ACR Meeting Abstracts

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Abstracts tagged "Systemic sclerosis"

  • Abstract Number: 0653 • ACR Convergence 2023

    Association Between Systemic Sclerosis and Increased Risk of Ischemic Stroke: A Meta-Analysis

    Christina Flourou1, Andreas Liampas1 and Konstantinos Parperis2, 1Nicosia General Hospital, Nicosia, Cyprus, 2University of Cyprus Medical School, Nicosia, Cyprus

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune rheumatic disease characterized by significant vascular abnormalities due to microvascular damage and intimal proliferation in the small arterioles.…
  • Abstract Number: 0787 • ACR Convergence 2023

    Understanding Distinct Resident and Migratory Fibroblast Populations in Systemic Sclerosis Skin Through Single-cell RNAseq and Immunohistochemistry

    Kristina Clark1, Shiwen Xu2, Voon Ong3, Christopher Buckley4 and Christopher Denton2, 1Barts Health NHS Trust, London, United Kingdom, 2University College London, London, United Kingdom, 3UCL Medical School Royal Free Campus, London, United Kingdom, 4University of Oxford, Oxford, United Kingdom

    Background/Purpose: We previously described distinct migratory and resident fibroblast populations from lesional skin biopsies in SSc patients. Both populations are profibrotic compared with those from…
  • Abstract Number: 0948 • ACR Convergence 2023

    Nintedanib Alters Fibroblast and Macrophage Diversity in a 3D Skin Model of Systemic Sclerosis (SSc)

    Noelle Kosarek1, Tamar Abel2, Sasha Shenk3, Tammara Wood2, Jonathan Garlick4, Patricia Pioli5 and Michael Whitfield5, 1Dartmouth Geisel School of Medicine, Lebanon, NH, 2Dartmouth College, Hanover, NH, 3Tufts University, Boston, MA, 4Tufts University School of Dental Medicine, Boston, MA, 5Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Systemic Sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and internal organs. While the tyrosine kinase inhibitor Nintedanib is…
  • Abstract Number: 1515 • ACR Convergence 2023

    Performance of the Revised CRISS in a Phase 3 Trial of Early Systemic Sclerosis

    Dinesh Khanna1, Christopher Denton2, Masataka Kuwana3, Daniel Furst4, Suiyuan Huang1, Barbara White5 and Robert Spiera6, 1University of Michigan, Ann Arbor, MI, 2University College London, London, United Kingdom, 3Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 4University of California Los Angeles, Los Angeles, CA, 5SFJ Pharmaceuticals, Towson, MD, 6Hosptial for Special Surgery, New York, NY

    Background/Purpose: Revised CRISS has been proposed an approvable outcome measure in early diffuse cutaneous SSc (dcSSc)1. The index is undergoing the FDA review as part…
  • Abstract Number: 1668 • ACR Convergence 2023

    Cell Specific Molecular Profiling of Scleroderma Associated Interstitial Lung Disease Subtypes

    Monica Yang1, Fred Deiter1, Emily Flynn1, Jessica Neely1, Seoyeon Lee2, John Greenland1, Marina Sirota3 and Paul Wolters1, 1University of California San Francisco, San Francisco, CA, 2Yale University School of Medicine, New Haven, CT, 3Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA

    Background/Purpose: Interstitial lung disease (ILD) is present in up to 90% of patients with systemic sclerosis (SSc) and the leading cause of SSc-related mortality. SSc-ILD…
  • Abstract Number: 2361 • ACR Convergence 2023

    Optimal Combination of Circulating Biomarkers for Predicting the Progression of Interstitial Lung Disease in Patients with Systemic Sclerosis

    Keina Yomono1, Dinesh Khanna2 and Masataka Kuwana3, 1Nippon Medical School University, Tokyo, Japan, 2University of Michigan, Ann Arbor, MI, 3Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: In patients with systemic sclerosis (SSc), progression of interstitial lung disease (ILD) is associated with an increased mortality. Since the course of SSc-ILD is…
  • Abstract Number: 0614 • ACR Convergence 2023

    Self-Reported Sexual Dysfunction and Perceptions of Rheumatologist Engagement on This Issue in Patients with Systemic Sclerosis

    Liza Morales1, Robert Spiera2, Jessica Gordon1, Deanna Jannat-Khah1 and Kimberly Lakin1, 1Hospital for Special Surgery, New York, NY, 2Hosptial for Special Surgery, New York, NY

    Background/Purpose: Few studies have investigated the prevalence and risk factors of sexual dysfunction among individuals with systemic sclerosis (SSc). The purpose of this study is…
  • Abstract Number: 0632 • ACR Convergence 2023

    A Longitudinal Analysis of Mouth Opening in 1101 Systemic Sclerosis Patients from the French National Cohort Study

    Benjamin Chaigne1, Alexandre Bense2, Christian AGARD3, Yannick ALLANORE4, Gregory Pugnet5, Eric Hachulla6, Jérôme Avouac7, Boris Bienvenu8, Sylvain Palat9, Claire Grange10, Sabine Berthier11, Emmanuel Chatelus12, sebastien riviere11, Marie-Elise Truchetet13, Jean-Emmanuel Kahn14, Francois Maurier15, elisabeth diot16, Alice Berezne11 and Luc Mouthon17, 1Paris Cité University, Paris, France, 2APHP, Paris, France, 3Internal medicine, Nantes University Hospital, Nantes, France, 4Université Paris Cité, Paris, France, 5CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France, 6University of Lille, Lille, France, 7Service de Rhumatologie, Hôpital Cochin, AP-HP.Centre – Université Paris Cité, Paris, France, 8Saint Joseph Hospital, Marseille, France, 9...., Paris, France, 10..., Paris, France, 11Internal Medicine - Cochin University Hospital, Paris, France, 12Internal Medicine - Cochin University Hospital, Strasbourg, France, 13Bordeaux University Hospital, Bordeaux, France, 14AP-HP, Suresnes Cedex, France, 15Hôpitaux privés de Metz, Vaux / Frankreich, France, 16Internal Medicine - Cochin University Hospital, Tours, France, 17Hopital Cochin - Paris University, Paris, France

    Background/Purpose: Few studies have evaluated mouth opening (MO) in systemic sclerosis (SSc). None have studied MO trajectories.Methods: We performed a multicentre study patients enrolled in…
  • Abstract Number: 0655 • ACR Convergence 2023

    A Novel Association Between Lipodermatosclerosis and Key Vascular Outcomes in Systemic Sclerosis

    Srijana Davuluri1, Puneet Kapoor2, Swarna Nandyala2, David Fiorentino3, Julia Simard4 and Lorinda Chung5, 1Stanford University- School of Medicine, Sunnyvale, CA, 2Stanford University- School of Medicine, Palo Alto, CA, 3Department of Dermatology, Stanford University, Redwood City, CA, 4Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, 5Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA

    Background/Purpose: Lipodermatosclerosis (LDS) is a progressive manifestation of chronic venous insufficiency characterized by distinctive lower extremity changes, including an "inverted champagne bottle" appearance, skin hyperpigmentation,…
  • Abstract Number: 0788 • ACR Convergence 2023

    Whole Exome Sequencing and Evolutionary Action Missense Mutation Analysis Identifies MICB as a New SSc Susceptibility Locus and the Interferon Pathway as Contributors to SSc Pathogenesis

    Shamika Ketkar1, Hongzheng Dai1, Brian Dawson1, Lindsay Burrage1, David Murdock1, Jennifer Asmussen1, Kevin Wilhelm1, Olivier Lichtarge1, Martin Kerick2, Javier Martin3, Shervin Assassi4, Brendan Lee1 and Maureen Mayes5, 1Baylor College of Medicine, Houston, TX, 2Spanish National Research Council, Granada, Spain, 3Instituto de Parasitologia y Biomedicina Lopez-Neyra - CSIC, Granada, Spain, 4University of Texas McGovern Medical School at Houston, Houston, TX, 5Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by fibrosis of the skin and internal organs associated with vasculopathy and autoantibodies and exhibiting wide clinical heterogeneity. Contributors…
  • Abstract Number: 0949 • ACR Convergence 2023

    Development of Interstitial Pneumonia with Autoimmune Features in Conditional Tgfb3 Deletion

    Toshihiko Komai1, Tomohisa Okamura2, Masanori Kono1, Kazuhiko Yamamoto3 and Keishi Fujio1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo and Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo and Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

    Background/Purpose: We found that TGF-β3 regulates humoral immunity in a context-dependent manner [1]. Recent genome-wide association study reveals that TGF-β3 might be a novel target…
  • Abstract Number: 1517 • ACR Convergence 2023

    Comparing Deep Neural Network to Modified Rodnan Skin Score in a Trial for Belumosudil in Systemic Sclerosis Patients

    Baran Gunes1, Lucy Duran Camacho1, Shawn Cowper2, Gauri Panse2, Elizabeth Bundschuh3, Alyssa Williams4, Nicolas Page5, Mary Karns6, Kathleen Aren6, Niki Pradhan7, Elana Bernstein8, Sarah Fantus9, Elizabeth Volkmann10, Heather Bukiri10, Chase Correia11, Francis Wilson1, Seamus Mawe12, J. Matthew Mahoney13, Monique Hinchcliff14 and Rui Wang15, 1Yale University School of Medicine, New Haven, CT, 2Yale School of Medicine - Dermatopathology, New Haven, CT, 3Yale University School of Medicine, New York, NY, 4Yale University School of Medicine, Winchester, MA, 5Yale University School of Medicine, Salem, CT, 6Northwestern University Division of Rheumatology, Chicago, IL, 7Columbia University Irving Medical Center, New York, NY, 8Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 9Kansas City Physician Partners- Center for Rheumatic Disease, Kansas City, MO, 10University of California Los Angeles, Los Angeles, CA, 11Riverside Medical Group, Hampton, VA, 12The Jackson Laboratory, Bar Harbor, ME, 13Jackson Laboratory, Bar Harbor, ME, 14Yale School of Medicine, Westport, CT, 15Sanofi, Cambridge, MA

    Background/Purpose: We previously published a proof-of-principle study demonstrating the potential utility of computer vision (Deep Neural Network/DNN) methods applied to stained skin biopsy sections from…
  • Abstract Number: 1699 • ACR Convergence 2023

    Immunosuppression with Targeted Therapies Reduces Morbidity and Mortality in Pre-Capillary Pulmonary Hypertension Associated with Systemic Sclerosis: A EUSTAR Analysis

    Cosimo Bruni1, Havard Fretheim2, Lorenzo Tofani3, Yannick Weber1, Eric Hachulla4, Patricia Carreira5, Dilia Giuggioli6, Paolo Airò7, Elise Siegert8, Ulf Müller-Ladner9, marco Matucci Cerinic10, Gabriela Riemekasten11, Carmen Pilar Simeon-Aznar12, Jeska de Vries-Bouwstra13, Lesley Ann Saketkoo14, Joerg Distler15, Alexandra Balbir-Gurman16, Ivan Castellvi17, Elisabetta Zanatta18, Vanessa Smith19, Christopher Denton20, Britta Maurer21, Alessandro Giollo18, Florenzo Iannone22, Lorenzo Dagna23, Marie-Elise Truchetet24, Masataka Kuwana25, Yannick ALLANORE26, Yoshiya Tanaka27, Mickael Martin28, Edoardo Rosato29, Ana Maria Gheorghiu30, Francesco Del Galdo31, Kamal Solanki32, Alessandra Vacca33, CATARINA RESENDE34, SUSANA VIEIRA35, Laszlo Czirjak36, Marko Barisic37, Francesco Paolo Cantatore38, valeria Riccieri39, Kristofer Andréasson40, Lorinda Chung41, Carolina Muller42, Daniela OPRIS-BELINSKI43, Simona Rednic44, Petros Sfikakis45, Yair Levy46, Anna Maria Hoffmann-Vold47, Oliver Distler1, Vivien Hsu48, Stefan Heitmann49, Gianluca Moroncini50, Michele Iudici51, Joerg Henes52, Ellen De Langhe53, Ariane Herrick54 and Carlomaurizio Montecucco55, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Oslo University Hospital, Oslo, Norway, 3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy, 4University of Lille, Lille, France, 5Hospital Universitario 12 de Octubre, Madrid, Spain, 6Scleroderma Unit, Rheumatology Unit, University Hospital of Modena and Reggio Emilia, Modena, Italy, 7Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, 8Department of Rheumatology, Charité University Hospital, Charité Platz 1, D-10117, Berlin, Germany, 9Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 10Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, 11University Clinic Schleswit-Holstein (UKSH), Lübeck, Germany, 12Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitario Vall d'Hebronh, Barcelona, Spain, 13Leiden University Medical Center, Leiden, Netherlands, 14University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 15Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, 16Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, 17Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, 18Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Padua, Italy, 19Ghent University Hospital, Gent, Belgium, 20University College London, London, United Kingdom, 21University Hospital Bern, University Bern, Bern, Switzerland, 22Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, 23Ospedale San Raffaele, Milano, Italy, 24Bordeaux University Hospital, Bordeaux, France, 25Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 26Université Paris Cité, Paris, France, 27University of Occupational and Environmental Health, Kitakyushu, Japan, 28Department of Internal Medicine, INSERM U1313, Poitiers University, Poitiers University Hospital, Poitiers, France, 29Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy, 30Department of Internal Medicine and Rheumatology, Ion Cantacuzino Clinical Hospital, Bucharest, Romania, 31University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom, 32Department of Rheumatology, Te Whatu Ora Health New Zealand Waikato, Hamilton, New Zealand, 33II Chair of Rheumatology, University of Cagliari-Policlinico Universitario, Monserrato, Italy, 34Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Lisboa, Portugal, 35Hospital Fernando Fonseca, Lisbon, Portugal, 36Dept. Rheumatol Immunol, Medical School, university of Pecs, Pecs, Hungary, 37Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia, 38Rheumatology Clinic – Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy, 39Department of Clinical, Internal and Cardiovascular Specialities, Sapienza University of Rome, Roma, Italy, 40Lund University, Lund, Sweden, 41Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 42Federal University of Parana, CURITIBA / PR, Brazil, 43Saint Mary Hospital, Bucharest, Romania, 44Prof Dr Simona Rednic, Cluj, Romania, 45National Kapodistrian University of Athens Medical School, Athens, Greece, 46Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 47Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 48Rutgers-RWJ Medical School, South Plainfield, NJ, 49Department of Rheumatology, Marienhospital Stuttgart, Böheimstrasse 37, D-70199, Stuttgart, Germany, 50Marche Polytechnic University, Ancona, Italy, 51Division of Rheumatology, Department of Internal Medicine Specialties, Geneva University Hospitals, Geneva, Switzerland, 52University Hospital Tuebingen, Tuebingen, Germany, 53Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium, 54University of Manchester, Salford, United Kingdom, 55Unità Operativa e Cattedra di Reumatologia, IRCCS Policlinico S Matteo, Pavia, Italy

    Background/Purpose: Systemic sclerosis (SSc) associated pre-capillary pulmonary hypertension (precapPH) is a severe condition that requires prompt treatment. Although immunosuppressants (IMS) are standard of care for…
  • Abstract Number: 2362 • ACR Convergence 2023

    Identification of Protein Biomarkers Associated with the Severity and Risk of Progression of Interstitial Lung Disease in VEDOSS and Established Systemic Sclerosis Patients

    Thierry Sornasse1, Vishal Kakkar2, Rebecca Ross3, Sunhwa Kim4 and Francesco Del Galdo5, 1AbbVie, Inc., North Chicago, IL, 2University of Leeds, Leeds, United Kingdom, 3Medicine and Health, University of Leeds, Leeds, United Kingdom, 4AbbVie, Inc., South San Francisco, CA, 5University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom

    Background/Purpose: Pulmonary Fibrosis (PF) is one of the primary causes of systemic sclerosis (SSc)-related death. Hence, monitoring and predicting the course of PF in SSc…
  • Abstract Number: 0615 • ACR Convergence 2023

    Prevalence of Barrett’s Esophagus in Patients with Systemic Sclerosis

    FNU Rida Ul Jannat1, Devanshu Verma1 and Laila Sakkal2, 1West Virginia University Hospital, Morgantown, WV, 2West Virginia University, Morgantown, WV

    Background/Purpose: Gastrointestinal manifestations of systemic sclerosis are common and include luminal dysmotility. Esophageal aperistalsis (scleroderma esophagus) presents with dysphagia and reflux; and can predispose patients…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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