Abstracts tagged "Systemic sclerosis"

Abstract Number: 2685 • 2017 ACR/ARHP Annual Meeting
Sensitivity and Specificity of YKL-40 for the Presence of Pulmonary Arterial Hypertension in Systemic Sclerosis
Tetsuya Furukawa¹, Kiyoshi Matsui², Masayasu Kitano², Yuichi Yokoyama³, Naoto Azuma² and Hajime Sano², ¹Division ofRheumatology Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan, ²Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, ³Division of Rheumatology, Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan
Background/Purpose: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes fibrosis of the skin and organs. The prognosis of this disease is affected…
Abstract Number: 2887 • 2017 ACR/ARHP Annual Meeting
Long-Term Follow-up Report on Japanese Patients with Severe Systemic Sclerosis after Autologous Hematopoietic Stem Cell Transplantation
Hiroyuki Nakamura¹, Shinsuke Yasuda¹, Atsushi Noguchi², Toshio Odani³, Yuichiro Fujieda¹, Masaru Kato¹, Kenji Oku¹, Junichi Sugita⁴, Toshiyuki Bohgaki¹, Tomoyuki Endo⁴, Takanori Teshima⁴ and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ³Third Department of Internal Medicine, Obihiro-Kosei General Hospital, Hokkaido, Japan, ⁴Department of Hematology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Background/Purpose: Systemic sclerosis (SSc) comprises diverse clinical phenotypes with variable disease courses. Some SSc patients take miserable and fatal clinical course due to rapid progressive…
Abstract Number: 832 • 2016 ACR/ARHP Annual Meeting
Defining Skin Ulcers in Systemic Sclerosis: A Systematic Literature Review of Skin Ulcer Definitions and a Preliminary Consensus-Based New SSc Skin Ulcer Definition
Yossra A Suliman¹, Cosimo Bruni², Sindhu R. Johnson³, Emanuela Praino⁴, Mohamed Alemam⁵, Nabeel Borazan⁶, Laura Cometi⁷, Bethany Myers⁸, Dinesh Khanna⁹, Yannick Allanore¹⁰, Murray Baron¹¹, Thomas Krieg¹², Ariane L. Herrick¹³, Suzanne Kafaja¹⁴, Christopher Denton¹⁵, Marco Matucci Cerinic¹⁶ and Daniel E. Furst¹⁷, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ³Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁴DIM, Rheumatology Unit, Bari, Italy, ⁵Clinical Pathology and Laboratory Medicine Department, Assistant Lecturer, Qena, Egypt, ⁶Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁷Division of Rheumatology, Department of Experimental and Clinical Medicine,, Florencei, Italy, ⁸UCLA Louise M. Darling Biomedical Library, Research Informationist, Los Angeles, CA, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Immunogenetics, Cochin Institute, Paris, France, ¹¹Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ¹²Universität zu Köln, Köln, Germany, ¹³Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ¹⁴Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ¹⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ¹⁶Department of BioMedicine, Division of Rheumatology, Transition Unit, University of Florence, Firenze, Italy, ¹⁷University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Skin ulcers in SSc are a major clinical challenge and there are various un-validated definitions of skin ulcers utilized in SSc-related clinical trials. We…
Abstract Number: 840 • 2016 ACR/ARHP Annual Meeting
Time Trends in Incidence and Mortality of Systemic Sclerosis in Denmark from 1995-2011: A Nationwide Cohort Study
Sheraz Butt¹, Charlotte Andersson², Søren Jacobsen³, Gunnar Gislason⁴ and Christian Torp-Pedersen⁵, ¹Department of Medicine, Glostrup Hospital, Glostrup, Denmark, ²Department of Medicine, Glostrup Hospital, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, ⁴Department of Cardiology, Gentofte Hospital, Copenhagen, Denmark, ⁵Aalborg University, Aalborg, Denmark
Time Trends In Incidence And Mortality Of Systemic Sclerosis In Denmark From 1995-2011: A Nationwide Cohort Study Background/Purpose: Epidemiological studies have documented an increasing incidence…
Abstract Number: 1849 • 2016 ACR/ARHP Annual Meeting
Fibroblast Growth Factor 9/ Fibroblast Growth Factor Receptor 3 Signaling Is Upstream of Several Profibrotic Pathways and Induces Fibroblast Activation and Tissue Fibrosis in SSc
Tatjana Mallano¹, Alfiya Distler¹, Clara Dees¹, Jingang Huang², Debomita Chakraborty³, Oliver Distler^4,5, Georg Schett⁶ and Joerg H.W Distler⁷, ¹Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Department of Internal Medicine III, Institute of Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁴Center of Exper Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ⁶Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
FGF9 / FGFR3 signaling is upstream of several profibrotic pathways and induces fibroblast activation and tissue fibrosis in SSc Background/Purpose: Systemic sclerosis (SSc)…
Abstract Number: 1878 • 2016 ACR/ARHP Annual Meeting
Speckle Tracking Echocardiography: A Sensitive Technique for Detecting Early Left Ventricular Dysfunction in Patients with Systemic Sclerosis
Duygu Temiz Karadag¹, Tayfun Sahin², Senem Tekeoglu¹, Ozlem Ozdemir Işik¹, Ayten Yazici³, Fatma Ceyla Eraldemir⁴ and Ayse Cefle¹, ¹Rheumatology, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ²Cardiology, Kocaeli University School of Medicine, Department of Cardiology, Kocaeli, Turkey, ³Umuttepe Yerleşkesi/IZMIT, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ⁴Biochemistry, Kocaeli University School of Medicine, Department of Biochemistry, Kocaeli, Turkey
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular damage and excessive fibrosis in the skin and internal organs. Myocardial fibrosis which contributes…
Abstract Number: 1888 • 2016 ACR/ARHP Annual Meeting
Reliability, Validity, and Sensitivity to Change of the Simplified Duruoz Hand Index in Systemic Sclerosis
Ana Maria Gheorghiu¹, Hermina Gyorfi¹, Razvan Capota¹, Alexandru Matei¹, Raida Oneata¹, Liviu Macovei¹, Mihaela Milicescu¹, Mariana Sasu¹, Mihai Bojinca², Victor Stoica¹ and Carina Mihai¹, ¹Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania, ²Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucuresti, Romania
Background/Purpose: Hand involvement is observed in almost all patients with Systemic Sclerosis (SSc), and is due in various proportions to skin and tendon fibrosis, arthritis…
Abstract Number: 1889 • 2016 ACR/ARHP Annual Meeting
Predictors of Acro-Osteolysis in Systemic Sclerosis
Ashraf Raslan¹ and Vivien Hsu², ¹Medicine, Rutgers-RWJ Medical School, Jersey City, NJ, ²Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Background/Purpose: Acro-osteolysis (AO) is the bony resorption on the distal tufts of the digits, a characteristic radiological finding in Systemic Sclerosis (SSc) with estimated prevalence…
Abstract Number: 1890 • 2016 ACR/ARHP Annual Meeting
Functional Disability and Its Predictors in Systemic Sclerosis: A Study from the Desscipher Project within the European Scleroderma Trials and Research Group
Veronika K. Jaeger¹, Lazlo Czirjak², Veronika Lóránd², Gabriele Valentini³, Serena Vettori⁴, Francesco Del Galdo⁵, Giuseppina Abignano⁶, Oliver Distler⁷, Britta Maurer⁷, Christopher Denton⁸, Svetlana Nihtyanova⁹, Yannick Allanore¹⁰, Jerome Avouac¹¹, Gabriela Riemekasten¹², Elise Siegert¹³, Dörte Huscher¹⁴, Marco Matucci-Cerinic¹⁵, Serena Guiducci¹⁶, Marc Frerix¹⁷, Ingo H. Tarner¹⁸, Beata Garay-Toth¹⁹, Lidiya P. Ananieva²⁰, Franco Cozzi²¹, Sule Yavuz²², Nicolas Hunzelmann²³, Alessandra Vacca²⁴, Tim Schmeiser²⁵, Simona Rednic²⁶, Valeria Riccieri²⁷, Brigitte Krummel-Lorenz²⁸, Armando Gabrielli²⁹, Paloma Garcia De La Peña³⁰, Codrina Ancuta³¹, Ulf Müller-Ladner³², Ulrich A. Walker¹ and on behalf of the DeSScipher Consortium and contributing EUSTAR centres, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ³Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁴Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁹Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, ¹⁰Rheumatology, Paris Descartes University, Paris, France, ¹¹Department of Rheumatology, University of Paris Descartes, Paris, France, ¹²Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany, ¹³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ¹⁴Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ¹⁵Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁶Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁷Department of Rheumatology and Clinical Immunology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁸Rheumatology and Clinical Immunology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁹FESCA, Budapest, Hungary, ²⁰Microcirculation and Inflammation, Research Institute of Rheumatology RAMS, Moscow, Russia, ²¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²²Marmara University Faculty of Medicine, Rheumatology, Istanbul, Turkey, ²³Department of Dermatology, University of Cologne, Cologne, Germany, ²⁴University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, ²⁵Krankenhaus St. Josef, Wuppertal, Germany, ²⁶Rheumatology, Emergency County Clinical Hospital Cluj Napoca, Cluj-Napoca, Romania, ²⁷Cattedra di Reumatologia, Dip Clinica e Terapia Medica, Sapienza Università di Roma, Roma, Italy, ²⁸Rheumatologist, Frankfurt, Germany, ²⁹Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università Politecnica delle Marche, Ancona, Italy, ³⁰Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ³¹G.T.Popa Center for Biomedical Research, Iasi, Romania, ³²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Systemic sclerosis (SSc) can greatly impact the patients’ quality of life due to its multisystem manifestations. The health assessment questionnaire (HAQ) is one of…
Abstract Number: 1891 • 2016 ACR/ARHP Annual Meeting
Excellent Reliability of Semiquantitative Nailfold Capillaroscopy Assessment in a Systemic Sclerosis Cohort – a Pilot Study
Ana Maria Gheorghiu, Raida Oneata, Alina Soare, Rucsandra Dobrota, Liviu Macovei, Mihaela Milicescu, Mariana Sasu, Marilena Gorga, Ioan Ancuta, Mihai Bojinca, Victor Stoica and Carina Mihai, Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania
Background/Purpose: Nailfold capillaroscopy (NFC) is essential in the evaluation and classification of systemic sclerosis (SSc). Semiquantitative capillaroscopy scoring is a promising tool for assessing disease…
Abstract Number: 2014 • 2016 ACR/ARHP Annual Meeting
A Deep Insight into Causes and Predictors of Death in Systemic Sclerosis
Muriel Elhai¹, Christophe Meune², Jerome Avouac¹, Fazia Amrouche³, Eric Hachulla⁴, Alexandra Balbir-Gurman⁵, Gabriela Riemekasten⁶, Paolo Airò⁷, Patricia E. Carreira⁸, Yannick Allanore⁹ and on behalf of EUSTAR co-authors, ¹Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, ²Paris XIII University, Bobigny, France, ³Paris Descartes University, Cochin Hospital, Paris, France, ⁴CHU Lille, Lille, France, ⁵B Shine Department of Rheumatology, Rambam Health Care Campus,. Rappaport Faculty of Medicine, Technion, Haifa, Israel, ⁶Department of Rheumatology, University of Luebeck, Lübeck, Germany, ⁷Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, ⁸Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, ⁹Immunogenetics, Cochin Institute, Paris, France
Background/Purpose : Systemic sclerosis (SSc), a connective tissue disease, is associated with high mortality rates. The main causes and risk factors for death are…
Abstract Number: 2893 • 2016 ACR/ARHP Annual Meeting
Usefulness of the Eustar Preliminary Criteria for Vey Early Systemic Sclerosis and Le Roy Criteria for Early-Systemic Sclerosis in Identifying Patients at Risk of Development of Systemic Sclerosis
Francisco Miguel Ortiz-Sanjuán¹, Jose Ivorra Cortes², Luis Gonzalez Puig², Inmaculada Chalmeta Verdejo², Elena Grau Garcia^2,3, Carlos Feced Olmos², Eztizen Labrador Sanchez², Karla Arevalo Ruales², Rosa Negueroles Albuixech², Jorge Fragio Gil², Isabel Martinez Cordellat², Jose Luis Valero Sanz², Cristina Alcañiz Escandell^2,3, Carmen Najera Herranz², Gema Poveda Marin^2,3 and Jose Andres Roman², ¹Department of Rheumatology, Hospital Universitario y Politecnico La Fe, Santander, Spain, ²Department of Rheumatology, Hospital Universitario y Politecnico La Fe, Valencia, Spain, ³IIS La Fe, Valencia, Spain
Background/Purpose: In our study, over the half of the patients initially classified as Early-SSc progressed to SSc during follow-up. EUSTAR preliminary criteria were more frequent…
Abstract Number: 2897 • 2016 ACR/ARHP Annual Meeting
Microvascular Function in Systemic Sclerosis Patients with End-Stage Vascular Manifestations of the Disease
Tracy M. Frech¹, Phillip E. Gates², Daniel Machin³ and Anthony Donato⁴, ¹Division of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ⁴University of Utah and Salt lake Veterans Affair Medical Center, Salt Lake City, UT
Background/Purpose: Vasculopathy is a prominent feature of systemic sclerosis (SSc, scleroderma) and is involved in end-stage manifestations such as pulmonary arterial hypertension (PAH), digital ulcer…
Abstract Number: 2900 • 2016 ACR/ARHP Annual Meeting
The Incidence and Prevalence of Systemic Sclerosis in Northwestern Part of Turkey
Omer Nuri Pamuk¹, Mehmet Ali Balci², Salim Donmez³ and Gulsum Emel Pamuk⁴, ¹Rheumatology, Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, Edirne, Turkey, ²Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ³PsART study group, Ankara, Turkey, ⁴Hematology, Trakya University Medical Faculty, Edirne, Turkey
Background/Purpose: Systemic sclerosis (SSc) is a multisystem, chronic, autoimmune disease. In this hospital based study, we aimed to evaluate the prevalence and incidence of SSc…
Abstract Number: 2901 • 2016 ACR/ARHP Annual Meeting
SSc and the Significance of Blood Group Antigens
Zsuzsanna Fabianne¹ and Annica Nordin², ¹Rheumatology, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology, Karolinska University Hospital Solna, Stockholm, Sweden
Background/Purpose : Systemic sclerosis (SSc) is a rare disease, with a mean incidence 3.8 cases, prevalence 99 per million in Sweden. The two most important…

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