Abstracts tagged "T Cell"

Abstract Number: 1521 • ACR Convergence 2020
A Novel Gut-joint Migratory TCRab+ Cell Subset Relies on sphingosine-1-phosphate for Tissue Localization
Adam Lefferts¹, Emilie Regner², Eric Norman³, David Claypool⁴, Hannah Schultz⁴, Danielle Sansone-Poe⁴ and Kristine Kuhn⁵, ¹University of Colorado, Anschutz Medical Campus, Aurora, CO, ²University of California San Francisco, San Francisco, CA, ³University of Colorado, Anschutz Medical Campus, Denver, ⁴University of Colorado, Anschutz Medical Campus, Aurora, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Despite findings of similar immune cellular phenotypes in the gut and joint of patients with spondyloarthritis, the mechanistic linkage between intestinal immunology and the…
Abstract Number: 90 • 2019 ACR/ARP Annual Meeting
SLAMF6 Clustering Is Required to Augment Autoimmune T Cell Activation
Matthew Dragovich¹ and Adam Mor ², ¹Columbia University, New York, NY, ²Columbia University School of Medicine, New York, NY
Background/Purpose: The signaling lymphocytic activation molecule (SLAM) family is encompassed by nine distinct receptors that are hematopoietic restricted. Among these, SLAMF6 is highly expressed in…
Abstract Number: 106 • 2019 ACR/ARP Annual Meeting
Increased T Cell Polyreactivity with Marked Accumulation of TNF-α DP (CD4+CD8+) in the Synovial Tissue of pre-RA, Arthralgia Subjects
Achilleas Floudas¹, Douglas Veale ² and Ursula Fearon ³, ¹Trinity Biomedical Sciences Institu, DUBLIN, Ireland, ²EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland, ³Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland
Background/Purpose: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window of opportunity following diagnosis. Identification of pathogenic immune mechanisms at a…
Abstract Number: 124 • 2019 ACR/ARP Annual Meeting
Treatment with Abatacept but Not with TNF Blockers, Is Associated with a Reduction of Constitutively Elevated Circulating Follicular Helper T Cells in Rheumatoid Arthritis
Maria-Eugenia Miranda-Carus¹, Paula Fortea-Gordo ², Laura Nuño ³, Alejandro Villalba ⁴, Maria-Jose Santos-Bornez ², Diana Peiteado ², Irene Monjo ¹ and Alejandro Balsa ⁵, ¹FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, Spain, ²FIBHULP-IdiPAZ-Hospital La Paz, Madrid, Spain, ³Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, Madrid, Spain, ⁴FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, ⁵Immuno-Rheumatology Research Group, IdiPaz & Rheumatology Department. La Paz University Hospital, Madrid, Spain
Background/Purpose: Circulating CD4 T cells that express CXCR5 together with PD-1 and/or ICOS are considered as counterparts of bona fide Tfh cells and function as…

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