Abstracts tagged "Systemic sclerosis"

Abstract Number: 2562 • 2013 ACR/ARHP Annual Meeting
Inhibition Of SOX9 Phosphorylation Abrogates The Increased Expression Of Profibrotic Genes In Systemic Sclerosis Dermal Fibroblasts
Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: SOX9, a high mobility group transcription factor is a master regulator of chondrogenesis and plays a crucial role in the regulation of chondrocyte gene…
Abstract Number: 2566 • 2013 ACR/ARHP Annual Meeting
Nilotinib Treatment Effect In The Skin As Measured By DNA Microarray In Patients With Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Tammara A. Wood², Robert F. Spiera¹ and Michael L. Whitfield², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Gene expression profiling by DNA microarray is used to identify potential biomarkers in Systemic Sclerosis (SSc). Discrete gene expression signatures have been observed to…
Abstract Number: 1480 • 2012 ACR/ARHP Annual Meeting
The 15% Rule in Scleroderma: A Systematic Review of the Frequency of Organ Complications in Systemic Sclerosis
Chayawee Muangchan¹, Murray Baron², Janet E. Pope³ and Canadian Scleroderma Research Group⁴, ¹Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁴Division of Rheumatology, SMBD Jewish General Hospital, Montreal, QC, Canada
Background/Purpose : The prevalence of each organ complication in scleroderma (SSc) varies by definition used. However, it is important to be aware of several complications…
Abstract Number: 1485 • 2012 ACR/ARHP Annual Meeting
Patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS) Present Esophageal and Anorectal Involvement: Data From a Single Centre
Gemma Lepri¹, Silvia Bellando-Randone², Serena Guiducci³, Iacopo Giani⁴, Cosimo Bruni⁵, Giulia Carnesecchi², Jelena Blagojevic², Alessandra Radicati², Filippo Pucciani⁶ and Marco Matucci Cerinic², ¹Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy, ²Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ³Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ⁴General Surgery, ASL 8, Arezzo, Italy, Arezzo, Italy, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶General and Urgency Surgery, University of Florence, Florence, Italy, Florence, Italy
Background/Purpose: Systemic Sclerosis (SSc) affects gastrointestinal tract in more than 80% of patients. Esophageal involvement is the most common manifestation with a prevalence ranging between…
Abstract Number: 1459 • 2012 ACR/ARHP Annual Meeting
Limited Utility of Pulmonary Function Tests and B-Type Natriuretic Peptide As Screening Tools for Pre-Capillary Pulmonary Hypertension in Patients with Systemic Sclerosis
Yuichiro Shirai¹, Yuichi Tamura², Hidekata Yasuoka¹, Tsutomu Takeuchi³, Toru Satoh⁴ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, ³Keio University School of Medicine, Tokyo, Japan, ⁴Department of Cardiology, Kyorin University School of Medicine, Tokyo, Japan
Background/Purpose: A series of recent studies indicate that early detection of pulmonary hypertension (PH) improves a survival in patients with systemic sclerosis (SSc). Thus, annual…
Abstract Number: 1460 • 2012 ACR/ARHP Annual Meeting
Unmasking Latent Pulmonary Arterial Hypertension by Fluid Challenge in Patients with Systemic Sclerosis
Amee Sonigra¹, Melanie Hurford², Patricia Lewis³, David Kilpatrick⁴, Nathan Dwyer⁴ and Jane Zochling³, ¹Medicine, Royal Hobart Hospital, Hobart, Australia, ²Menzies Research Institute, Hobart, Australia, ³Menzies Research Institute Tasmania, Hobart, Australia, ⁴Cardiology, Royal Hobart Hospital, Hobart, Australia
Background/Purpose: Pulmonary arterial hypertension (PAH) is associated with high morbidity and mortality in Systemic Sclerosis. Early diagnosis and treatment leads to substantial improvements in quality…
Abstract Number: 1467 • 2012 ACR/ARHP Annual Meeting
Association of Gastroesophageal Factors and Progression of Interstitial Lung Disease in the Canadian Scleroderma Research Group, a Large, Multicenter Database
Xuli Jerry Zhang¹, Ashley Bonner², Murray Baron³, Marie Hudson⁴, Janet E. Pope⁵ and Canadian Scleroderma Research Group⁶, ¹Western University, London, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁶Montreal, Canada
Background/Purpose: Interstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc) and is a leading contributor to mortality in SSc patients. Once lung…
Abstract Number: 125 • 2012 ACR/ARHP Annual Meeting
Borderline Right Ventricular Involvement in Patients with Systemic Sclerosis without Pulmonary Hypertension
Luna Gargani¹, Piotr Gosciniak², Cosimo Bruni³, Serena Guiducci³, Silvia Bellando Randone³, Lorenza Pratali¹, Gergely Agoston⁴, Alberto Moggi Pignone⁵, Albert Varga⁴, Rosa Sicari¹, Eugenio Picano¹ and Marco Matucci Cerinic⁶, ¹Institute of Clinical Physiology, National Research Council, Pisa, Italy, ²WSZ, Department of Cardiology, Szczecin, Poland, ³Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ⁴University of Szeged, Faculty of Medicine, 2nd Dept of Internal Medicine & Cardiology Center, Szeged, Hungary, ⁵University of Florence, Department of Medicine, Division of Rheumatology, Florence, Italy, ⁶Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy
Background/Purpose: Cardiac dysfunction in systemic sclerosis (SSc) is associated with poor prognosis. Right ventricular involvement is tipically associated to pulmonary hypertension (PH) in these patients.…
Abstract Number: 94 • 2012 ACR/ARHP Annual Meeting
Medical Costs and Health Care Resource Use in Patients with Systemic Sclerosis in an Insured Population
Daniel Furst¹, Ancilla W. Fernandes², Serban R. Iorga³, Warren Greth⁴ and Tim Bancroft³, ¹Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ²MedImmune, LLC, Gaithersburg, MD, ³OptumInsight, Eden Prairie, MN, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Systemic sclerosis (SSc) is a chronic connective tissue disease affecting the skin and/or internal organs. Data on US economic burden of SSc is scant…
Abstract Number: 2307 • 2012 ACR/ARHP Annual Meeting
Role of Endosomal and Cell Membrane Toll-Like Receptors in Keratinocyte Activation by Systemic Sclerosis Autoantibodies
James M. Watson¹, Joanna Nikitorowicz Buniak², Xu Shiwen³, David J. Abraham⁴, Christopher P. Denton⁵ and Richard J. Stratton², ¹Centre for Rheumatology & Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴UCL Medical School, London, United Kingdom, ⁵Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune rare connective tissue disorder of unknown aetiology, heterogeneous clinical manifestations and an often progressive course which includes skin…
Abstract Number: 2287 • 2012 ACR/ARHP Annual Meeting
Altered Regulation of Metabolic Pathways in Systemic Sclerosis Evidenced by Metabolomics
Emmanuel Chatelus¹, Jacques-Eric Gottenberg¹, François-Marie Moussallieh¹, Christelle Sordet¹, Arnaud Theulin¹, Alain Meyer¹, Jean-Francois Kleimann¹, Jean Sibilia¹ and Izzie Jacques Namer², ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Nuclear Medicine, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Systemic sclerosis (SSc) currently lacks prognostic biomarkers…
Abstract Number: 2292 • 2012 ACR/ARHP Annual Meeting
Increased Synthesis of Leukotrienes by Peripheral Blood Mononuclear Cells Is Associated with More Severe Disease and Worse Prognosis in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Anna Lapinska², Marek Bielecki³, Oliver Distler⁴, Izabela Domyslawska¹, Lech Chyczewski², Stanislaw Sierakowski⁵, Steffen Gay⁶ and Krzysztof Kowal⁷, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ³Department of Orthopedics and Traumatology, Medical University in Bialystok, Bialystok, Poland, ⁴Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Rheumatology and Internal Diseases, Medical University in Bialystok, Bialystok, Poland, ⁶Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland, ⁷Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Eicosanoids are a group of arachidonic acid-derived lipid mediators which play a key role in the regulation of inflammatory response and connective tissue remodeling.…
Abstract Number: 2298 • 2012 ACR/ARHP Annual Meeting
The Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) Polymorphism Is Associated with Risk of Scleroderma-Related Interstitial Lung Disease: A Multicenter Study From the EULAR Scleroderma Trial and Research Group
Otylia M. Kowal-Bielecka¹, Sylwia Chwiesko-Minarowska², Pawel Bernatowicz², Yannick Allanore³, Timothy RD Radstake⁴, Jasper Broen⁵, Marco Matucci-Cerinic⁶, Roger Hesselstrand⁷, Dorota Krasowska⁸, Gabriela Riemekasten⁹, Madelon C. Vonk¹⁰, Oksana Kowalczuk², Marek Bielecki¹¹, Robert Milewski¹², Lech Chyczewski¹³, Jacek Niklinski² and Krzysztof Kowal¹⁴, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, ⁶Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁷Rheumatology, Lund University, Lund, Sweden, ⁸Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹¹Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ¹²Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland, ¹³Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ¹⁴Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by chronic inflammation, vascular injury and profound fibrosis of the skin and internal organ. Leukotrienes…
Abstract Number: 1714 • 2012 ACR/ARHP Annual Meeting
Gender Differences in Systemic Sclerosis: Relationship to Disease Specific Clinical Manifestations and Estradiol Levels
Christine Peoples¹, Mary Lucas², Zengbiao Qi², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by inflammation, autoantibody production, and increased production of extracellular matrix (ECM), resulting in fibrosis. We…
Abstract Number: 1716 • 2012 ACR/ARHP Annual Meeting
Outcomes Linked to Intensive Treatment Trials in Systemic Sclerosis
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: A number of clinical trials using intensive immunosuppression followed by autologous haematopoietic stem cell transplantation (HSCT) in systemic sclerosis (SSc) are underway or have…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].