Abstracts tagged "Systemic sclerosis"

Abstract Number: 1645 • 2019 ACR/ARP Annual Meeting
Comparison of Automated Capture and Analysis System of Sublingual Microvessels and Nailfold Videocapillarscopy for Microvascular Assessment in Systemic Sclerosis
Mislav Radic¹, Julie Thomas ² and Tracy Frech ³, ¹University Hospital Split, Split, Croatia, ²University of Utah, Division of Rheumatology, Salt Lake City, UT, ³Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT
Background/Purpose: Similar to nailfold videocapillaroscopy (NVC), automated capture and analysis of sublingual microvessel segments (intravital microscopy) can define vasculopathy, and distinguish systemic sclerosis (SSc) patients…
Abstract Number: 1954 • 2019 ACR/ARP Annual Meeting
Association of Functional (GA)n Microsatellite Polymorphism in the FLI1 Gene with Susceptibility to Human Systemic Sclerosis
Aya Kawasaki¹, Keita Yamashita ², Takashi Matsushita ³, Hiroshi Furukawa ⁴, Yuya Kondo ⁵, Naoko Okiyama ⁶, Shouhei Nagaoka ⁷, Kota Shimada ⁸, Shoji Sugii ⁹, Masao Katayama ¹⁰, Shunsei Hirohata ¹¹, Akira Okamoto ¹², Noriyuki Chiba ¹³, Eiichi Suematsu ¹⁴, Keigo Setoguchi ¹⁵, Kiyoshi Migita ¹⁶, Takayuki Sumida ⁵, Shigeto Tohma ¹⁷, Minoru Hasegawa ¹⁸, Yasuhito Hamaguchi ³, Shinichi Sato ¹⁹, Yasushi Kawaguchi ²⁰, Kazuhiko Takehara ³ and Naoyuki Tsuchiya ¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan, ³Department of Dermatology, Kanazawa University, Kanazawa, Japan, ⁴Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁶Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan, ⁸Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, ⁹Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, Japan, ¹⁰National Hospital Organization Nagoya Medical Center, Nagoya, Japan, ¹¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, ¹²National Hospital Organization HImeji Medical Center, Himeji, Hyogo, Japan, ¹³National Hospital Organization Morioka Medical Center, Morioka, Iwate, Japan, ¹⁴National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, ¹⁵Tokyo Metropolitan Cancer and Infectious Dease Center Komagome Hospital, Tokyo, Tokyo, Japan, ¹⁶Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, ¹⁷National Hospital Organization Tokyo National Hospital, Kiyose, Japan, ¹⁸Department of Dermatology, Fukui University, Fukui, ¹⁹University of Tokyo Graduate School of Medicine, Department of Dermatology, Tokyo, Japan, ²⁰Department of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Susceptibility genes which can account for the characteristic features of systemic sclerosis (SSc) such as fibrosis, vasculopathy and autoimmunity remain to be determined. A…
Abstract Number: 2606 • 2019 ACR/ARP Annual Meeting
Evolution of Systemic Sclerosis-Related Interstitial Lung Disease After Autologous Hematopoietic Stem Cell Transplantation
Jacopo Ciaffi¹, Nina van Leeuwen ², Maaike Boonstra ², Lucia Kroft ³, Anne Schouffoer ³, Maarten Ninaber ², Thomas Huizinga ² and Jeska de Vries-Bouwstra ², ¹Leiden University Medical Center, Bologna, Emilia-Romagna, Italy, ²Leiden University Medical Center, Leiden, Netherlands, ³Leiden University Medical Centre, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Three trials demonstrated the overall superiority of autologous hematopoietic stem cell transplantation (HSCT) compared to pulsed cyclophosphamide (CYC) in SSc. An improvement in forced…
Abstract Number: 717 • 2019 ACR/ARP Annual Meeting
Dental Health in Systemic Sclerosis Patients Risk Factors and Comorbidities
Sabrina Paolino ¹, Francesco Cattelan ², Schenone Carlotta ³, Alberto Sulli ⁴, Andrea Casabella ⁵, Carmen Pizzorni ¹ and Maurizio Cutolo⁶, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic Hospital San Martino, University of Genoa, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, genova, Liguria, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁵1 Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ⁶Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
Background/Purpose: Background: Systemic sclerosis (SSc) is a rare multisystemic autoimmune disease characterized by microvascular damage and progressive fibrosis of skin and internal organs. Global oral health…
Abstract Number: 793 • 2019 ACR/ARP Annual Meeting
Rituximab for Rapidly Progressive Juvenile Systemic Sclerosis: A Proof-of-concept Study in Four Patients
Roberto Dal Pozzolo ¹, Alessandra Meneghel ¹, Biagio Castaldi ¹, Giorgia Martini ¹, Renzo Marcolongo ² and Francesco Zulian³, ¹Dept. of Woman's and Child's Health, University of Padua, Italy, Padua, Italy, ²Clinical Immunology, Dept. of Medicine, University of Padua, Padua, Italy, ³Department of Woman and Child Health, University of Padua, Italy, Padova, Italy
Background/Purpose: Juvenile Systemic Sclerosis (JSSc) is a rare multi-systemic disease characterized by fibrous changes of the skin and internal organs [1]. Patients with “rapidly progressive”…
Abstract Number: 1060 • 2019 ACR/ARP Annual Meeting
The Diversity and Community Metrics of the Esophageal Microbiome of SSc Patients
Monica Espinoza¹, Bhaven Mehta ², Yue Wang ³, Aileen Hoffman ⁴, Kathleen Aren ⁵, Mary Carns ⁶, Noelle Kosarek ², Tammara Wood ³, Monique Hinchcliff ⁷ and Michael Whitfield ⁸, ¹Dartmouth College, Hanover, NH, ²Dartmouth College, Hanover, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Northwestern University, Chicago, ⁵Northwestern.edu, Chicago, ⁶Northwestern University, Hanover, ⁷Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT, ⁸Geisel School of Medicine at Dartmouth College, Biomedical Data Science at Dartmouth College, Hanover
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and inflammation. Multiple organ systems are affected including the skin, gastrointestinal tract, vasculature, and…
Abstract Number: 1647 • 2019 ACR/ARP Annual Meeting
The Collaborative National Quality and Efficacy Registry for Scleroderma: Data Completion Outcomes from a Multicenter United States Cohort Using Guideline-Based Registry Practices
Victoria Shanmugam¹, Tracy Frech ², Virginia Steen ³, Laura Hummers ⁴, Ami Shah ⁵, Elana Bernstein ⁶, Dinesh Khanna ⁷, Jessica Gordon ⁸, Flavia Castelino ⁹, Lorinda Chung ¹⁰, Faye Hant ¹¹, Emily Startup ¹², John VanBuren ¹², Luke Evnin ¹³ and Shervin Assassi ¹⁴, ¹George Washington University, Georgetown, DC, ²Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ³Georgetown University, Washington, D.C., USA, Georgetown, ⁴Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, USA, Baltimore, MD, ⁵Johns Hopkins Hospital, Baltimore, MD, ⁶Division of Rheumatology, Columbia University, New York, NY, ⁷Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ⁸Hospital for Special Surgery, New York, NY, ⁹Harvard University, Boston, MA, ¹⁰Stanford University, Palo Alto, CA, ¹¹Medical University of South Carolina, Charleston, SC, ¹²University of Utah, Salt Lake City, UT, ¹³Scleroderma Research Foundation, San Francisco, CA, ¹⁴Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX
Background/Purpose: The Collaborative National Quality and Efficacy Registry (CONQUER) for Scleroderma is a multicenter US-based longitudinal study of patients with systemic sclerosis (SSc) within 5…
Abstract Number: 2262 • 2019 ACR/ARP Annual Meeting
Evaluation of Illness Perception in Systemic Sclerosis Patients with Pulmonary Involvement
Bruna Giusto Bunjes¹, Percival Degrava Sampaio-Barros ² and Ana Paula Luppino-Assad ³, ¹1- Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Brazil, Sao Paulo, Brazil, ³Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Sao Paulo, Brazil
Background/Purpose: Lung disease is the current leading cause of death and the most common severe complication of systemic sclerosis (SSc), causing a significant adverse impact in quality of…
Abstract Number: 2607 • 2019 ACR/ARP Annual Meeting
Ultrasound Detection of Calcinosis and Correlation with Ulnar Artery Occlusion in Patients with Systemic Sclerosis
Robert Fairchild¹, Melody Chung ¹, Laurel Sharpless ¹, Shufeng Li ² and Lorinda Chung ¹, ¹Stanford University, Palo Alto, CA, ²Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA
Background/Purpose: Systemic Sclerosis (SSc) is a progressive fibrotic and vascular disease affecting multiple organs. Calcinosis cutis in SSc is characterized by calcium deposition in the…
Abstract Number: 718 • 2019 ACR/ARP Annual Meeting
Diagnosing Pulmonary Hypertension Using the Proposed 6th World Symposium on Pulmonary Hypertensions New Definitions
Håvard Fretheim¹, Øyvind Midtvedt ², Torhild Garen ², Arne Kristian Andreassen ², Einar Gude ², Øyvind Molberg ³ and Anna Maria Hoffmann-Vold ⁴, ¹Oslo University Hospital, Oslo, ²Oslo University Hospital, Oslo, Norway, ³University Hospital Oslo, Oslo, Norway, ⁴Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Pre-capillary pulmonary hypertension (PH) is a feared complication in patients with systemic sclerosis (SSc) and is associated with high mortality despite new treatment options.…
Abstract Number: 864 • 2019 ACR/ARP Annual Meeting
Change in Scleroderma Skin Histology Correlates with the Combined Response Index in Systemic Sclerosis (CRISS) in Patients with Early, Diffuse Cutaneous Systemic Sclerosis
Kimberly Showalter¹, Robert Spiera ¹, Dana Orange ², Cynthia Magro ³, Yaxia Zhang ⁴, Jackie Finik ⁵ and Jessica Gordon ¹, ¹Hospital for Special Surgery, New York, NY, ²Rockefeller University, New York, ³Weill Cornell Medicine, New York, ⁴Hospital for Special Surgery, New York, ⁵Hospital for Special Surgery, New York, NY, New York, NY
Background/Purpose: The Combined Response Index in Systemic Sclerosis (CRISS) is a composite outcome measure provisionally endorsed by the American College of Rheumatology for use in…
Abstract Number: 1063 • 2019 ACR/ARP Annual Meeting
Effects of Abatacept on T Regulatory Cells in Early Diffuse Systemic Sclerosis
David Fox¹, Michael Whitfield ², Veronica Berrocal ³, Steven K. Lundy ⁴, Phillip Campbell ⁵, Stephanie Rasmussen ⁵, Ray Ohara ⁶, Alexander Stinson ⁶, Evan Wiewiora ⁷, Cathie Spino ⁷, Erica Bush ⁸, Daniel Furst ⁹, Shiv Pillai ¹⁰ and Dinesh Khanna ¹¹, ¹Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, ²Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hannover, NH, ³Department of Biostatistics, School of Publich Health, University of Michigan, Ann Arbor, MI, ⁴TBD, Seattle, WA, ⁵Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁶Washington University, St. Louis, MO, ⁷Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, ⁸Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁹University of California at Los Angeles, Los Angeles, CA, ¹⁰Ragon Institude of MGH, MIT and Harvard, Charlestown, MA, ¹¹Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor
Background/Purpose: Background: In a randomized controlled trial of abatacept in early diffuse systemic sclerosis (Khanna D, et al ACR 2018), we observed early clinical flares…
Abstract Number: 1648 • 2019 ACR/ARP Annual Meeting
Systemic Sclerosis Auto-antibody Profiles Predict Interstitial Lung Disease Onset but Not Progression
Boyang Zheng¹, Mianbo Wang ², Marvin Fritzler ³, May Choi ³, Murray Baron ⁴ and Marie Hudson ⁵, ¹Jewish General Hospital, McGill University, Montreal, QC, Canada, ²Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, ³Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Jewish General Hospital, McGill University, Montreal, Canada, ⁵Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada
Background/Purpose: Interstitial lung disease (ILD) is frequent manifestation and a leading cause of mortality in systemic sclerosis (SSc). Some SSc-related autoantibodies (aAbs), especially anti-topoisomerase I…
Abstract Number: 2588 • 2019 ACR/ARP Annual Meeting
Myositis-specific and -associated Antibodies in Systemic Sclerosis: Prevalence and Clinical Associations
Amélie Leurs ¹, Sylvain Dubucquoi ¹, François Machuron ¹, Maité Balden ¹, Florence Renaud ¹, Stéphanie Rogeau ¹, Benjamin Lopez ², Marc LAMBERT ³, Sandrine Morell-Dubois ⁴, Hélène Maillard ⁴, Hélène Behal ¹, Eric Hachulla ⁵, David Launay ¹ and Vincent Sobanski¹, ¹CHU Lille, Lille, France, ²Institute of Immunology, CHU Lille, University of Lille, Lille, France, ³Lille University Hospital, Lille, France, ⁴Department of Internal Medicine and Clinical Immunology, CHU Lille, University of Lille, Lille, France, ⁵Dept. of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, Lille, France
Background/Purpose: In systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM), auto-antibodies are used in daily practice as potent biomarkers of clinical phenotypes. This study aimed…
Abstract Number: 2609 • 2019 ACR/ARP Annual Meeting
Anti-angiogenic VEGF-A165b Is Associated with Systemic Sclerosis Peripheral Vasculopathy
Victoria Flower¹, Shaney Barratt ², Darren Hart ³, Amanda Mackenzie ⁴, Jacqueline Shipley ³, Stephen Ward ⁴ and John Pauling ¹, ¹Department of Rheumatology, Royal National Hospital of Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, England, United Kingdom, ²North Bristol NHS Trust, Bristol, England, United Kingdom, ³Department of Clinical Measurement, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Trust, Bath, England, United Kingdom, ⁴Centre for Therapeutic Innovation & Department of Pharmacy and Pharmacology, University of Bath, Bath, England, United Kingdom
Background/Purpose: The anti-angiogenic isoform of Vascular Endothelial Growth Factor-A (VEGF-A165b) has been implicated in Systemic sclerosis (SSc) vasculopathy. High frequency ultrasound (HFUS) is a novel…

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