Abstracts tagged "Systemic sclerosis"

Abstract Number: 2903 • 2016 ACR/ARHP Annual Meeting
Transition of Nailfold Microangiopathy throughout Different Patterns of Microvascular Damage and Correlations with Organ Involvement in Systemic Sclerosis: A Twelve Year Follow-up
Alberto Sulli¹, Sabrina Paolino¹, Barbara Ruaro¹, Amelia Chiara Trombetta¹, Vanessa Smith², Maurizio Cutolo¹ and Carmen Pizzorni¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ²Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Nailfold capillaroscopy is the validated technique to assess scleroderma microangiopathy, an early and dynamic event that may progress through different patterns of microvascular damage…
Abstract Number: 2915 • 2016 ACR/ARHP Annual Meeting
An Increased Circulating Level of Periostin in Patients with Systemic Sclerosis: Associations with Functional Impairment in Various Affected Organs
Yukie Yamaguchi¹, Yuichiro Shirai², Junya Ono^3,4, Yasushi Kawaguchi⁵, Kenji Izuhara³, Masataka Kuwana² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ⁴Shino-Test Corporation, Sagamihara, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Periostin is one of the matricellular proteins, a class of ECM-related molecules defined by their ability to modulate cell–matrix interactions. Several lines of evidences…
Abstract Number: 818 • 2016 ACR/ARHP Annual Meeting
The Role of Endothelin 1 in Activation of Vascular Smooth Muscle Cells in Systemic Sclerosis; Increased Cell Proliferation and Resistance to Apoptosis Mediated By Endotehlin B Receptors
Shadia Nada¹, Yongqing Wang^1,2, Nezam Altorok¹ and Bashar Kahaleh¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: is overexpressed in SSc as illustrated by elevated circulating levels and increased tissue expression in involved organs. We previously reported vascular smooth muscle…
Abstract Number: 2917 • 2016 ACR/ARHP Annual Meeting
Nailfold Capillaroscopy and Mortality in Systemic Sclerosis
Thais Rohde Pavan, Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Porto Alegre, Brazil
Background/Purpose: To test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). Methods: One hundred and seventy SSc…
Abstract Number: 412 • 2015 ACR/ARHP Annual Meeting
Update on the Juvenile Systemic Sclerosis Inception Cohort Project. Characteristics of the First 50 Patients at First Assessment. Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Staņeviča³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, Riga Stradiņš University, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Immunology & Rheumatology., Hospital de Pediatrìa Garrahan, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Currently just retrospective data exist regarding evolvement of organ involvement. In the previous retrospective studies…
Abstract Number: 413 • 2015 ACR/ARHP Annual Meeting
Is There a Difference in the Presentation of Diffuse and Limited Subtype of Juvenile Systemic Sclerosis in Childhood? Results from the Juvenile Scleroderma Inception Cohort Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Maria M. Katsicas⁴, Maria Teresa Terreri⁵, Ana Paula Sakamoto⁶, Rolando Cimaz⁷, Mikhail Kostik⁸, Tadey Avcin⁹, Maria Jose Santos¹⁰, Monika Moll¹¹, Dana Nemkova¹², Flavio Sztajnbok¹³, Cristina Battagliotti¹⁴, Juergen Brunner¹⁵, Despina Eleftheriou¹⁶, Alberto Sifuentes Giraldo¹⁷, Liora Harel¹⁸, Mahesh Janarthanan¹⁹, Tilmann Kallinich²⁰, Kirsten Minden²¹, Susan Mary Nielsen²², Kathryn S. Torok²³, Yosef Uziel²⁴ and Nicola Helmus²⁵, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, University Childrens Hospital, Riga, Latvia, ⁴Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Buenos Aires, Argentina, ⁵Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁶Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁷Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁸State Pediatric Medical University, Saint-Petersburg, Russia, ⁹University Children's Hospital, Ljubljana, Slovenia, ¹⁰Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹¹Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹²Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹³Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁴Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁵Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁶Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁷Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁸Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ¹⁹Pediatric Rheumatology, Chennai, India, ²⁰Charite, University Medicine Berlin, Berlin, Germany, ²¹Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²²Rigshospitalet, Copenhagen, Denmark, ²³Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁴Meir Medical Center, Kfar Saba, Israel, ²⁵Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Several publications in adults looked at the differences between limited and diffuse subtypes. There is…
Abstract Number: 414 • 2015 ACR/ARHP Annual Meeting
Performance of the Adult Systemic Sclerosis Classification in Juvenile Systemic Sclerosis Patients. Results from the Juvenile Systemic Sclerosis Inception Cohorte Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³University Childrens Hospital, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Hospital de Pediatria, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Pediatric Rheumatology, Anna Meyer Children's Hospital, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Pediatric Rheumatology Division, Adolescent Health Care Unit, Universida de do Estado do Rio de Janeiro., Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Epidemiology, Charite, DRFZ, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: The new adult classifiction criteria (1) for Systemic Sclerosis (SSc) were recently published and the pediatric criteria were published in 2007 (2). None of…
Abstract Number: 824 • 2015 ACR/ARHP Annual Meeting
Familial Risk of Systemic Sclerosis and Co-Aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Ana Valdes³, Shue-Fen Luo⁴, Lai-Chu See⁵, Kuang-Hui Yu⁶, Weiya Zhang⁷ and Michael Doherty⁸, ¹Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memorial Hospital, Tayuan, Taiwan, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ⁴Rheumatology, Chang Gung Memorial Hosp, Taipei, Taiwan, ⁵Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ⁶Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memoria Hospital, Tayuan, Taiwan, ⁷Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁸Academic Rheumatology, City Hospital, Nottingham, United Kingdom
Background/Purpose: To investigate familial aggregation of systemic sclerosis and the relative risks (RRs) of other autoimmune disease in relatives of affected patients. Methods: We identified…
Abstract Number: 827 • 2015 ACR/ARHP Annual Meeting
Reliability of the Quantitative Assessment of Peripheral Blood Perfusion By Laser Speckle Contrast Analysis in a Systemic Sclerosis Cohort
Valérie Lambrecht¹, Maurizio Cutolo², Filip De Keyser³, Saskia Decuman⁴, Barbara Ruaro², Alberto Sulli⁵, Ellen Deschepper⁶ and Vanessa Smith⁷, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, UGent, Ghent, Belgium, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy, ⁶Biostatistics Unit, Biostatistics Unit, Ghent University, Ghent, Belgium, ⁷Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Laser speckle contrast analysis (LASCA) is an innovative technique to quantify peripheral blood perfusion (PBP) over a given area. Quantification of blood flow might…
Abstract Number: 1875 • 2015 ACR/ARHP Annual Meeting
Deep Vein Thrombosis and Pulmonary Embolism in Systemic Sclerois
Nabil Hakami^1,2 and Sindhu R. Johnson³, ¹Rheumatology, Toronto Scleroderma Program,Toronto Western Hospital, Mount Sinai Hospital,, Toronto, ON, Canada, ²King Fahad Central Hospital, Riyad, Saudi Arabia, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada
Background/Purpose: In systemic sclerosis (SSc) vasculopathy causes frequent episodes of reperfusion injury and free radical mediated endothelial dysfunction, which may influence the onset of local…
Abstract Number: 1876 • 2015 ACR/ARHP Annual Meeting
Caveolin 1 Gene Variants May Effect Disease Progression in Systemic Sclerosis Related Interstitial Lung Disease
Sule Yavuz¹, Elena Lopez-Isac², Ahmet Mesut Onat³, Neslihan Yilmaz⁴, Levent Kilic⁵, Ali Akdogan⁵ and Javier Martín⁶, ¹Rheumatology, Istanbul Bilim University, Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey, ²Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Istanbul Bilim University, Faculty of Medicine, Rheumatology Department, Istanbul, Turkey, ⁵Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, ⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: To determine possible association of Cav-1 genetic variants: rs926198, rs959173 and rs9920 with SSc and/or SSc-related ILD progression. Methods: Three Cav-1 single nucleotide polymorphisms…
Abstract Number: 1878 • 2015 ACR/ARHP Annual Meeting
Diagnostic Performance of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis: Results from a Brazilian Validation Cohort
Farley Carvalho¹, Cintia Camargo², Bruna Fernandez¹ and Cristiane Kayser², ¹Universidade Federal de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: New classification criteria for systemic sclerosis (SSc) were proposed by the ACR/EULAR in 2013, due to the low sensitivity of the 1980 ACR classification…
Abstract Number: 1900 • 2015 ACR/ARHP Annual Meeting
Performance of the Detect Protocol for Pulmonary Arterial Detection in Systemic Sclerosis Patients in Clinical Practice
Otto Martin Olivas Vergara¹, Beatriz E. Joven¹, Belen Diaz Anton², Carmen Jiménez², Maria Martin Lopez³, Pilar Escribano² and Patricia E. Carreira^1,2, ¹Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ²Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, ³RHEUMATOLOGY, Hospital Universitario 12 de Octubre, Madrid, Spain
Background/Purpose: To analyze the usefulness of the DETECT protocol (1) for the prediction of pulmonary hypertension (PH) and pulmonary arterial hypertension (PAH) in routine clinical…
Abstract Number: 1921 • 2015 ACR/ARHP Annual Meeting
Role of TLRs in the Abnormal Secretion of CXCL-4 By Plasmacytoid Dendritic Cells of Patients with Systemic Sclerosis
Marie-Dominique Ah Kioon¹, Eliza Pelrine², Robert F. Spiera³, Jessica K. Gordon³ and Franck J. Barrat¹, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder of the connective tissue due to excessive extracellular matrix deposition, leading to fibrosis of the skin and…
Abstract Number: 2975 • 2015 ACR/ARHP Annual Meeting
Induced Sputum Analysis in Systemic Sclerosis Patients
Irena Litinsky¹, Elizabeth Fireman², Ari Polachek¹, Adi Broyde¹, Amir Sharabi¹, Marina Anouk¹, Daphna Paran¹ and Ori Elkayam¹, ¹Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Institute of Pulmonary and Allergic Diseases, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: Induced sputum (IS) is a noninvasive tool, aimed at collecting cellular and soluble materials from lung airways. IS is well accepted by patients, safer…

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