Abstracts tagged "Systemic sclerosis"

Abstract Number: 1651 • 2019 ACR/ARP Annual Meeting
Multicenter Double-Blind, Proof-of-Concept, Randomized Placebo-Controlled Trial of Riociguat in Systemic Sclerosis-associated Digital Ulcers
Vivek Nagaraja¹, Cathie Spino ¹, Pei-Suen Tsou ¹, Robyn Domsic ², Robert Lafyatis ², Tracy Frech ³, Jessica Gordon ⁴, Virginia Steen ⁵ and Dinesh Khanna ⁶, ¹University of Michigan, Ann Arbor, MI, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ⁴Hospital for Special Surgery, New York, NY, ⁵Georgetown University, Washington, D.C., USA, Georgetown, ⁶Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor
Background/Purpose: The soluble guanylate cyclase stimulator riociguat (RIO) is a vasodilator with efficacy in patients with pulmonary arterial hypertension associated with connective tissue disease. Our…
Abstract Number: 2592 • 2019 ACR/ARP Annual Meeting
Longitudinal Changes in Health-related Quality of Life in Systemic Sclerosis Treated with Autologous Hematopoietic Stem Cell Transplant Compared to Standard of Care
Nancy Maltez¹, Mathieu Puyade ², Pauline Lansiaux ³, Mianbo Wang ⁴, Murray Baron ⁵, Ines Colmegna ⁶, Dominique Farge ⁷ and Marie Hudson ⁸, ¹The Ottawa Hospital, Ottawa, ²CHU de Poitiers Unité d'Hospitalisation d'Aval, Poitiers Cédex, France, ³Institut de Recherche Saint-Louis, Paris, France, ⁴Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, ⁵Jewish General Hospital, McGill University, Montreal, Canada, ⁶McGill University Health Center, Montreal, QC, Canada, ⁷Hôpital Saint-Louis, AP-HP Assistance Publique des Hôpitaux de Paris, Centre de Référence des Maladies Auto-Immunes Systémiques Rares d’Ile-de-France, Filière ‘FAI2R’, Unité de Médecine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Université de Paris, EA 3518, Paris, France; Department of Medicine, McGill University, Montreal, QC, Canada, Paris, France, ⁸Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada
Background/Purpose: In severe, early progressive systemic sclerosis (SSc), autologous hematopoietic stem cell transplantation (AHSCT) allows significant improvements in overall and event free survival. The objectives…
Abstract Number: 2612 • 2019 ACR/ARP Annual Meeting
Minocycline for Refractory Calcinosis in Systemic Sclerosis: A Single-Centre Observational Cohort Study
Carmen Fonseca¹, Voon Ong ² and Christopher Denton ³, ¹UCL Medical School, Royal Free Campus, London, United Kingdom, ²UCL Medical School, Royal Free Campus, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: Calcinosis represents a major challenge for patients with systemic sclerosis (SSc) for which there is no standard therapy. Minocycline has been proposed for treatment…
Abstract Number: 723 • 2019 ACR/ARP Annual Meeting
Diagnosis of Systemic Sclerosis: How and When
Cristina Sobrino¹ and Carlos De la Puente ², ¹Rheumatology Department, Ramón y Cajal University Hospital & IRYCIS, Madrid, Spain, ²Hospital Universitario Ramon y Cajal, Madrid, Spain
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous disease regarding its clinical expression, evolution and forms of presentation. In spite of the lack of a disease…
Abstract Number: 961 • 2019 ACR/ARP Annual Meeting
Microenvironment in Systemic Sclerosis Provides a Protective Niche for Tissue-resident B Cells During B Cell Depletion Therapy with Anti-CD20 Antibody
Ai Kuzumi¹, Ayumi Yoshizaki ¹, Takemichi Fukasawa ¹, Satoshi Ebata ¹, Yoshihide Asano ¹ and Shinichi Sato ¹, ¹University of Tokyo Graduate School of Medicine, Department of Dermatology, Tokyo, Japan
Background/Purpose: B cell depletion therapy with anti-CD20 antibody rituximab has emerged as a potential treatment for systemic sclerosis (SSc). Rituximab, which has been used to…
Abstract Number: 1069 • 2019 ACR/ARP Annual Meeting
CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis
Alisa Mueller¹, Andrea Fava ², Deepak Rao ¹ and Francesco Boin ³, ¹Brigham and Women's Hospital, Boston, MA, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³UCSF, San Francisco, CA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by tissue fibrosis, vascular injury, and autoantibody production. CXCR5+ PD-1+ T follicular helper (Tfh) cells, which…
Abstract Number: 1652 • 2019 ACR/ARP Annual Meeting
Anticentromere Antibody Levels and Isotypes Associate with Disease Severity in Systemic Sclerosis
Nina van Leeuwen¹, Jaap Bakker ¹, Annette Grummels ¹, Corrie Wortel ¹, Suzana Jordan ², Oliver Distler ³, Håvard Fretheim ⁴, Anna Maria Hoffmann-Vold ⁵, Hans Ulrich Scherer ⁶, René Toes ¹, Thomas Huizinga ¹ and Jeska de Vries-Bouwstra ¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁴University Hospital Oslo, Oslo, Norway, ⁵Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands
Background/Purpose: Although some studies suggest a possible association between clinical characteristics and isotypes of anticentromere antibodies (ACA) in patients with systemic sclerosis (SSc), characteristics of…
Abstract Number: 2593 • 2019 ACR/ARP Annual Meeting
Cyclophosphamide for the Treatment of Skin Fibrosis in Systemic Sclerosis: A Systematic Review
Marie Hudson ¹, Nancy Maltez², Catherine Ivory ² and Melissa Demery-Varin ³, ¹Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ²The Ottawa Hospital, Ottawa, ³University of Ottawa, Ottawa
Background/Purpose: Systemic sclerosis (SSc) is a chronic disease characterized by multi-organ involvement. Excess collagen deposition and fibrosis is thought to result from a complex interplay…
Abstract Number: 2614 • 2019 ACR/ARP Annual Meeting
Association of Body Composition in Scleroderma Patients with Disease Activity, Serum Levels of Inflammatory Cytokines and Parameters of Nutrition and Lipid Metabolism
Sabina Oreska¹, Maja Spiritovic ², Petr Cesak ³, Michal Cesak ³, Hana Storkanova ⁴, Hana Smucrova ⁵, Barbora Hermankova ³, Olga Ruzickova ⁴, Herman Mann ¹, Karel Pavelka ¹, Ladislav Senolt ¹, Jiří Vencovský ¹, Radim Becvar ¹ and Michal Tomcik ¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, ²Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague 2, Hlavni mesto Praha, Czech Republic, ³Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Fibrosis of the skin and visceral organs, especially digestive tract, and musculoskeletal involvement in systemic sclerosis (SSc) can have a negative impact on body…
Abstract Number: 725 • 2019 ACR/ARP Annual Meeting
Amniotic Membrane Dressings Provide an Effective Treatment for Systemic Sclerosis Digital Ulcers
Tracy Frech¹, Jan Pierce ², Greg Stoddard ³, Constance McNeill ⁴, Mislav Radic ⁵ and Jo -Anna Reems ⁶, ¹Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ²University of Utah Regenerative Medicine, Salt Lake City, United Kingdom, ³University of Utah Study Design and Biostatics Core, Salt Lake City, UT, ⁴University of Utah Hospitals and Clinics, Salt Lake City, UT, ⁵University Hospital Split, Split, Croatia, ⁶University of Utah Regenerative Medicine, Salt Lake City, UT
Background/Purpose: Systemic sclerosis (SSc)-related digital ulcers are a major burden for patients. The purpose of this study was to assess the effectiveness of amnion membrane…
Abstract Number: 1040 • 2019 ACR/ARP Annual Meeting
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
Walcy Teodoro¹, Ana Paula Velosa ², Zelita Aparecida Queiroz ¹, Lais Araujo ³, Sergio Catanozi ¹, Antonio dos Santos Filho ⁴, Cleonice Bueno ⁴, Margarete Vendramini ⁴, Sandra Moraes Fernezlian ¹, Esmeralda Eher ⁴, Jurandir Tomaz de Miranda ¹, Fernanda Lopes ⁴, Sandra G. Pasoto ⁵, Percival Degrava Sampaio-Barros ⁶ and Vera Luiza Capelozzi ¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ³Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Brazil, Sao Paulo, Brazil
Background/Purpose: A better knowledge of the mechanisms and biomarkers of skin and lung damage in systemic sclerosis (SSc) related fibrosis remain a challenge. Our aim was…
Abstract Number: 1070 • 2019 ACR/ARP Annual Meeting
Cytokine Signatures Differentiate Systemic Sclerosis Patients at High versus Low Risk for Pulmonary Arterial Hypertension
Kathleen Kolstad¹, Avani Khatri ², Michele Donato ³, Sarah Chang ⁴, Shufeng Li ⁵, Virginia Steen ⁶, Paul Utz ⁴, Purvesh Khatri ³ and Lorinda Chung ⁷, ¹Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, ²Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, ³Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto, ⁴Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, ⁵Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁶Georgetown University, Washington, D.C., USA, Georgetown, ⁷Stanford University, Palo Alto, CA
Background/Purpose: Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. Screening algorithms using clinical…
Abstract Number: 1654 • 2019 ACR/ARP Annual Meeting
Esophageal Dilation and Other Clinical Factors Associated with Pulmonary Function Decline in Patients with Systemic Sclerosis
Kimberly Showalter¹, Aileen Hoffmann ², Carrie Richardson ³, Kimberly Koloms ², Gerald Rouleau ², David Aaby ², Julia (Jungwha) Lee ⁴, Jane Dematte ², Rishi Agrawal ², Xiaoping Wu ⁵, Rowland Chang ⁴ and Monique Hinchcliff ⁶, ¹Hospital for Special Surgery, New York, NY, ²Northwestern University Feinberg School of Medicine, Chicago, ³Rush University, Chicago, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵New York Presbyterian/Weill Cornell, New York, ⁶Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT
Background/Purpose: Prior work has shown that Scl-70 positive autoantibody status and baseline c-reactive protein (CRP) are associated with more rapid pulmonary function decline in patients…
Abstract Number: 2596 • 2019 ACR/ARP Annual Meeting
The Contribution of Left Heart Disease in Patients with Systemic Sclerosis-associated Pulmonary Hypertension Having Normal Pulmonary Artery Wedge Pressure
Yoshioki Yamasaki¹, Kanako Suzuki ¹, Keiichi Sakurai ², Yusa Asari ¹, Hidehiro Yamada ³ and Kimito Kawahata ², ¹Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki, Japan, ²Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, ³Center for Rheumatic diseases, Seirei Yokohama Hospital, Kawasaki, Japan
Background/Purpose: Patients with systemic sclerosis (SSc) complicates variety of cardiopulmonary diseases which can result in pulmonary hypertension (PH). The types of PH are usually classified…
Abstract Number: 2618 • 2019 ACR/ARP Annual Meeting
Anti-RNPC-3 Antibodies Are Associated with Nuclear Speckled Immunofluorescence Pattern and Enriched in Triple Negative Systemic Sclerosis Patients
Michael Mahler¹, Fabrece Roup ¹, Chelsea Bentow ¹, Marie Hudson ², Murray Baron ³, May Choi ⁴ and Marvin Fritzler ⁵, ¹Inova Diagnostics, San Diego, CA, ²Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ³Jewish General Hospital, McGill University, Montreal, Canada, ⁴Cumming School of Medicine, University of Calgary, Calgary, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important diagnostic and prognostic role in…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].