Abstracts tagged "Systemic sclerosis"

Abstract Number: 2685 • 2017 ACR/ARHP Annual Meeting
Sensitivity and Specificity of YKL-40 for the Presence of Pulmonary Arterial Hypertension in Systemic Sclerosis
Tetsuya Furukawa¹, Kiyoshi Matsui², Masayasu Kitano², Yuichi Yokoyama³, Naoto Azuma² and Hajime Sano², ¹Division ofRheumatology Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan, ²Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, ³Division of Rheumatology, Department of internal medicine, Hyogo College of Medicine, Nishinomiya, Japan
Background/Purpose: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes fibrosis of the skin and organs. The prognosis of this disease is affected…
Abstract Number: 2887 • 2017 ACR/ARHP Annual Meeting
Long-Term Follow-up Report on Japanese Patients with Severe Systemic Sclerosis after Autologous Hematopoietic Stem Cell Transplantation
Hiroyuki Nakamura¹, Shinsuke Yasuda¹, Atsushi Noguchi², Toshio Odani³, Yuichiro Fujieda¹, Masaru Kato¹, Kenji Oku¹, Junichi Sugita⁴, Toshiyuki Bohgaki¹, Tomoyuki Endo⁴, Takanori Teshima⁴ and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ³Third Department of Internal Medicine, Obihiro-Kosei General Hospital, Hokkaido, Japan, ⁴Department of Hematology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Background/Purpose: Systemic sclerosis (SSc) comprises diverse clinical phenotypes with variable disease courses. Some SSc patients take miserable and fatal clinical course due to rapid progressive…
Abstract Number: 2901 • 2016 ACR/ARHP Annual Meeting
SSc and the Significance of Blood Group Antigens
Zsuzsanna Fabianne¹ and Annica Nordin², ¹Rheumatology, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology, Karolinska University Hospital Solna, Stockholm, Sweden
Background/Purpose : Systemic sclerosis (SSc) is a rare disease, with a mean incidence 3.8 cases, prevalence 99 per million in Sweden. The two most important…
Abstract Number: 2903 • 2016 ACR/ARHP Annual Meeting
Transition of Nailfold Microangiopathy throughout Different Patterns of Microvascular Damage and Correlations with Organ Involvement in Systemic Sclerosis: A Twelve Year Follow-up
Alberto Sulli¹, Sabrina Paolino¹, Barbara Ruaro¹, Amelia Chiara Trombetta¹, Vanessa Smith², Maurizio Cutolo¹ and Carmen Pizzorni¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ²Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Nailfold capillaroscopy is the validated technique to assess scleroderma microangiopathy, an early and dynamic event that may progress through different patterns of microvascular damage…
Abstract Number: 2915 • 2016 ACR/ARHP Annual Meeting
An Increased Circulating Level of Periostin in Patients with Systemic Sclerosis: Associations with Functional Impairment in Various Affected Organs
Yukie Yamaguchi¹, Yuichiro Shirai², Junya Ono^3,4, Yasushi Kawaguchi⁵, Kenji Izuhara³, Masataka Kuwana² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ⁴Shino-Test Corporation, Sagamihara, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Periostin is one of the matricellular proteins, a class of ECM-related molecules defined by their ability to modulate cell–matrix interactions. Several lines of evidences…
Abstract Number: 818 • 2016 ACR/ARHP Annual Meeting
The Role of Endothelin 1 in Activation of Vascular Smooth Muscle Cells in Systemic Sclerosis; Increased Cell Proliferation and Resistance to Apoptosis Mediated By Endotehlin B Receptors
Shadia Nada¹, Yongqing Wang^1,2, Nezam Altorok¹ and Bashar Kahaleh¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: is overexpressed in SSc as illustrated by elevated circulating levels and increased tissue expression in involved organs. We previously reported vascular smooth muscle…
Abstract Number: 2917 • 2016 ACR/ARHP Annual Meeting
Nailfold Capillaroscopy and Mortality in Systemic Sclerosis
Thais Rohde Pavan, Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Rheumatology Service at the Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre – RS, Brazil., Porto Alegre, Brazil
Background/Purpose: To test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). Methods: One hundred and seventy SSc…
Abstract Number: 832 • 2016 ACR/ARHP Annual Meeting
Defining Skin Ulcers in Systemic Sclerosis: A Systematic Literature Review of Skin Ulcer Definitions and a Preliminary Consensus-Based New SSc Skin Ulcer Definition
Yossra A Suliman¹, Cosimo Bruni², Sindhu R. Johnson³, Emanuela Praino⁴, Mohamed Alemam⁵, Nabeel Borazan⁶, Laura Cometi⁷, Bethany Myers⁸, Dinesh Khanna⁹, Yannick Allanore¹⁰, Murray Baron¹¹, Thomas Krieg¹², Ariane L. Herrick¹³, Suzanne Kafaja¹⁴, Christopher Denton¹⁵, Marco Matucci Cerinic¹⁶ and Daniel E. Furst¹⁷, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ³Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁴DIM, Rheumatology Unit, Bari, Italy, ⁵Clinical Pathology and Laboratory Medicine Department, Assistant Lecturer, Qena, Egypt, ⁶Medicine, David Geffen School of Medicine, Los Angeles, CA, ⁷Division of Rheumatology, Department of Experimental and Clinical Medicine,, Florencei, Italy, ⁸UCLA Louise M. Darling Biomedical Library, Research Informationist, Los Angeles, CA, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Immunogenetics, Cochin Institute, Paris, France, ¹¹Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ¹²Universität zu Köln, Köln, Germany, ¹³Centre for Musculoskeletal Research, University of Manchester, MAHSC, Salford Royal Hospital, Manchester, United Kingdom, ¹⁴Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ¹⁵Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ¹⁶Department of BioMedicine, Division of Rheumatology, Transition Unit, University of Florence, Firenze, Italy, ¹⁷University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Skin ulcers in SSc are a major clinical challenge and there are various un-validated definitions of skin ulcers utilized in SSc-related clinical trials. We…
Abstract Number: 840 • 2016 ACR/ARHP Annual Meeting
Time Trends in Incidence and Mortality of Systemic Sclerosis in Denmark from 1995-2011: A Nationwide Cohort Study
Sheraz Butt¹, Charlotte Andersson², Søren Jacobsen³, Gunnar Gislason⁴ and Christian Torp-Pedersen⁵, ¹Department of Medicine, Glostrup Hospital, Glostrup, Denmark, ²Department of Medicine, Glostrup Hospital, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, ⁴Department of Cardiology, Gentofte Hospital, Copenhagen, Denmark, ⁵Aalborg University, Aalborg, Denmark
Time Trends In Incidence And Mortality Of Systemic Sclerosis In Denmark From 1995-2011: A Nationwide Cohort Study Background/Purpose: Epidemiological studies have documented an increasing incidence…
Abstract Number: 1849 • 2016 ACR/ARHP Annual Meeting
Fibroblast Growth Factor 9/ Fibroblast Growth Factor Receptor 3 Signaling Is Upstream of Several Profibrotic Pathways and Induces Fibroblast Activation and Tissue Fibrosis in SSc
Tatjana Mallano¹, Alfiya Distler¹, Clara Dees¹, Jingang Huang², Debomita Chakraborty³, Oliver Distler^4,5, Georg Schett⁶ and Joerg H.W Distler⁷, ¹Department of Internal Medicine III, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Department of Internal Medicine III, Institute of Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁴Center of Exper Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ⁶Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
FGF9 / FGFR3 signaling is upstream of several profibrotic pathways and induces fibroblast activation and tissue fibrosis in SSc Background/Purpose: Systemic sclerosis (SSc)…
Abstract Number: 1878 • 2016 ACR/ARHP Annual Meeting
Speckle Tracking Echocardiography: A Sensitive Technique for Detecting Early Left Ventricular Dysfunction in Patients with Systemic Sclerosis
Duygu Temiz Karadag¹, Tayfun Sahin², Senem Tekeoglu¹, Ozlem Ozdemir Işik¹, Ayten Yazici³, Fatma Ceyla Eraldemir⁴ and Ayse Cefle¹, ¹Rheumatology, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ²Cardiology, Kocaeli University School of Medicine, Department of Cardiology, Kocaeli, Turkey, ³Umuttepe Yerleşkesi/IZMIT, Kocaeli University School of Medicine, Department of Rheumatology, Kocaeli, Turkey, ⁴Biochemistry, Kocaeli University School of Medicine, Department of Biochemistry, Kocaeli, Turkey
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular damage and excessive fibrosis in the skin and internal organs. Myocardial fibrosis which contributes…
Abstract Number: 1888 • 2016 ACR/ARHP Annual Meeting
Reliability, Validity, and Sensitivity to Change of the Simplified Duruoz Hand Index in Systemic Sclerosis
Ana Maria Gheorghiu¹, Hermina Gyorfi¹, Razvan Capota¹, Alexandru Matei¹, Raida Oneata¹, Liviu Macovei¹, Mihaela Milicescu¹, Mariana Sasu¹, Mihai Bojinca², Victor Stoica¹ and Carina Mihai¹, ¹Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania, ²Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucuresti, Romania
Background/Purpose: Hand involvement is observed in almost all patients with Systemic Sclerosis (SSc), and is due in various proportions to skin and tendon fibrosis, arthritis…
Abstract Number: 1889 • 2016 ACR/ARHP Annual Meeting
Predictors of Acro-Osteolysis in Systemic Sclerosis
Ashraf Raslan¹ and Vivien Hsu², ¹Medicine, Rutgers-RWJ Medical School, Jersey City, NJ, ²Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ
Background/Purpose: Acro-osteolysis (AO) is the bony resorption on the distal tufts of the digits, a characteristic radiological finding in Systemic Sclerosis (SSc) with estimated prevalence…
Abstract Number: 1890 • 2016 ACR/ARHP Annual Meeting
Functional Disability and Its Predictors in Systemic Sclerosis: A Study from the Desscipher Project within the European Scleroderma Trials and Research Group
Veronika K. Jaeger¹, Lazlo Czirjak², Veronika Lóránd², Gabriele Valentini³, Serena Vettori⁴, Francesco Del Galdo⁵, Giuseppina Abignano⁶, Oliver Distler⁷, Britta Maurer⁷, Christopher Denton⁸, Svetlana Nihtyanova⁹, Yannick Allanore¹⁰, Jerome Avouac¹¹, Gabriela Riemekasten¹², Elise Siegert¹³, Dörte Huscher¹⁴, Marco Matucci-Cerinic¹⁵, Serena Guiducci¹⁶, Marc Frerix¹⁷, Ingo H. Tarner¹⁸, Beata Garay-Toth¹⁹, Lidiya P. Ananieva²⁰, Franco Cozzi²¹, Sule Yavuz²², Nicolas Hunzelmann²³, Alessandra Vacca²⁴, Tim Schmeiser²⁵, Simona Rednic²⁶, Valeria Riccieri²⁷, Brigitte Krummel-Lorenz²⁸, Armando Gabrielli²⁹, Paloma Garcia De La Peña³⁰, Codrina Ancuta³¹, Ulf Müller-Ladner³², Ulrich A. Walker¹ and on behalf of the DeSScipher Consortium and contributing EUSTAR centres, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ³Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁴Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁹Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Hospital, London, United Kingdom, ¹⁰Rheumatology, Paris Descartes University, Paris, France, ¹¹Department of Rheumatology, University of Paris Descartes, Paris, France, ¹²Department of Rheumatology, Universitatsklinikum Schleswig-Holstein, Lubeck, Germany, ¹³Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ¹⁴Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ¹⁵Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁶Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹⁷Department of Rheumatology and Clinical Immunology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁸Rheumatology and Clinical Immunology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁹FESCA, Budapest, Hungary, ²⁰Microcirculation and Inflammation, Research Institute of Rheumatology RAMS, Moscow, Russia, ²¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²²Marmara University Faculty of Medicine, Rheumatology, Istanbul, Turkey, ²³Department of Dermatology, University of Cologne, Cologne, Germany, ²⁴University Hospital of Cagliari, Rheumatology Unit, Monserrato, Italy, ²⁵Krankenhaus St. Josef, Wuppertal, Germany, ²⁶Rheumatology, Emergency County Clinical Hospital Cluj Napoca, Cluj-Napoca, Romania, ²⁷Cattedra di Reumatologia, Dip Clinica e Terapia Medica, Sapienza Università di Roma, Roma, Italy, ²⁸Rheumatologist, Frankfurt, Germany, ²⁹Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Università Politecnica delle Marche, Ancona, Italy, ³⁰Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ³¹G.T.Popa Center for Biomedical Research, Iasi, Romania, ³²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Systemic sclerosis (SSc) can greatly impact the patients’ quality of life due to its multisystem manifestations. The health assessment questionnaire (HAQ) is one of…
Abstract Number: 1891 • 2016 ACR/ARHP Annual Meeting
Excellent Reliability of Semiquantitative Nailfold Capillaroscopy Assessment in a Systemic Sclerosis Cohort – a Pilot Study
Ana Maria Gheorghiu, Raida Oneata, Alina Soare, Rucsandra Dobrota, Liviu Macovei, Mihaela Milicescu, Mariana Sasu, Marilena Gorga, Ioan Ancuta, Mihai Bojinca, Victor Stoica and Carina Mihai, Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology Department, Cantacuzino Clinical Hospital, Bucharest, Romania
Background/Purpose: Nailfold capillaroscopy (NFC) is essential in the evaluation and classification of systemic sclerosis (SSc). Semiquantitative capillaroscopy scoring is a promising tool for assessing disease…

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