Abstracts tagged "Systemic sclerosis"

Abstract Number: 2159 • ACR Convergence 2022
Gastroesophageal Reflux Disease in an Australian Scleroderma Cohort – Associations and Effect of Treatment
Alannah Quinlivan¹, Dennis Neuen², Dylan Hansen³, Wendy Stevens³, Laura Ross⁴, Nava Ferdowsi³, Susanna Proudman⁵, Jenny Walker⁶, Jo Sahhar⁷, Gene-Siew Ngian⁸, Diane Apostolopoulos⁹, Lauren Host¹⁰, Gabor Major¹¹, Kathleen Morrisroe³ and Mandana Nikpour¹², ¹St Vincent's Hospital Melbourne and the University of Melbourne, Melbourne, Australia, ²Liverpool Hospital, Sydney, Australia, ³St Vincent's Hospital Melbourne, Melbourne, Australia, ⁴The University of Melbourne at St. Vincent's Hospital, Brunswick, Australia, ⁵University of Adelaide, Medindie, Australia, ⁶Flinders Medical Centre, Flinders University, Daw Park, Australia, ⁷Monash Health, Melbourne, Australia, ⁸Melbourne Health, Northcote, Australia, ⁹Monash University, Melbourne, Australia, ¹⁰Fiona Stanley Hospital, London, United Kingdom, ¹¹Hunter New England Health Service, Rankin Park - Newcastle, New South Wales, Australia, ¹²The University of Melbourne at St. Vincent's Hospital Melbourne, Melbourne, Australia
Background/Purpose: To investigate the association between gastroesophageal reflux disease (GORD) and interstitial lung disease (ILD) and determine the effect of GORD treatment on survival in…
Abstract Number: 0516 • ACR Convergence 2022
Identifying Current Assessment and Treatment Strategies in Juvenile Systemic Sclerosis: An International Effort to Improve Patient Outcomes
Natalia Vasquez Canizares¹, Clare Pain², Marinka Twilt³, Amra Adrovic Yildiz⁴, Simone Appenzeller⁵, Edoardo Marrani⁶, Emanuela Del Giudice⁷, Antonella Petaccia⁸, Francesca Tirelli⁹, Gabriele Simonini¹⁰, Marco Cattalini¹¹, Ozgur Kasapcopur¹², Raju Khubchandani¹³, Kathryn Torok¹⁴, Betul Sozeri¹⁵, Biagio Castaldi¹⁶, Katherine Clarke¹⁷, Phuoc Duong¹⁷, Aybuke Gunalp¹⁸, meiping lu¹⁹, Hanna Lythgoe², Amanda Robinson¹⁴, Lauren Robinson²⁰, Paulo Rogerio Julio²¹, Susan Shenoi²², Emily Willis²³, Mustafa Çakan¹⁵, Valentina Leone²⁴, Rongjun Zheng¹⁹, Phillip Lawrence¹⁷, Franziska Rosser²⁵, Sarah Mayell², Lusine Ambartsumyan²⁶, Aurelia Minuti²⁷, Francesco Zulian²⁸ and Suzanne Li²⁹, ¹Children's Hospital at Montefiore/ Albert Einstein College of Medicine, New York, NY, ²Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom, ³Alberta Children's Hospital, Calgary, AB, Canada, ⁴School of Medicine, KOC University, Istanbul, Turkey, ⁵Unicamp, Campinas, São Paulo, Brazil, ⁶AOU Meyer, Florence, Italy, ⁷Sapienza University of Rome, Pediatric and Neonatology Unit, Maternal and Child Department, Rome, Italy, ⁸Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, ⁹Women's and Child's Health, University Hospital of Padova, Padova, Italy, ¹⁰Meyer Children's Hospital, Florence, Italy, ¹¹Pediatric Clinic, University of Brescia, Brescia, Italy, ¹²Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey, ¹³SRCC Children's Hospital, Mumbai, India, ¹⁴Pediatric Rheumatology, Children's Hospital of UPMC, Pittsburgh, PA, ¹⁵University of Health Sciences, Istanbul, Turkey, ¹⁶Women's and Child's Health, University Hospital of Padova, Padua, Italy, ¹⁷Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ¹⁸Istanbul University Cerrahpaşa Medical School, Istanbul, Turkey, ¹⁹Children’s Hospital of Zhejiang University Medical School, Zhejiang, China, ²⁰Hospital for Special Surgery, New York, NY, ²¹University of Campinas, Campinas, São Paulo, Brazil, ²²Seattle Children's Hospital and Research Center / University of Washington, Seattle, WA, ²³Royal Manchester Children’s Hospital, Manchester, United Kingdom, ²⁴Ismett, UPMC, Palermo, Italy, ²⁵University of Pittsburgh, Children’s Hospital of UPMC, Pittsburgh, PA, ²⁶Seattle Children's Hospital, University of Washington, Seattle, WA, ²⁷D. Samuel Gottesman Library Research and Education, Albert Einstein College of Medicine, Bronx, NY, ²⁸University of Padua, Padua, Italy, ²⁹Hackensack Meridian School of Medicine, Joseph M. Sanzari Children's Hospital, West Orange, NJ
Background/Purpose: Juvenile Systemic Sclerosis (jSSc) is an autoimmune and fibrosing disease associated with significant morbidity and mortality risk. Data on treatment is limited and based…
Abstract Number: 1063 • ACR Convergence 2022
Assessment of Calcinosis in Portuguese Patients with Systemic Sclerosis – a Multicenter Study
Beatriz Samões¹, Diogo Fonseca¹, Tiago Beirão¹, Flavio Costa¹, Romana Vieira¹, Georgina Terroso², Raquel Ferreira², Rafaela teixeira³, André Saraiva⁴, Maria João Henriques⁵, Ana Catarina Duarte⁶, Ana Cristina Cordeiro⁶, Paulo Vilas-Boas⁷, Inês Genrinho³, Ana Bento da Silva⁸, Laura Gago⁸, Catarina Resende⁹, Patricia Martins⁹, Nathalie Madeira¹⁰, Sara Paiva Dinis¹⁰, Maura Couto³, Inês Santos³, Filipe Araújo¹¹, Ana Filipa Mourão¹¹, Miguel Guerra¹², Margarida Oliveira¹², Alexandra Daniel¹³, Marília Rodrigues¹³, Catarina Soares¹⁴, Hugo Parente¹⁵, Carolina Furtado¹⁶, Tomás Fontes¹⁶ and Joana Abelha-Aleixo¹, ¹Rheumatology Department, Centro Hospitalar de Vila Nova de Gaia / Espinho, Vila Nova de Gaia, Portugal, ²Rheumatology department, Centro Hospitalar Universitário de São João, Porto, Portugal, ³Rheumatology department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, ⁴Rheumatology department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ⁵Rheumatology department, Centro Hospitalar e Universitário de Coimbra, Lisboa, Portugal, ⁶Rheumatology department, Hospital Garcia de Orta, Almada, Portugal, ⁷Rheumatology Department, Centro Hospitalar Baixo Vouga, Aveiro, Portugal, ⁸Rheumatology department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal, ⁹Rheumatology department, Centro Hospitalar e Universitário de Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisboa, Portugal, ¹⁰Rheumatology department, Unidade Local de Saúde da Guarda - Hospital Sousa Martins, Guarda, Portugal, ¹¹Rheumatology and Osteoporosis Unit, Hospital de Sant´Ana, SCML, Lisboa, Portugal, ¹²Rheumatology Department, Centro Hospitalar Universitário da Cova da Beira, Covilhã, Portugal, ¹³Rheumatology department, Hospital Distrital de Leiria, Leiria, Portugal, ¹⁴Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Viana do Castelo, Portugal, ¹⁵Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal, ¹⁶Rheumatology department, Hospital do Divino Espírito Santo, Ponta Delgada, Portugal
Background/Purpose: Calcinosis is a challenging problem among Systemic Sclerosis (SSc) patients with a reported prevalence of 18-49%. We aim to define the prevalence of clinical…
Abstract Number: 1185 • ACR Convergence 2022
Interleukin-11 Promotes Fibrosis Through Classic and Trans-signaling Pathway in Systemic Sclerosis
Wenjing Ye¹, Qian Wang¹, Li Zhao², Changcheng Wang³, Dandan Zhang⁴, Mengyu Zhou⁴, Fangfang Chen², Zaihua Zhu², Weiguo Wang², Wenyu Guo⁵, Yun Liu⁴, Hejian Zou² and Yu Xue², ¹epartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ²Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ³Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China, ⁴MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China, ⁵Clinical Development, I-Mab Biopharma (Hangzhou) Co., Ltd, Shanghai, China
Background/Purpose: Interleukin-11 (IL-11) was found significantly upregulated in Systemic sclerosis (SSc), the aim of this study is to explore the pathological role of IL-11 and…
Abstract Number: 1540 • ACR Convergence 2022
Correlations of Soluble Interleukin-2 Receptor Serum Levels with Markers of Inflammation and Pathological High-sensitivity Troponin T and Its Possible Role as a Predictor of Early Clinical Progress in Systemic Sclerosis
Luise Schumacher¹, Sebastian Klapa², Antje Mueller³ and Gabriela Riemekasten⁴, ¹University of Lübeck, Lübeck, Germany, ²Universityhospital Schleswig-Holstein; University of Lübeck; Clinic of Rheumatology and Clinical Immunology, Luebeck, Germany, ³University Hospital Schleswig-Holstein (UKSH), Lübeck, ⁴University Clinic Schleswit-Holstein (UKSH), Luebeck, Germany
Background/Purpose: Systemic sclerosis (SSc) is characterized by chronic inflammation leading to damage of the vascular endothelium and excessive collagen deposition in several target organs. The…
Abstract Number: 2167 • ACR Convergence 2022
Autoantibodies in Patients with Early Systemic Sclerosis in the Collaborative National Quality and Efficacy Registry
Alyssa Bosso¹, Shervin Assassi², Tracy Frech³, Jessica Gordon⁴, Elana Bernstein⁵, Carrie Richardson⁶, Nora Sandorfi⁷, Laura Hummers⁸, Ami Shah⁹, Dinesh Khanna¹⁰, Lorinda Chung¹¹, Flavia Castelino¹², Faye Hant¹³, Victoria Shanmugam¹⁴, John VanBuren¹⁵, Angela Larkin¹⁶, Luke Evnin¹⁷ and Virginia Steen¹⁸, ¹Medstar Georgetown University Hospital, Washington, DC, ²McGovern Medical School, University of Texas, Houston, TX, ³Vanderbilt University Medical Center, Nashville, TN, ⁴Hospital for Special Surgery, New York, NY, ⁵Columbia University, New York, NY, ⁶Northwestern University, Riverside, IL, ⁷University of Pennsylvania, Philadelphia, PA, ⁸Johns Hopkins Univerisity, Baltimore, MD, ⁹Johns Hopkins Rheumatology, Baltimore, MD, ¹⁰Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, ¹¹Stanford University, Stanford, CA, ¹²Massachusetts General Hospital, Boston, MA, ¹³Medical University of South Carolina, Charleston, SC, ¹⁴George Washington University, Great Falls, VA, ¹⁵University of Utah, Salt Lake City, UT, ¹⁶University of Utah Health, Salt Lake City, UT, ¹⁷Scleroderma Research Foundation, Brisbane, CA, ¹⁸Georgetown University School of Medicine, Washington, DC
Background/Purpose: We sought to describe the autoantibody profile of SSc patients with early disease and examine the clinical, laboratory and prognostic features associated with these…
Abstract Number: 0518 • ACR Convergence 2022
Changes in Skin Fibroblast Polarization Gene Expression Herald Clinical Improvement in Early, Diffuse Cutaneous Systemic Sclerosis
Kimberly Showalter Lakin¹, Deanna Jannat-Khah, DrPH, MSPH¹, Yajas Shah², Olivier Elemento², Aliza Bloostein¹, Jessica Gordon¹, Michael Whitfield³, Barbara White⁴, Dana Orange⁵ and Robert Spiera¹, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH, ⁴Corbus Pharmaceuticals, Pleasanton, CA, ⁵The Rockefeller University, New York, NY
Background/Purpose: We previously identified a group of genes associated with high alpha-smooth muscle actin (aSMA) and low CD34 fibroblast staining in lesional systemic sclerosis (SSc)…
Abstract Number: 1066 • ACR Convergence 2022
Capillaroscopic Findings in Autoimmune Connective Tissue Diseases: Results from 20 Years of Experience in a Training Referral Center
Elvis Hysa, Carmen Pizzorni, Silvia Sammori, Emanuele Gotelli, Andrea Pogna, andrea cere, Carlotta Schenone, Veronica Gerli, sabrina Paolino, Alberto Sulli and Maurizio Cutolo, Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genova, Italy
Background/Purpose: Nailfold videocapillaroscopy (NVC) allows the safe and fast detection of different microvascular patterns in patients affected by autoimmune connective tissue diseases (CTDs). The prevalence of…
Abstract Number: 1191 • ACR Convergence 2022
The Risk of Major Adverse Cardiovascular Events in Patients with Systemic Sclerosis: A Population-Based, Matched Cohort Study
HSIN-HUA CHEN¹ and Tsai-Hung Yen², ¹Taichung Veterans General Hospital, Taichung, Taiwan, ²Division of General Medicine, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan
Background/Purpose: The pathologic hallmarks of systemic sclerosis (SSc) included a non-inflammatory obliterative vasculopathy affecting small arteries and arterioles in multiple vascular beds. Whether macrovascular involvement…
Abstract Number: 1541 • ACR Convergence 2022
MRI Digital Artery Volume Index (DAVIX) Predicts Future Digital Ulcers and Disease Progression in Systemic Sclerosis
Michael Hughes¹, Stefano Di Donato², Klodian Gjeloshi³, Giuseppina Abignano⁴, Fiammetta Danzo³, Giovanni Lettieri G⁴, Enrico De Lorenzis², Dominic Bertham⁵, Philip O’Connor², Olga Kubassova⁶ and Francesco Del Galdo², ¹Department of Rheumatology, Tameside and Glossop Integrated Care NHS Foundation Trust & The University of Manchester, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health and NIHR Biomedical Research Centre, University of Leeds, Leeds, United Kingdom, ³University of Campania ‘‘Luigi Vanvitelli’’, Napoli, Italy, ⁴Istituto Reumatologico Lucano (IReL), Azienda Ospedaliera Regionale San Carlo, Potenza, Italy, ⁵NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁶Image Analysis Group, London, United Kingdom
Background/Purpose: Fibroproliferative vasculopathy in systemic sclerosis (SSc) is caused by neointima proliferation is a key pathologic feature of SSc which results in arterial vessel narrowing…
Abstract Number: 2168 • ACR Convergence 2022
A Novel Pharmaco-Interventional Approach for the Treatment of Refractory Digital Ischemia in Systemic Sclerosis – Percutaneous Revascularization Combined with Intravenous Vasodilatory Therapy
Lily Romero Karam¹, Kevin Honan¹, Salman Arain¹ and Maureen Mayes², ¹University of Texas Health Science Center at Houston, Houston, TX, ²Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX
Background/Purpose: The combination of Raynaud´s Phenomenon (RP) and vasculopathy, characterized by intimal proliferation and fibrosis, endothelial dysfunction, and smooth-muscle activation, can lead to severe digital…
Abstract Number: 0519 • ACR Convergence 2022
Myeloablation Followed by Hematopoietic Stem Cell Transplantation Leads to Long-term Normalization of Systemic Sclerosis Molecular Signatures
Nancy Wareing¹, Xuan Wang², Lynette Keyes-Elstein³, Ellen Goldmuntz⁴, Marka Lyons⁵, Peter McSweeney⁶, Daniel Furst⁷, Richard Nash⁶, Leslie Crofford⁸, Beverly Welch⁹, Ashley Pinckney¹⁰, Maureen Mayes¹¹, Keith Sullivan¹² and Shervin Assassi¹³, ¹UTHealth Houston McGovern Medical School, Houston, TX, ²Baylor Institute for Immunology Research, Dallas, TX, ³Rho, Chapel Hill, NC, ⁴NIAID/ NIH, Washington, DC, ⁵University of Texas McGovern Medical School at Houston, Houston, TX, ⁶Colorado Blood Cancer Institute, Denver, CO, ⁷University of California Los Angeles, Los Angeles, CA, ⁸Vanderbilt University Medical Center, Nashville, TN, ⁹NIAID/NIH, Bethesda, MD, ¹⁰Rho, St. Louis Park, MN, ¹¹Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, ¹²Duke University, Durham, NC, ¹³McGovern Medical School, University of Texas, Houston, TX
Background/Purpose: In the randomized Scleroderma: Cyclophosphamide Or Transplantation (SCOT trial), normalization of systemic sclerosis (SSc) peripheral blood gene expression signatures at the 26-month visit was…
Abstract Number: 1070 • ACR Convergence 2022
Discordance of Patient, Physician and Nurse Practitioner Assessment of Disease Burden in Systemic Sclerosis
Maylen Nordgård Carstens¹, Håvard Fretheim¹, Imon Barua¹, Henriette Didriksen², Torhild Garen¹, Øyvind Midtvedt¹, Øyvind Molberg³ and Anna-Maria Hoffmann-Vold¹, ¹Oslo University Hospital, Oslo, Norway, ²Oslo University Hospital, Moss, Norway, ³Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Assessment of disease burden is crucial in the management of systemic sclerosis (SSc). The patient global assessment (PatGA) is a patient self-reported measure widely…
Abstract Number: 1231 • ACR Convergence 2022
[68Ga]- CPCR4 Trifluoroacetate PET/CT Imaging of Chemokine Receptor CXCR4- Expression in Systemic Sclerosis Related Interstitial Lung Disease
Chirag Rajkumar Kopp¹, Shefali Sharma², Venkata Subramanian Krishnaraju³, Chandra Bhushan Prasad³, Jagdeep Singh³, Shashi Anand³, Ranjana Minz³, Ashwani Sood³, Anindita Sinha³, Rajender Kumar Basher³, Sahajal Dhooria³, Varun Dhir⁴ and sanjay jain³, ¹Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²PGIMER< Chandigarh, Chandigarh, India, ³Postgraduate Institute of Medical Education and Research, Chandigarh, India, ⁴PGIMER, CHD, INDIA, Chandigarh, India
Background/Purpose: Interstitial lung disease (ILD) in Systemic sclerosis (SSc) is a major contributor of morbidity and mortality. CXCR4/CXCL12 axis has been implicated in the pathogenesis…
Abstract Number: 1542 • ACR Convergence 2022
Exploratory Clinical Subgroup Clustering in Systemic Sclerosis – Results from the Indian Progressive Systemic Sclerosis Registry
Shery Susan Philip¹, Ramya Janardana¹, Revanesh S Mirji¹, Chengappa Kavadichanda², Devender Bairwa³, Geetabali Sircar⁴, Parasar Ghosh⁵, Anupam Wakhlu⁶, Padmanabha Shenoy⁷, Sumithra Selvam⁸ and Vineeta Shobha¹, ¹St. John’s Medical College Hospital, Bangalore, India, ²JIPMER, Pondicherry, Puducherry, India, ³Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Puducherry, India, ⁴Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India, ⁵Govt of West Bengal, Kolkata, India, Kolkata, West Bengal, India, ⁶Apollo Medics Super Speciality Hospitals, Lucknow, India, ⁷Centre for Arthritis and Rheumatism Excellence (CARE), Cochi, India, ⁸Division of Epidemiology and Biostatistics, St. John’s Research Institute, St. John's Medical College Hospital, Bangalore, India
Background/Purpose: Classification of systemic sclerosis (SSc) into subsets has been a challenge due to it's heterogeneity. This study attempts to identify SSc subsets based on…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].