Abstracts tagged "Systemic sclerosis"

Abstract Number: 2915 • 2016 ACR/ARHP Annual Meeting
An Increased Circulating Level of Periostin in Patients with Systemic Sclerosis: Associations with Functional Impairment in Various Affected Organs
Yukie Yamaguchi¹, Yuichiro Shirai², Junya Ono^3,4, Yasushi Kawaguchi⁵, Kenji Izuhara³, Masataka Kuwana² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ⁴Shino-Test Corporation, Sagamihara, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Periostin is one of the matricellular proteins, a class of ECM-related molecules defined by their ability to modulate cell–matrix interactions. Several lines of evidences…
Abstract Number: 818 • 2016 ACR/ARHP Annual Meeting
The Role of Endothelin 1 in Activation of Vascular Smooth Muscle Cells in Systemic Sclerosis; Increased Cell Proliferation and Resistance to Apoptosis Mediated By Endotehlin B Receptors
Shadia Nada¹, Yongqing Wang^1,2, Nezam Altorok¹ and Bashar Kahaleh¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: is overexpressed in SSc as illustrated by elevated circulating levels and increased tissue expression in involved organs. We previously reported vascular smooth muscle…
Abstract Number: 2917 • 2016 ACR/ARHP Annual Meeting
Nailfold Capillaroscopy and Mortality in Systemic Sclerosis
Thais Rohde Pavan, Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Porto Alegre, Brazil
Background/Purpose: To test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). Methods: One hundred and seventy SSc…
Abstract Number: 832 • 2016 ACR/ARHP Annual Meeting
Defining Skin Ulcers in Systemic Sclerosis: A Systematic Literature Review of Skin Ulcer Definitions and a Preliminary Consensus-Based New SSc Skin Ulcer Definition
Yossra A Suliman¹, Cosimo Bruni², Sindhu R. Johnson³, Emanuela Praino⁴, Mohamed Alemam⁵, Nabeel Borazan⁶, Laura Cometi⁷, Bethany Myers⁸, Dinesh Khanna⁹, Yannick Allanore¹⁰, Murray Baron¹¹, Thomas Krieg¹², Ariane L. Herrick¹³, Suzanne Kafaja¹⁴, Christopher Denton¹⁵, Marco Matucci Cerinic¹⁶ and Daniel E. Furst¹⁷, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ³Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁴DIM, Rheumatology Unit, Bari, Italy, ⁵Clinical Pathology and Laboratory Medicine Department, Assistant Lecturer, Qena, Egypt, ⁶Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁷Division of Rheumatology, Department of Experimental and Clinical Medicine,, Florencei, Italy, ⁸UCLA Louise M. Darling Biomedical Library, Research Informationist, Los Angeles, CA, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Immunogenetics, Cochin Institute, Paris, France, ¹¹Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ¹²Universität zu Köln, Köln, Germany, ¹³Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ¹⁴Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ¹⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ¹⁶Department of BioMedicine, Division of Rheumatology, Transition Unit, University of Florence, Firenze, Italy, ¹⁷University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Skin ulcers in SSc are a major clinical challenge and there are various un-validated definitions of skin ulcers utilized in SSc-related clinical trials. We…
Abstract Number: 840 • 2016 ACR/ARHP Annual Meeting
Time Trends in Incidence and Mortality of Systemic Sclerosis in Denmark from 1995-2011: A Nationwide Cohort Study
Sheraz Butt¹, Charlotte Andersson², Søren Jacobsen³, Gunnar Gislason⁴ and Christian Torp-Pedersen⁵, ¹Department of Medicine, Glostrup Hospital, Glostrup, Denmark, ²Department of Medicine, Glostrup Hospital, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, ⁴Department of Cardiology, Gentofte Hospital, Copenhagen, Denmark, ⁵Aalborg University, Aalborg, Denmark
Time Trends In Incidence And Mortality Of Systemic Sclerosis In Denmark From 1995-2011: A Nationwide Cohort Study Background/Purpose: Epidemiological studies have documented an increasing incidence…
Abstract Number: 1849 • 2016 ACR/ARHP Annual Meeting
Fibroblast Growth Factor 9/ Fibroblast Growth Factor Receptor 3 Signaling Is Upstream of Several Profibrotic Pathways and Induces Fibroblast Activation and Tissue Fibrosis in SSc
Tatjana Mallano¹, Alfiya Distler¹, Clara Dees¹, Jingang Huang², Debomita Chakraborty³, Oliver Distler^4,5, Georg Schett⁶ and Joerg H.W Distler⁷, ¹Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Department of Internal Medicine III, Institute of Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁴Center of Exper Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ⁶Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
FGF9 / FGFR3 signaling is upstream of several profibrotic pathways and induces fibroblast activation and tissue fibrosis in SSc Background/Purpose: Systemic sclerosis (SSc)…
Abstract Number: 1878 • 2016 ACR/ARHP Annual Meeting
Speckle Tracking Echocardiography: A Sensitive Technique for Detecting Early Left Ventricular Dysfunction in Patients with Systemic Sclerosis
Duygu Temiz Karadag¹, Tayfun Sahin², Senem Tekeoglu¹, Ozlem Ozdemir Işik¹, Ayten Yazici³, Fatma Ceyla Eraldemir⁴ and Ayse Cefle¹, ¹Rheumatology, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ²Cardiology, Kocaeli University School of Medicine, Department of Cardiology, Kocaeli, Turkey, ³Umuttepe Yerleşkesi/IZMIT, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ⁴Biochemistry, Kocaeli University School of Medicine, Department of Biochemistry, Kocaeli, Turkey
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular damage and excessive fibrosis in the skin and internal organs. Myocardial fibrosis which contributes…
Abstract Number: 827 • 2015 ACR/ARHP Annual Meeting
Reliability of the Quantitative Assessment of Peripheral Blood Perfusion By Laser Speckle Contrast Analysis in a Systemic Sclerosis Cohort
Valérie Lambrecht¹, Maurizio Cutolo², Filip De Keyser³, Saskia Decuman⁴, Barbara Ruaro², Alberto Sulli⁵, Ellen Deschepper⁶ and Vanessa Smith⁷, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, UGent, Ghent, Belgium, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy, ⁶Biostatistics Unit, Biostatistics Unit, Ghent University, Ghent, Belgium, ⁷Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Laser speckle contrast analysis (LASCA) is an innovative technique to quantify peripheral blood perfusion (PBP) over a given area. Quantification of blood flow might…
Abstract Number: 1875 • 2015 ACR/ARHP Annual Meeting
Deep Vein Thrombosis and Pulmonary Embolism in Systemic Sclerois
Nabil Hakami^1,2 and Sindhu R. Johnson³, ¹Rheumatology, Toronto Scleroderma Program,Toronto Western Hospital, Mount Sinai Hospital,, Toronto, ON, Canada, ²King Fahad Central Hospital, Riyad, Saudi Arabia, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada
Background/Purpose: In systemic sclerosis (SSc) vasculopathy causes frequent episodes of reperfusion injury and free radical mediated endothelial dysfunction, which may influence the onset of local…
Abstract Number: 1876 • 2015 ACR/ARHP Annual Meeting
Caveolin 1 Gene Variants May Effect Disease Progression in Systemic Sclerosis Related Interstitial Lung Disease
Sule Yavuz¹, Elena Lopez-Isac², Ahmet Mesut Onat³, Neslihan Yilmaz⁴, Levent Kilic⁵, Ali Akdogan⁵ and Javier Martín⁶, ¹Rheumatology, Istanbul Bilim University, Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey, ²Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Istanbul Bilim University, Faculty of Medicine, Rheumatology Department, Istanbul, Turkey, ⁵Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, ⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: To determine possible association of Cav-1 genetic variants: rs926198, rs959173 and rs9920 with SSc and/or SSc-related ILD progression. Methods: Three Cav-1 single nucleotide polymorphisms…
Abstract Number: 1878 • 2015 ACR/ARHP Annual Meeting
Diagnostic Performance of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis: Results from a Brazilian Validation Cohort
Farley Carvalho¹, Cintia Camargo², Bruna Fernandez¹ and Cristiane Kayser², ¹Universidade Federal de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: New classification criteria for systemic sclerosis (SSc) were proposed by the ACR/EULAR in 2013, due to the low sensitivity of the 1980 ACR classification…
Abstract Number: 1900 • 2015 ACR/ARHP Annual Meeting
Performance of the Detect Protocol for Pulmonary Arterial Detection in Systemic Sclerosis Patients in Clinical Practice
Otto Martin Olivas Vergara¹, Beatriz E. Joven¹, Belen Diaz Anton², Carmen Jiménez², Maria Martin Lopez³, Pilar Escribano² and Patricia E. Carreira^1,2, ¹Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ²Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, ³RHEUMATOLOGY, Hospital Universitario 12 de Octubre, Madrid, Spain
Background/Purpose: To analyze the usefulness of the DETECT protocol (1) for the prediction of pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) in routine clinical…
Abstract Number: 1921 • 2015 ACR/ARHP Annual Meeting
Role of TLRs in the Abnormal Secretion of CXCL-4 By Plasmacytoid Dendritic Cells of Patients with Systemic Sclerosis
Marie-Dominique Ah Kioon¹, Eliza Pelrine², Robert F. Spiera³, Jessica K. Gordon³ and Franck J. Barrat¹, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder of the connective tissue due to excessive extracellular matrix deposition, leading to fibrosis of the skin and…
Abstract Number: 2975 • 2015 ACR/ARHP Annual Meeting
Induced Sputum Analysis in Systemic Sclerosis Patients
Irena Litinsky¹, Elizabeth Fireman², Ari Polachek¹, Adi Broyde¹, Amir Sharabi¹, Marina Anouk¹, Daphna Paran¹ and Ori Elkayam¹, ¹Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: Induced sputum (IS) is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. IS is well accepted by patients, safer…
Abstract Number: 2988 • 2015 ACR/ARHP Annual Meeting
Novel Use of Musculoskeletal Ultrasound (MSUS) to Measure Ulcers in the Skin of Systemic Sclerosis (SSc) Patients.
Yossra Suliman^1,2, Veena K. Ranganath², Suzanne Kafaja³ and Daniel E. Furst⁴, ¹Rheumatology and Rehabilitation department, Assiut university, Faculty of Medicine,, Assiut, Egypt, ²Medicine, Division of Rheumatology, David Geffen School of Medicine, Los Angeles, CA, ³Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: 1) To describe the role of MSUS, using both grey scale (GS) and Power Doppler (PD), to detect skin ulcers in SSc patients. 2)…

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