Abstracts tagged "Systemic sclerosis"

Abstract Number: 840 • 2016 ACR/ARHP Annual Meeting
Time Trends in Incidence and Mortality of Systemic Sclerosis in Denmark from 1995-2011: A Nationwide Cohort Study
Sheraz Butt¹, Charlotte Andersson², Søren Jacobsen³, Gunnar Gislason⁴ and Christian Torp-Pedersen⁵, ¹Department of Medicine, Glostrup Hospital, Glostrup, Denmark, ²Department of Medicine, Glostrup Hospital, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, ⁴Department of Cardiology, Gentofte Hospital, Copenhagen, Denmark, ⁵Aalborg University, Aalborg, Denmark
Time Trends In Incidence And Mortality Of Systemic Sclerosis In Denmark From 1995-2011: A Nationwide Cohort Study Background/Purpose: Epidemiological studies have documented an increasing incidence…
Abstract Number: 1849 • 2016 ACR/ARHP Annual Meeting
Fibroblast Growth Factor 9/ Fibroblast Growth Factor Receptor 3 Signaling Is Upstream of Several Profibrotic Pathways and Induces Fibroblast Activation and Tissue Fibrosis in SSc
Tatjana Mallano¹, Alfiya Distler¹, Clara Dees¹, Jingang Huang², Debomita Chakraborty³, Oliver Distler^4,5, Georg Schett⁶ and Joerg H.W Distler⁷, ¹Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Department of Internal Medicine III, Institute of Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁴Center of Exper Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ⁶Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
FGF9 / FGFR3 signaling is upstream of several profibrotic pathways and induces fibroblast activation and tissue fibrosis in SSc Background/Purpose: Systemic sclerosis (SSc)…
Abstract Number: 1878 • 2016 ACR/ARHP Annual Meeting
Speckle Tracking Echocardiography: A Sensitive Technique for Detecting Early Left Ventricular Dysfunction in Patients with Systemic Sclerosis
Duygu Temiz Karadag¹, Tayfun Sahin², Senem Tekeoglu¹, Ozlem Ozdemir Işik¹, Ayten Yazici³, Fatma Ceyla Eraldemir⁴ and Ayse Cefle¹, ¹Rheumatology, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ²Cardiology, Kocaeli University School of Medicine, Department of Cardiology, Kocaeli, Turkey, ³Umuttepe Yerleşkesi/IZMIT, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ⁴Biochemistry, Kocaeli University School of Medicine, Department of Biochemistry, Kocaeli, Turkey
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular damage and excessive fibrosis in the skin and internal organs. Myocardial fibrosis which contributes…
Abstract Number: 1888 • 2016 ACR/ARHP Annual Meeting
Reliability, Validity, and Sensitivity to Change of the Simplified Duruoz Hand Index in Systemic Sclerosis
Ana Maria Gheorghiu¹, Hermina Gyorfi¹, Razvan Capota¹, Alexandru Matei¹, Raida Oneata¹, Liviu Macovei¹, Mihaela Milicescu¹, Mariana Sasu¹, Mihai Bojinca², Victor Stoica¹ and Carina Mihai¹, ¹Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania, ²Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucuresti, Romania
Background/Purpose: Hand involvement is observed in almost all patients with Systemic Sclerosis (SSc), and is due in various proportions to skin and tendon fibrosis, arthritis…
Abstract Number: 1889 • 2016 ACR/ARHP Annual Meeting
Predictors of Acro-Osteolysis in Systemic Sclerosis
Ashraf Raslan¹ and Vivien Hsu², ¹Medicine, Rutgers-RWJ Medical School, Jersey City, NJ, ²Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Background/Purpose: Acro-osteolysis (AO) is the bony resorption on the distal tufts of the digits, a characteristic radiological finding in Systemic Sclerosis (SSc) with estimated prevalence…
Abstract Number: 1890 • 2016 ACR/ARHP Annual Meeting
Functional Disability and Its Predictors in Systemic Sclerosis: A Study from the Desscipher Project within the European Scleroderma Trials and Research Group
Veronika K. Jaeger¹, Lazlo Czirjak², Veronika Lóránd², Gabriele Valentini³, Serena Vettori⁴, Francesco Del Galdo⁵, Giuseppina Abignano⁶, Oliver Distler⁷, Britta Maurer⁷, Christopher Denton⁸, Svetlana Nihtyanova⁹, Yannick Allanore¹⁰, Jerome Avouac¹¹, Gabriela Riemekasten¹², Elise Siegert¹³, Dörte Huscher¹⁴, Marco Matucci-Cerinic¹⁵, Serena Guiducci¹⁶, Marc Frerix¹⁷, Ingo H. Tarner¹⁸, Beata Garay-Toth¹⁹, Lidiya P. Ananieva²⁰, Franco Cozzi²¹, Sule Yavuz²², Nicolas Hunzelmann²³, Alessandra Vacca²⁴, Tim Schmeiser²⁵, Simona Rednic²⁶, Valeria Riccieri²⁷, Brigitte Krummel-Lorenz²⁸, Armando Gabrielli²⁹, Paloma Garcia De La Peña³⁰, Codrina Ancuta³¹, Ulf Müller-Ladner³², Ulrich A. Walker¹ and on behalf of the DeSScipher Consortium and contributing EUSTAR centres, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ³Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁴Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁹Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, ¹⁰Rheumatology, Paris Descartes University, Paris, France, ¹¹Department of Rheumatology, University of Paris Descartes, Paris, France, ¹²Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany, ¹³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ¹⁴Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ¹⁵Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁶Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁷Department of Rheumatology and Clinical Immunology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁸Rheumatology and Clinical Immunology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁹FESCA, Budapest, Hungary, ²⁰Microcirculation and Inflammation, Research Institute of Rheumatology RAMS, Moscow, Russia, ²¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²²Marmara University Faculty of Medicine, Rheumatology, Istanbul, Turkey, ²³Department of Dermatology, University of Cologne, Cologne, Germany, ²⁴University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, ²⁵Krankenhaus St. Josef, Wuppertal, Germany, ²⁶Rheumatology, Emergency County Clinical Hospital Cluj Napoca, Cluj-Napoca, Romania, ²⁷Cattedra di Reumatologia, Dip Clinica e Terapia Medica, Sapienza Università di Roma, Roma, Italy, ²⁸Rheumatologist, Frankfurt, Germany, ²⁹Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università Politecnica delle Marche, Ancona, Italy, ³⁰Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ³¹G.T.Popa Center for Biomedical Research, Iasi, Romania, ³²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Systemic sclerosis (SSc) can greatly impact the patients’ quality of life due to its multisystem manifestations. The health assessment questionnaire (HAQ) is one of…
Abstract Number: 1891 • 2016 ACR/ARHP Annual Meeting
Excellent Reliability of Semiquantitative Nailfold Capillaroscopy Assessment in a Systemic Sclerosis Cohort – a Pilot Study
Ana Maria Gheorghiu, Raida Oneata, Alina Soare, Rucsandra Dobrota, Liviu Macovei, Mihaela Milicescu, Mariana Sasu, Marilena Gorga, Ioan Ancuta, Mihai Bojinca, Victor Stoica and Carina Mihai, Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania
Background/Purpose: Nailfold capillaroscopy (NFC) is essential in the evaluation and classification of systemic sclerosis (SSc). Semiquantitative capillaroscopy scoring is a promising tool for assessing disease…
Abstract Number: 1900 • 2015 ACR/ARHP Annual Meeting
Performance of the Detect Protocol for Pulmonary Arterial Detection in Systemic Sclerosis Patients in Clinical Practice
Otto Martin Olivas Vergara¹, Beatriz E. Joven¹, Belen Diaz Anton², Carmen Jiménez², Maria Martin Lopez³, Pilar Escribano² and Patricia E. Carreira^1,2, ¹Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ²Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, ³RHEUMATOLOGY, Hospital Universitario 12 de Octubre, Madrid, Spain
Background/Purpose: To analyze the usefulness of the DETECT protocol (1) for the prediction of pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) in routine clinical…
Abstract Number: 1921 • 2015 ACR/ARHP Annual Meeting
Role of TLRs in the Abnormal Secretion of CXCL-4 By Plasmacytoid Dendritic Cells of Patients with Systemic Sclerosis
Marie-Dominique Ah Kioon¹, Eliza Pelrine², Robert F. Spiera³, Jessica K. Gordon³ and Franck J. Barrat¹, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder of the connective tissue due to excessive extracellular matrix deposition, leading to fibrosis of the skin and…
Abstract Number: 2975 • 2015 ACR/ARHP Annual Meeting
Induced Sputum Analysis in Systemic Sclerosis Patients
Irena Litinsky¹, Elizabeth Fireman², Ari Polachek¹, Adi Broyde¹, Amir Sharabi¹, Marina Anouk¹, Daphna Paran¹ and Ori Elkayam¹, ¹Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: Induced sputum (IS) is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. IS is well accepted by patients, safer…
Abstract Number: 2988 • 2015 ACR/ARHP Annual Meeting
Novel Use of Musculoskeletal Ultrasound (MSUS) to Measure Ulcers in the Skin of Systemic Sclerosis (SSc) Patients.
Yossra Suliman^1,2, Veena K. Ranganath², Suzanne Kafaja³ and Daniel E. Furst⁴, ¹Rheumatology and Rehabilitation department, Assiut university, Faculty of Medicine,, Assiut, Egypt, ²Medicine, Division of Rheumatology, David Geffen School of Medicine, Los Angeles, CA, ³Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: 1) To describe the role of MSUS, using both grey scale (GS) and Power Doppler (PD), to detect skin ulcers in SSc patients. 2)…
Abstract Number: 3011 • 2015 ACR/ARHP Annual Meeting
The Homeoprotein Engrailed-1 Regulates Canonical TGF Beta Signaling in Experimental Systemic Sclerosis
Tatjana Mallano¹, Katrin Palumbo-Zerr¹, Christian Beyer^1,2, Clara Dees¹, Jingang Huang¹, Thomas Wohlfahrt¹, Oliver Distler³, Georg Schett¹ and Jeorg HW Distler^1,2, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology, Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth factor-β (TGFβ) has…
Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting
Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes
Antonella Farina¹, Giovanna Peruzzi^2,3, Valentina Lacconi⁴, Edoardo Rosato⁵, Silvia Quarta⁶, Stefania Morrone¹, Alberto Faggioni¹, Maria Trojanowska⁴ and Giuseppina Alessandra Farina⁴, ¹Department of Experimental Medicine, Sapienza University, Department of Experimental Medicine, Rome, Italy, ²Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Rome, Italy, ³Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Viale Regina Elena 291, 00161, Rome, Italy, Rome, Italy, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA, ⁵Department of Clinical Medicine, Clinical Immunology Unit,, Sapienza University,Department of Clinical Medicine, Rome, Italy, ⁶Department of Clinical Medicine, Clinical Immunology Unit., Sapienza University,Department of Clinical Medicine, Rome, Italy
Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…
Abstract Number: 3135 • 2015 ACR/ARHP Annual Meeting
Incidences and Predictors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal Study
Veronika K. Jaeger¹, Elina G. Wirz^2,3, Yannick Allanore⁴, Gabriela Riemekasten⁵, Eric Hachulla⁶, Oliver Distler⁷, Paolo Airo⁸, Patricia E. Carreira⁹, Alexandra Balbir-Gurman¹⁰, Mohammed Tikly¹¹, Serena Vettori¹², Nemanja Damjanov¹³, Ulf Müller-Ladner¹⁴, Jorg HW. Distler¹⁵, Mangtao Li¹⁶, Ulrich A. Walker¹⁷ and EUSTAR collaborators, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ³Department of Dermatology, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Clinic of Rheumatology, University of Luebeck, Lübeck, Germany, ⁶Service de Médecine Interne, Hôpital Huriez, Université de Lille, Lille, France, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸UO Reumatologia ed Immunologia Clinica, Spedali Civili, Brescia, Italy, ⁹Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰B. Shine Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel, ¹¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ¹²Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ¹³Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ¹⁴Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁵Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁶Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China, ¹⁷Rheumatology, University Hospital, Basel, Basel, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs, particularly…
Abstract Number: 412 • 2015 ACR/ARHP Annual Meeting
Update on the Juvenile Systemic Sclerosis Inception Cohort Project. Characteristics of the First 50 Patients at First Assessment. Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Staņeviča³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, Riga Stradiņš University, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Immunology & Rheumatology., Hospital de Pediatrìa Garrahan, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Currently just retrospective data exist regarding evolvement of organ involvement. In the previous retrospective studies…

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