ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 0969 • ACR Convergence 2021

    Loss of Balance Between Protective and Pro-inflammatory Synovial Tissue T Cell Polyfunctionality Predates Clinical Onset of Rheumatoid Arthritis

    Achilleas Floudas1, Nuno Neto2, Carl Orr3, Mary Canavan4, Phil Gallagher3, Conor Hurson5, Michael Monaghan2, Nagpar Sunil6, Ronan Mullan7, Douglas Veale8 and Ursula Fearon2, 1Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 2Trinity College Dublin, Dublin, Ireland, 3St Vincent's Hospital, Dublin, Ireland, 4Trinity College, Santry, Ireland, 5St Vincents University Hospital, Dublin, Ireland, 6Janssen R&D, Spring House, PA, 7Tallaght University Hospital, Dublin, Ireland, 8University College Dublin, Dublin, Ireland

    Background/Purpose: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window of opportunity. T-cells are early drivers of synovial inflammation of RA,…
  • Abstract Number: 1505 • ACR Convergence 2021

    Inflammatory Dendritic Cell and Th17 Polarization in Mouse Model of Lupus Nephritis

    Latha Prabha Ganesan1, Noushin Saljoughian1, James Turman1, Murugesan Rajaram1, Brad Rovin2, Wael Jarjour1 and Samir Parikh2, 1Ohio State University, Columbus, OH, 2Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: We have recently identified inflammatory dendritic cells (InfDC) in human lupus kidneys. These cells are over expressed in LN patients compared to healthy controls.…
  • Abstract Number: 1506 • ACR Convergence 2021

    SLAMF6 Compartmentalization Regulates Autoimmune T Cell Responses

    Yevgeniya Gartshteyn1, Anca Askanase2 and Adam Mor3, 1Columbia University Medical Center, Glen Rock, NJ, 2Columbia University Medical Center, New York, NY, 3CUIMC, New York, NY

    Background/Purpose: T cell activation is initiated by engagement of the T cell receptor (TCR) complex and requires co-receptor signaling. SLAMF6 is a major T cell…
  • Abstract Number: 1889 • ACR Convergence 2021

    Arthritogenic T Cells Harbor a Transcriptional Program of T Cell Activation and a Repertoire Pruned by Endogenous Superantigen

    JUDITH F ASHOURI, Elizabeth McCarthy, Steven Yu, Noah Perlmutter, Charles Lin, Chun Jimmie Yu and Arthur Weiss, University of California San Francisco, San Francisco, CA

    Background/Purpose: It is widely accepted that activation of specific CD4 T cells through their TCRs by self-antigen (Ag) is necessary for rheumatoid arthritis (RA) onset.…
  • Abstract Number: 154 • 2020 Pediatric Rheumatology Symposium

    T Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis

    Anna Patrick1, Tashawna Esmond 2, David Flaherty 2, Thomas Brent Graham 2, Susan Thompson 3 and Thomas Aune 1, 1Vanderbilt University Medical Center, Nashville, Tennessee, 2Vanderbilt University Medical Center, Nashville, 3Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children.  Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes…
  • Abstract Number: 166 • 2020 Pediatric Rheumatology Symposium

    Resident Memory T Cells in Human RA Synovium Display Restricted TCR Clones

    Margaret Chang1, Anais Levescot 2, Nathan Nelson-Maney 3, Rachel Blaustein 4, Kellen Winden 1, Allyn Morris 4, Spoorthi Balu 4, Alexandra Wactor 4, Kevin Wei 5, Lauren Henderson 6, Rachael Clark 4, Deepak Rao 4, Robert Fuhlbrigge 7 and Peter Nigrovic 8, 1Boston Children's Hospital, Boston, 2Boston, 3, 4Brigham and Women's Hospital, Boston, 5BWH, Boston, 6Boston Children's Hospital, Watertown, Massachusetts, 7University of Colorado, Aurora, 8Boston Children's Hospital, Boston, Massachusetts

    Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in pathogen defense. Dysregulated…
  • Abstract Number: 102 • 2019 ACR/ARP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)

    Takayuki Katsuyama1, Kotaro Otomo 1, Hao Li 2, Michihito Kono 3, Nobuya Yoshida 1, George Tsokos 1 and Vaishali R. Moulton 1, 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Background/Purpose: CD4 T helper 1 (Th1) and Th17 cells producing IFN-γ and IL-17 are aberrantly increased and contribute to inflammatory responses in autoimmune diseases including…
  • Abstract Number: 2420 • 2019 ACR/ARP Annual Meeting

    Role of T Follicular Helper Cells and T Peripheral Helper Cells in the Activation of B Cells in Sjögren Syndrome

    Anastasia Dupré1, Juliette Pascaud 1, Elodie Rivière 2, Michael Mingueneau 3, Gaetane Nocturne 4 and Xavier Mariette 5, 1IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, 2IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, 3Biomarker Discovery Platform UTechS CB, Hub de Bioinformatique et biostatistique, C3IB, Institut Pasteur, Paris, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, 5Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a rare systemic autoimmune disease characterized by a dysregulation of cellular and humoral immunity, leading to a hyper-activation of…
  • Abstract Number: 109 • 2019 ACR/ARP Annual Meeting

    Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis

    Yan Li 1, Jeffrey H. Ruth 2, Stephanie Rasmussen 3, Kalana S. Athukorala 2, Daniel P. Weber 2, M. Asif Amin 2, Phillip Campbell 3, Nora Singer 4, David Fox5 and Feng Lin 1, 1Cleveland Clinic, Cleveland, OH, 2University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 4The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, 5Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI

    Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
  • Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting

    Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome

    Ji-Won Kim1, Jaeseon Lee 2, Ui Hong Jung 1, Sung-Hoon Park 1, Jennifer Lee 3, Seung-Ki Kwok 3 and Sung-Hwan Park 3, 1Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, 2Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
  • Abstract Number: 110 • 2019 ACR/ARP Annual Meeting

    Bioinformatics Analysis of Transcriptomics Data Reveals That SRSF1 Is a Novel Molecular Brake for the T Cell Activation Program and Controls Key Cytokine Signaling Genes Implicated in Systemic Lupus Erythematosus

    Rhea Bhargava1, Michelle S. Lee 2, Takayuki Katsuyama 3 and Vaishali R. Moulton 3, 1Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: T cells from systemic lupus erythematosus (SLE) patients exhibit a hyperactive phenotype with defects in homeostasis, signaling and cytokine production. By discovery approaches, we…
  • Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting

    An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium

    Anna Helena Jonsson1, Fan Zhang 2, Gerald Watts 2, Kevin Wei 1, Deepak Rao 2, Soumya Raychaudhuri 2 and Michael Brenner 3, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital:, Boston

    Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
  • Abstract Number: 111 • 2019 ACR/ARP Annual Meeting

    The Transcription Factor STAT3 Regulates Pathogenic Th17 Responses in Autoimmune Disease via Noncanonical Roles

    Catherine Poholek1, Itay Raphael 2 and Mandy McGeachy 2, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The Th17 lineage of CD4 T cells drives autoimmune diseases such as RA, SLE, IBD, and MS. The JAK2/STAT3 signaling pathway is required for…
  • Abstract Number: 2818 • 2019 ACR/ARP Annual Meeting

    Differences in the Phenotypic Landscape and Antigen Specificity of CD4+ T Cells Are Present in CCP+ Subjects Before the Onset of Rheumatoid Arthritis

    Virginia Muir 1, Cliff Rims 1, Kevin Deane 2, Jeffrey Carlin 3, Sylvia Posso 1, Sunil Nagpal 4, Navin Rao 4, Frédéric Baribaud 5, George Vratsanos 6, William Robinson 7, Gary Firestein 8, V. Michael Holers 9, Peter Linsley 1, Eddie James1 and Jane Buckner 1, 1Benaroya Research Institute, Seattle, WA, 2University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 3Virginia Mason Medical Center, Seattle, WA, 4Janssen R&D, Spring House, PA, 5Janssen Research & Development, LLC, Spring House, PA, 6JNJ, Raritan, NJ, 7Stanford University, Palo Alto, CA, 8University of California, San Diego, San Diego, 9University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…
  • Abstract Number: 113 • 2019 ACR/ARP Annual Meeting

    In Vitro Characterization of the Effect of Cenerimod, a Potent and Selective Sphingosine 1-Phosphate Receptor 1 (S1P1) Modulator, on S1P1 Receptor Expression, Receptor Internalization, and Migration of Primary Human T Cells in the Presence or Absence of Glucocorticoids

    Paulina Kulig 1, Mark Murphy 1 and Marcel Keller1, 1Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland

    Background/Purpose: Cenerimod is a potent, selective, and orally active sphingosine 1-phosphate receptor 1 (S1P1) modulator that is currently being evaluated in a Phase 2b study…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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