ACR Meeting Abstracts

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Abstracts tagged "Systemic sclerosis"

  • Abstract Number: 708 • 2019 ACR/ARP Annual Meeting

    Improvement and Stabilization of Lung Function in Patients with SSc-ILD Treated with Nintedanib vs Placebo in a Randomized, Placebo-Controlled Phase III Trial: Proportions of Patients with FVC Changes Using Cutoffs Previously Proposed to Define Minimally Clinically Important Differences

    Yannick Allanore1, Dinesh Khanna 2, Elizabeth Volkmann 3, Christian Stock 4, Martina Gahlemann 5, Nils Schoof 6, Oliver Distler 7 and Toby Maher 8, 1Dept. of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, Paris, France, 2Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 4Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 5Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, 6Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, 7Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 8National Heart and Lung Institute, Imperial College London, UK and National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK, London, United Kingdom

    Background/Purpose: Mean change in forced vital capacity percent predicted (FVC %pred) is a common endpoint in the assessment of treatment-related outcomes in patients with interstitial…
  • Abstract Number: 735 • 2019 ACR/ARP Annual Meeting

    The Relationship Between Gastrointestinal Symptoms and Severity and Whole Gut Transit in Patients with Systemic Sclerosis

    Zsuzsanna McMahan* 1, Ana Tucker*2, Jamie Perin 3, Jay Pasricha 4, Harvey Ziessman 5, Antony Rosen 1 and Frederick Wigley 1, 1Johns Hopkins University, Division of Rheumatology, Baltimore, 2Johns Hopkins Bayview Medical Center, Baltimore, MD, 3Johns Hopkins University School of Public Health, Department of International Health, Baltimore, 4Johns Hopkins University, Division of Gastroenterology, Baltimore, 5Johns Hopkins University, Division of Radiology, Baltimore

    Background/Purpose: The gastrointestinal (GI) tract is the most commonly affected internal organ system in systemic sclerosis (SSc), resulting in significant morbidity and mortality. Several studies…
  • Abstract Number: 1048 • 2019 ACR/ARP Annual Meeting

    Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis

    Takashi Maehara 1, Cory Perugino2, Naoki Kaneko 1, Hamid Mattoo 3, Jesper Kers 4, Hugues Allard-Chamard 5, Vinay Mahajan 5, Hang Liu 5, Samuel Murphy 5, Musie Ghebremichael 5, Yesim Tuncay 5, Emanuel Della Torre 6, Lloyd Liang 2, Sydney Montesi 7, Zachary Wallace 2, David Fox 8, Robert Lafyatis 9, John Stone 10, Dinesh Khanna 11 and Shiv Pillai 12, 1Kyushu University, Fukuoka, Japan, 2Massachusetts General Hospital, Boston, 3Sanofi, Cambridge, 4University of Amsterdam, Amsterdam, Netherlands, 5Ragon Institute of MGH, MTI and Harvard, Cambridge, 6Hospital San Raffaele, milan, Italy, 7Massachusetts General Hospital, Boston, MA, 8University of Michigan, Ann Arbor, 9University of Pittsburgh, Pittsburgh, PA, 10Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 11Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 12Ragon Institude of MGH, MIT and Harvard, Charlestown, MA

    Background/Purpose: The CD4+ T cell subset driving the pathogenesis of systemic sclerosis (SSc) remains poorly understood. Many different CD4+ T cell subsets have been implicated,…
  • Abstract Number: 1632 • 2019 ACR/ARP Annual Meeting

    Evidence-based Consensus Statements for the Identification and Management of Interstitial Lung Disease in Systemic Sclerosis

    Anna-Maria Hoffmann-Vold1, Toby M. Maher 2, Edward E. Philpot 3, Ali Ashrafzadeh 4 and Oliver Distler 5, 1Dept. of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 2National Heart and Lung Institute, Imperial College London; Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK, London, United Kingdom, 3Respiratory Center of Excellence, IQVIA, Durham, NC, USA, Durham, NC, 4Rheumatology Center of Excellence, IQVIA, San Diego, CA, USA, San Diego, CA, 5Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Guidelines are needed to aid early recognition and treatment of interstitial lung disease in systemic sclerosis (SSc-ILD). This study was conducted to develop expert…
  • Abstract Number: 1660 • 2019 ACR/ARP Annual Meeting

    Serial Sublingual Videomicroscopy in Systemic Sclerosis Clinic: Are the Microcirculation Measurements Correlated with Gastrointestinal Symptoms?

    Tracy Frech1, Guo Wei 2 and Maureen Murtaugh 3, 1Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT, 3University of Utah and Salt Lake VAMC, Salt Lake City

    Background/Purpose: Intravital microscopy of the sublingual microcirculation provides estimates of perfused barrier region (PBR) and red blood cell fraction (RBCfract), which quantifies vasculopathy and, similar…
  • Abstract Number: 2601 • 2019 ACR/ARP Annual Meeting

    Trabecular Bone Score and Malnutrition in a Cohort of Systemic Sclerosis Patients

    Massimo Patane' 1, Sabrina Paolino 1, Veronica Tomatis 2, Andrea Casabella 3, Carmen Pizzorni 1, Luca Carmisciano 4, Alessio Signori 4 and Maurizio Cutolo5, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic Hospital San Martino, University of Genoa, Genoa, Italy.2Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy, genova, Liguria, Italy, 31 Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 4Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by microvascular damage, immune system activation and progressive fibrosis of the skin and internal organs.…
  • Abstract Number: 2913 • 2019 ACR/ARP Annual Meeting

    Serum Interferon Score Predicts Clinical Outcome at 12 Months in Diffuse Cutaneous Systemic Sclerosis as Measured by Global Ranked Composite Score (GRCS) and Composite Response Index in SSc (CRISS)

    Antonio Carriero 1, Giuseppina Abignano 2, MIchelle Hutchinson 3, Karri Ballard 4 and Francesco Del Galdo5, 1University of Leeds, Leeds, England, United Kingdom, 23Rheumatology Institute of Lucania (IReL) and University of Leeds, Leeds, United Kingdom, 3University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, England, United Kingdom, 4Myriad RBM, austin, TX, 5University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a highly heterogeneous disease orphan of effective disease modifying agents. The diffuse cutaneous clinical subset (dcSSc) is currently targeted in…
  • Abstract Number: 709 • 2019 ACR/ARP Annual Meeting

    Structural Abnormalities of the Optic Nerve Head and Retinal Nerve Fiber Layer Using Optical Coherence Tomography in Patients with Systemic Sclerosis

    Cecilia Agapito Tito1, Izabela Almeida 2, Elise Taniguchi 2, Juliana Silvatti 2, Tiago Prata 2, Augusto Paranhos 2 and CRISTIANE KAYSER 1, 1Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2Universidade Federal de Sao Paulo, sao paulo, Brazil

    Background/Purpose: Vascular dysfunction, characterized by vasospasm and endothelial activation, represents a central and early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve…
  • Abstract Number: 736 • 2019 ACR/ARP Annual Meeting

    Reduced Circulating Levels of Inorganic Pyrophosphate Are Associated with Ectopic Calcification in Scleroderma Spectrum Disorders

    Vivien Hsu1, Naomi Schlesinger 2, Qiaoli Li 3 and John Varga 4, 1Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, 2Rutgers Health- RWJ Medical School, New Brunswick, NJ, 3Thomas Jefferson University, Philadelphia, PA, 4Northwestern University, Chicago,, IL

    Background/Purpose: Calcinosis cutis due to ectopic mineralization is a common and disabling complication of systemic sclerosis (SSc) that has poorly understood pathogenesis and no effective…
  • Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting

    Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis

    Peter Allen1, Jena Wirth 2, Nathan Wilson 2, Jim Oates 3, Melissa Cunningham 2, Devin Absher 4 and Paula Ramos 2, 1University of Alabama at Birmingham, Birmingham, AL, 2Medical University of South Carolina, Charleston, 3Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, 4HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
  • Abstract Number: 1633 • 2019 ACR/ARP Annual Meeting

    Relationship Between YKL-40, VEGF, and IL-5 in Borderline mPAP and Pulmonary Hypertension in Systemic Sclerosis

    Tetsuya Furukawa1, Yuichi Yokoyama 2, Teppei Hashimoto 3, Naoto Azuma 4 and Kiyoshi Matsui 4, 1Hyogo College of Medicine, Nishinomiya, Japan, 2Hyogo College of Medicine, Kyoto, Japan, 3Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Hyogo, Japan, 4Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Background/Purpose: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis, and its prognosis is affected by pulmonary hypertension (PH).…
  • Abstract Number: 1830 • 2019 ACR/ARP Annual Meeting

    Short- and Long-term Morbidity and Mortality Outcomes of African American Patients with Systemic Sclerosis-Related Interstitial Lung Disease

    Elizabeth Volkmann1, Virginia Steen 2, Ning Li 3, Michael Roth 4, Philip Clements 3, Dinesh Khanna 5, Daniel Furst 6, Shervin Assassi 7, Grace Kim 3, Jonathan Goldin 3, Robert Elashoff 3 and Donald Tashkin 3, 1University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 2Georgetown University, Washington, D.C., USA, Georgetown, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 4University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 5Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 6University of California, Los Angeles, CA, 7Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX

    Background/Purpose: Observational studies have demonstrated that African American (AA) patients with systemic sclerosis (SSc) have a more unfavorable prognosis compared with non-AA. However, no studies…
  • Abstract Number: 2602 • 2019 ACR/ARP Annual Meeting

    Changes in Fecal Microbiota Composition After Fecal Microbiota Transplantation in Systemic Sclerosis

    Anna Maria Hoffmann-Vold1, Håvard Fretheim 2, Brian Chung 3, Henriette Didriksen 3, Espen Bækkevold 3, Øyvind Midtvedt 3, Cathrine Brunborg 3, Kristian Holm 3, Anders Tennøe 3, Torhild Garen 3, Tore Midtvedt 4, Marius Trøseid 3, Johannes Hov 3, Knut Lundin 3 and Øyvind Molberg 2, 1Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 2University Hospital Oslo, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway, 4Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: In the double-blind, placebo-controlled 16-week pilot including 10 systemic sclerosis (SSc) patients with upper and lower gastrointestinal (GI) symptoms we found that fecal microbiota…
  • Abstract Number: 2914 • 2019 ACR/ARP Annual Meeting

    Predictors to Develop Definite Systemic Sclerosis (SSc): Results from an International Multicentre Study on Very Early DiagnOsis of Systemic Sclerosis (VEDOSS)

    Silvia Bellando-Randone1, Gemma Lepri 1, Dorte Huscher 2, Tunde Minier 3, Serena Guiducci 4, Cosimo Bruni 1, Laszlo Czirjak 3, Maurizio Cutolo 5, Vanessa Smith 6, Jerome Avouac 7, Daniel Furst 8, Yannick Allanore 7, Oliver Distler 9 and Marco Matucci-Cerinic 10, 1Dept. Experimental and Clinical Medicine, Division of Rheumatology, Azienda Ospedaliera Universitaria Careggi – University of Florence, Florence, Italy, 2Charitè-Universitaetsmedizin Berlin, Berlin, Germany, 3University of Pecs, Pecs, Hungary, 4Dept. of Clinical and Experimental Medicine, Section of Rheumatology, University of Florence, Italy, Florence, Italy, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, 6Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium, 7Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, 8University of California, Los Angeles, CA, 9Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 10University of Florence, Department of Medicine, Florence, Italy, Florence, Italy

    Background/Purpose: The very early diagnosis of SSc is a challenge today. The aim of the VEDOSS project was to study in an at-risk population, the…
  • Abstract Number: 711 • 2019 ACR/ARP Annual Meeting

    Ultrasound Evaluation of the Hands in Patients with Systemic Sclerosis: Osteophytosis Is a Major Contributor to Tender Joints

    Robert Fairchild1, Melody Chung 1, Laurel Sharpless 1, Shufeng Li 2, Jison Hong 1, Khushboo Sheth 1 and Lorinda Chung 1, 1Stanford University, Palo Alto, CA, 2Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA

    Background/Purpose: Systemic Sclerosis (SSc) is a progressive fibrotic and vascular disease with peripheral manifestations including arthritis, tendinopathy, sclerodactyly, contractures, calcinosis, acroosteolysis, and vascular disease which…
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