Abstracts tagged "Systemic sclerosis"

Abstract Number: 2287 • 2012 ACR/ARHP Annual Meeting
Altered Regulation of Metabolic Pathways in Systemic Sclerosis Evidenced by Metabolomics
Emmanuel Chatelus¹, Jacques-Eric Gottenberg¹, François-Marie Moussallieh¹, Christelle Sordet¹, Arnaud Theulin¹, Alain Meyer¹, Jean-Francois Kleimann¹, Jean Sibilia¹ and Izzie Jacques Namer², ¹Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Nuclear Medicine, Strasbourg University Hospital, Strasbourg, France
Background/Purpose: High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Systemic sclerosis (SSc) currently lacks prognostic biomarkers…
Abstract Number: 2292 • 2012 ACR/ARHP Annual Meeting
Increased Synthesis of Leukotrienes by Peripheral Blood Mononuclear Cells Is Associated with More Severe Disease and Worse Prognosis in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Anna Lapinska², Marek Bielecki³, Oliver Distler⁴, Izabela Domyslawska¹, Lech Chyczewski², Stanislaw Sierakowski⁵, Steffen Gay⁶ and Krzysztof Kowal⁷, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ³Department of Orthopedics and Traumatology, Medical University in Bialystok, Bialystok, Poland, ⁴Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Department of Rheumatology and Internal Diseases, Medical University in Bialystok, Bialystok, Poland, ⁶Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland, ⁷Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Eicosanoids are a group of arachidonic acid-derived lipid mediators which play a key role in the regulation of inflammatory response and connective tissue remodeling.…
Abstract Number: 2298 • 2012 ACR/ARHP Annual Meeting
The Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) Polymorphism Is Associated with Risk of Scleroderma-Related Interstitial Lung Disease: A Multicenter Study From the EULAR Scleroderma Trial and Research Group
Otylia M. Kowal-Bielecka¹, Sylwia Chwiesko-Minarowska², Pawel Bernatowicz², Yannick Allanore³, Timothy RD Radstake⁴, Jasper Broen⁵, Marco Matucci-Cerinic⁶, Roger Hesselstrand⁷, Dorota Krasowska⁸, Gabriela Riemekasten⁹, Madelon C. Vonk¹⁰, Oksana Kowalczuk², Marek Bielecki¹¹, Robert Milewski¹², Lech Chyczewski¹³, Jacek Niklinski² and Krzysztof Kowal¹⁴, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland, ³Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁴Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Rheumatology & Clinical Immunology, University Medical Center, Utrecht, Netherlands, ⁶Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁷Rheumatology, Lund University, Lund, Sweden, ⁸Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, ¹⁰Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹¹Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ¹²Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland, ¹³Department of Medical Pathomorphology, Medical University in Bialystok, Bialystok, Poland, ¹⁴Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by chronic inflammation, vascular injury and profound fibrosis of the skin and internal organ. Leukotrienes…
Abstract Number: 1714 • 2012 ACR/ARHP Annual Meeting
Gender Differences in Systemic Sclerosis: Relationship to Disease Specific Clinical Manifestations and Estradiol Levels
Christine Peoples¹, Mary Lucas², Zengbiao Qi², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by inflammation, autoantibody production, and increased production of extracellular matrix (ECM), resulting in fibrosis. We…
Abstract Number: 1716 • 2012 ACR/ARHP Annual Meeting
Outcomes Linked to Intensive Treatment Trials in Systemic Sclerosis
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: A number of clinical trials using intensive immunosuppression followed by autologous haematopoietic stem cell transplantation (HSCT) in systemic sclerosis (SSc) are underway or have…
Abstract Number: 1521 • 2012 ACR/ARHP Annual Meeting
A Possible Contribution of Decreased Cathepsin V Expression to the Development of Dermal Fibrosis, Proliferative Vasculopathy, and Altered Keratinocyte Phenotype in Systemic Sclerosis
Yoshihide Asano, Shinji Noda, Takehiro Takahashi, Sayaka Shibata, Kaname Akamata, Naohiko Aozasa, Takashi Taniguchi, Yohei Ichimura, Tetsuo Toyama, Hayakazu Sumida, Yoshihiro Kuwano, Koichi Yanaba and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Cathepsin V (CTSV) is a proteolytic enzyme potentially modulating angiogenic processes, collagen degradation, and keratinocyte differentiation. Although our latest paper demonstrated that cathepsin B,…
Abstract Number: 1478 • 2012 ACR/ARHP Annual Meeting
Gender-Associated Differences in Disease Characteristics and Outcome in Systemic Sclerosis
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Although significant female gender predominance is seen in majority of large systemic sclerosis (SSc) cohorts, multiple studies have suggested that male gender generally associates…
Abstract Number: 1480 • 2012 ACR/ARHP Annual Meeting
The 15% Rule in Scleroderma: A Systematic Review of the Frequency of Organ Complications in Systemic Sclerosis
Chayawee Muangchan¹, Murray Baron², Janet E. Pope³ and Canadian Scleroderma Research Group⁴, ¹Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁴Division of Rheumatology, SMBD Jewish General Hospital, Montreal, QC, Canada
Background/Purpose : The prevalence of each organ complication in scleroderma (SSc) varies by definition used. However, it is important to be aware of several complications…
Abstract Number: 1485 • 2012 ACR/ARHP Annual Meeting
Patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS) Present Esophageal and Anorectal Involvement: Data From a Single Centre
Gemma Lepri¹, Silvia Bellando-Randone², Serena Guiducci³, Iacopo Giani⁴, Cosimo Bruni⁵, Giulia Carnesecchi², Jelena Blagojevic², Alessandra Radicati², Filippo Pucciani⁶ and Marco Matucci Cerinic², ¹Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy, ²Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ³Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ⁴General Surgery, ASL 8, Arezzo, Italy, Arezzo, Italy, ⁵Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, ⁶General and Urgency Surgery, University of Florence, Florence, Italy, Florence, Italy
Background/Purpose: Systemic Sclerosis (SSc) affects gastrointestinal tract in more than 80% of patients. Esophageal involvement is the most common manifestation with a prevalence ranging between…
Abstract Number: 1459 • 2012 ACR/ARHP Annual Meeting
Limited Utility of Pulmonary Function Tests and B-Type Natriuretic Peptide As Screening Tools for Pre-Capillary Pulmonary Hypertension in Patients with Systemic Sclerosis
Yuichiro Shirai¹, Yuichi Tamura², Hidekata Yasuoka¹, Tsutomu Takeuchi³, Toru Satoh⁴ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, ³Keio University School of Medicine, Tokyo, Japan, ⁴Department of Cardiology, Kyorin University School of Medicine, Tokyo, Japan
Background/Purpose: A series of recent studies indicate that early detection of pulmonary hypertension (PH) improves a survival in patients with systemic sclerosis (SSc). Thus, annual…
Abstract Number: 1460 • 2012 ACR/ARHP Annual Meeting
Unmasking Latent Pulmonary Arterial Hypertension by Fluid Challenge in Patients with Systemic Sclerosis
Amee Sonigra¹, Melanie Hurford², Patricia Lewis³, David Kilpatrick⁴, Nathan Dwyer⁴ and Jane Zochling³, ¹Medicine, Royal Hobart Hospital, Hobart, Australia, ²Menzies Research Institute, Hobart, Australia, ³Menzies Research Institute Tasmania, Hobart, Australia, ⁴Cardiology, Royal Hobart Hospital, Hobart, Australia
Background/Purpose: Pulmonary arterial hypertension (PAH) is associated with high morbidity and mortality in Systemic Sclerosis. Early diagnosis and treatment leads to substantial improvements in quality…
Abstract Number: 1467 • 2012 ACR/ARHP Annual Meeting
Association of Gastroesophageal Factors and Progression of Interstitial Lung Disease in the Canadian Scleroderma Research Group, a Large, Multicenter Database
Xuli Jerry Zhang¹, Ashley Bonner², Murray Baron³, Marie Hudson⁴, Janet E. Pope⁵ and Canadian Scleroderma Research Group⁶, ¹Western University, London, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁶Montreal, Canada
Background/Purpose: Interstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc) and is a leading contributor to mortality in SSc patients. Once lung…
Abstract Number: 125 • 2012 ACR/ARHP Annual Meeting
Borderline Right Ventricular Involvement in Patients with Systemic Sclerosis without Pulmonary Hypertension
Luna Gargani¹, Piotr Gosciniak², Cosimo Bruni³, Serena Guiducci³, Silvia Bellando Randone³, Lorenza Pratali¹, Gergely Agoston⁴, Alberto Moggi Pignone⁵, Albert Varga⁴, Rosa Sicari¹, Eugenio Picano¹ and Marco Matucci Cerinic⁶, ¹Institute of Clinical Physiology, National Research Council, Pisa, Italy, ²WSZ, Department of Cardiology, Szczecin, Poland, ³Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ⁴University of Szeged, Faculty of Medicine, 2nd Dept of Internal Medicine & Cardiology Center, Szeged, Hungary, ⁵University of Florence, Department of Medicine, Division of Rheumatology, Florence, Italy, ⁶Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy
Background/Purpose: Cardiac dysfunction in systemic sclerosis (SSc) is associated with poor prognosis. Right ventricular involvement is tipically associated to pulmonary hypertension (PH) in these patients.…
Abstract Number: 94 • 2012 ACR/ARHP Annual Meeting
Medical Costs and Health Care Resource Use in Patients with Systemic Sclerosis in an Insured Population
Daniel Furst¹, Ancilla W. Fernandes², Serban R. Iorga³, Warren Greth⁴ and Tim Bancroft³, ¹Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ²MedImmune, LLC, Gaithersburg, MD, ³OptumInsight, Eden Prairie, MN, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Systemic sclerosis (SSc) is a chronic connective tissue disease affecting the skin and/or internal organs. Data on US economic burden of SSc is scant…

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