchi¹, Shuji Sumitomo¹, Akari Suzuki², Keishi Fujio¹ and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by peripheral polyarthritis. The importance of CD4+ T cell in the pathophysiology of RA is well-known…
Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting
Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets
Davide Simone¹, Hussein Al Mossawi¹, Anna Ridley², Jelle De Wit¹, Takuya Sekine¹, Nuha Ansar¹, Karen Doig¹ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…
Abstract Number: 3036 • 2016 ACR/ARHP Annual Meeting
IL-22 Is Dysregulated in Psoriatic Arthritis and Acts to Limit IFN-γ Driven Inflammatory Chemokine Production
Amara Ezeonyeji¹, Helen Baldwin², Milica Vukmanovic-Stejic³ and Michael R. Ehrenstein⁴, ¹Rheumatology, Medicine, University College London, London, United Kingdom, ²Rheumatology, Centre for Rheumatology Research, University College London, london, United Kingdom, ³Infection & Immunity, University College London, london, United Kingdom, ⁴Medicine, University College London, London, United Kingdom
Background/Purpose: IL-22 is an IL-10 family cytokine with both pro-inflammatory and anti-inflammatory effects and its dysregulation is associated with the development of autoimmune disease including…
Abstract Number: 268 • 2016 ACR/ARHP Annual Meeting
Effect of Abatacept Treatment on T Cells in Muscle Tissue and Peripheral Blood in Polymyositis and Dermatomyositis Patients
Quan Tang¹, Daniel Ramsköld², Olga Krystufkova³, Herman F Mann⁴, Cecilia Wick⁵, Maryam Dastmalchi⁶, Peter Brodin⁷, Vivianne Malmström⁸, Jiri Vencovsky⁹ and Ingrid E. Lundberg⁶, ¹Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ⁵Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁷Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁹Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Abatacept (CTLA4-Ig), a blocking agent for T cell co-stimulation, has been proven beneficial in several autoimmune diseases. The aim of the study was to…
Abstract Number: 1749 • 2016 ACR/ARHP Annual Meeting
The Role of Mucosal-Associated Invariant T (MAIT) Cells in Lupus Dermatitis
Goh Murayama¹, Asako Chiba², Hirofumi Amano³, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake⁴, ¹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan, ⁴Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by MHC-related molecule-1 (MR1) and express a semi-invariant TCRa chain: Va7.2-Ja33 in…
Abstract Number: 1920 • 2016 ACR/ARHP Annual Meeting
Vitamin D Induces a Type 1 Regulatory T Cell (Tr1)-like Phenotype in Human C-C Chemokine Receptor Type 6 (Ccr6)+ th Cells and Promotes Their Migration to an Inflammatory Environment
Wendy Dankers¹, Jan Piet van Hamburg¹, Nadine Davelaar¹, Patrick Asmawidjaja¹, Hoyan Wen¹, Johannes van Leeuwen², Edgar Colin³ and Erik Lubberts¹, ¹Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose: The active vitamin D metabolite 1,25(OH)2D3 suppresses various experimental autoimmune diseases. In addition, serum vitamin D levels, vitamin D intake and polymorphisms in the…
Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Neha Ohri^1,2,3, Mark Gerich^3,4, Blair Fennimore^3,5, Diana Ir⁶, Charles Robertson⁶, Daniel Frank⁶, Liron Caplan⁷, Brandie Wagner⁸ and Kristine Kuhn^9,10, ¹Division of Rheumatology, Mount Sinai West, New York City, NY, ²Division of Rheumatology, University of Colorado, Aurora, CO, ³Mucosal Inflammation Program, University of Colorado, Aurora, CO, ⁴Division of Gastroenterology, University of Colorado, Aurora, CO, ⁵Department of Gastroenterology, University of Colorado, Aurora, CO, ⁶Division of Infectious Disease, University of Colorado, Aurora, CO, ⁷Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁸Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, ⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ¹⁰Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
Abstract Number: 3040 • 2016 ACR/ARHP Annual Meeting
Th17 Migration into the Synovial Fluid of Patients with Active Psoriatic Arthritis Is Enhanced By Regulatory T Cells
Helen Baldwin¹, Amara Ezeonyeji², Mohammed Rohan Butt² and Michael R. Ehrenstein³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Medicine, University College London, London, United Kingdom, ³Medicine, University College London, London, United Kingdom
Background/Purpose: Uncontrolled migration of Th17 cells into the skin and joints is a major driver in the pathogenesis of psoriatic arthritis (PsA). Modulation of T…

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